BR112019015075A2 - Compostos bicíclicos como inibidores de shp2 alostéricos - Google Patents
Compostos bicíclicos como inibidores de shp2 alostéricos Download PDFInfo
- Publication number
- BR112019015075A2 BR112019015075A2 BR112019015075-7A BR112019015075A BR112019015075A2 BR 112019015075 A2 BR112019015075 A2 BR 112019015075A2 BR 112019015075 A BR112019015075 A BR 112019015075A BR 112019015075 A2 BR112019015075 A2 BR 112019015075A2
- Authority
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- Brazil
- Prior art keywords
- formula
- modalities
- optionally substituted
- compound according
- heterocycle
- Prior art date
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- 0 *C1C(*)*(*)(CCCCCCC2)C2C(*N*)*1 Chemical compound *C1C(*)*(*)(CCCCCCC2)C2C(*N*)*1 0.000 description 12
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- VJEXYPZHDCYVLR-UHFFFAOYSA-N Cc(nc(c1cnc[n]11)Cl)c1Br Chemical compound Cc(nc(c1cnc[n]11)Cl)c1Br VJEXYPZHDCYVLR-UHFFFAOYSA-N 0.000 description 2
- CGXKWAJDTOSBHZ-UHFFFAOYSA-N Nc1nccc(S)c1Cl Chemical compound Nc1nccc(S)c1Cl CGXKWAJDTOSBHZ-UHFFFAOYSA-N 0.000 description 2
- UHEQBGJPFSQMDJ-UHFFFAOYSA-N CC(C)(C)OC(NC(C)(CC1)CCN1c(c1nnc[n]11)nc(C)c1Br)=O Chemical compound CC(C)(C)OC(NC(C)(CC1)CCN1c(c1nnc[n]11)nc(C)c1Br)=O UHEQBGJPFSQMDJ-UHFFFAOYSA-N 0.000 description 1
- NDYDPZJYJVWOGO-UHFFFAOYSA-N CC(C)(C)OC(NC(C)(CC1)CCN1c(c1nnc[n]11)nc(C)c1Sc(ccnc1N)c1Cl)=O Chemical compound CC(C)(C)OC(NC(C)(CC1)CCN1c(c1nnc[n]11)nc(C)c1Sc(ccnc1N)c1Cl)=O NDYDPZJYJVWOGO-UHFFFAOYSA-N 0.000 description 1
- UPBBKJXXYHYJIT-UHFFFAOYSA-N CC(CC1)(CCN1c(c1n[o]nc11)ncc1Sc1ccnc(N)c1Cl)N Chemical compound CC(CC1)(CCN1c(c1n[o]nc11)ncc1Sc1ccnc(N)c1Cl)N UPBBKJXXYHYJIT-UHFFFAOYSA-N 0.000 description 1
- ZMWWKWRVTSLLJL-UHFFFAOYSA-N CC(CC1)(CCN1c(c1nnc[n]11)nc(C)c1Sc1ccnc(N)c1Cl)N Chemical compound CC(CC1)(CCN1c(c1nnc[n]11)nc(C)c1Sc1ccnc(N)c1Cl)N ZMWWKWRVTSLLJL-UHFFFAOYSA-N 0.000 description 1
- FVUWZHPOFUDRKZ-UHFFFAOYSA-N CC(CC1)(CCN1c1nc(C)c(-c(cccc2Cl)c2Cl)[n]2c1cnc2)N Chemical compound CC(CC1)(CCN1c1nc(C)c(-c(cccc2Cl)c2Cl)[n]2c1cnc2)N FVUWZHPOFUDRKZ-UHFFFAOYSA-N 0.000 description 1
- KCIQZTHOCAHXIS-UHFFFAOYSA-N CC(CC1)(CCN1c1nc(C)c[n]2c1cnc2)N Chemical compound CC(CC1)(CCN1c1nc(C)c[n]2c1cnc2)N KCIQZTHOCAHXIS-UHFFFAOYSA-N 0.000 description 1
- KRRBTUJMHLCTRS-UHFFFAOYSA-N CC(CC1)(CCN1c1nc(N)c(-c(cccc2Cl)c2Cl)[n]2c1cnc2)N Chemical compound CC(CC1)(CCN1c1nc(N)c(-c(cccc2Cl)c2Cl)[n]2c1cnc2)N KRRBTUJMHLCTRS-UHFFFAOYSA-N 0.000 description 1
- KABFQORLYBDNDG-FQNRMIAFSA-N CC1OCC(CC2)(CCN2c(c2ncc[n]22)nc(C)c2Sc2ccnc(N)c2Cl)[C@@H]1N Chemical compound CC1OCC(CC2)(CCN2c(c2ncc[n]22)nc(C)c2Sc2ccnc(N)c2Cl)[C@@H]1N KABFQORLYBDNDG-FQNRMIAFSA-N 0.000 description 1
- ZNDGNFOELHQWDF-UHFFFAOYSA-N CCOC(c(cc12)n[n]1c(-c(cccc1Cl)c1Cl)c(C)nc2N(CC1)CCC1(C)NC(OC(C)(C)C)=O)=O Chemical compound CCOC(c(cc12)n[n]1c(-c(cccc1Cl)c1Cl)c(C)nc2N(CC1)CCC1(C)NC(OC(C)(C)C)=O)=O ZNDGNFOELHQWDF-UHFFFAOYSA-N 0.000 description 1
- RKKGOXSUGWUWDZ-UHFFFAOYSA-N CCOC(c(cc12)n[n]1c(Br)c(C)nc2N(CC1)CCC1(C)NC(OC(C)(C)C)=O)=O Chemical compound CCOC(c(cc12)n[n]1c(Br)c(C)nc2N(CC1)CCC1(C)NC(OC(C)(C)C)=O)=O RKKGOXSUGWUWDZ-UHFFFAOYSA-N 0.000 description 1
