CN101695495A - 用于治疗外分泌障碍的组合物 - Google Patents

用于治疗外分泌障碍的组合物 Download PDF

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Publication number
CN101695495A
CN101695495A CN200910205219A CN200910205219A CN101695495A CN 101695495 A CN101695495 A CN 101695495A CN 200910205219 A CN200910205219 A CN 200910205219A CN 200910205219 A CN200910205219 A CN 200910205219A CN 101695495 A CN101695495 A CN 101695495A
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China
Prior art keywords
ketone
chemical compound
group
dihydro
pge
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CN200910205219A
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Chinese (zh)
Inventor
上野隆司
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Sucampo GmbH
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Sucampo GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200910205219A 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物 Pending CN101695495A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14362799P 1999-07-14 1999-07-14
US60/143627 1999-07-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN00810238A Division CN1399548A (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物

Publications (1)

Publication Number Publication Date
CN101695495A true CN101695495A (zh) 2010-04-21

Family

ID=22504885

Family Applications (4)

Application Number Title Priority Date Filing Date
CN00810238A Pending CN1399548A (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物
CNB2006101215152A Expired - Fee Related CN100548977C (zh) 1999-07-14 2000-07-13 前列腺素样化合物及其用于治疗外分泌障碍的用途
CN2010101574518A Expired - Fee Related CN101829120B (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物
CN200910205219A Pending CN101695495A (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN00810238A Pending CN1399548A (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物
CNB2006101215152A Expired - Fee Related CN100548977C (zh) 1999-07-14 2000-07-13 前列腺素样化合物及其用于治疗外分泌障碍的用途
CN2010101574518A Expired - Fee Related CN101829120B (zh) 1999-07-14 2000-07-13 用于治疗外分泌障碍的组合物

Country Status (25)

Country Link
US (3) US6566398B1 (enExample)
EP (1) EP1223925B1 (enExample)
JP (2) JP4167828B2 (enExample)
KR (1) KR100750553B1 (enExample)
CN (4) CN1399548A (enExample)
AR (2) AR029381A1 (enExample)
AT (1) ATE344027T1 (enExample)
AU (1) AU779936B2 (enExample)
BR (1) BRPI0012387B1 (enExample)
CA (1) CA2377661C (enExample)
CZ (1) CZ303958B6 (enExample)
DE (1) DE60031710T2 (enExample)
DK (1) DK1223925T3 (enExample)
ES (1) ES2273706T3 (enExample)
HK (1) HK1048443B (enExample)
HU (1) HU229318B1 (enExample)
IL (2) IL147440A0 (enExample)
MX (1) MXPA02000437A (enExample)
NO (1) NO323908B1 (enExample)
PT (1) PT1223925E (enExample)
RU (1) RU2264816C2 (enExample)
TR (1) TR200200065T2 (enExample)
TW (1) TWI225398B (enExample)
WO (1) WO2001005388A2 (enExample)
ZA (1) ZA200109726B (enExample)

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HU229318B1 (hu) 2013-10-28
CN101829120A (zh) 2010-09-15
CA2377661C (en) 2012-05-08
US6566398B1 (en) 2003-05-20
KR20020060149A (ko) 2002-07-16
TWI225398B (en) 2004-12-21
NO20020133D0 (no) 2002-01-11
MXPA02000437A (es) 2004-05-21
ES2273706T3 (es) 2007-05-16
WO2001005388A3 (en) 2002-05-10
RU2264816C2 (ru) 2005-11-27
CN101829120B (zh) 2013-09-18
AR029381A1 (es) 2003-06-25
ATE344027T1 (de) 2006-11-15
DE60031710T2 (de) 2007-09-06
DK1223925T3 (da) 2007-03-19
HUP0202400A3 (en) 2005-02-28
AU5853300A (en) 2001-02-05
EP1223925A2 (en) 2002-07-24
AU779936B2 (en) 2005-02-17
CZ303958B6 (cs) 2013-07-17
HUP0202400A2 (hu) 2002-11-28
WO2001005388A2 (en) 2001-01-25
JP5052423B2 (ja) 2012-10-17
NO20020133L (no) 2002-03-13
DE60031710D1 (de) 2006-12-14
EP1223925B1 (en) 2006-11-02
CA2377661A1 (en) 2001-01-25
CN100548977C (zh) 2009-10-14
TR200200065T2 (tr) 2002-10-21
JP2009007360A (ja) 2009-01-15
BR0012387A (pt) 2002-03-26
JP2003504397A (ja) 2003-02-04
US20050090556A1 (en) 2005-04-28
NO323908B1 (no) 2007-07-16
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US20030171438A1 (en) 2003-09-11
IL147440A0 (en) 2002-08-14
AR074465A2 (es) 2011-01-19
JP4167828B2 (ja) 2008-10-22
KR100750553B1 (ko) 2007-08-20
HK1048443B (en) 2007-06-08
HK1048443A1 (en) 2003-04-04
US7396946B2 (en) 2008-07-08
CZ2002133A3 (cs) 2002-06-12
IL147440A (en) 2008-11-03
CN1399548A (zh) 2003-02-26
BRPI0012387B1 (pt) 2016-11-08
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