IT1285405B1 - Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. - Google Patents
Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.Info
- Publication number
- IT1285405B1 IT1285405B1 IT96TO000496A ITTO960496A IT1285405B1 IT 1285405 B1 IT1285405 B1 IT 1285405B1 IT 96TO000496 A IT96TO000496 A IT 96TO000496A IT TO960496 A ITTO960496 A IT TO960496A IT 1285405 B1 IT1285405 B1 IT 1285405B1
- Authority
- IT
- Italy
- Prior art keywords
- electrotransport
- modification
- increase flow
- polypeptide drugs
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46661095A | 1995-06-06 | 1995-06-06 |
Publications (3)
Publication Number | Publication Date |
---|---|
ITTO960496A0 ITTO960496A0 (it) | 1996-06-05 |
ITTO960496A1 ITTO960496A1 (it) | 1997-12-05 |
IT1285405B1 true IT1285405B1 (it) | 1998-06-03 |
Family
ID=23852435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96TO000496A IT1285405B1 (it) | 1995-06-06 | 1996-06-05 | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
Country Status (12)
Country | Link |
---|---|
US (2) | US7324846B2 (it) |
JP (2) | JP4354529B2 (it) |
AU (1) | AU6590396A (it) |
BE (1) | BE1009704A3 (it) |
BR (1) | BR9609149A (it) |
CA (1) | CA2220146A1 (it) |
DE (1) | DE19681439T1 (it) |
FR (1) | FR2735132B1 (it) |
GB (1) | GB2317179B (it) |
IT (1) | IT1285405B1 (it) |
NL (1) | NL1003283C2 (it) |
WO (1) | WO1996039422A2 (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
DE60031709T2 (de) | 1999-10-14 | 2007-06-28 | Pola Chemical Industries, Inc. | Zusammensetzungen für die elektroporation |
US6946548B2 (en) * | 2000-09-08 | 2005-09-20 | Massachusetts Institute Of Technology | G-CSF analog compositions and methods |
US7497855B2 (en) | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
NZ539218A (en) * | 2002-09-18 | 2008-03-28 | Univ Montreal Ct Hospitalier Chum | Synthetic GHRH analogues of 29 amino acids or more |
JP5840148B2 (ja) | 2010-03-04 | 2016-01-06 | フェニックス インク. | 変性させることなく可溶性組換えインターフェロンタンパク質を産生する方法 |
NZ603033A (en) | 2010-04-01 | 2014-06-27 | Pfenex Inc | Methods for g-csf production in a pseudomonas host cell |
CN104080441B (zh) * | 2011-11-30 | 2020-02-28 | 3M创新有限公司 | 包括肽治疗剂和氨基酸的微针装置、制备和使用其的方法 |
EP4039253A1 (en) | 2015-04-29 | 2022-08-10 | Radius Pharmaceuticals, Inc. | Methods of treating cancer |
EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
JP7473486B2 (ja) | 2018-07-04 | 2024-04-23 | ラジウス ファーマシューティカルズ,インコーポレイテッド | Rad1901-2hclの多形形態 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4250878A (en) | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US4722726A (en) | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US5250022A (en) | 1990-09-25 | 1993-10-05 | Rutgers, The State University Of New Jersey | Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose |
AU609769B2 (en) | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
EP0647133A4 (en) * | 1992-06-12 | 1997-10-29 | Affymax Tech Nv | COMPOSITIONS AND METHODS FOR IMPROVED DRUG DELIVERY. |
US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
AU676711B2 (en) * | 1992-12-31 | 1997-03-20 | Alza Corporation | Electrotransport system having flexible means |
JP2809510B2 (ja) * | 1993-06-08 | 1998-10-08 | 久光製薬株式会社 | イオントフォレーゼ用システム |
EP0643981B1 (en) * | 1993-09-22 | 2002-01-09 | Hisamitsu Pharmaceutical Co., Inc. | A matrix for iontophoreses |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
-
1996
- 1996-06-05 IT IT96TO000496A patent/IT1285405B1/it active IP Right Grant
- 1996-06-06 BE BE9600517A patent/BE1009704A3/fr not_active IP Right Cessation
- 1996-06-06 WO PCT/US1996/009377 patent/WO1996039422A2/en active Application Filing
- 1996-06-06 JP JP50171097A patent/JP4354529B2/ja not_active Expired - Fee Related
- 1996-06-06 FR FR9607002A patent/FR2735132B1/fr not_active Expired - Fee Related
- 1996-06-06 CA CA002220146A patent/CA2220146A1/en not_active Abandoned
- 1996-06-06 GB GB9725981A patent/GB2317179B/en not_active Expired - Fee Related
- 1996-06-06 NL NL1003283A patent/NL1003283C2/nl not_active IP Right Cessation
- 1996-06-06 AU AU65903/96A patent/AU6590396A/en not_active Abandoned
- 1996-06-06 BR BR9609149A patent/BR9609149A/pt not_active Application Discontinuation
- 1996-06-06 DE DE19681439T patent/DE19681439T1/de not_active Withdrawn
-
2001
- 2001-12-10 US US10/016,403 patent/US7324846B2/en not_active Expired - Fee Related
-
2007
- 2007-11-27 US US11/945,536 patent/US20090275877A1/en not_active Abandoned
-
2008
- 2008-12-12 JP JP2008316824A patent/JP2009149639A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH11507341A (ja) | 1999-06-29 |
GB2317179B (en) | 1999-07-28 |
ITTO960496A0 (it) | 1996-06-05 |
DE19681439T1 (de) | 1998-07-23 |
AU6590396A (en) | 1996-12-24 |
ITTO960496A1 (it) | 1997-12-05 |
FR2735132B1 (fr) | 1998-04-24 |
US7324846B2 (en) | 2008-01-29 |
US20020107505A1 (en) | 2002-08-08 |
WO1996039422A3 (en) | 1997-03-06 |
BR9609149A (pt) | 1999-02-23 |
NL1003283A1 (nl) | 1996-12-09 |
NL1003283C2 (nl) | 1997-05-02 |
JP4354529B2 (ja) | 2009-10-28 |
CA2220146A1 (en) | 1996-12-12 |
BE1009704A3 (fr) | 1997-07-01 |
US20090275877A1 (en) | 2009-11-05 |
JP2009149639A (ja) | 2009-07-09 |
FR2735132A1 (fr) | 1996-12-13 |
WO1996039422A2 (en) | 1996-12-12 |
GB2317179A (en) | 1998-03-18 |
IE960413A1 (en) | 1996-12-11 |
GB9725981D0 (en) | 1998-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |