BR112014013099A8 - Dispositivo de microagulhas incluindo um agente terapêutico peptídeo e um aminoácido e métodos para produzir e usar o dispositivo - Google Patents
Dispositivo de microagulhas incluindo um agente terapêutico peptídeo e um aminoácido e métodos para produzir e usar o dispositivoInfo
- Publication number
- BR112014013099A8 BR112014013099A8 BR112014013099A BR112014013099A BR112014013099A8 BR 112014013099 A8 BR112014013099 A8 BR 112014013099A8 BR 112014013099 A BR112014013099 A BR 112014013099A BR 112014013099 A BR112014013099 A BR 112014013099A BR 112014013099 A8 BR112014013099 A8 BR 112014013099A8
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic agent
- amino acid
- peptide therapeutic
- making
- methods
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229940124597 therapeutic agent Drugs 0.000 title abstract 6
- 150000001413 amino acids Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/225—Calcitonin gene related peptide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01007—Inulinase (3.2.1.7)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
DISPOSITIVO DE MICROAGULHAS INCLUINDO UM AGENTE TERAPÊUTICO PEPTÍDEO E UM AMINOÁCIDO E MÉTODOS PARA PRODUZIR E USAR O DISPOSITIVO. A presente invenção descreve um dispositivo médico que inclui um arranjo de microagulhas e um revestimento disposto na superfície ou no interior das microagulhas e um método de produzir tal dispositivo. O revestimento inclui um agente terapêutico peptídeo e um aminoácido. Também é descrito um método de estabilizar o agente terapêutico peptídeo com um aminoácido em um arranjo de microagulhas. Em alguns casos, o agente terapêutico peptídeo e o aminoácido ou têm, ambos, uma carga líquida positiva, ou têm, ambos, uma carga líquida negativa. Em alguns casos, o agente terapêutico peptídeo é a histidina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161565247P | 2011-11-30 | 2011-11-30 | |
US201161565227P | 2011-11-30 | 2011-11-30 | |
PCT/US2012/067292 WO2013082427A1 (en) | 2011-11-30 | 2012-11-30 | Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014013099A2 BR112014013099A2 (pt) | 2017-06-13 |
BR112014013099A8 true BR112014013099A8 (pt) | 2023-05-09 |
Family
ID=47352020
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014013099A BR112014013099A8 (pt) | 2011-11-30 | 2012-11-30 | Dispositivo de microagulhas incluindo um agente terapêutico peptídeo e um aminoácido e métodos para produzir e usar o dispositivo |
BR112014013151-1A BR112014013151B1 (pt) | 2011-11-30 | 2012-11-30 | Dispositivo médico compreendendo microagulhas incluindo um agente terapêutico peptídeo e um aminoácido, métodos para produzir o dispositivo e método para estabilizar um agente terapêutico peptídeo |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014013151-1A BR112014013151B1 (pt) | 2011-11-30 | 2012-11-30 | Dispositivo médico compreendendo microagulhas incluindo um agente terapêutico peptídeo e um aminoácido, métodos para produzir o dispositivo e método para estabilizar um agente terapêutico peptídeo |
Country Status (8)
Country | Link |
---|---|
US (3) | US9623087B2 (pt) |
EP (2) | EP2785406A4 (pt) |
KR (2) | KR102143482B1 (pt) |
CN (2) | CN104080441B (pt) |
AU (2) | AU2012345768B2 (pt) |
BR (2) | BR112014013099A8 (pt) |
CA (2) | CA2857502C (pt) |
WO (2) | WO2013082418A1 (pt) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2664323B1 (en) | 2007-04-16 | 2020-07-29 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
ES2719595T3 (es) | 2010-05-04 | 2019-07-11 | Corium Int Inc | Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección |
