BR9611507A - Processo para a obtenção de um extrato de cartilagem lìquido, para o tratamento de uma inflamação, da psorìase e de doenças ou quadros clìnicos, para a inibição da angiogênese, da atividade de colagenase, da proliferação de células endoteliais e da diferenciação de queratinócitos ativada, para a melhoria da função de barreira da pele, para o amolecimento da pele, para a redução de inflamação e da acne na pele, para a regulagem de rugas ou atropia e para o retardamento do envelhecimento prematuro, extrato de cartilagem, composição para o tratamento de doenças ou quadros clìnicos e do câncer e composição tópica. - Google Patents
Processo para a obtenção de um extrato de cartilagem lìquido, para o tratamento de uma inflamação, da psorìase e de doenças ou quadros clìnicos, para a inibição da angiogênese, da atividade de colagenase, da proliferação de células endoteliais e da diferenciação de queratinócitos ativada, para a melhoria da função de barreira da pele, para o amolecimento da pele, para a redução de inflamação e da acne na pele, para a regulagem de rugas ou atropia e para o retardamento do envelhecimento prematuro, extrato de cartilagem, composição para o tratamento de doenças ou quadros clìnicos e do câncer e composição tópica.Info
- Publication number
- BR9611507A BR9611507A BR9611507-6A BR9611507A BR9611507A BR 9611507 A BR9611507 A BR 9611507A BR 9611507 A BR9611507 A BR 9611507A BR 9611507 A BR9611507 A BR 9611507A
- Authority
- BR
- Brazil
- Prior art keywords
- skin
- diseases
- extract
- inflammation
- clinical conditions
- Prior art date
Links
- 239000000284 extract Substances 0.000 title abstract 15
- 210000000845 cartilage Anatomy 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 8
- 230000008569 process Effects 0.000 title abstract 8
- 206010061218 Inflammation Diseases 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 230000004054 inflammatory process Effects 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000035755 proliferation Effects 0.000 title abstract 3
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract 2
- 102000029816 Collagenase Human genes 0.000 title abstract 2
- 108060005980 Collagenase Proteins 0.000 title abstract 2
- 206010063493 Premature ageing Diseases 0.000 title abstract 2
- 208000032038 Premature aging Diseases 0.000 title abstract 2
- 201000004681 Psoriasis Diseases 0.000 title abstract 2
- 206010000496 acne Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229960002424 collagenase Drugs 0.000 title abstract 2
- 230000014399 negative regulation of angiogenesis Effects 0.000 title abstract 2
- 230000037303 wrinkles Effects 0.000 title abstract 2
- 210000003491 skin Anatomy 0.000 title 3
- 230000004888 barrier function Effects 0.000 title 1
- 230000004069 differentiation Effects 0.000 title 1
- 210000002889 endothelial cell Anatomy 0.000 title 1
- 210000002510 keratinocyte Anatomy 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 241000251730 Chondrichthyes Species 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 230000008591 skin barrier function Effects 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000033228 biological regulation Effects 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 230000009467 reduction Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Electrically Operated Instructional Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
