ES2656962T3 - Métodos para evaluar la receptividad del endometrio de una paciente - Google Patents

Métodos para evaluar la receptividad del endometrio de una paciente Download PDF

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Publication number
ES2656962T3
ES2656962T3 ES11725888.9T ES11725888T ES2656962T3 ES 2656962 T3 ES2656962 T3 ES 2656962T3 ES 11725888 T ES11725888 T ES 11725888T ES 2656962 T3 ES2656962 T3 ES 2656962T3
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Spain
Prior art keywords
endometrium
patient
receptivity
genes
biopsy sample
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ES11725888.9T
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English (en)
Inventor
Samir Hamamah
Delphine Haouzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Universitaire de Montpellier CHUM
Universite de Montpellier
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Universitaire de Montpellier CHUM
Universite de Montpellier
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medical Informatics (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un método para evaluar la receptividad del endometrio de una paciente, que comprende las etapas que consisten en: i) medir el nivel de expresión de once genes en una muestra de biopsia del endometrio obtenida de dicha paciente, en el que dichos genes son MFAP5, ANGPTL1, PROK1, NLF2, LAMB3, BCL2L10, CD68, TRPC4, SORCS1, FST y KRT80; y (ii) comparar el nivel de expresión de los genes en la muestra de biopsia del endometrio con un control, en el que la detección de una sobreexpresión de los genes en la muestra de biopsia del endometrio en comparación con el control es indicativa de que el endometrio es receptivo.

Description

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Claims (1)

  1. imagen1
ES11725888.9T 2010-05-27 2011-05-27 Métodos para evaluar la receptividad del endometrio de una paciente Active ES2656962T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10305561 2010-05-27
EP10305561 2010-05-27
US35431010P 2010-06-14 2010-06-14
US354310P 2010-06-14
PCT/EP2011/058757 WO2011147976A1 (en) 2010-05-27 2011-05-27 Methods for assessing endometrium receptivity of a patient

Publications (1)

Publication Number Publication Date
ES2656962T3 true ES2656962T3 (es) 2018-03-01

Family

ID=42396421

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11725888.9T Active ES2656962T3 (es) 2010-05-27 2011-05-27 Métodos para evaluar la receptividad del endometrio de una paciente

Country Status (6)

Country Link
US (1) US9260748B2 (es)
EP (1) EP2576825B1 (es)
JP (2) JP6219164B2 (es)
ES (1) ES2656962T3 (es)
PT (1) PT2576825T (es)
WO (1) WO2011147976A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2987446B1 (fr) * 2012-02-28 2016-01-01 Univ Nice Sophia Antipolis Test diagnostic de la resistance a l'azacitidine
EP2687851A1 (en) * 2012-07-20 2014-01-22 Matricelab Innove Method for increasing implantation success in assisted fertilization
ES2898849T3 (es) * 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
US11541040B2 (en) 2014-10-28 2023-01-03 Kouchi Yamaguchi Medicine for improving state of pregnancy, and use thereof
IL256203B (en) * 2015-06-12 2022-09-01 Genea Ip Holdings Pty Ltd A method and system for identifying and tracking a biological sample and a patient
CN105784983B (zh) * 2016-01-13 2017-10-31 深圳中山生殖与遗传研究所 一种评估子宫内膜容受性的试剂盒及其使用方法
IT201700045856A1 (it) * 2017-04-27 2018-10-27 Molipharma Srl Kit di determinazione della recettivita’ endometriale
EP3569718A1 (en) * 2018-05-16 2019-11-20 Integrated Genetic Lab Services SLU Kit and method for determining the receptivity status of an endometrium
US20230102503A1 (en) * 2020-02-10 2023-03-30 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy
CN111778326B (zh) * 2020-07-14 2021-10-22 和卓生物科技（上海）有限公司 用于子宫内膜容受性评估的基因标志物组合及其应用
JP2023136665A (ja) * 2022-03-17 2023-09-29 国立大学法人 東京大学 着床能の検出方法および着床障害の予測方法
EP4311862A1 (en) 2022-07-29 2024-01-31 Ivi Rma Global, Sl. Methods for detection of embryo implantation failure of endometrial origen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6196965B1 (en) * 1998-05-21 2001-03-06 Cryofacets, Inc. Compositions methods and devices for embryo implantation for in vitro fertilization
US7354742B2 (en) * 2002-02-22 2008-04-08 Ortho-Mcneil Pharmaceutical, Inc. Method for generating amplified RNA
FR2876701B1 (fr) 2004-10-15 2010-09-17 Genevrier Lab Procede de preparation d'un systeme de culture d'endometre autologue pour la co-culture endometre-embryon

Also Published As

Publication number Publication date
EP2576825B1 (en) 2017-11-08
US9260748B2 (en) 2016-02-16
JP2016171802A (ja) 2016-09-29
JP6219164B2 (ja) 2017-10-25
PT2576825T (pt) 2018-02-02
US20130072748A1 (en) 2013-03-21
JP2013528052A (ja) 2013-07-08
WO2011147976A1 (en) 2011-12-01
EP2576825A1 (en) 2013-04-10

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