AR074465A2 - Uso de derivados de acidos grasos para tratamiento de desordenes de secrecion externa - Google Patents
Uso de derivados de acidos grasos para tratamiento de desordenes de secrecion externaInfo
- Publication number
- AR074465A2 AR074465A2 ARP090104665A ARP090104665A AR074465A2 AR 074465 A2 AR074465 A2 AR 074465A2 AR P090104665 A ARP090104665 A AR P090104665A AR P090104665 A ARP090104665 A AR P090104665A AR 074465 A2 AR074465 A2 AR 074465A2
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- hydroxyl
- lower alkyl
- csc
- oxo
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Uso de un compuesto derivado de ácido graso que está representado por la fórmula general (1) en donde L y M son hidrógeno, hidroxilo, halógeno, alquilo inferior, hidroxialquilo (inferior) u oxo, en donde por lo menos uno de L y M es un grupo distinto do hidrógeno, y el anillo de cinco miembros puede tener al menos un enlace doble; A es -CH2OH, -COCH2OH, -COOH o su derivado funcional; B es un enlace simple, -CH2-CH2-, -CH=CH-, -CsC-, -CH2-CH2-CH2-, -CH=CH-CH2-, -CH2-CH=CH-, -CsC-CH2-, o -CH2-CsC-; Z se selecciona del grupo de fórmulas (2), en donde R4 y R5 son H, hidroxilo, halógeno, alquilo inferior, alcoxilo inferior o hidroxialquilo (inferior), en donde R4 y R5 no son hidroxilo y alcoxilo inferior al mismo tiempo; X1 y X2 son hidrógeno, alquilo inferior o halógeno; R1 es un residuo de hidrocarburo alifático medio-inferior no saturado o suturado divalente que es sustituido o no sustituido por halógeno, oxo, hidroxilo alquilo inferior, arilo o heterocíclico; R2 es un enlace simple o alquileno inferior; y R3 es alquilo inferior, alcoxilo inferior, cicloalquilo (inferior), cicloalquiloxilo (inferior), arilo, ariloxilo, heterocíclico o heterocíclico-oxilo, con la provisión que Z es oxo y/o al menos uno de X1 y X2 es halógeno, excluyendo el compuesto 11-deshidroxi-13,14-dihidro-15-ceto-16,16-difluoro PGE1, sus sales, éteres, ésteres y amidas del mismo, el cual es para preparar una composición farmacéutica para inducir la secreción externa en un paciente con desórdenes de la secreción externa. Reivindicación 2: El uso de acuerdo con la reivindicación 1, caracterizado porque dicho desorden externo es el síndrome de ojo seco. Reivindicación 5: El uso de acuerdo con la reivindicación 1, caracterizado porque dicho desorden externo es hiposalivación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14362799P | 1999-07-14 | 1999-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074465A2 true AR074465A2 (es) | 2011-01-19 |
Family
ID=22504885
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103635A AR029381A1 (es) | 1999-07-14 | 2000-07-14 | Composicion para tratamiento de los desordenes de secrecion externa, metodo que la emplea y uso de un derivado de acido graso para prepararla |
| ARP090104665A AR074465A2 (es) | 1999-07-14 | 2009-12-03 | Uso de derivados de acidos grasos para tratamiento de desordenes de secrecion externa |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103635A AR029381A1 (es) | 1999-07-14 | 2000-07-14 | Composicion para tratamiento de los desordenes de secrecion externa, metodo que la emplea y uso de un derivado de acido graso para prepararla |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6566398B1 (es) |
| EP (1) | EP1223925B1 (es) |
| JP (2) | JP4167828B2 (es) |
| KR (1) | KR100750553B1 (es) |
| CN (4) | CN1399548A (es) |
| AR (2) | AR029381A1 (es) |
| AT (1) | ATE344027T1 (es) |
| AU (1) | AU779936B2 (es) |
| BR (1) | BRPI0012387B1 (es) |
| CA (1) | CA2377661C (es) |
| CZ (1) | CZ303958B6 (es) |
| DE (1) | DE60031710T2 (es) |
| DK (1) | DK1223925T3 (es) |
| ES (1) | ES2273706T3 (es) |
| HK (1) | HK1048443B (es) |
| HU (1) | HU229318B1 (es) |
| IL (2) | IL147440A0 (es) |
| MX (1) | MXPA02000437A (es) |
| NO (1) | NO323908B1 (es) |
| PT (1) | PT1223925E (es) |
| RU (1) | RU2264816C2 (es) |
| TR (1) | TR200200065T2 (es) |
| TW (1) | TWI225398B (es) |
