AR005868A1 - Compuesto derivado de azo- y diazocicloheptano y -cicloctano sustituido, composición farmacologica que lo contiene y uso del mismo - Google Patents

Compuesto derivado de azo- y diazocicloheptano y -cicloctano sustituido, composición farmacologica que lo contiene y uso del mismo

Info

Publication number
AR005868A1
AR005868A1 ARP970100120A ARP970100120A AR005868A1 AR 005868 A1 AR005868 A1 AR 005868A1 AR P970100120 A ARP970100120 A AR P970100120A AR P970100120 A ARP970100120 A AR P970100120A AR 005868 A1 AR005868 A1 AR 005868A1
Authority
AR
Argentina
Prior art keywords
ring
substituted
alkyl
radical
alkylene group
Prior art date
Application number
ARP970100120A
Other languages
English (en)
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR005868A1 publication Critical patent/AR005868A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)

Abstract

Compuestos azo- y diazocicloheptano y -cicloctano que poseen la fórmula (I) : Ar1-A-B-Ar2, donde Ar1 es (II) o (III) o un anillo heteroaromático de 5 o6 miembros con 1, 2 o 3 heteroátomos que se seleccionan, independientemente entre sí de O, N,y S; donde Ar1 puede tener 1, 2, 3 o 4 sustituyentes que seseleccionan independientemente entre si, de OR1, un alquilo sustituido o no, o un alquenilo de C2-C6, un alquinilo de C2-C6, un cicloalquilo, entre otros,donde R1 es H, un alquilosustituido o no, por OH, OC1-C6-alquilo, fenilo o un halógeno; A es un grupo alquileno de C3-C15 cuando Ar1 es C6H5CONH o biencuando Ar1 es un anillo heteroatómico de 5 o 6 miembros es un grupo alquileno de C4-C15 o un grupo alquileno deC3-C15; B es un anillo saturado de 7 u 8miembros con uno o dos heteroátomos de nitrógeno los que se ubican en la posición 1,4 o 1,5 y el anillo está unido en la posición 1 al radical A y enla posición 4 o 5 al radical Ar2, y además es posibleque el anillo po sea un doble enlace en la posición 3 o 4 en el anillo monoazo y en la posición 6 enel anillo 1,4-diazo; Ar2 es un fenilo, piridilo, piridinilo o triazinilo, siendo posible que Ar2 tenga 1, 2, 3 o 4 sustituyentes que seseleccionan,independie ntemente entre sí, de OR, un alquilo, un alquenilo de C2-C6, un alquinilo de C2-C6, alcoxialquilo, haloalquilo, halógeno, entre otros y Ar1también se puede fusionar con un anillo carbocíclico, y donde Ar2 no puedeser un radical pirimidini lo sustituido por 2 grupos hidroxilo; así como lassales de los mismos formados con ácidos tolerables fisiológicamente, que poseen una alta afinidad por el receptor de dopamina D3 y por lo tanto puedenemplearse paratratar los trastornos que re sponden a lo ligandos del receptor de dopamina D3, mediante el uso de una composición farmacéutica que lo contiene
ARP970100120A 1996-01-12 1997-01-13 Compuesto derivado de azo- y diazocicloheptano y -cicloctano sustituido, composición farmacologica que lo contiene y uso del mismo AR005868A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19600934A DE19600934A1 (de) 1996-01-12 1996-01-12 Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung

Publications (1)

Publication Number Publication Date
AR005868A1 true AR005868A1 (es) 1999-07-21

Family

ID=7782613

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100120A AR005868A1 (es) 1996-01-12 1997-01-13 Compuesto derivado de azo- y diazocicloheptano y -cicloctano sustituido, composición farmacologica que lo contiene y uso del mismo

Country Status (26)

Country Link
US (2) US6214822B1 (es)
EP (1) EP0877744B1 (es)
JP (1) JP4349657B2 (es)
KR (1) KR100441073B1 (es)
CN (2) CN1075070C (es)
AR (1) AR005868A1 (es)
AT (1) ATE273301T1 (es)
AU (1) AU717726B2 (es)
BG (1) BG64098B1 (es)
CA (1) CA2241787C (es)
CO (1) CO4790173A1 (es)
CZ (1) CZ297981B6 (es)
DE (2) DE19600934A1 (es)
ES (1) ES2225947T3 (es)
HR (1) HRP970021A2 (es)
HU (1) HU228457B1 (es)
IL (1) IL125076A (es)
MX (1) MX9805499A (es)
NO (1) NO316753B1 (es)
NZ (1) NZ326332A (es)
PL (1) PL327692A1 (es)
SK (1) SK284987B6 (es)
TR (1) TR199801302T2 (es)
TW (1) TW475929B (es)
WO (1) WO1997025324A1 (es)
ZA (1) ZA97209B (es)

