CN102803510A - 生物样品中多个靶的检测 - Google Patents

生物样品中多个靶的检测 Download PDF

Info

Publication number
CN102803510A
CN102803510A CN2010800583058A CN201080058305A CN102803510A CN 102803510 A CN102803510 A CN 102803510A CN 2010800583058 A CN2010800583058 A CN 2010800583058A CN 201080058305 A CN201080058305 A CN 201080058305A CN 102803510 A CN102803510 A CN 102803510A
Authority
CN
China
Prior art keywords
target
signal
probes
biological sample
targets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800583058A
Other languages
English (en)
Chinese (zh)
Inventor
A.索德
J.R.尼尔逊
M.格德斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN102803510A publication Critical patent/CN102803510A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2010800583058A 2009-10-21 2010-10-21 生物样品中多个靶的检测 Pending CN102803510A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/582,745 US9677125B2 (en) 2009-10-21 2009-10-21 Detection of plurality of targets in biological samples
US12/582745 2009-10-21
PCT/EP2010/065876 WO2011048184A1 (en) 2009-10-21 2010-10-21 Detection of plurality of targets in biological samples

Publications (1)

Publication Number Publication Date
CN102803510A true CN102803510A (zh) 2012-11-28

Family

ID=43103438

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800583058A Pending CN102803510A (zh) 2009-10-21 2010-10-21 生物样品中多个靶的检测

Country Status (11)

Country Link
US (1) US9677125B2 (enExample)
EP (1) EP2491132B1 (enExample)
JP (1) JP2013507941A (enExample)
KR (1) KR20120088716A (enExample)
CN (1) CN102803510A (enExample)
AU (1) AU2010309739A1 (enExample)
BR (1) BR112012009481A2 (enExample)
CA (1) CA2777421A1 (enExample)
IN (1) IN2012DN03156A (enExample)
RU (1) RU2012115681A (enExample)
WO (1) WO2011048184A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106290812A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法
CN106290877A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法
CN107422122A (zh) * 2012-06-14 2017-12-01 鹿特丹伊拉斯姆斯大学医疗中心 用于检测微小残留病的方法、试剂以及试剂盒
CN112543872A (zh) * 2018-09-25 2021-03-23 株式会社日立高新技术 试验方法、分注装置

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2952728T3 (es) 2011-12-22 2023-11-03 Harvard College Métodos para la detección de analitos
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
US8568991B2 (en) 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
KR101460439B1 (ko) * 2012-05-14 2014-11-12 서울대학교산학협력단 나노프로브 및 이를 이용한 표적 물질 검출방법
US10677802B2 (en) * 2012-12-17 2020-06-09 Ge Healthcare Bio-Sciences Corp. Chemical bleaching of dyes using radical photoinitiators
WO2014138197A1 (en) 2013-03-06 2014-09-12 General Electric Company Methods of analyzing an h&e stained biological sample
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
KR102874079B1 (ko) 2013-03-15 2025-10-22 더 제너럴 하스피탈 코포레이션 Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
CN110669826B (zh) † 2013-04-30 2025-01-07 加州理工学院 通过顺序杂交编条形码的分子多重标记
US10011850B2 (en) 2013-06-21 2018-07-03 The General Hospital Corporation Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
HK1221747A1 (zh) 2013-07-30 2017-06-09 哈佛学院院长及董事 基於dna的定量成像和超分辨成像
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
KR20230054509A (ko) 2013-11-07 2023-04-24 에디타스 메디신, 인코포레이티드 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
JP6757255B2 (ja) * 2014-03-11 2020-09-16 プレジデント アンド フェローズ オブ ハーバード カレッジ プログラム可能な核酸プローブを用いた高スループット及び高度多重化イメージング
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
ES3014093T3 (en) 2014-07-30 2025-04-16 Harvard College Method for determining nucleic acids
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
CN116064727A (zh) 2016-07-27 2023-05-05 斯坦福大学托管董事会 高度复用荧光成像
US12421540B2 (en) 2016-08-01 2025-09-23 California Institute Of Technology Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism
AU2017370751B2 (en) 2016-12-09 2023-11-09 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
US11788123B2 (en) 2017-05-26 2023-10-17 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
US11807623B2 (en) * 2017-11-30 2023-11-07 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN113366116A (zh) 2018-12-13 2021-09-07 哈佛学院院长及董事 用于merfish和其他应用的扩增方法和系统
US11397179B2 (en) 2018-12-31 2022-07-26 Robert Bosch Gmbh PH-modulated imaging of targets close to a solid surface
JP7405400B2 (ja) * 2019-11-20 2023-12-26 Ｎｅｃソリューションイノベータ株式会社 核酸分子およびその用途
JP2023529682A (ja) 2020-06-18 2023-07-11 リゾルブ バイオサイエンシズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中の異なる分析物を検出するための多重的方法
EP4322837A4 (en) 2021-04-16 2025-02-26 Advanced Cell Diagnostics, Inc. MATERIALS AND METHODS RELATED TO IMAGE PROCESSING
WO2023017513A1 (en) * 2021-08-09 2023-02-16 Neuroquest Ltd. Compositions, kits, and methods for detecting preclinical alzheimer's disease
EP4474793A1 (en) * 2023-06-09 2024-12-11 Leica Biosystems Richmond, Inc. Automated melanin bleaching

