BR112012004692B8 - solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano - Google Patents

solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano

Info

Publication number
BR112012004692B8
BR112012004692B8 BR112012004692A BR112012004692A BR112012004692B8 BR 112012004692 B8 BR112012004692 B8 BR 112012004692B8 BR 112012004692 A BR112012004692 A BR 112012004692A BR 112012004692 A BR112012004692 A BR 112012004692A BR 112012004692 B8 BR112012004692 B8 BR 112012004692B8
Authority
BR
Brazil
Prior art keywords
human
solution
levofloxacin
cystic fibrosis
treating cystic
Prior art date
Application number
BR112012004692A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112012004692A2 (pt
BR112012004692B1 (pt
Inventor
c griffith David
e morgan Elizabeth
S Loutit Jefferey
N DUDLEY Michael
Lomovskaya Olga
Original Assignee
Mpex Pharmaceuticals Inc
Raptor Pharmaceuticals Inc
Tripex Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012004692(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mpex Pharmaceuticals Inc, Raptor Pharmaceuticals Inc, Tripex Pharmaceuticals Llc filed Critical Mpex Pharmaceuticals Inc
Publication of BR112012004692A2 publication Critical patent/BR112012004692A2/pt
Publication of BR112012004692B1 publication Critical patent/BR112012004692B1/pt
Publication of BR112012004692B8 publication Critical patent/BR112012004692B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR112012004692A 2009-09-04 2010-09-03 solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano BR112012004692B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24009209P 2009-09-04 2009-09-04
US61/240,092 2009-09-04
US24923109P 2009-10-06 2009-10-06
US61/249,231 2009-10-06
PCT/US2010/047903 WO2011029059A1 (en) 2009-09-04 2010-09-03 Use of aerosolized levofloxacin for treating cystic fibrosis

Publications (3)

Publication Number Publication Date
BR112012004692A2 BR112012004692A2 (pt) 2020-06-02
BR112012004692B1 BR112012004692B1 (pt) 2021-04-13
BR112012004692B8 true BR112012004692B8 (pt) 2021-05-25

Family

ID=43649672

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012004692A BR112012004692B8 (pt) 2009-09-04 2010-09-03 solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano

Country Status (26)

Country Link
US (4) US9700564B2 (enExample)
EP (2) EP3569235A1 (enExample)
JP (2) JP6180012B2 (enExample)
KR (1) KR20120100904A (enExample)
CN (1) CN102724983A (enExample)
AU (1) AU2010289326B2 (enExample)
BR (1) BR112012004692B8 (enExample)
CA (2) CA2773033C (enExample)
CL (1) CL2012000586A1 (enExample)
CY (1) CY1121883T1 (enExample)
DK (1) DK2473170T3 (enExample)
ES (1) ES2739979T3 (enExample)
HR (1) HRP20191408T1 (enExample)
HU (1) HUE045469T2 (enExample)
IL (1) IL218458A0 (enExample)
IN (1) IN2012DN02477A (enExample)
LT (1) LT2473170T (enExample)
MX (1) MX353288B (enExample)
NZ (1) NZ598484A (enExample)
PL (1) PL2473170T3 (enExample)
PT (1) PT2473170T (enExample)
RU (2) RU2015130524A (enExample)
SI (1) SI2473170T1 (enExample)
SM (1) SMT201900440T1 (enExample)
WO (1) WO2011029059A1 (enExample)
ZA (1) ZA201202434B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
US8524735B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
KR20110091510A (ko) 2008-10-07 2011-08-11 엠펙스 파마슈티컬즈, 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
CN102325532B (zh) 2008-10-07 2015-06-17 Mpex医药有限公司 用于减轻肺部炎症的左氧氟沙星吸入剂
ES2739979T3 (es) 2009-09-04 2020-02-05 Horizon Orphan Llc Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística
WO2014201305A1 (en) * 2013-06-13 2014-12-18 University Of Southern California Compositions and methods for the treatment of burkholderia infections
WO2015044177A1 (en) * 2013-09-24 2015-04-02 Universität Zu Köln Compounds useful in the treatment of neoplastic diseases
EP3328429B1 (en) 2015-07-31 2025-07-16 The Research Institute at Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
JP6966835B2 (ja) * 2016-02-05 2021-11-17 ホライズン オーファン リミテッド ライアビリティ カンパニー 嚢胞性線維症のためのフルオロキノロン製剤
CN110151793A (zh) * 2018-03-29 2019-08-23 中国人民解放军军事科学院军事医学研究院 鼠疫菌液体气溶胶肺递送感染小鼠模型
UY38630A (es) 2019-04-03 2020-10-30 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
EP4013741B1 (en) 2019-08-14 2024-04-17 Vertex Pharmaceuticals Incorporated Process of making cftr modulators
WO2021030552A1 (en) 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
KR20230118123A (ko) 2020-12-10 2023-08-10 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 치료 방법
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WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung

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