SG10201708052XA - Increasing virus-like particle yield in plants - Google Patents

Increasing virus-like particle yield in plants

Info

Publication number
SG10201708052XA
SG10201708052XA SG10201708052XA SG10201708052XA SG10201708052XA SG 10201708052X A SG10201708052X A SG 10201708052XA SG 10201708052X A SG10201708052X A SG 10201708052XA SG 10201708052X A SG10201708052X A SG 10201708052XA SG 10201708052X A SG10201708052X A SG 10201708052XA
Authority
SG
Singapore
Prior art keywords
plants
particle yield
increasing virus
virus
increasing
Prior art date
Application number
SG10201708052XA
Inventor
Marc-Andre D'aoust
Manon Couture
Louis-Philippe Vezina
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of SG10201708052XA publication Critical patent/SG10201708052XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16251—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
SG10201708052XA 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants SG10201708052XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161541780P 2011-09-30 2011-09-30

Publications (1)

Publication Number Publication Date
SG10201708052XA true SG10201708052XA (en) 2017-11-29

Family

ID=47994080

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201708052XA SG10201708052XA (en) 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants
SG11201400712VA SG11201400712VA (en) 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201400712VA SG11201400712VA (en) 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants

Country Status (27)

Country Link
US (1) US11155581B2 (en)
EP (2) EP2760882B1 (en)
JP (1) JP6248040B2 (en)
KR (1) KR101974017B1 (en)
CN (2) CN103930435A (en)
AU (1) AU2012315421C1 (en)
BR (1) BR112014007474A2 (en)
CA (1) CA2850407C (en)
DK (1) DK2760882T5 (en)
ES (1) ES2951259T3 (en)
FI (1) FI2760882T3 (en)
HK (1) HK1200179A1 (en)
HR (1) HRP20230695T1 (en)
HU (1) HUE062759T2 (en)
IL (1) IL231587B (en)
IN (1) IN2014CN03077A (en)
MX (2) MX358883B (en)
MY (1) MY184072A (en)
NZ (1) NZ622731A (en)
PL (1) PL2760882T3 (en)
PT (1) PT2760882T (en)
RU (1) RU2682752C2 (en)
SG (2) SG10201708052XA (en)
SI (1) SI2760882T1 (en)
TW (1) TWI700368B (en)
WO (1) WO2013044390A1 (en)
ZA (1) ZA201403059B (en)

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CN112592389A (en) 2013-03-28 2021-04-02 莫迪卡戈公司 Production of influenza-like virus particles in plants
CN105980561B (en) * 2014-01-10 2020-06-02 莫迪卡戈公司 CPMV enhancer element
US10563213B2 (en) 2014-03-27 2020-02-18 Medicago Inc. Modified CPMV enhancer elements
CN112400021A (en) * 2018-03-14 2021-02-23 麦迪卡格公司 Plant expression enhancer
EP3814507A4 (en) * 2018-06-27 2022-07-06 Medicago Inc. Influenza virus hemagglutinin mutants
EP3938511A4 (en) * 2019-03-14 2023-02-08 Mitsubishi Tanabe Pharma Corporation Endogenous plant expression enhancer
WO2021236908A2 (en) * 2020-05-20 2021-11-25 Biomarin Pharmaceutical Inc. Use of regulatory proteins for the production of adeno-associated virus

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Also Published As

Publication number Publication date
SI2760882T1 (en) 2023-10-30
EP2760882A1 (en) 2014-08-06
CN116218900A (en) 2023-06-06
SG11201400712VA (en) 2014-04-28
KR20140068260A (en) 2014-06-05
ES2951259T3 (en) 2023-10-19
CN103930435A (en) 2014-07-16
DK2760882T3 (en) 2023-07-03
HRP20230695T1 (en) 2023-12-22
TWI700368B (en) 2020-08-01
IL231587B (en) 2020-06-30
EP3626733B1 (en) 2024-01-24
PT2760882T (en) 2023-08-07
MY184072A (en) 2021-03-17
IL231587A0 (en) 2014-05-28
WO2013044390A1 (en) 2013-04-04
TW201329235A (en) 2013-07-16
ZA201403059B (en) 2019-07-31
EP2760882A4 (en) 2015-06-10
RU2682752C2 (en) 2019-03-21
EP2760882B1 (en) 2023-05-24
HUE062759T2 (en) 2023-12-28
US11155581B2 (en) 2021-10-26
IN2014CN03077A (en) 2015-07-03
CA2850407C (en) 2021-11-23
MX2018006627A (en) 2020-11-12
AU2012315421A1 (en) 2014-04-10
JP6248040B2 (en) 2017-12-13
BR112014007474A2 (en) 2017-04-04
NZ622731A (en) 2016-04-29
CA2850407A1 (en) 2013-04-04
AU2012315421B2 (en) 2017-10-19
MX2014003776A (en) 2014-08-21
HK1200179A1 (en) 2015-07-31
JP2014530006A (en) 2014-11-17
RU2014116371A (en) 2015-11-10
US20150104480A1 (en) 2015-04-16
AU2012315421C1 (en) 2019-12-05
DK2760882T5 (en) 2024-06-24
EP3626733A1 (en) 2020-03-25
KR101974017B1 (en) 2019-04-30
FI2760882T3 (en) 2023-07-17
PL2760882T3 (en) 2023-09-11
MX358883B (en) 2018-08-31

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