- DSYOWFBXVUKQDF-GOEBONIOSA-N C[C@@H]1OCC(CC2)(CCN2c(c2ccn[n]22)nc(C)c2Br)[C@@H]1NC(OC(C)(C)C)=O Chemical compound C[C@@H]1OCC(CC2)(CCN2c(c2ccn[n]22)nc(C)c2Br)[C@@H]1NC(OC(C)(C)C)=O DSYOWFBXVUKQDF-GOEBONIOSA-N 0.000 description 1
- JNSWGZNWWAEDNC-CCWRPAJNSA-N C[C@@H]1OCC(CC2)(CCN2c(c2cnc[n]22)nc(C)c2Br)[C@@H]1NS(C(C)(C)C)=O Chemical compound C[C@@H]1OCC(CC2)(CCN2c(c2cnc[n]22)nc(C)c2Br)[C@@H]1NS(C(C)(C)C)=O JNSWGZNWWAEDNC-CCWRPAJNSA-N 0.000 description 1
- CDXGRWDTBBFMDA-KSFYIVLOSA-N C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c(cccc3C#N)c3Cl)[n]3nccc23)[C@@H]1N=C Chemical compound C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c(cccc3C#N)c3Cl)[n]3nccc23)[C@@H]1N=C CDXGRWDTBBFMDA-KSFYIVLOSA-N 0.000 description 1
- VRKRUCLLRMWHMW-MGPUTAFESA-N C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c3cccc(Cl)c3)[n]3c2cnc3)[C@@H]1N Chemical compound C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c3cccc(Cl)c3)[n]3c2cnc3)[C@@H]1N VRKRUCLLRMWHMW-MGPUTAFESA-N 0.000 description 1
- NFCWAHYNSYSOBI-VBKZILBWSA-N C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c3cccc(Cl)c3Cl)[n]3nccc23)[C@@H]1N Chemical compound C[C@@H]1OCC(CC2)(CCN2c2nc(C)c(-c3cccc(Cl)c3Cl)[n]3nccc23)[C@@H]1N NFCWAHYNSYSOBI-VBKZILBWSA-N 0.000 description 1
- QORIMRSQLRAMSF-JGVFFNPUSA-N C[C@@H]1OCC2(CCNCC2)[C@@H]1N Chemical compound C[C@@H]1OCC2(CCNCC2)[C@@H]1N QORIMRSQLRAMSF-JGVFFNPUSA-N 0.000 description 1
- OPGHKYUUEHBICN-UHFFFAOYSA-N Cc(nc(c1ccn[n]11)Cl)c1Br Chemical compound Cc(nc(c1ccn[n]11)Cl)c1Br OPGHKYUUEHBICN-UHFFFAOYSA-N 0.000 description 1
- GKBQDVMCJAVFDF-GFCCVEGCSA-N Cc(nc(c1cnc[n]11)N(CC2)CCC2(COC2)[C@@H]2N)c1Br Chemical compound Cc(nc(c1cnc[n]11)N(CC2)CCC2(COC2)[C@@H]2N)c1Br GKBQDVMCJAVFDF-GFCCVEGCSA-N 0.000 description 1
- DGTUYSKBTAEDDD-UHFFFAOYSA-N Cc(nc(c1ncn[n]11)O)c1Br Chemical compound Cc(nc(c1ncn[n]11)O)c1Br DGTUYSKBTAEDDD-UHFFFAOYSA-N 0.000 description 1
- UPAOWFRREBXVDZ-UHFFFAOYSA-N Clc1ncc[n]2nccc12 Chemical compound Clc1ncc[n]2nccc12 UPAOWFRREBXVDZ-UHFFFAOYSA-N 0.000 description 1
- NKWCGTOZTHZDHB-UHFFFAOYSA-N OC(c1cnc[nH]1)=O Chemical compound OC(c1cnc[nH]1)=O NKWCGTOZTHZDHB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449530P | 2017-01-23 | 2017-01-23 | |
| US62/449,530 | 2017-01-23 | ||
| PCT/US2018/013023 WO2018136265A1 (en) | 2017-01-23 | 2018-01-09 | Bicyclic compounds as allosteric shp2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019015075A2 true BR112019015075A2 (pt) | 2020-03-10 |
Family
ID=61054566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019015075-7A BR112019015075A2 (pt) | 2017-01-23 | 2018-01-09 | Compostos bicíclicos como inibidores de shp2 alostéricos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11739093B2 (enExample) |
| EP (1) | EP3571199A1 (enExample) |
| JP (2) | JP7240319B2 (enExample) |
| KR (1) | KR102665763B1 (enExample) |
| CN (2) | CN117327075A (enExample) |
| AR (1) | AR110740A1 (enExample) |
| AU (2) | AU2018210770B2 (enExample) |
| BR (1) | BR112019015075A2 (enExample) |
| CA (1) | CA3051206A1 (enExample) |
| IL (2) | IL296456A (enExample) |
| MX (2) | MX2019008695A (enExample) |
| SG (1) | SG11201906209SA (enExample) |