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1313908A (zh) * 1998-08-21 2001-09-19 纳克斯科尔公司 使用可交联的固定的核酸的检测法
US20030073149A1 (en) * 2001-10-12 2003-04-17 Archer Robert A. Antibody complexes and methods for immunolabeling
WO2008064067A2 (en) * 2006-11-16 2008-05-29 General Electric Company Method for the sequential analysis of different components in a single biological sample and reagents therefor

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405720A (en) 1981-03-04 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services Silver stains for protein in gels
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
JPH01196567A (ja) * 1988-02-01 1989-08-08 Hitachi Ltd 核酸検査方法及び核酸検査装置
US5401469A (en) 1989-04-19 1995-03-28 Ibiden Co., Ltd. Plastic optical biomaterials assay device
JP3130513B2 (ja) 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
JP3188303B2 (ja) * 1992-04-10 2001-07-16 株式会社日立製作所 ポリヌクレオチド検出法
US5843640A (en) 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
US5776755A (en) 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
AU5355594A (en) 1992-10-09 1994-05-09 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue
EP0712444A1 (en) 1993-07-20 1996-05-22 University Of Massachusetts Medical Center In vivo nucleic acid hybridization method
FR2711671A1 (fr) 1993-10-22 1995-05-05 Centre Nat Rech Scient Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5571643A (en) 1994-07-22 1996-11-05 Martin; Mark T. Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5763152A (en) 1995-03-31 1998-06-09 Fuji Photo Film Co., Ltd. Silver halide photographic light-sensitive material
EP0801306A1 (en) 1996-04-10 1997-10-15 Becton, Dickinson and Company Method for immunohistochemically quantitating co-localized molecules
DE19709348C2 (de) 1996-05-29 1999-07-01 Schubert Walter Dr Md Automatisches Multi-Epitop-Ligand-Kartierungsverfahren
WO1998002577A1 (en) 1996-07-15 1998-01-22 The Children's Medical Center Corporation Method to co-detect introduced genes and their products
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6635435B1 (en) 1998-07-10 2003-10-21 Chromagen, Inc. Fluorogenic substrates and their use
DE19835284C2 (de) 1998-08-05 2001-03-01 Tuhh Tech Gmbh Vorrichtung und Verfahren zur automatischen Fokussierung und Belichtung von Bildaufnahmesystemen
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
NZ511408A (en) 1998-10-09 2004-04-30 Licentia Ltd Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
US6391649B1 (en) 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
DE10014685B4 (de) 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
WO2001086296A2 (en) 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
IL136232A0 (en) 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20020114742A1 (en) 2001-02-20 2002-08-22 Hitachi, Ltd. Test chamber
JP2002323416A (ja) 2001-02-20 2002-11-08 Hitachi Ltd 検査容器
US20050230255A1 (en) 2001-03-30 2005-10-20 Sumner Lloyd W Silver destaining method
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20020173053A1 (en) 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
JP3899845B2 (ja) 2001-05-23 2007-03-28 日本光電工業株式会社 染色標本の脱色方法および装置
AU2002319613A1 (en) 2001-07-19 2003-03-03 Signet Laboratories, Inc. Human tissue specific drug screening procedure
DE10143757A1 (de) 2001-09-06 2003-03-27 Werner M Methode zur Darstellung von Merkmalen in Geweben
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
US6731831B2 (en) 2002-02-27 2004-05-04 Xiang Zheng Tu Optical switch array assembly for DNA probe synthesis and detection
US7776195B2 (en) 2002-05-28 2010-08-17 Autogenomics, Inc. Integrated sample processing platform
JP2004041121A (ja) 2002-07-12 2004-02-12 Hitachi Ltd アレルギー解析方法及びシステム
AU2003287527A1 (en) 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Single cell analysis of membrane molecules
WO2005017485A2 (en) 2003-05-22 2005-02-24 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
JP3936689B2 (ja) 2003-09-09 2007-06-27 日本碍子株式会社 シアニン系有機色素劣化環境の検知方法
US7463778B2 (en) 2004-01-30 2008-12-09 Hewlett-Packard Development Company, L.P Motion estimation for compressing multiple view images
JP4538628B2 (ja) 2004-03-16 2010-09-08 学校法人慶應義塾 遺伝子発現検出方法
JP4189495B2 (ja) 2004-08-02 2008-12-03 国立大学法人群馬大学 ゲノムｄｎａのメチル化検出方法
JP2008526249A (ja) * 2005-01-13 2008-07-24 プロジェニカ・バイオファーマ・エス・アー ｉｎｖｉｔｒｏ遺伝子タイピングのための方法および製品
US20070072211A1 (en) * 2005-06-30 2007-03-29 Roche Molecular Systems, Inc. Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
JP2007033159A (ja) 2005-07-25 2007-02-08 Assay Corp 蛍光分子で標識された測定対象物質
WO2007055302A1 (ja) 2005-11-10 2007-05-18 National University Corporation University Of Toyama 生体物質と生体物質結合性物質との結合性評価方法
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
JP2009232707A (ja) * 2008-03-26 2009-10-15 Canon Inc 一塩基多型の検出法及びプローブ固定担体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1313908A (zh) * 1998-08-21 2001-09-19 纳克斯科尔公司 使用可交联的固定的核酸的检测法
US20030073149A1 (en) * 2001-10-12 2003-04-17 Archer Robert A. Antibody complexes and methods for immunolabeling
WO2008064067A2 (en) * 2006-11-16 2008-05-29 General Electric Company Method for the sequential analysis of different components in a single biological sample and reagents therefor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107422122A (zh) * 2012-06-14 2017-12-01 鹿特丹伊拉斯姆斯大学医疗中心 用于检测微小残留病的方法、试剂以及试剂盒
CN107422122B (zh) * 2012-06-14 2020-06-26 鹿特丹伊拉斯姆斯大学医疗中心 用于检测微小残留病的方法、试剂以及试剂盒
CN106290812A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法
CN106290877A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法
CN112543872A (zh) * 2018-09-25 2021-03-23 株式会社日立高新技术 试验方法、分注装置