| WO (1) | WO2001005388A2 (es) |
| ZA (1) | ZA200109726B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| US20030232858A1 (en) * | 2002-06-14 | 2003-12-18 | Barker Ronnie C. | Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth |
| US20040076695A1 (en) * | 2002-07-08 | 2004-04-22 | Advanced Vision Research | EPA and DHA enriched omega-3 supplement for the treatment of dry eye, meibomianitis and xerostomia |
| US20040185075A1 (en) | 2003-01-31 | 2004-09-23 | Maria Dalko | Use of at least one (dihydro)jasmonic acid derivative for treating dry skin |
| FR2850571B1 (fr) * | 2003-01-31 | 2006-07-07 | Oreal | Utilisation d'un derive d'acide(dihydro) jasmonique pour le traitement des peaux seches |
| US20050074497A1 (en) * | 2003-04-09 | 2005-04-07 | Schultz Clyde L. | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| US9216106B2 (en) * | 2003-04-09 | 2015-12-22 | Directcontact Llc | Device and method for the delivery of drugs for the treatment of posterior segment disease |
| US20050208102A1 (en) * | 2003-04-09 | 2005-09-22 | Schultz Clyde L | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| CA2541302A1 (en) | 2003-10-06 | 2005-04-14 | Ophtecs Corporation | Ophthalmic composition for treating tear dysfunction |
| US7923471B2 (en) | 2004-05-14 | 2011-04-12 | Alcon, Inc. | Method of treating dry eye disorders and uveitis |
| US20070265341A1 (en) * | 2004-07-01 | 2007-11-15 | The Schepens Eye Research Institute Inc. | Compositions and methods for treating eye disorders and conditions |
| US20060009522A1 (en) * | 2004-07-01 | 2006-01-12 | Reza Dana | Compositions and methods for treating eye disorders and conditions |
| ES2375082T3 (es) * | 2005-01-27 | 2012-02-24 | Sucampo Ag | Composición para el tratamiento de trastornos del sistema nervioso central. |
| JP5213448B2 (ja) * | 2005-03-04 | 2013-06-19 | スキャンポ・アーゲー | 末梢血管疾患の処置のための方法および組成物 |
| US7638142B2 (en) * | 2005-10-12 | 2009-12-29 | Vitamin Science, Inc. | Therapeutic composition for the treatment of dry eye syndrome |
| EP1984027B1 (en) | 2006-01-24 | 2015-12-30 | R-Tech Ueno, Ltd. | Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound |
| US20080207759A1 (en) * | 2007-02-27 | 2008-08-28 | Sucampo Ag | Method for protecting mitochondria |
| US20090053309A1 (en) * | 2007-08-24 | 2009-02-26 | Axiomedic Ltd., Gibraltar | Adhesive compositions for the treatment of xerostomia |
| US9161909B2 (en) | 2007-08-24 | 2015-10-20 | Axiomedic Ltd. | Adhesive compositions for the treatment of xerostomia |
| US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
| US9884082B2 (en) | 2008-11-13 | 2018-02-06 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
| US9597278B2 (en) | 2008-11-13 | 2017-03-21 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
| EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| ES2739490T3 (es) | 2010-11-16 | 2020-01-31 | Univ Leland Stanford Junior | Sistemas para el tratamiento del ojo seco |
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| US9115078B2 (en) | 2011-07-18 | 2015-08-25 | Physicians Recommended Nutriceuticals, Llc | Compositions for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands |
| US9381183B2 (en) | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US10709680B2 (en) | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| US20210121430A1 (en) | 2011-07-18 | 2021-04-29 | Prn Physician Recommended Nutriceuticals, Llc | Omega-3 fatty acid supplementation for use in treating dry eye |
| US8592483B2 (en) * | 2011-08-05 | 2013-11-26 | Sucampo Ag | Method for treating schizophrenia |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| NZ704579A (en) | 2013-04-19 | 2018-10-26 | Oculeve Inc | Nasal stimulation devices and methods |
| RU2707167C2 (ru) | 2014-10-22 | 2019-11-22 | Окулив, Инк. | Устройства для стимуляции и способы лечения болезни "сухого глаза" |
| EP3452166A4 (en) | 2016-05-02 | 2019-12-18 | Oculeve, Inc. | INTRANASAL STIMULATION FOR THE TREATMENT OF DISEASES OF MEIBOM'S GLANDS AND BLEPHARITIS |