"PROCESSOS PARA A OBTENçãO DE UM EXTRATO DE CARTILAGEM LìQUIDO, PARA O TRATAMENTO DE UMA INFLAMAçãO, DA PSORìASE E DE DOENçAS OU QUADROS CLìNICOS, PARA A INIBIçãO DA ANGIOGêNESE, DA ATIVIDADE DE COLAGENASE, DA PROLIFERAçãO DE CéLULAS ENDOTELIAIS E DA DIFERENCIAçãO DE QUERATINóCITOS ATIVADA, PARA A MELHORIA DA FUNçãO DE BARREIRA DA PELE, PARA O AMOLECIMENTO DA PELE, PARA A REDUçãO DE INFLAMAçãO E DA ACNE NA PELE, PARA A REGULAGEM DE RUGAS OU ATROPIA E PARA RETARDAMENTO DO ENVELHECIMENTO PREMATURO, EXTRATO DE CARTILAGEM, COMPOSIçãO PARA O TRATAMENTO DE DOENçAS OU QUADROS CLìNICOS E DO CâNCER E COMPOSIçãO TóPICA". A presente invenção refere-se a extratos de cartilagem e a um processo para produzi-los. Os extratos de cartilagem de tubarão possuindo atividades anti-angiogênicas, antitumorosas, antiinflamatórias e anticolagenolíticas foram obtidos por meio de uma processo aperfeiçoado. O processo compreende as etapas de obter um homogeneizado de cartilagem em uma solução aquosa, sendo que este homogeneizado é separado numa fração sólida (EXTRATO SóLIDO) e uma fração líquida que será ainda mais fracionada para se obter um EXTRATO LìQUIDO com moléculas que apresentam um peso molecular compreendido entre 0 e 500 kDa. A composição do extrato líquido tem sido, então, pesquisada por diferentes vias. O fracionamento ulterior deste extrato levou à caracterização preliminar de alguns de seus componentes ativos. Devido à multiplicidade das atividades biológicas do extrato líquido tota, este pode ser utilizado para se tratar numerosas doenças ou quadros clínicos, como aqueles que possuem componentes selecionados do grupo que consiste de: proliferação de tumores, angiogênese, inflamação e colagenólise. Diversas aplicações cosméticas baseadas na capacidade de o extrato melhora a função de barreira da pele também encontram-se sob o escopo desta invenção. Estes extratos não exercem efeito ofensivo sobre as funções corporais. Portanto estes extratos de cartilagem de tubarão possuem um valor terapêutico muito promissor. O processo para a obtenção dos extratos de cartilagem é simples e eficiente. os produtos inesperadamente valiosos obtidos segundo este processo constituem, portanto, uma indicação de um processo novo e não-óbvio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/550,003 US6025334A (en) | 1994-04-28 | 1995-10-30 | Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof |
| PCT/CA1996/000549 WO1997016197A1 (en) | 1995-10-30 | 1996-08-07 | Extracts of shark cartilage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9611507A true BR9611507A (pt) | 1999-12-28 |
Family
ID=24195326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9611507-6A BR9611507A (pt) | 1995-10-30 | 1996-08-07 | Processo para a obtenção de um extrato de cartilagem lìquido, para o tratamento de uma inflamação, da psorìase e de doenças ou quadros clìnicos, para a inibição da angiogênese, da atividade de colagenase, da proliferação de células endoteliais e da diferenciação de queratinócitos ativada, para a melhoria da função de barreira da pele, para o amolecimento da pele, para a redução de inflamação e da acne na pele, para a regulagem de rugas ou atropia e para o retardamento do envelhecimento prematuro, extrato de cartilagem, composição para o tratamento de doenças ou quadros clìnicos e do câncer e composição tópica. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6025334A (pt) |
| EP (1) | EP0859622B1 (pt) |
| JP (2) | JPH11513990A (pt) |
| KR (1) | KR100296016B1 (pt) |
| CN (1) | CN1187060C (pt) |
| AT (1) | ATE230604T1 (pt) |
| BG (1) | BG63907B1 (pt) |
| BR (1) | BR9611507A (pt) |
| CA (1) | CA2236021C (pt) |
