JP7300446B2 - 外分泌促進剤 - Google Patents
外分泌促進剤 Download PDFInfo
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- JP7300446B2 JP7300446B2 JP2020516311A JP2020516311A JP7300446B2 JP 7300446 B2 JP7300446 B2 JP 7300446B2 JP 2020516311 A JP2020516311 A JP 2020516311A JP 2020516311 A JP2020516311 A JP 2020516311A JP 7300446 B2 JP7300446 B2 JP 7300446B2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
Description
角層水分量増加剤として、松樹皮抽出物、ヒアルロン酸及びセラミドを有効成分とする技術(例えば、特許文献1参照)や、キツネノマゴの抽出物を有効成分とする技術(例えば、特許文献2参照)が提案されている。
涙液分泌と唾液分泌の両方の増加を目的として、PAR-2活性化作用を有するペプチド誘導体を有効成分とする技術(例えば、特許文献3参照)や、脂肪酸誘導体を有効成分とする技術が提案されている(例えば、特許文献4参照)。
即ち、本発明者らは、下記の〔1〕~〔7〕を提供する。
〔1〕下記一般式(1)で表される化合物を有効成分とする外分泌促進剤。
〔2〕前記一般式(1)中、R4及びR6の少なくとも一方として表される-C6H11O5基が、テトラヒドロピラン骨格を有する基である上記〔1〕に記載の外分泌促進剤。
〔3〕前記一般式(1)中、R4及びR6の少なくとも一方として表される-C6H11O5基が、4つの水酸基を有する基である上記〔1〕又は〔2〕に記載の外分泌促進剤。
〔4〕下記一般式(2)で表される化合物で表される化合物をさらに含有し、前記一般式(1)で表される化合物に対する前記一般式(2)で表される化合物の比率(一般式(2)で表される化合物/一般式(1)で表される化合物)が、0.001~1である上記〔1〕~〔3〕のいずれかに記載の外分泌促進剤。
〔6〕角層水分量増加剤、唾液分泌促進剤、又は涙液分泌促進剤である上記〔1〕~〔5〕のいずれかに記載の外分泌促進剤。
〔7〕上記〔1〕~〔6〕のいずれかに記載の外分泌促進剤を含む外分泌促進用食品組成物。
本発明の外分泌促進剤、より詳細には、角層水分量増加剤、唾液分泌促進剤、及び涙液分泌促進剤は、一般式(1)で表される化合物を共通の有効成分とする。
これらの中でも、R1~R3、R5及びR7は、(水酸基、水酸基、水素原子、水酸基、水酸基)の組み合わせが好ましい。
R4及びR6の少なくとも一方が-C6H11O5基であるC-配糖体は、O-配糖体と比較して、配糖体部が腸で切れにくく、配糖体が結合したまま血中に巡ると考えられる。また、式(1)のO-配糖体は、抗酸化能力を持つことが知られており、C-配糖体になることでその効果が強く現れるものと考えられる。
一般式(1)で表される化合物の1日当たりの摂取量は、0.001~1000mgが好ましく、0.05~100mgがより好ましく、0.1~50mgがさらに好ましく、0.2~10mgがさらにより好ましい。
なお、一般式(1)で表される化合物は、有効成分として、1種単独でもよく、2種以上を併用してもよい。
本発明の外分泌促進剤、より詳細には、角層水分量増加剤、唾液分泌促進剤、涙液分泌促進剤(以下、総称して単に「剤」とも記載する)は、上記一般式(1)で表される化合物を有効成分とする。
上記した効能を考慮すれば、本発明の外分泌促進剤、より詳細には、角層水分量増加剤、唾液分泌促進剤、涙液分泌促進剤は、それぞれ、肌乾燥改善剤、口腔乾燥改善剤、眼乾燥改善剤として利用を期待し得る。
一般式(2)で表される化合物を上記有効成分の助剤として含有する場合、一般式(1)で表される化合物に対する一般式(2)で表される化合物の比率(一般式(2)で表される化合物/一般式(1)で表される化合物)は、0.001~1が好ましい。比率の範囲が斯かる範囲内であると、本発明の効果をさらに向上し得る。比率の上限値は、0.3以下が好ましく、0.2以下がより好ましく、0.1以下がさらに好ましい。また、下限値は、0.002以上が好ましく、0.01以上がより好ましく、0.04以上がさらに好ましい。なお、一般式(2)で表される化合物を上記有効成分の助剤として含有する場合、比率が1超であると、一般式(1)で表される化合物の有効成分としての効果を顕著に低下させる場合がある。
