DE19681439T1 - Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses - Google Patents
Modifizierung von Polypeptidarzneimitteln zur Erhöhung des ElektrotransportflussesInfo
- Publication number
- DE19681439T1 DE19681439T1 DE19681439T DE19681439T DE19681439T1 DE 19681439 T1 DE19681439 T1 DE 19681439T1 DE 19681439 T DE19681439 T DE 19681439T DE 19681439 T DE19681439 T DE 19681439T DE 19681439 T1 DE19681439 T1 DE 19681439T1
- Authority
- DE
- Germany
- Prior art keywords
- electrotransport
- modification
- increase
- flow
- polypeptide drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Electrotherapy Devices (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46661095A | 1995-06-06 | 1995-06-06 | |
PCT/US1996/009377 WO1996039422A2 (en) | 1995-06-06 | 1996-06-06 | Modification of polypeptide drugs to increase electrotransport flux |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19681439T1 true DE19681439T1 (de) | 1998-07-23 |
Family
ID=23852435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19681439T Withdrawn DE19681439T1 (de) | 1995-06-06 | 1996-06-06 | Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses |
Country Status (12)
Country | Link |
---|---|
US (2) | US7324846B2 (de) |
JP (2) | JP4354529B2 (de) |
AU (1) | AU6590396A (de) |
BE (1) | BE1009704A3 (de) |
BR (1) | BR9609149A (de) |
CA (1) | CA2220146A1 (de) |
DE (1) | DE19681439T1 (de) |
FR (1) | FR2735132B1 (de) |
GB (1) | GB2317179B (de) |
IT (1) | IT1285405B1 (de) |
NL (1) | NL1003283C2 (de) |
WO (1) | WO1996039422A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
DE60031709T2 (de) | 1999-10-14 | 2007-06-28 | Pola Chemical Industries, Inc. | Zusammensetzungen für die elektroporation |
JP4799803B2 (ja) * | 2000-09-08 | 2011-10-26 | マサチューセッツ インスティテュート オブ テクノロジー | G−csfアナログ組成物および方法 |
AU2003278766A1 (en) * | 2002-09-04 | 2004-03-29 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
NZ602255A (en) | 2010-03-04 | 2014-04-30 | Pfenex Inc | Method for producing soluble recombinant interferon protein without denaturing |
US8455218B2 (en) | 2010-04-01 | 2013-06-04 | Pfenex, Inc. | Methods for G-CSF production in a Pseudomonas host cell |
CA2857502C (en) | 2011-11-30 | 2019-08-13 | 3M Innovative Properties Company | Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same |
KR20240097966A (ko) | 2015-04-29 | 2024-06-27 | 래디어스 파마슈티컬스, 인코포레이티드 | 암을 치료하는 방법 |
MX2019007748A (es) | 2017-01-05 | 2019-09-09 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
WO2020010216A1 (en) | 2018-07-04 | 2020-01-09 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad 1901-2hcl |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4250878A (en) | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4628043A (en) * | 1983-04-26 | 1986-12-09 | The Salk Institute For Biological Studies | Hypothalamic GRF agonists |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US4722726A (en) | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US5250022A (en) | 1990-09-25 | 1993-10-05 | Rutgers, The State University Of New Jersey | Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose |
AU609769B2 (en) | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
EP0429842B1 (de) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten |
GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
CA2087087C (en) | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
AU4534593A (en) * | 1992-06-12 | 1994-01-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
ATE162728T1 (de) * | 1992-12-31 | 1998-02-15 | Alza Corp | Elektrophorese-system mit biegsamen mitteln |
EP0716863B1 (de) * | 1993-06-08 | 2002-05-08 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoretisches system |
ATE211655T1 (de) * | 1993-09-22 | 2002-01-15 | Hisamitsu Pharmaceutical Co | Iontophoresematrix |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
-
1996
