BRPI0012387B1 - uso 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e2, 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina f2a-metil éster, 11-dehidroxi-13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e1 e 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e1 na indução de secreção lacrimal em um paciente com distúrbios envolvendo hipossecreção lacrimal - Google Patents
uso 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e2, 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina f2a-metil éster, 11-dehidroxi-13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e1 e 13,14-diidro-15-ceto-16,16-diflúor-prostaglandina e1 na indução de secreção lacrimal em um paciente com distúrbios envolvendo hipossecreção lacrimal Download PDFInfo
- Publication number
- BRPI0012387B1 BRPI0012387B1 BRPI0012387A BR0012387A BRPI0012387B1 BR PI0012387 B1 BRPI0012387 B1 BR PI0012387B1 BR PI0012387 A BRPI0012387 A BR PI0012387A BR 0012387 A BR0012387 A BR 0012387A BR PI0012387 B1 BRPI0012387 B1 BR PI0012387B1
- Authority
- BR
- Brazil
- Prior art keywords
- keto
- dihydro
- prostaglandin
- difluor
- secretion
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| WO2003105823A1 (en) * | 2002-06-14 | 2003-12-24 | Alcon, Inc. | Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth |
| US20040076695A1 (en) * | 2002-07-08 | 2004-04-22 | Advanced Vision Research | EPA and DHA enriched omega-3 supplement for the treatment of dry eye, meibomianitis and xerostomia |
| US20040185075A1 (en) | 2003-01-31 | 2004-09-23 | Maria Dalko | Use of at least one (dihydro)jasmonic acid derivative for treating dry skin |
| FR2850571B1 (fr) * | 2003-01-31 | 2006-07-07 | Oreal | Utilisation d'un derive d'acide(dihydro) jasmonique pour le traitement des peaux seches |
| US20050208102A1 (en) * | 2003-04-09 | 2005-09-22 | Schultz Clyde L | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| US9216106B2 (en) * | 2003-04-09 | 2015-12-22 | Directcontact Llc | Device and method for the delivery of drugs for the treatment of posterior segment disease |
| US20050074497A1 (en) * | 2003-04-09 | 2005-04-07 | Schultz Clyde L. | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| CA2541302A1 (en) | 2003-10-06 | 2005-04-14 | Ophtecs Corporation | Ophthalmic composition for treating tear dysfunction |
| US7923471B2 (en) | 2004-05-14 | 2011-04-12 | Alcon, Inc. | Method of treating dry eye disorders and uveitis |
| US20070265341A1 (en) * | 2004-07-01 | 2007-11-15 | The Schepens Eye Research Institute Inc. | Compositions and methods for treating eye disorders and conditions |
| AU2005262392A1 (en) * | 2004-07-01 | 2006-01-19 | Johnson & Johnson Vision Care, Inc. | Compositions and methods for treating eye disorders and conditions |
| JP5147404B2 (ja) * | 2005-01-27 | 2013-02-20 | スキャンポ・アーゲー | 中枢神経系障害の処置のための方法および組成物 |
| AU2006219152B2 (en) * | 2005-03-04 | 2011-02-24 | Sucampo Ag | Method and composition for treating peripheral vascular diseases |
| US7638142B2 (en) * | 2005-10-12 | 2009-12-29 | Vitamin Science, Inc. | Therapeutic composition for the treatment of dry eye syndrome |
| BRPI0707333B8 (pt) | 2006-01-24 | 2021-05-25 | R Tech Ueno Ltd | composição farmacêutica que compreende um composto bicíclico, método de estabilização do composto bicíclico e formulação de cápsula de gelatina mole |
| WO2008108322A2 (en) * | 2007-02-27 | 2008-09-12 | Sucampo Ag | Composition and method for protecting mitochondria |
| US20090053309A1 (en) * | 2007-08-24 | 2009-02-26 | Axiomedic Ltd., Gibraltar | Adhesive compositions for the treatment of xerostomia |
| US9161909B2 (en) | 2007-08-24 | 2015-10-20 | Axiomedic Ltd. | Adhesive compositions for the treatment of xerostomia |
| US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
| US9884082B2 (en) | 2008-11-13 | 2018-02-06 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
| US9597278B2 (en) | 2008-11-13 | 2017-03-21 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
| EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| US8918181B2 (en) | 2010-11-16 | 2014-12-23 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treatment of dry eye |
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| US20210121430A1 (en) | 2011-07-18 | 2021-04-29 | Prn Physician Recommended Nutriceuticals, Llc | Omega-3 fatty acid supplementation for use in treating dry eye |
| US10709680B2 (en) | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| US9381183B2 (en) | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US9115078B2 (en) | 2011-07-18 | 2015-08-25 | Physicians Recommended Nutriceuticals, Llc | Compositions for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands |
| CA2842455A1 (en) * | 2011-08-05 | 2013-02-14 | Sucampo Ag | Method for treating schizophrenia |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| CN108744272A (zh) | 2013-04-19 | 2018-11-06 | 奥库利维公司 | 鼻刺激装置和方法 |
| KR20170074926A (ko) * | 2014-10-22 | 2017-06-30 | 오큘레브, 인크. | 안구 건조증을 치료하기 위한 자극 장치 및 방법 |
| US10918864B2 (en) | 2016-05-02 | 2021-02-16 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
