BR112012028977A2 - polímero estímulo- responsivo para purificação de biomoléculas. - Google Patents

polímero estímulo- responsivo para purificação de biomoléculas.

Info

Publication number
BR112012028977A2
BR112012028977A2 BR112012028977-2A BR112012028977A BR112012028977A2 BR 112012028977 A2 BR112012028977 A2 BR 112012028977A2 BR 112012028977 A BR112012028977 A BR 112012028977A BR 112012028977 A2 BR112012028977 A2 BR 112012028977A2
Authority
BR
Brazil
Prior art keywords
stimulus
responsive polymer
purification
biomolecule purification
biomolecule
Prior art date
Application number
BR112012028977-2A
Other languages
English (en)
Other versions
BR112012028977B1 (pt
Inventor
Jad Jaber
Wilson Moya
James Hamzik
Arezki Boudif
Yu Zhanf
Neil Soice
John Charkoudian
Nripen Sigh
Original Assignee
Emd Millipore Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emd Millipore Corporation filed Critical Emd Millipore Corporation
Publication of BR112012028977A2 publication Critical patent/BR112012028977A2/pt
Publication of BR112012028977B1 publication Critical patent/BR112012028977B1/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B01J41/14—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B01J41/13—Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F126/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F126/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
    • C08F26/04—Diallylamine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

polímeros estímulo-responsivos para a purificação de biomoléculas, a presente invenção fornece polímeros estímulo-responsivos novos e melhorados e métodos de utilização dos mesmos para a purificação de biornolécu las.
BR112012028977A 2010-05-17 2011-05-16 método de purificação de biomolécula por meio de polímeros estímulo-responsivos BR112012028977B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39576910P 2010-05-17 2010-05-17
US61/395,769 2010-05-17
PCT/US2011/036648 WO2011146394A1 (en) 2010-05-17 2011-05-16 Stimulus responsive polymers for the purification of biomolecules

Publications (2)

Publication Number Publication Date
BR112012028977A2 true BR112012028977A2 (pt) 2019-02-12
BR112012028977B1 BR112012028977B1 (pt) 2020-05-05

Family

ID=44626632

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012028977A BR112012028977B1 (pt) 2010-05-17 2011-05-16 método de purificação de biomolécula por meio de polímeros estímulo-responsivos

Country Status (10)

Country Link
US (3) US8691918B2 (pt)
EP (2) EP3597671B1 (pt)
JP (3) JP5612761B2 (pt)
KR (3) KR101551295B1 (pt)
CN (2) CN102892791B (pt)
BR (1) BR112012028977B1 (pt)
DK (1) DK2571903T3 (pt)
ES (1) ES2754210T3 (pt)
SG (2) SG10201804385YA (pt)
WO (1) WO2011146394A1 (pt)

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US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
CN105037535A (zh) 2008-12-16 2015-11-11 Emd密理博公司 搅拌槽反应器及方法
US8992668B2 (en) * 2010-03-29 2015-03-31 Fujifilm Corporation Gas separation membrane and method for producing the same, and method for separating gas mixture, gas separation membrane module and gas separation apparatus using the same
EP3597671B1 (en) 2010-05-17 2022-09-21 EMD Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
WO2011156467A2 (en) * 2010-06-08 2011-12-15 Millipore Corporation Methods of detecting residual amounts of polymers used in the purification of biomolecules
JP2015520026A (ja) * 2012-06-06 2015-07-16 イー・エム・デイー・ミリポア・コーポレイシヨン 溶媒抽出法で処理される低有機抽出物デプスフィルター媒体
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ES2721155T3 (es) * 2012-12-20 2019-07-29 Merck Patent Gmbh Copolímeros para precipitación de proteínas
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WO2016068249A1 (ja) * 2014-10-31 2016-05-06 国立大学法人東京農工大学 細胞単離方法及び細胞捕捉フィルタ
US10450345B2 (en) * 2017-06-09 2019-10-22 General Electric Company Method of isolation of polypeptide-aptamer-polymer conjugates
EP3816177A4 (en) * 2018-06-29 2021-12-01 Mitsubishi Chemical Corporation POLYPEPTIDE ISOLATION PROCESS, POLYPEPTIDE PRODUCTION PROCESS AND POLYPEPTIDE PURIFICATION APPARATUS
CN109574296B (zh) * 2018-11-27 2021-05-07 合肥工业大学 一种从含蟹肉蛋白废水中回收蛋白的方法
HU231498B1 (hu) 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával
KR102504821B1 (ko) * 2021-05-24 2023-03-02 한양대학교 산학협력단 생체친화성 고체 전해질을 포함하는 신경 자극기용 전극, 이의 제조방법 및 이를 포함하는 신경 자극기
US20220412008A1 (en) * 2021-06-29 2022-12-29 Solenis Technologies, L.P. N-vinyllactam-containing polymers for papermaking

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CN105026418B (zh) 2013-02-06 2019-01-11 新加坡科技研究局 蛋白质纯化方法
KR20150115745A (ko) 2013-02-06 2015-10-14 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 제제로부터 응집체 함량을 감소시키는 방법
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JP7063593B2 (ja) * 2017-12-12 2022-05-09 ロレアル 油と、少なくとも１つの脂肪鎖を有するセルロース系カチオン性ポリマーを含むポリイオンコンプレックスとを含む組成物

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US20110313066A1 (en) 2011-12-22
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