- 1996-06-05 IT IT96TO000496A patent/IT1285405B1/it active IP Right Grant
- 1996-06-06 FR FR9607002A patent/FR2735132B1/fr not_active Expired - Fee Related
- 1996-06-06 GB GB9725981A patent/GB2317179B/en not_active Expired - Fee Related
- 1996-06-06 BR BR9609149A patent/BR9609149A/pt not_active Application Discontinuation
- 1996-06-06 JP JP50171097A patent/JP4354529B2/ja not_active Expired - Fee Related
- 1996-06-06 WO PCT/US1996/009377 patent/WO1996039422A2/en active Application Filing
- 1996-06-06 BE BE9600517A patent/BE1009704A3/fr not_active IP Right Cessation
- 1996-06-06 CA CA002220146A patent/CA2220146A1/en not_active Abandoned
- 1996-06-06 DE DE19681439T patent/DE19681439T1/de not_active Withdrawn
- 1996-06-06 AU AU65903/96A patent/AU6590396A/en not_active Abandoned
- 1996-06-06 NL NL1003283A patent/NL1003283C2/nl not_active IP Right Cessation
-
2001
- 2001-12-10 US US10/016,403 patent/US7324846B2/en not_active Expired - Fee Related
-
2007
- 2007-11-27 US US11/945,536 patent/US20090275877A1/en not_active Abandoned
-
2008
- 2008-12-12 JP JP2008316824A patent/JP2009149639A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FR2735132B1 (fr) | 1998-04-24 |
GB9725981D0 (en) | 1998-02-04 |
US20020107505A1 (en) | 2002-08-08 |
WO1996039422A2 (en) | 1996-12-12 |
ITTO960496A1 (it) | 1997-12-05 |
GB2317179B (en) | 1999-07-28 |
US7324846B2 (en) | 2008-01-29 |
IT1285405B1 (it) | 1998-06-03 |
AU6590396A (en) | 1996-12-24 |
BE1009704A3 (fr) | 1997-07-01 |
BR9609149A (pt) | 1999-02-23 |
US20090275877A1 (en) | 2009-11-05 |
NL1003283C2 (nl) | 1997-05-02 |
WO1996039422A3 (en) | 1997-03-06 |
GB2317179A (en) | 1998-03-18 |
JP4354529B2 (ja) | 2009-10-28 |
IE960413A1 (en) | 1996-12-11 |
JP2009149639A (ja) | 2009-07-09 |
CA2220146A1 (en) | 1996-12-12 |
ITTO960496A0 (it) | 1996-06-05 |
NL1003283A1 (nl) | 1996-12-09 |
JPH11507341A (ja) | 1999-06-29 |
FR2735132A1 (fr) | 1996-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE19681286T1 (de) | Neue Kristallform von Olanzapin | |
DE69122494D1 (de) | Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten | |
DE69630328D1 (de) | Präziser kontrollierter Niederschlag von Sauerstoff in Silizium | |
NO963049L (no) | Modulatorer av forankrende proteinfunksjon | |
DE69634998D1 (de) | Kontrolle von Kanten | |
DE69411692D1 (de) | Mittel zur Förderung der Proliferationen von Bifidobacterium | |
ATE216979T1 (de) | Anwendung von amides zur kontrolle des biobewuchses | |
DE69507215D1 (de) | Reinigung von Bisphenol-A | |
DE59708157D1 (de) | System zur Form- und Farbstrukturbestimmung von Zähnen | |
DE68912685D1 (de) | Reinigung von Glucosaminoglucan abbauenden Enzymen. | |
DE69518743D1 (de) | Modifizierung von nukleotidanalogen | |
DE69628195D1 (de) | Verwendung von xyloglucanendotransglycosylase | |
DE19681439T1 (de) | Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses | |
DE59606486D1 (de) | Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden | |
DE68923680D1 (de) | Oberflächenbehandlung zur Verbesserung des Haftvermögens von Anstrichen an Polydicyclopentadienen. | |
DE69717677D1 (de) | Koproduktion von perfluormethylperfluorvinylether und perfluorethylperfluorvinylether | |
ITRM920658A0 (it) | Procedimento per la purificazione della proteina endotelina | |
DE3891306T1 (de) | Konzentrator zur aufbereitung von nutzbaren mineralien | |
DE69431829D1 (de) | Befestigungselement zur Lagesicherung von Elektrodenverbindungsstellen | |
DK75393D0 (da) | Production of protein | |
DE69605708D1 (de) | Reinigung von Pentafluorethan | |
NO944025D0 (no) | Forbedret fremstilling av rekombinant protein | |
DE3671698D1 (de) | Anordnung zur stimulation von akupunkturpunkten. | |
DE3891307T1 (de) | Konzentrator zur aufbereitung von nutzbaren mineralien | |
DE59501871D1 (de) | Monocarbonsäureamide von Polyaminen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8139 | Disposal/non-payment of the annual fee |