BR112012009481A2 - método e dispositivo para detectar uma pluralidade de alvos em uma amostra biológica, e, kit para detectar uma pluralidade de alvos múltiplos em uma amostra biológica - Google Patents
método e dispositivo para detectar uma pluralidade de alvos em uma amostra biológica, e, kit para detectar uma pluralidade de alvos múltiplos em uma amostra biológicaInfo
- Publication number
- BR112012009481A2 BR112012009481A2 BR112012009481A BR112012009481A BR112012009481A2 BR 112012009481 A2 BR112012009481 A2 BR 112012009481A2 BR 112012009481 A BR112012009481 A BR 112012009481A BR 112012009481 A BR112012009481 A BR 112012009481A BR 112012009481 A2 BR112012009481 A2 BR 112012009481A2
- Authority
- BR
- Brazil
- Prior art keywords
- biological sample
- detecting
- targets
- kit
- target
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/582,745 US9677125B2 (en) | 2009-10-21 | 2009-10-21 | Detection of plurality of targets in biological samples |
| PCT/EP2010/065876 WO2011048184A1 (en) | 2009-10-21 | 2010-10-21 | Detection of plurality of targets in biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012009481A2 true BR112012009481A2 (pt) | 2016-11-29 |
Family
ID=43103438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012009481A BR112012009481A2 (pt) | 2009-10-21 | 2010-10-21 | método e dispositivo para detectar uma pluralidade de alvos em uma amostra biológica, e, kit para detectar uma pluralidade de alvos múltiplos em uma amostra biológica |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9677125B2 (enExample) |
| EP (1) | EP2491132B1 (enExample) |
| JP (1) | JP2013507941A (enExample) |
| KR (1) | KR20120088716A (enExample) |
| CN (1) | CN102803510A (enExample) |
| AU (1) | AU2010309739A1 (enExample) |
| BR (1) | BR112012009481A2 (enExample) |
| CA (1) | CA2777421A1 (enExample) |
| IN (1) | IN2012DN03156A (enExample) |
| RU (1) | RU2012115681A (enExample) |
| WO (1) | WO2011048184A1 (enExample) |
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| ES2952728T3 (es) | 2011-12-22 | 2023-11-03 | Harvard College | Métodos para la detección de analitos |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| US8568991B2 (en) | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| KR101460439B1 (ko) * | 2012-05-14 | 2014-11-12 | 서울대학교산학협력단 | 나노프로브 및 이를 이용한 표적 물질 검출방법 |
| CA2876405C (en) * | 2012-06-14 | 2020-01-07 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for detecting minimal residual disease |
| US10677802B2 (en) * | 2012-12-17 | 2020-06-09 | Ge Healthcare Bio-Sciences Corp. | Chemical bleaching of dyes using radical photoinitiators |
| WO2014138197A1 (en) | 2013-03-06 | 2014-09-12 | General Electric Company | Methods of analyzing an h&e stained biological sample |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| KR102874079B1 (ko) | 2013-03-15 | 2025-10-22 | 더 제너럴 하스피탈 코포레이션 | Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용 |
| CN110669826B (zh) † | 2013-04-30 | 2025-01-07 | 加州理工学院 | 通过顺序杂交编条形码的分子多重标记 |
| US10011850B2 (en) | 2013-06-21 | 2018-07-03 | The General Hospital Corporation | Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing |
| HK1221747A1 (zh) | 2013-07-30 | 2017-06-09 | 哈佛学院院长及董事 | 基於dna的定量成像和超分辨成像 |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| KR20230054509A (ko) | 2013-11-07 | 2023-04-24 | 에디타스 메디신, 인코포레이티드 | 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물 |
| JP6757255B2 (ja) * | 2014-03-11 | 2020-09-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| ES3014093T3 (en) | 2014-07-30 | 2025-04-16 | Harvard College | Method for determining nucleic acids |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| CN116064727A (zh) | 2016-07-27 | 2023-05-05 | 斯坦福大学托管董事会 | 高度复用荧光成像 |
| US12421540B2 (en) | 2016-08-01 | 2025-09-23 | California Institute Of Technology | Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism |
| CN106290812A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法 |
| CN106290877A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法 |
| AU2017370751B2 (en) | 2016-12-09 | 2023-11-09 | Ultivue, Inc. | Improved methods for multiplex imaging using labeled nucleic acid imaging agents |
| US11788123B2 (en) | 2017-05-26 | 2023-10-17 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| US11807623B2 (en) * | 2017-11-30 | 2023-11-07 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| JP6999527B2 (ja) * | 2018-09-25 | 2022-01-18 | 株式会社日立ハイテク | 試験方法、分注装置 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN113366116A (zh) | 2018-12-13 | 2021-09-07 | 哈佛学院院长及董事 | 用于merfish和其他应用的扩增方法和系统 |
| US11397179B2 (en) | 2018-12-31 | 2022-07-26 | Robert Bosch Gmbh | PH-modulated imaging of targets close to a solid surface |
| JP7405400B2 (ja) * | 2019-11-20 | 2023-12-26 | Ｎｅｃソリューションイノベータ株式会社 | 核酸分子およびその用途 |
| JP2023529682A (ja) | 2020-06-18 | 2023-07-11 | リゾルブ バイオサイエンシズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 試料中の異なる分析物を検出するための多重的方法 |
| EP4322837A4 (en) | 2021-04-16 | 2025-02-26 | Advanced Cell Diagnostics, Inc. | MATERIALS AND METHODS RELATED TO IMAGE PROCESSING |
| WO2023017513A1 (en) * | 2021-08-09 | 2023-02-16 | Neuroquest Ltd. | Compositions, kits, and methods for detecting preclinical alzheimer's disease |
| EP4474793A1 (en) * | 2023-06-09 | 2024-12-11 | Leica Biosystems Richmond, Inc. | Automated melanin bleaching |
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-
2009
- 2009-10-21 US US12/582,745 patent/US9677125B2/en active Active
-
2010
- 2010-10-21 WO PCT/EP2010/065876 patent/WO2011048184A1/en not_active Ceased
- 2010-10-21 CN CN2010800583058A patent/CN102803510A/zh active Pending
- 2010-10-21 JP JP2012534702A patent/JP2013507941A/ja active Pending
- 2010-10-21 BR BR112012009481A patent/BR112012009481A2/pt not_active IP Right Cessation
- 2010-10-21 IN IN3156DEN2012 patent/IN2012DN03156A/en unknown
- 2010-10-21 EP EP10768028.2A patent/EP2491132B1/en active Active
- 2010-10-21 KR KR1020127010261A patent/KR20120088716A/ko not_active Withdrawn
- 2010-10-21 AU AU2010309739A patent/AU2010309739A1/en not_active Abandoned
- 2010-10-21 CA CA2777421A patent/CA2777421A1/en not_active Abandoned
- 2010-10-21 RU RU2012115681/10A patent/RU2012115681A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012115681A (ru) | 2013-11-27 |
| KR20120088716A (ko) | 2012-08-08 |
| US20110092381A1 (en) | 2011-04-21 |
| JP2013507941A (ja) | 2013-03-07 |
| EP2491132A1 (en) | 2012-08-29 |
| WO2011048184A1 (en) | 2011-04-28 |
| CA2777421A1 (en) | 2011-04-28 |
| IN2012DN03156A (enExample) | 2015-09-18 |
| AU2010309739A1 (en) | 2012-05-03 |
| EP2491132B1 (en) | 2018-03-21 |
| CN102803510A (zh) | 2012-11-28 |
| US9677125B2 (en) | 2017-06-13 |
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