| JP7300446B2 (ja) | 2018-04-26 | 2023-06-29 | ライオン株式会社 | 外分泌促進剤 |
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| JP3183615B2 (ja) * | 1994-06-03 | 2001-07-09 | 株式会社アールテック・ウエノ | 肝・胆道系疾患処置剤 |
| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| TW420611B (en) * | 1995-03-10 | 2001-02-01 | R Tech Ueno Ltd | Pharmaceutical composition containing prostanoic acid compounds for the treatment of optic nerve disorder |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| WO2000038690A2 (en) * | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of dry eye |
| AU2183900A (en) * | 1998-12-24 | 2000-07-31 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
| ES2375082T3 (es) * | 2005-01-27 | 2012-02-24 | Sucampo Ag | Composición para el tratamiento de trastornos del sistema nervioso central. |
| JP5213448B2 (ja) * | 2005-03-04 | 2013-06-19 | スキャンポ・アーゲー | 末梢血管疾患の処置のための方法および組成物 |
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2000
- 2000-07-12 TW TW089113876A patent/TWI225398B/zh not_active IP Right Cessation
- 2000-07-13 CN CN00810238A patent/CN1399548A/zh active Pending
- 2000-07-13 AT AT00944426T patent/ATE344027T1/de active
- 2000-07-13 DE DE60031710T patent/DE60031710T2/de not_active Expired - Lifetime
- 2000-07-13 HU HU0202400A patent/HU229318B1/hu not_active IP Right Cessation
- 2000-07-13 TR TR2002/00065T patent/TR200200065T2/xx unknown
- 2000-07-13 CN CN200910205219A patent/CN101695495A/zh active Pending
- 2000-07-13 PT PT00944426T patent/PT1223925E/pt unknown
- 2000-07-13 CN CN2010101574518A patent/CN101829120B/zh not_active Expired - Fee Related
- 2000-07-13 IL IL14744000A patent/IL147440A0/xx unknown
- 2000-07-13 WO PCT/JP2000/004696 patent/WO2001005388A2/en not_active Application Discontinuation
- 2000-07-13 CA CA2377661A patent/CA2377661C/en not_active Expired - Lifetime
- 2000-07-13 BR BRPI0012387A patent/BRPI0012387B1/pt not_active IP Right Cessation
- 2000-07-13 JP JP2001510445A patent/JP4167828B2/ja not_active Expired - Fee Related
- 2000-07-13 EP EP00944426A patent/EP1223925B1/en not_active Expired - Lifetime
- 2000-07-13 RU RU2002103597/15A patent/RU2264816C2/ru not_active IP Right Cessation
- 2000-07-13 CZ CZ20020133A patent/CZ303958B6/cs not_active IP Right Cessation
- 2000-07-13 AU AU58533/00A patent/AU779936B2/en not_active Ceased
- 2000-07-13 DK DK00944426T patent/DK1223925T3/da active
- 2000-07-13 KR KR1020027000471A patent/KR100750553B1/ko active IP Right Grant
- 2000-07-13 ES ES00944426T patent/ES2273706T3/es not_active Expired - Lifetime
- 2000-07-13 MX MXPA02000437A patent/MXPA02000437A/es active IP Right Grant
- 2000-07-13 CN CNB2006101215152A patent/CN100548977C/zh not_active Expired - Fee Related
- 2000-07-13 US US09/615,703 patent/US6566398B1/en not_active Expired - Lifetime
- 2000-07-14 AR ARP000103635A patent/AR029381A1/es not_active Application Discontinuation
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2001
- 2001-11-27 ZA ZA200109726A patent/ZA200109726B/en unknown
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2002
- 2002-01-02 IL IL147440A patent/IL147440A/en active IP Right Grant
- 2002-01-11 NO NO20020133A patent/NO323908B1/no not_active IP Right Cessation
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2003
- 2003-01-21 HK HK03100518.0A patent/HK1048443B/zh not_active IP Right Cessation
- 2003-03-04 US US10/377,743 patent/US20030171438A1/en not_active Abandoned
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2004
- 2004-11-23 US US10/994,364 patent/US7396946B2/en not_active Expired - Fee Related
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2008
- 2008-06-24 JP JP2008164252A patent/JP5052423B2/ja not_active Expired - Fee Related
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2009
- 2009-12-03 AR ARP090104665A patent/AR074465A2/es not_active Application Discontinuation
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