LT2568806T (lt) | 2010-05-12 | 2016-09-26 | Radius Health, Inc. | Terapiniai režimai |
CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
JP5965909B2 (ja) | 2010-09-28 | 2016-08-10 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
CN104531812A (zh) | 2010-10-01 | 2015-04-22 | 现代治疗公司 | 设计核酸及其使用方法 |
WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
RU2707251C2 (ru) | 2011-10-03 | 2019-11-25 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
CA2857502C (en) | 2011-11-30 | 2019-08-13 | 3M Innovative Properties Company | Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same |
KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
KR20140138900A (ko) * | 2012-03-09 | 2014-12-04 | 온코세라피 사이언스 가부시키가이샤 | 펩티드를 포함한 의약 조성물 |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS AND PEPTIDES ASSOCIATED WITH ONCOLOGY |
JP6144355B2 (ja) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 化学修飾mRNA |
EP2934660B1 (en) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Microarray for delivery of therapeutic agent and method of making same |
JP6246784B2 (ja) * | 2013-02-13 | 2017-12-13 | 久光製薬株式会社 | マイクロニードルコーティング用組成物及びマイクロニードルデバイス |
JP6175485B2 (ja) * | 2013-02-13 | 2017-08-02 | 久光製薬株式会社 | マイクロニードルコーティング用組成物及びマイクロニードルデバイス |
CA2903748C (en) | 2013-03-12 | 2021-11-02 | Corium International, Inc. | Microprojection applicators |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
CN105246458B (zh) | 2013-03-15 | 2020-09-15 | 考里安公司 | 用于治疗剂递送的微阵列及其使用方法 |
CA2923010C (en) * | 2013-09-03 | 2022-08-30 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
JP6211169B2 (ja) * | 2014-02-27 | 2017-10-11 | 久光製薬株式会社 | マイクロニードル |
US10828478B2 (en) * | 2014-04-24 | 2020-11-10 | Georgia Tech Research Corporation | Microneedles and methods of manufacture thereof |
WO2015178730A1 (ko) * | 2014-05-22 | 2015-11-26 | 연세대학교 산학협력단 | Ccdp 방법에 의한 마이크로구조체의 제조 |
JP5892303B1 (ja) * | 2014-06-13 | 2016-03-23 | 凸版印刷株式会社 | 針状体の製造方法 |
WO2016036866A1 (en) * | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
CN106687172B (zh) | 2014-09-11 | 2020-06-23 | 久光制药株式会社 | 微针装置 |
JP6621754B2 (ja) * | 2014-10-27 | 2019-12-18 | 久光製薬株式会社 | 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス |
EP3216482B1 (en) * | 2014-11-06 | 2019-03-20 | Toppan Printing Co., Ltd. | Transdermal delivery device and method for manufacturing transdermal delivery device |
EP3250228A1 (en) * | 2015-01-27 | 2017-12-06 | 3M Innovative Properties Company | Alum-containing coating formulations for microneedle vaccine patches |
IL310069A (en) | 2015-04-29 | 2024-03-01 | Radius Pharmaceuticals Inc | Cancer treatment methods |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
CN105126242A (zh) * | 2015-07-26 | 2015-12-09 | 北京化工大学 | 一种便于抗生素皮试的高分子涂层微针贴片及其制备方法 |
JP6652352B2 (ja) * | 2015-09-04 | 2020-02-19 | 久光製薬株式会社 | マイクロニードルデバイスの製造方法 |
CN108135837B (zh) * | 2015-10-09 | 2022-05-31 | 3M创新有限公司 | 用于涂布微针阵列的锌组合物 |
SG11201802871UA (en) * | 2015-10-09 | 2018-05-30 | Radius Health Inc | Formulations of pthrp analogues, transdermal patches thereof, and uses thereof |
BR112018014109A2 (pt) * | 2016-01-11 | 2018-12-11 | Verndari Inc | composições de microagulhas e métodos de uso das mesmas |
KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
EP3998061A1 (en) | 2016-04-18 | 2022-05-18 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
JP6537072B2 (ja) * | 2016-05-16 | 2019-07-03 | 富士フイルム株式会社 | モールド及びパターンシートの製造方法 |
KR102397890B1 (ko) | 2016-06-22 | 2022-05-12 | 일립시스 파마 리미티드 | Ar+ 유방암 치료 방법 |
US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
WO2018129419A1 (en) | 2017-01-05 | 2018-07-12 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
