BRPI0515649A - processo para preparação de composições de anticorpos altamente concentradas e processo para concentrar proteìnas - Google Patents

processo para preparação de composições de anticorpos altamente concentradas e processo para concentrar proteìnas

Info

Publication number
BRPI0515649A
BRPI0515649A BRPI0515649-1A BRPI0515649A BRPI0515649A BR PI0515649 A BRPI0515649 A BR PI0515649A BR PI0515649 A BRPI0515649 A BR PI0515649A BR PI0515649 A BRPI0515649 A BR PI0515649A
Authority
BR
Brazil
Prior art keywords
highly concentrated
concentrated antibody
antibody compositions
preparing highly
concentrating proteins
Prior art date
Application number
BRPI0515649-1A
Other languages
English (en)
Inventor
Charles Matthew Winter
Original Assignee
Genentech Inc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35996499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0515649(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc, Novartis Ag filed Critical Genentech Inc
Publication of BRPI0515649A publication Critical patent/BRPI0515649A/pt
Publication of BRPI0515649B1 publication Critical patent/BRPI0515649B1/pt
Publication of BRPI0515649B8 publication Critical patent/BRPI0515649B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/145Ultrafiltration
    • B01D61/146Ultrafiltration comprising multiple ultrafiltration steps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/16Feed pretreatment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/04Specific process operations in the feed stream; Feed pretreatment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/16Flow or flux control
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE COMPOSIçõES DE ANTICORPOS ALTAMENTE CONCENTRADAS E PROCESSO PARA CONCENTRAR PROTEINAS". A presente divulgação fornece um processo para concentrar proteínas incluindo ultrafiltração, diafiltração e uma segunda seqüência ultrafiltração, em temperaturas elevadas, tais como aproximadamente acima de 30<198>C. A divulgação inclui também um processo para preparar composições altamente concentradas de anticorpo e produtos de anticorpo altamente concentrados.
BRPI0515649A 2004-09-09 2005-09-08 Processo para preparação de composições de anticorpo monoclonal altamente concentradas BRPI0515649B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60909204P 2004-09-09 2004-09-09
US60/609,092 2004-09-09
US11/220,362 US20060051347A1 (en) 2004-09-09 2005-09-06 Process for concentration of antibodies and therapeutic products thereof
US11/220,362 2005-09-06
PCT/US2005/031844 WO2006031560A2 (en) 2004-09-09 2005-09-08 Process for concentration of antibodies and therapeutic products thereof

Publications (3)

Publication Number Publication Date
BRPI0515649A true BRPI0515649A (pt) 2008-07-29
BRPI0515649B1 BRPI0515649B1 (pt) 2021-10-13
BRPI0515649B8 BRPI0515649B8 (pt) 2021-11-03

Family

ID=35996499

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515649A BRPI0515649B8 (pt) 2004-09-09 2005-09-08 Processo para preparação de composições de anticorpo monoclonal altamente concentradas

Country Status (33)

Country Link
US (6) US20060051347A1 (pt)
EP (5) EP2292636B9 (pt)
JP (2) JP5210633B2 (pt)
KR (2) KR20070109975A (pt)
CN (3) CN104961797B (pt)
AR (1) AR050641A1 (pt)
AU (1) AU2005285243C1 (pt)
BR (1) BRPI0515649B8 (pt)
CA (1) CA2577317C (pt)
DK (5) DK1786830T3 (pt)
EC (1) ECSP077282A (pt)
ES (4) ES2528541T3 (pt)
FI (4) FI4104859T3 (pt)
GT (1) GT200500254A (pt)
HK (2) HK1101249A1 (pt)
HU (2) HUE061899T2 (pt)
IL (2) IL181372A (pt)
LT (4) LT3805248T (pt)
MA (1) MA28991B1 (pt)
MX (2) MX342788B (pt)
MY (2) MY162525A (pt)
NO (1) NO333660B1 (pt)
NZ (1) NZ553239A (pt)
PE (1) PE20060816A1 (pt)
PL (5) PL4104859T3 (pt)
PT (5) PT4104859T (pt)
RU (1) RU2390524C2 (pt)
SG (1) SG177161A1 (pt)
SI (5) SI4104859T1 (pt)
TN (1) TNSN07069A1 (pt)
TW (1) TWI372630B (pt)
WO (1) WO2006031560A2 (pt)
ZA (1) ZA200701626B (pt)

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