中でも、カプセル中の粉末又は濃縮液であるピルの形態;粉末茶を飲むのと同様に、水やお湯等の液体に入れたり又は溶かしたりした後で摂取され得る粉末形態;フリーズドライ顆粒等の顆粒形態;チュアブル状等のタブレット形態で摂取(投与)することが好ましい。
本発明の剤は、そのまま摂取(投与)してもよい。また、本発明の剤は、飲食品や機能性食品、組成物に、涙液分泌促進作用、眼精疲労予防・改善作用及び眼の調節力低下予防・改善作用、唾液量増加作用、並びに涙液量増加作用からなる群から選ばれる少なくとも1つの作用を付与するための添加剤としても使用し得る。
下記の評価試験で使用したチュアブル錠剤、プラセボ錠剤の調製方法を記載する。化合物A~Dを0.05mg~1mg、デキストリン(パインデックス#2、松谷化学工業社製)49~49.95mg(化合物A~D量に合わせ変動し、総量を50mgとする。)、エリスリトール(「エリスリトール50M」、物産フードサイエンス社製)100mg、結晶セルロース(「セオラスST-100」、旭化成社製)90mg、ステアリン酸カルシウム(「ステアリン酸カルシウム」、太平化学産業社製)10mgを均一に混合し、12kNで直打して錠剤を調製した。但し、プラセボ錠剤の場合、化合物A~Dを0mgとし、代わりにデキストリンを50mgとする。
被験者10名に、化合物A~Dをそれぞれ0.3mg単独で配合したチュアブル錠剤、化合物BとDをそれぞれ0.3mgずつ配合したチュアブル錠剤、及び化合物A~D非配合のプラセボ錠を摂取させた。被験者は、摂取から測定終了まで21±2℃、50±5%RHの恒温室で過ごし、摂取前と摂取120分後に、右腕内腕部の角層水分量を、SKICON-200(IBS社製)を用いて測定した。角層水分量は、皮膚表面より約30μm深部(主に角層)に微弱な電気を流し、抵抗値を測定することで得られる。但し、血管部は除外するものとする。摂取前と摂取120分後の角質水分量の変化量を算出した。変化量の平均値の結果を図1及び表1に記す。
同被験者10名に、化合物Dをそれぞれ0.05mg~1mg配合したチュアブル錠剤を摂取させた。評価試験1と同じ状況で過ごしてもらい、摂取120分後の角層水分量を同様の方法にて測定した。摂取前と摂取120分後の角質水分量の変化量を算出した。変化量の平均値の結果を図2及び表2に記す。
被験者10名に、化合物Dを0.3mg配合したチュアブル錠剤とプラセボ錠を1日1回、1週間摂取させた。摂取開始1日目、3日目、7日目に肌乾燥感の改善度について、VAS(Visual Analogue Scale)法(Ahlsio B,Britton M,Murray V,Theorell T;Disablement and quality of life after stroke Stroke 15:886-890,1984.参照)にて評価した。回答は、摂取前に比べ肌の乾燥感が「非常に改善した」場合を100とし、「まったく改善しなかった」場合を0とし、各被験者の改善度をその間の数値で自己評価した。数値の平均値の結果を図3及び表3に記す。
被験者10名に、化合物A~Dをそれぞれ0.3mg単独で配合したチュアブル錠剤、化合物BとDをそれぞれ0.3mgずつ配合したチュアブル錠剤、及び化合物A~D非配合のプラセボ錠を摂取させた。被験者は、摂取から測定終了まで21±2℃、50±5%RHの恒温室で過ごし、摂取前と摂取120分後に、安静にした状態で10分間唾液を吐出させた。但し、測定1時間前よりオーラルアクティビティは禁じた。摂取前と摂取120分後の唾液量の変化量を測定した。変化量の平均値の結果を図4及び表4に記す。
評価試験4の試験の後、光干渉断層計(RS-3000 Advance、ニデック社製)を用い、2回瞬目後の2秒後に瞳孔下の角膜-下瞼間に貯留した涙液のメニスカス高を測定した。但し、測定1時間前よりオーラルアクティビティは禁じた。摂取前と摂取120分後の涙液メニスカス高の変化量を測定した。変化量の平均値の結果を図5及び表5に記す。
また、図5及び表5からわかるように、化合物B~Dをそれぞれ0.3mg単独で配合したチュアブル錠剤を摂取すると、被験者の涙液メニスカス高が増加した。また、化合物BとDをそれぞれ0.3mgずつ配合したチュアブル錠剤を摂取すると、被験者の涙液メニスカス高増加効果が顕著に向上した。一方、プラセボ錠及び化合物Aを0.3mg配合したチュアブル錠剤には、涙液メニスカス高の増加効果が認められなかった。