WO2018155433A1 (ja) * | 2017-02-24 | 2018-08-30 | 久光製薬株式会社 | マイクロニードルデバイスの製造方法 |
KR102208178B1 (ko) * | 2017-12-01 | 2021-01-28 | 가천대학교 산학협력단 | 마이크로 니들 및 이의 제조방법 |
CN108969879B (zh) * | 2018-06-05 | 2021-06-22 | 南京工业大学 | 一种复合微针及微针贴片 |
SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
TW202103731A (zh) * | 2019-02-27 | 2021-02-01 | 日商富士軟片股份有限公司 | 微針陣列及微針陣列之製造方法 |
CN110270007A (zh) * | 2019-07-15 | 2019-09-24 | 上海交通大学 | 一种担载生物分子微针及其制备方法 |
EP4110371A1 (en) | 2020-01-24 | 2023-01-04 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
WO2021221972A1 (en) * | 2020-04-28 | 2021-11-04 | Ticona Llc | Microneedle assembly |
CN114306917A (zh) * | 2021-01-12 | 2022-04-12 | 广州新济药业科技有限公司 | 可溶性微针贴片及其制备方法 |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
CN113599501B (zh) * | 2021-08-25 | 2022-11-29 | 北京三元基因药业股份有限公司 | 一种稳定的干扰素微针制剂及其制备方法与应用 |
KR102484179B1 (ko) * | 2021-11-29 | 2023-01-04 | 주식회사 쿼드메디슨 | 펩타이드 계열 유효 성분을 포함하는 마이크로 니들 및 이를 제조하기 위한 제형 조성물 |
US20240189564A1 (en) * | 2021-12-31 | 2024-06-13 | Small'lab Co., Ltd. | Microneedles comprising hormone-containing surface-modified microspheres and method of preparing the same |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3939346A1 (de) | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
GB9930882D0 (en) | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
US7186683B2 (en) | 2000-09-18 | 2007-03-06 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
US7963935B2 (en) | 2001-04-20 | 2011-06-21 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
EP1539212A4 (en) | 2002-07-12 | 2007-05-02 | Medarex Inc | METHOD AND COMPOSITIONS FOR PREVENTING OXIDATIVE DEGRADATION OF PROTEINS |
JP2005533625A (ja) | 2002-07-19 | 2005-11-10 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルデバイスおよびマイクロニードル送達装置 |
IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines |
AU2004255228A1 (en) * | 2003-06-30 | 2005-01-20 | Alza Corporation | Method for coating skin piercing microprojections |
EP1638523B8 (en) | 2003-06-30 | 2013-12-25 | ALZA Corporation | Formulations for coated microprojections containing non-volatile counterions |
US7141544B2 (en) | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
AU2004292954A1 (en) | 2003-11-13 | 2005-06-09 | Alza Corporation | Composition and apparatus for transdermal delivery |
WO2005051455A2 (en) | 2003-11-21 | 2005-06-09 | Alza Corporation | Ultrasound assisted transdermal vaccine delivery method and system |
IL159273A0 (en) | 2003-12-09 | 2004-06-01 | Transpharma Medical Ltd | Transdermal delivery system for sustained release of polypeptides |
EP1765406A4 (en) | 2004-05-21 | 2012-11-28 | Mediplex Corp | ADDITIVES FOR IMPROVED MUCOSAL ABSORPTION OF THERAPEUTIC AGENTS |
US20090069226A1 (en) * | 2004-05-28 | 2009-03-12 | Amylin Pharmaceuticals, Inc. | Transmucosal delivery of peptides and proteins |
TW200621282A (en) | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
EP1848498A4 (en) | 2004-11-18 | 2009-12-16 | Transpharma Medical Ltd | ASSOCIATED MICRO-CHANNEL PRODUCTION AND IONTOPHORESIS FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS |
JP2008528509A (ja) * | 2005-01-21 | 2008-07-31 | アルザ コーポレイション | 少なくとも1つの対イオンを含む、向上した安定性でマイクロニードルをコーティングするための治療用ペプチド製剤 |
KR100700869B1 (ko) * | 2005-06-03 | 2007-03-29 | 재단법인 목암생명공학연구소 | Pth, 완충제 및 안정제를 포함하는 안정한 pth조성물 |
JP2009522288A (ja) * | 2005-12-28 | 2009-06-11 | アルザ コーポレイション | 安定な治療剤形 |
CA2680690A1 (en) | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