| CO (1) | CO4750839A1 (pt) |
| CZ (1) | CZ129398A3 (pt) |
| DE (1) | DE69625698T2 (pt) |
| DK (1) | DK0859622T3 (pt) |
| ES (1) | ES2190475T3 (pt) |
| HK (1) | HK1015683A1 (pt) |
| HU (1) | HU225490B1 (pt) |
| IL (1) | IL119030A (pt) |
| IN (1) | IN188198B (pt) |
| IS (1) | IS2017B (pt) |
| MX (1) | MX9803419A (pt) |
| NO (1) | NO981781L (pt) |
| NZ (1) | NZ313957A (pt) |
| PL (1) | PL187989B1 (pt) |
| RO (1) | RO118567B1 (pt) |
| RU (1) | RU2181292C2 (pt) |
| TW (1) | TW503108B (pt) |
| WO (1) | WO1997016197A1 (pt) |
| ZA (1) | ZA966726B (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380366B1 (en) * | 1994-04-28 | 2002-04-30 | Les Laboratoires Aeterna Inc. | Shark cartilage extract:process of making, methods of using and compositions thereof |
| GB9621630D0 (en) * | 1996-10-17 | 1996-12-11 | Kappa Pharmaceuticals Ltd | Treatment of skin disorders |
| EP0842670A1 (en) * | 1996-11-13 | 1998-05-20 | Katsunari Nishihara | Biomedical materials |
| CA2288269A1 (en) | 1997-02-20 | 1998-08-27 | Industrial Research Limited | Angiogenesis inhibitors and activators from shark cartilage |
| WO1998040088A1 (en) | 1997-03-11 | 1998-09-17 | Les Laboratoires Aeterna Inc. | Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents |
| CN1288165C (zh) * | 1997-07-11 | 2006-12-06 | Cv技术公司 | 用于治疗与phf过多或细胞内钙过多相关疾病的来自鲨软骨的制剂 |
| JPH11171782A (ja) * | 1997-12-03 | 1999-06-29 | Kaoru Yamane | 液体鮫軟骨の製造方法 |
| FR2778558B1 (fr) * | 1998-05-12 | 2001-02-16 | Oreal | Utilisation d'inhibiteur de metalloproteinases pour induire et/ou stimuler la croissance des cheveux ou des poils et/ou freiner leur chute |
| US6168807B1 (en) * | 1998-07-23 | 2001-01-02 | Les Laboratoires Aeterna Inc. | Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof |
| US20020009501A1 (en) * | 1998-07-23 | 2002-01-24 | Eric Dupont | Preparation of cartilage extracts using organic solvents |
| WO2000010552A2 (en) * | 1998-08-24 | 2000-03-02 | Global Vascular Concepts, Inc. | Use of anti-angiogenic agents for inhibiting vessel wall injury |
| KR100355952B1 (ko) * | 2000-03-15 | 2002-10-11 | 주식회사 코리아나화장품 | 상어 연골추출물과 비타민 케이 유도체를 함유하는 화장료조성물 |
| AU2001242502A1 (en) * | 2000-03-31 | 2001-10-15 | Henkel Kommanditgesellschaft Auf Aktien | Use of protease inhibitors in cosmetics and pharmacy |
| CN1245991C (zh) * | 2000-12-20 | 2006-03-22 | 工业研究有限公司 | 鲨鱼肉提取物 |
| TWI233361B (en) * | 2001-04-13 | 2005-06-01 | Gen Hospital Corp | Methods of preventing UVB-induced skin damage |
| WO2003018620A2 (en) * | 2001-08-27 | 2003-03-06 | Les Laboratoires Aeterna Inc. | Serine protease inhibitor and processes for the preparation thereof |
| US7504115B2 (en) | 2002-02-15 | 2009-03-17 | Ocean Nutrition Canada Limited | Shark cartilage extracts and use thereof for immunomodulation |
| US20080063677A1 (en) * | 2004-03-10 | 2008-03-13 | New Life Resources, Llc | Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations |
| JPWO2004083257A1 (ja) * | 2003-03-20 | 2006-06-22 | ホソカワミクロン株式会社 | 軟骨魚類から単離されたプロテオグリカンおよびその製造方法 |
| US20050222687A1 (en) * | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
| US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US20090291112A1 (en) * | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
| US7901457B2 (en) * | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| ES2223291B1 (es) * | 2003-08-06 | 2006-03-16 | Bioiberica, S.A. | Nuevo uso terapeutico de condroitin sulfato. |
| EP2338441B1 (en) | 2003-12-11 | 2013-01-23 | Isto Technologies Inc. | Particulate cartilage system |
