CA2777421A1 - Detection of plurality of targets in biological samples - Google Patents
Detection of plurality of targets in biological samples Download PDFInfo
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- CA2777421A1 CA2777421A1 CA2777421A CA2777421A CA2777421A1 CA 2777421 A1 CA2777421 A1 CA 2777421A1 CA 2777421 A CA2777421 A CA 2777421A CA 2777421 A CA2777421 A CA 2777421A CA 2777421 A1 CA2777421 A1 CA 2777421A1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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| AU2013274965B2 (en) * | 2012-06-14 | 2018-07-19 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for detecting minimal residual disease |
| WO2014099222A1 (en) * | 2012-12-17 | 2014-06-26 | Clarient Diagnostic Services, Inc. | Chemical bleaching of dyes using radical photoinitiators |
| EP2965087B1 (en) | 2013-03-06 | 2018-10-17 | General Electric Company | Methods of analyzing an h&e stained biological sample |
| CN105408483A (zh) | 2013-03-15 | 2016-03-16 | 通用医疗公司 | 遗传和表观遗传调节蛋白至特定基因组基因座的rna引导的靶向 |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| KR102368591B1 (ko) | 2013-04-30 | 2022-02-25 | 캘리포니아 인스티튜트 오브 테크놀로지 | 순차적 하이브리드화 바코딩에 의한 분자의 멀티플렉스 표지화 |
| US10011850B2 (en) | 2013-06-21 | 2018-07-03 | The General Hospital Corporation | Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing |
| US20160161472A1 (en) | 2013-07-30 | 2016-06-09 | President And Fellows Of Harvard College | Quantitative dna-based imaging and super-resolution imaging |
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| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| EP3117214B1 (en) * | 2014-03-11 | 2020-05-06 | President and Fellows of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| EP4273263A3 (en) | 2014-07-30 | 2024-01-31 | President and Fellows of Harvard College | Systems and methods for determining nucleic acids |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| EP3490616B1 (en) | 2016-07-27 | 2022-09-28 | The Board of Trustees of the Leland Stanford Junior University | Highly-multiplexed fluorescent imaging |
| US12421540B2 (en) | 2016-08-01 | 2025-09-23 | California Institute Of Technology | Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism |
| CN106290812A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法 |
| CN106290877A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法 |
| CN110050071A (zh) | 2016-12-09 | 2019-07-23 | 乌尔蒂维尤股份有限公司 | 用于使用标记的核酸成像剂进行多路复用成像的改进方法 |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| MX2020003695A (es) | 2017-11-30 | 2020-08-03 | Arrakis Therapeutics Inc | Fotosondas de union a acido nucleico y usos de las mismas. |
| JP6999527B2 (ja) * | 2018-09-25 | 2022-01-18 | 株式会社日立ハイテク | 試験方法、分注装置 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3122569A1 (en) | 2018-12-13 | 2020-06-18 | President And Fellows Of Harvard College | Amplification methods and systems for merfish and other applications |
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| JP7405400B2 (ja) * | 2019-11-20 | 2023-12-26 | Ｎｅｃソリューションイノベータ株式会社 | 核酸分子およびその用途 |
| JP7828901B2 (ja) | 2020-06-18 | 2026-03-12 | リゾルブ バイオサイエンシズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 試料中の異なる分析物及び分析物の異なるサブグループ／変形物を検出するための多重的方法 |
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| US9677125B2 (en) | 2017-06-13 |
| WO2011048184A1 (en) | 2011-04-28 |
| IN2012DN03156A (enExample) | 2015-09-18 |
| KR20120088716A (ko) | 2012-08-08 |
| EP2491132A1 (en) | 2012-08-29 |
| RU2012115681A (ru) | 2013-11-27 |
| CN102803510A (zh) | 2012-11-28 |
| JP2013507941A (ja) | 2013-03-07 |
| BR112012009481A2 (pt) | 2016-11-29 |
| US20110092381A1 (en) | 2011-04-21 |
| AU2010309739A1 (en) | 2012-05-03 |
| EP2491132B1 (en) | 2018-03-21 |
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