EA200802166A1 (ru) | 2006-04-20 | 2009-06-30 | Эмджен Инк. | Стабильная фармацевтическая композиция с защитным действием от раздражения (варианты), способ ее получения и способ лечения кальций-миметиком с ее помощью |
KR101512377B1 (ko) | 2006-10-03 | 2015-04-28 | 라디우스 헬쓰, 인코포레이티드 | 골 아나볼릭 단백질을 위한 약물 전달 방법 |
US7803770B2 (en) | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
EP2664323B1 (en) | 2007-04-16 | 2020-07-29 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
GB0707938D0 (en) | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
US8450481B2 (en) | 2007-06-14 | 2013-05-28 | The Regents Of The University Of California | Compounds for inhibiting protein aggregation, and methods for making and using them |
US20120150023A1 (en) | 2007-08-06 | 2012-06-14 | Kaspar Roger L | Microneedle arrays for active agent delivery |
US20090117158A1 (en) | 2007-10-23 | 2009-05-07 | Mahmoud Ameri | Transdermal sustained release drug delivery |
EP2052736A1 (en) | 2007-10-26 | 2009-04-29 | Nycomed Danmark ApS | Parathyroid hormone formulations und uses thereof |
CN101795680A (zh) | 2007-11-16 | 2010-08-04 | 波苏蛋白试剂公司 | 稳定蛋白质的辅剂 |
WO2010022176A1 (en) | 2008-08-19 | 2010-02-25 | Ferring International Center S.A. | Methods of treatment for skeletal conditons |
NZ592113A (en) | 2008-10-15 | 2012-04-27 | Intarcia Therapeutics Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
EP3300765A1 (en) | 2008-11-18 | 2018-04-04 | 3M Innovative Properties Co. | Hollow microneedle array |
WO2010074239A1 (ja) | 2008-12-26 | 2010-07-01 | 久光製薬株式会社 | マイクロニードルデバイス |
US20100203014A1 (en) | 2009-02-04 | 2010-08-12 | Aegis Therapeutics Llc | Zwitterionic buffered acidic peptide and protein formulations |
DE102009001636A1 (de) | 2009-03-18 | 2010-09-23 | Henkel Ag & Co. Kgaa | Bleichmittel mit verzögertem Bleichbeginn |
ES2634667T3 (es) | 2009-04-24 | 2017-09-28 | Corium International, Inc. | Métodos para fabricar conjuntos de microproyección |
EP3354312A1 (en) | 2009-07-31 | 2018-08-01 | 3M Innovative Properties Co. | Hollow microneedle arrays |
WO2011051916A2 (en) | 2009-11-02 | 2011-05-05 | Universite De Geneve | Stabilized protein formulations and use thereof |
CN101912600B (zh) | 2010-01-11 | 2014-01-29 | 杨国汉 | 改善胰岛素在溶液中稳定性的方法 |
KR101808635B1 (ko) * | 2010-05-04 | 2017-12-13 | 코리움 인터네셔널, 인크. | 미세 바늘을 위한 어플리케이터 |
ES2719595T3 (es) | 2010-05-04 | 2019-07-11 | Corium Int Inc | Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección |
US9693950B2 (en) * | 2010-05-28 | 2017-07-04 | 3M Innovative Properties Company | Aqueous formulations for coating microneedle arrays |
WO2012145665A2 (en) * | 2011-04-22 | 2012-10-26 | Radius Health, Inc. | Method of drug delivery for pth, pthrp and related peptides |
CA2857502C (en) | 2011-11-30 | 2019-08-13 | 3M Innovative Properties Company | Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same |
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BR112014013151A2 (pt) | 2017-06-13 |
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EP2785406A4 (en) | 2015-10-21 |
KR20140097454A (ko) | 2014-08-06 |
AU2012345777B2 (en) | 2016-05-12 |
CN104080506A (zh) | 2014-10-01 |
US10154957B2 (en) | 2018-12-18 |
CN104080441B (zh) | 2020-02-28 |
BR112014013151B1 (pt) | 2022-02-08 |
EP2785406A1 (en) | 2014-10-08 |
BR112014013099A2 (pt) | 2017-06-13 |
AU2012345777A1 (en) | 2014-06-19 |
CA2857501C (en) | 2020-06-23 |
CA2857502A1 (en) | 2013-06-06 |
AU2012345768B2 (en) | 2016-05-12 |
US20140343499A1 (en) | 2014-11-20 |
CN104080506B (zh) | 2017-03-08 |
KR102143482B1 (ko) | 2020-08-11 |
EP2785327A1 (en) | 2014-10-08 |
WO2013082418A1 (en) | 2013-06-06 |
US9675675B2 (en) | 2017-06-13 |
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