Also Published As

Publication number Publication date
RU2012115681A (ru) 2013-11-27
KR20120088716A (ko) 2012-08-08
US20110092381A1 (en) 2011-04-21
JP2013507941A (ja) 2013-03-07
BR112012009481A2 (pt) 2016-11-29
EP2491132A1 (en) 2012-08-29
WO2011048184A1 (en) 2011-04-28
CA2777421A1 (en) 2011-04-28
IN2012DN03156A (enExample) 2015-09-18
AU2010309739A1 (en) 2012-05-03
EP2491132B1 (en) 2018-03-21
US9677125B2 (en) 2017-06-13

Similar Documents

Publication Publication Date Title
CN102803510A (zh) 生物样品中多个靶的检测
US9201063B2 (en) Sequential analysis of biological samples
KR102608653B1 (ko) 절편화된 조직의 사용자-한정된 영역에서의 유전자 발현의 동시적인 정량화
CN109789228B (zh) 高度复用荧光成像
CN104620107B (zh) 检测生物样品中dna、rna和蛋白质的方法
JP5149303B2 (ja) 生体試料の連続分析
KR102545430B1 (ko) 절편화된 조직의 사용자-한정된 영역에서의 복수의 단백질의 동시적인 정량화
JP5123314B2 (ja) 生体試料の連続分析
JP5335686B2 (ja) 生体試料の連続分析
KR20150091477A (ko) Ish 분석 결과를 선택적으로 정제하기 위한 면역염색 마스크의 사용 시스템 및 방법
KR102046194B1 (ko) 염료의 광활성화된 화학적 표백
KR20140142715A (ko) 단일 샘플에 대한 면역형광 및 형광-기반 핵산 분석
US20150099650A1 (en) Probing of biological samples
KR20140145141A (ko) 생물학적 샘플의 영상 생성 방법
US10597697B2 (en) Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample
US20140134645A1 (en) Method of isolating or counting target cells by using photocleavable linker coupled with fluorescent dye
HK1179307A (en) Detection of plurality of targets in biological samples
Byers et al. Multiplexed Bioimaging Using Quantum Dots
Gavrilovic et al. Automated classification of multicolored rolling circle products in dual‐channel wide‐field fluorescence microscopy

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1179307

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121128