| JP4390809B2 (ja) * | 2004-01-07 | 2009-12-24 | イーエルシー マネージメント エルエルシー | 発毛遅延のための化粧品組成物及び方法 |
| US8580315B2 (en) * | 2004-03-10 | 2013-11-12 | Esm Technologies, Llc | Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations |
| US20050288796A1 (en) * | 2004-06-23 | 2005-12-29 | Hani Awad | Native soft tissue matrix for therapeutic applications |
| US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20080220044A1 (en) * | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
| WO2006059236A2 (en) * | 2004-11-16 | 2006-06-08 | Aeterna Zentaris Inc. | Method of using cartilage extract for increasing blood parameters |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
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| WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| JP4834671B2 (ja) | 2005-09-29 | 2011-12-14 | 株式会社マルハニチロ水産 | 成人病の予防及び治療に有効な組成物 |
| US20080154233A1 (en) * | 2006-12-20 | 2008-06-26 | Zimmer Orthobiologics, Inc. | Apparatus for delivering a biocompatible material to a surgical site and method of using same |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| US8435551B2 (en) * | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
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| CA2708147A1 (en) * | 2007-12-05 | 2009-06-18 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
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| EP2262469A4 (en) * | 2008-04-15 | 2013-12-04 | Immanence Integrale Dermo Correction Inc | SKIN CARE COMPOSITIONS AND METHODS OF USE |
| CN103429608B (zh) * | 2011-01-19 | 2016-08-03 | 国立大学法人弘前大学 | 蛋白多糖的大量制备方法 |
| ES2403804B1 (es) * | 2011-09-21 | 2014-07-15 | Bioib�Rica, S.A. | Producto de cartílago. |
| US9347081B2 (en) | 2011-04-19 | 2016-05-24 | Bioiberica, S.A. | Cartilage product |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| RU2526825C1 (ru) * | 2013-06-18 | 2014-08-27 | Вера Геннадьевна Лихванцева | Фармацевтическая антиангиогенная композиция для лечения заболеваний глаз |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| CN104877009B (zh) * | 2015-05-11 | 2020-08-11 | 浙江海洋学院 | 一种赤魟软骨多肽类血管生成抑制因子 |
| KR101901568B1 (ko) | 2016-07-04 | 2018-09-28 | 주식회사 강스템바이오텍 | 연골 무세포 파쇄물 및 줄기세포를 포함하는 연골분화 촉진용 복합체 및 그의 용도 |
| KR102154976B1 (ko) * | 2018-08-30 | 2020-09-11 | 전남대학교산학협력단 | 구내염 치료용 하이드로겔 |
| KR102369902B1 (ko) * | 2021-04-23 | 2022-03-02 | 이수한 | 전 처리된 캐비아가 함유된 철갑상어 진액 및 그 제조 방법 |
| KR20220166032A (ko) | 2021-06-09 | 2022-12-16 | 아스코코리아 주식회사 | 조립식 캠핑 테이블 |
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| US4042457A (en) * | 1975-11-10 | 1977-08-16 | Rush-Presbyterian-St. Luke's Medical Center | Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor |
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| US4243582A (en) * | 1979-04-26 | 1981-01-06 | Monsanto Company | Novel glycoproteins from bovine cartilage |
| US4350682A (en) * | 1979-05-11 | 1982-09-21 | Lescarden Ltd. | Cartilage extraction processes and products |
| US4356261A (en) * | 1980-04-22 | 1982-10-26 | Rush-Presbyterian-St. Luke's Medical Center | Anti-invasion factor containing cultures |
| US4473551A (en) * | 1982-08-23 | 1984-09-25 | Faxon Pharmaceuticals, Inc. | Anti-inflammatory composition |
| US4656137A (en) * | 1985-09-12 | 1987-04-07 | Lescarden Inc | Method of processing animal cartilage |
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| US4746729A (en) * | 1986-07-30 | 1988-05-24 | Kuettner Klaus E | Cartilage-derived leukocyte elastase-inhibitor |
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