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DE19728996A1 (de) * 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
EA200100428A1 (ru) 1998-10-08 2001-10-22 Смитклайн Бичам Плс Производные тетрагидробензазепина, полезные в качестве модуляторов допаминовых d3 рецепторов (антипсихотические агенты)
AR022229A1 (es) * 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion
DE19922443A1 (de) * 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
US20030087917A1 (en) * 2000-03-27 2003-05-08 Dorothea Strack Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system
EP1632483B1 (en) 2001-02-16 2008-10-29 Aventis Pharmaceuticals Inc. Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10131543A1 (de) * 2001-06-29 2003-01-16 Abbott Lab Pyrimidinoxyalkylpiperazine und ihre therapeutische Verwendung
US20050154039A1 (en) * 2001-11-28 2005-07-14 Marie-Odile Glacera Contour 5-Sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine
CN1642422A (zh) * 2002-03-15 2005-07-20 西巴特殊化学品控股有限公司 4－氨基嘧啶及其在表面抗菌处理中的应用
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10358004A1 (de) * 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
US7935706B2 (en) * 2006-02-23 2011-05-03 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
EP1882688A1 (en) 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
JP4840440B2 (ja) * 2008-12-24 2011-12-21 ソニー株式会社 画像処理装置およびその方法、並びにプログラム
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
BR112012018500A2 (pt) * 2010-01-25 2016-08-16 Chdi Foundation Inc alguns inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de uso destas
US9156822B2 (en) * 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
SG2014011654A (en) 2011-08-30 2014-08-28 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
HUE034802T2 (en) 2011-08-30 2018-02-28 Chdi Foundation Inc Kinurenin-3-monooxygenase inhibitors, pharmaceutical preparations and methods of use
PT3087051T (pt) 2013-12-24 2020-10-21 Oncotartis Inc Compostos de nicotinamida e benzamida e métodos para utilizar os mesmos
KR20170026633A (ko) 2014-07-17 2017-03-08 씨에이치디아이 파운데이션, 인코포레이티드 Hiv-관련 장애의 치료 방법 및 치료용 조성물

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Also Published As

Publication number Publication date
CA2241787A1 (en) 1997-07-17
HRP970021A2 (en) 1998-04-30
EP0877744B1 (de) 2004-08-11
KR19990077127A (ko) 1999-10-25
PL327692A1 (en) 1998-12-21
JP2000505072A (ja) 2000-04-25
CZ215998A3 (cs) 1999-05-12
AU717726B2 (en) 2000-03-30
KR100441073B1 (ko) 2004-11-16
CO4790173A1 (es) 1999-05-31
CN1146551C (zh) 2004-04-21
NZ326332A (en) 1999-04-29
WO1997025324A1 (de) 1997-07-17
DE19600934A1 (de) 1997-07-17
BG102616A (en) 1999-04-30
DE59711847D1 (de) 2004-09-16
SK94198A3 (en) 1999-03-12
US6352981B1 (en) 2002-03-05
MX9805499A (es) 1998-11-30
ES2225947T3 (es) 2005-03-16
BG64098B1 (bg) 2003-12-31
TW475929B (en) 2002-02-11
NO983187L (no) 1998-09-09
CN1212692A (zh) 1999-03-31
ZA97209B (en) 1998-07-10
SK284987B6 (sk) 2006-04-06
HUP9901590A2 (hu) 1999-08-30
CA2241787C (en) 2006-04-04
CN1348956A (zh) 2002-05-15
JP4349657B2 (ja) 2009-10-21
HUP9901590A3 (en) 2002-01-28
CZ297981B6 (cs) 2007-05-16
AU1440797A (en) 1997-08-01
TR199801302T2 (xx) 1998-11-23
IL125076A0 (en) 1999-01-26
CN1075070C (zh) 2001-11-21
IL125076A (en) 2001-05-20
ATE273301T1 (de) 2004-08-15
EP0877744A1 (de) 1998-11-18
US6214822B1 (en) 2001-04-10
HU228457B1 (en) 2013-03-28
NO316753B1 (no) 2004-04-26

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