同被験者10名に、チュアブル錠剤について、化合物Dをそれぞれ0.05mg~1mg配合したこと以外は、評価試験4と同様にして唾液量の変化量を測定した。変化量の平均値の結果を図6及び表6に記す。
同被験者10名に、チュアブル錠剤について、化合物Dをそれぞれ0.05mg~1mg配合したこと以外は、評価試験5と同様にして涙液メニスカス高の変化量を測定した。変化量の平均値の結果を図7及び表7に記す。
また、図7及び表7からわかるように、0.05mg以上の化合物Dを配合したチュアブル錠剤を摂取すると、被験者の涙液メニスカス高の増加効果が認められた。また、0.1mg以上の化合物Dを配合したチュアブル錠剤を摂取すると、被験者の顕著な涙液メニスカス高の増加効果が認められた。
被験者12名に、化合物Dを0.3mg配合したチュアブル錠剤とプラセボ錠を1日1回、1週間摂取させた。摂取開始1日目、3日目、7日目に口腔乾燥感の改善度についてVAS(Visual Analogue Scale)法にて評価した。回答は、摂取前に比べ、口腔内の乾燥感が「非常に改善した」場合を100とし、「まったく改善しなかった」を0とし、各被験者の改善度をその間の数値で自己評価した。数値の平均値の結果を図8及び表8に記す。
被験者12名に、化合物Dを0.3mg配合したチュアブル錠剤とプラセボ錠を1日1回、1週間摂取させた。摂取開始1日目、3日目、7日目に眼乾燥感の改善度についてVAS(Visual Analogue Scale)法にて評価した。回答は、摂取前に比べ、眼の乾燥感が「非常に改善した」場合を100とし、「まったく改善しなかった」を0とし、各被験者の改善度をその間の数値で自己評価した。数値の平均値の結果を図9及び表9に記す。
また、図9及び表9からわかるように、化合物Dを0.3mg配合したチュアブル錠剤を摂取すると、眼乾燥感は、1日で改善が見られた。また、同錠剤を3日以上摂取し続けると、顕著な眼乾燥感の改善効果が確認された。
なお、処方例に用いた化合物(1)~(5)を表10に記す。表10中、R1~R7は、下記一般式(1)のR1~R7に対応する。-C6H11O5基は、下記式(3)で表される立体構造である。
化合物(1) 0.3mg
デキストリン 49.7mg
エリスリトール 100mg
結晶セルロース 90mg
ステアリン酸カルシウム 10mg
合計 250mg
化合物(1) 0.3mg
化合物(2) 0.3mg
デキストリン 49.4mg
エリスリトール 100mg
結晶セルロース 90mg
ステアリン酸カルシウム 10mg
合計 250mg
化合物(3) 0.3mg
化合物(4) 0.3mg
デキストリン 49.4mg
エリスリトール 100mg
結晶セルロース 90mg
ステアリン酸カルシウム 10mg
合計 250mg
化合物(2) 0.3mg
化合物(5) 0.3mg
デキストリン 49.4mg
エリスリトール 100mg
結晶セルロース 90mg
ステアリン酸カルシウム 10mg
合計 250mg
化合物(3) 0.3mg
化合物(5) 0.3mg
黒糖ぶどう糖液糖 250mg
エリスリトール 200mg
甘味料製剤 1.4mg
アスコルビン酸 3mg
香料 12mg
リコピンベース 8mg
精製水 適量
合計 10g
被験者10名に、化合物Dを0.2mg及び化合物Eをそれぞれ0.001mg~0.4mg配合したチュアブル錠剤を摂取させた。評価試験1と同じ状況で過ごしてもらい、摂取120分後の角層水分量を同様の方法にて測定した。摂取前と摂取120分後の角質水分量の変化量を算出した。変化量の平均値の結果を図10及び表11に記す。
被験者10名に、化合物Dを0.2mg及び化合物Eをそれぞれ0.001mg~0.4mg配合したチュアブル錠剤を摂取させた。評価試験4と同様にして唾液量の変化量を測定した。変化量の平均値の結果を図11及び表12に記す。
被験者10名に、化合物Dを0.2mg及び化合物Eをそれぞれ0.001mg~0.4mg配合したチュアブル錠剤を摂取させた。評価試験5と同様にして涙液メニスカス高の変化量を測定した。変化量の平均値の結果を図12及び表13に記す。
Claims (8)
- 前記一般式(1)で表される化合物がS体である、請求項1~3のいずれか1項に記載の剤。
- 前記一般式(1)で表される化合物の1日当たりの摂取量が、0.001~1000mgであり、3日間以上摂取する請求項1~3のいずれか1項に記載の剤。
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