| TW (1) | TWI820013B (enExample) |
| WO (1) | WO2018136265A1 (enExample) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| AU2017274199B2 (en) | 2016-05-31 | 2021-09-23 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| CN109415360B (zh) | 2016-06-14 | 2021-11-02 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
| KR102598895B1 (ko) | 2016-07-12 | 2023-11-07 | 레볼루션 메디슨즈, 인크. | 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 |
| US11529347B2 (en) | 2016-09-22 | 2022-12-20 | Relay Therapeutics, Inc. | SHP2 phosphatase inhibitors and methods of use thereof |
| TW202500565A (zh) | 2016-10-24 | 2025-01-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| WO2018218133A1 (en) | 2017-05-26 | 2018-11-29 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors |
| WO2019051084A1 (en) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER |
| TW202517628A (zh) | 2017-09-11 | 2025-05-01 | 美商克魯松藥物公司 | Shp2之八氫環戊烷并[c]吡咯別構抑制劑 |
| US11701354B2 (en) | 2017-09-29 | 2023-07-18 | D. E. Shaw Research, Llc | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors |
| MX2020003579A (es) | 2017-10-12 | 2020-07-22 | Revolution Medicines Inc | Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos. |
| TW201927791A (zh) * | 2017-12-15 | 2019-07-16 | 美商銳新醫藥公司 | 作為變構shp2抑制劑的多環化合物 |
| US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
| BR112020019385A2 (pt) | 2018-03-21 | 2021-03-30 | Relay Therapeutics, Inc. | Inibidores de shp2 fosfatase e métodos de uso dos mesmos |
| WO2019183364A1 (en) | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof |
| CN112368272B (zh) | 2018-03-21 | 2023-04-21 | 苏州浦合医药科技有限公司 | Shp2抑制剂及其用途 |
| MX2020011528A (es) | 2018-05-02 | 2021-02-09 | Navire Pharma Inc | Inhibidores heterociclicos sustituidos de ptpn11. |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| CN113166153B (zh) | 2018-07-05 | 2024-11-01 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| SG11202100199UA (en) | 2018-08-10 | 2021-02-25 | Navire Pharma Inc | 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer |
| CN112996795B (zh) | 2018-09-18 | 2024-11-12 | 尼坎治疗公司 | 作为src同源-2磷酸酶抑制剂的稠合的三环衍生物 |
| KR20210068472A (ko) * | 2018-09-29 | 2021-06-09 | 노파르티스 아게 | Shp2 활성의 억제를 위한 화합물 및 조성물의 제조 |
| IL305106B2 (en) | 2018-09-29 | 2025-08-01 | Novartis Ag | Process of manufacture of a compound for inhibiting the activity of shp2 |
| US11179397B2 (en) | 2018-10-03 | 2021-11-23 | Gilead Sciences, Inc. | Imidazopyrimidine derivatives |
| WO2020076723A1 (en) | 2018-10-08 | 2020-04-16 | Revolution Medicines, Inc. | Shp2 inhibitor compositions for use in treating cancer |
| MA53921A (fr) * | 2018-10-17 | 2022-01-26 | Array Biopharma Inc | Inhibiteurs de protéine tyrosine phosphatase |
| CN117143079A (zh) * | 2018-11-06 | 2023-12-01 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
| WO2020094104A1 (zh) * | 2018-11-07 | 2020-05-14 | 如东凌达生物医药科技有限公司 | 一类含氮稠杂环类shp2抑制剂化合物、制备方法和用途 |
| CN111153899B (zh) * | 2018-11-08 | 2023-12-01 | 四川科伦博泰生物医药股份有限公司 | 一种取代吡啶化合物、其制备方法和用途 |
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| CA3051206A1 (en) | 2018-07-26 |
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