| WO2019208435A1 (ja) | 2018-04-26 | 2019-10-31 | ライオン株式会社 | 外分泌促進剤 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4131651A (en) * | 1977-10-25 | 1978-12-26 | Barnes-Hind Pharmaceuticals, Inc. | Treatment of dry eye |
| US4409205A (en) * | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| IE49783B1 (en) | 1979-05-18 | 1985-12-11 | Efamol Ltd | Pharmaceutical and dietary composition comprising epsilon-linolenic acids |
| GB8319073D0 (en) * | 1983-07-14 | 1983-08-17 | Efamol Ltd | Fatty acid compositions |
| JPH07103096B2 (ja) * | 1987-01-28 | 1995-11-08 | 株式会社上野製薬応用研究所 | プロスタグランジンｄ類およびそれを含む鎮静・睡眠剤 |
| JPH0688966B2 (ja) * | 1987-01-28 | 1994-11-09 | 株式会社アールテック・ウエノ | プロスタグランジンｅ類およびそれを含む抗潰瘍剤 |
| DE3711164A1 (de) | 1987-04-02 | 1988-10-20 | Zeiss Carl Fa | Steckelementeinrichtung zur halterung von bauteilen in stapeln |
| CA1324129C (en) * | 1987-04-30 | 1993-11-09 | Ryuzo Ueno | Prostaglandins of the f series |
| JPS63277604A (ja) * | 1987-05-11 | 1988-11-15 | Showa Denko Kk | α−リノレン酸含有化粧料 |
| JPH0692305B2 (ja) * | 1987-05-15 | 1994-11-16 | 株式会社上野製薬応用研究所 | 体温上昇剤 |
| GB2209939B (en) * | 1987-09-18 | 1992-01-02 | R Tech Ueno Ltd | The use of 13,14-dihydro-15-keto-prostaglandins as ocular hypotensive agents |
| SU1673123A1 (ru) * | 1987-12-04 | 1991-08-30 | Научно-исследовательский институт морфологии человека АМН СССР | Способ лечени болезни и синдрома Шегрена |
| JP2579193B2 (ja) | 1988-07-19 | 1997-02-05 | 小野薬品工業株式会社 | １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体 |
| WO1990001323A1 (en) | 1988-08-12 | 1990-02-22 | Bernstein Joel E | Method and composition for treating and preventing dry skin disorders |
| CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
| TW249226B (enExample) * | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| JPH07100655B2 (ja) * | 1990-04-04 | 1995-11-01 | 株式会社アールテック・ウエノ | 白内障処置剤 |
| DE69130586T2 (de) * | 1990-05-01 | 1999-06-17 | R-Tech Ueno, Ltd., Osaka | Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten |
| JPH07113012B2 (ja) * | 1991-01-29 | 1995-12-06 | 株式会社アールテック・ウエノ | 新規１５−ケト−プロスタグランジン類 |
| ATE141794T1 (de) * | 1991-03-14 | 1996-09-15 | R Tech Ueno Ltd | Stimulierung von wundheilung mit 15-keto- prostaglandinverbindungen |
| US5369127A (en) | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
| JP3183615B2 (ja) * | 1994-06-03 | 2001-07-09 | 株式会社アールテック・ウエノ | 肝・胆道系疾患処置剤 |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| TW420611B (en) * | 1995-03-10 | 2001-02-01 | R Tech Ueno Ltd | Pharmaceutical composition containing prostanoic acid compounds for the treatment of optic nerve disorder |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| AU2183900A (en) | 1998-12-24 | 2000-07-31 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
| WO2000038690A2 (en) * | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of dry eye |
| JP5147404B2 (ja) * | 2005-01-27 | 2013-02-20 | スキャンポ・アーゲー | 中枢神経系障害の処置のための方法および組成物 |
| AU2006219152B2 (en) * | 2005-03-04 | 2011-02-24 | Sucampo Ag | Method and composition for treating peripheral vascular diseases |
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2000
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- 2000-07-13 US US09/615,703 patent/US6566398B1/en not_active Expired - Lifetime
- 2000-07-13 HK HK03100518.0A patent/HK1048443B/en not_active IP Right Cessation
- 2000-07-13 JP JP2001510445A patent/JP4167828B2/ja not_active Expired - Fee Related
- 2000-07-13 DE DE60031710T patent/DE60031710T2/de not_active Expired - Lifetime
- 2000-07-13 CN CN200910205219A patent/CN101695495A/zh active Pending
- 2000-07-13 BR BRPI0012387A patent/BRPI0012387B1/pt not_active IP Right Cessation
- 2000-07-13 IL IL14744000A patent/IL147440A0/xx unknown
- 2000-07-13 CZ CZ20020133A patent/CZ303958B6/cs not_active IP Right Cessation
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- 2000-07-13 AT AT00944426T patent/ATE344027T1/de active
- 2000-07-13 PT PT00944426T patent/PT1223925E/pt unknown
- 2000-07-13 HU HU0202400A patent/HU229318B1/hu not_active IP Right Cessation
- 2000-07-13 AU AU58533/00A patent/AU779936B2/en not_active Ceased
- 2000-07-13 TR TR2002/00065T patent/TR200200065T2/xx unknown
- 2000-07-13 CA CA2377661A patent/CA2377661C/en not_active Expired - Lifetime
- 2000-07-13 CN CN00810238A patent/CN1399548A/zh active Pending
- 2000-07-13 MX MXPA02000437A patent/MXPA02000437A/es active IP Right Grant
- 2000-07-13 RU RU2002103597/15A patent/RU2264816C2/ru not_active IP Right Cessation
- 2000-07-13 WO PCT/JP2000/004696 patent/WO2001005388A2/en not_active Ceased
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- 2000-07-13 DK DK00944426T patent/DK1223925T3/da active
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- 2000-07-14 AR ARP000103635A patent/AR029381A1/es not_active Application Discontinuation
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2003
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2004
- 2004-11-23 US US10/994,364 patent/US7396946B2/en not_active Expired - Fee Related
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2008
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