US3507277A - Inhalation device - Google Patents

Inhalation device Download PDF

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Publication number
US3507277A
US3507277A US3507277DA US3507277A US 3507277 A US3507277 A US 3507277A US 3507277D A US3507277D A US 3507277DA US 3507277 A US3507277 A US 3507277A
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United States
Prior art keywords
device
shaft
housing
container
diameter
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Roger Edward Colling Altounyan
Harry Howell
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Fisons Pharmaceuticals Ltd
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Fisons Pharmaceuticals Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Description

April 1970 R. E. c. ALTQOUINYAN ET AL 3,507,277

INHALATION DEVICE Filed Sept. 15, 1967 INVENTORS ROGER E.C. ALTOUNYAN HARRY HOWELL BY f y /g a ,2 z/ww' ATTORNEYS United States Patent 3,507,277 INHALATION DEVICE Roger Edward Collingwood Altounyan, Wilmslow, and Harry Howell, Castle Donnington, England, asslgnors to Fisons Pharmaceuticals Limited, Loughborough, Leicestershire, England Filed Sept. 15, 1967, Ser. No. 667,975 Claims priority, application Great Britain, Sept. 17, 1966,

. 41,595/ 66 Int. Cl. A61m 15/00, 15/08; B26f 1/24 U.S. Cl. 128208 6 Claims ABSTRACT OF THE DISCLOSURE A device for the oral inhalation of medicaments in finely divided form which comprises a hollow elongate housing having at both ends thereof one or more passageways to permit the passage of air and having one end thereof adapted for insertion into the mouth; and a propeller-like device rotatably mounted in the said housing on a rigid shaft mounted in said housing and co-axial with the longitudinal axis of the housing, said propellerlike device having, on the end thereof furthest from the end of the housing adapted for insertion in the mouth, mounting means adapted to receive a container for the finely divided medicament; which device is provided with means for perforating the container of medicament in situ in the device.

This invention is concerned with improvements in or relating to a device for the application of medicaments in finely divided form by oral inhalation.

More particularly the invention is concerned with a device for the oral inhalation of medicaments in finely divided form which comprises a hollow elongate housing, suitably a tubular housing, having at both ends thereof one or more passageways to permit the passage of air and having one end thereof adapted for insertion into the mouth; and a propeller-like device rotatably mounted in the said housing on a rigid shaft mounted in said housing and co-axial with the longitudinal axis of thehousing, said propeller-like device having, on the partthereof furtherest from the end of the housing adaptedQfor insertion in the mouth, mounting means adapted to receive a container for the finely divided medicament such as a gelatine or like capsule. (By the term propeller-like device is meant a device having two or more blades or vanes disposed about a central axis or hub, such that impingement of an air stream on the said vanes or blades tends to cause rotation of the device about said axis or hub.)

In order to dispense its contents the container of the finely powdered medicament must be perforated and it has been found very convenient to perforate the container in situ in the dispensing device.

According to the invention, therefore, there is provided a dispensing device of the type described provided with means for perforating the container of the finely powdered medicament in situ in the device.

The device according to the invention is particularly convenient since it may be carried by the user with the closed container already in place in the device and is simply used by actuating the container perforating means and then inhaling the contents of the container by inspiration through the device. Since the container is closed or sealed until it is desired to use the device there is no risk of contamination of the contents of the container and, in the case of medicament powders showing hydroscopic tendencies, there is no risk of caking of the medicament prior to use.

Suitably the container used in the device is a capsule, for example a gelatin capsule, and conveniently the capsule perforating means is so arranged to provide one or more holes, suitably of about 0.60.65 mm. in diameter, desirably in the part of the capsule furthest from the propeller-like device, advantageously in the shoulders of the capsule. Where the perforating means is so arranged as to provide two or more holes in the container, these are conveniently positioned symmetrically around the container.

Suitably, the container perforating means may take the form of one or more spring-loaded piercing pins mounted in the housing so that they are normally urged, by the springs, away from the container but which may be pressed inwards to perforate the container by the action of push buttons located on the exterior of the housing.

It has been found that, in order to obtain optimum perforation of a gelatin capsule, the perforating ends of the piercing pins should not be sharpened to a conventional conical point but should be sharpened with a plane face at an acute angle. Further, the acute angled plane face should desirably face away from propeller-like device.

It is desirable that the propeller-like device he so mounted upon the shaft that the passage of an air stream causes not only rotational movement of the propeller-like device but also a vibrational component of motion. This vibrational component of the motion has been found to contribute to the release of the powdered medicament from the capsule.

In order that the propeller-like device should be capable of undergoing vibrational movement, it has been found desirable that the bearing in the propeller-like device in which the shaft engages. should have certain dimensional characteristics. Thus the bearing takes the form of an elongate cavity of circular cross-section and the shaft is, of course, also of circular cross-section.

The internal diameter of the bearing at its inner end, i.e. the end housing the free end of the shaft, is desirably from 1.5% to 6% preferably 2.5 to 5%, e.g. 3.75% greater than the diameter of the shaft and the diameter of the hearing at its outer end is equal to the diameter of the shaft plus from 1.3 to 3.5% e.g. about 2.5% of the total length of the bearing. The actual length of the bearing is not critical but may be, for example, from 4 to 10 times the diameter of the shaft.

The inner end wall of the bearing is preferably flat and the end of the shaft which engages with it is suitably of frusto conical shape, preferably terminating in a hemispllliefrical portion e.g. of a radius of about half that of the s a t.

The shaft itself should be rigidly mounted since we have found that undue flexibility of the shaft and mounting causes malfunctioning of the device.

The device according to the invention is suit-able for the administration of medicaments for the alleviation of a lments of the bronchial tract and of the lungs. The device may also be used for the administration of medicaments having systemic action, for example it may be used for the administration of antidotes to poisonous substances such as nerve gases as it provides a very simple method of carrying medicaments which have to be used rapidly or in emergency.

In order that the invention may be well understood, one embodiment thereof will now be described with reference to the accompanying drawing which is a longitudinal crosssection through the device.

Referring now to the drawing, an inhalation device comprises a housing of approximately circular cross-section comprising two engaging members 1 and 2, housing 2 being adapted for insertion into the mouth and having passage- 3 ways 3 therein to permit the passage of air. Mounted rigidly in and co-axially with housing member 2 is shaft 4 upon which is loosely and rotatably mounted propeller-like device 5 having blades 6.

Propeller-like device 5 has a cup shaped member adapted to receive and hold a capsule or container of finely powdered medicament 7.

Shaft 4 engages in bearing 8 in propeller 5. The diameter at the inner end of bearing 8 is about 3.75% greater than the diameter of shaft 4 and the diameter at the outer end of bearing 8 is equal to the diameter of shaft 4 plus about 2.5% of the total length of the bearing, which is about 7 times the diameter of shaft 4.

The tip 9 of shaft 4 is conical in shape, having a cone angle of about 30, and terminates in a substantially hemispherical portion having a diameter of about half the diameter of shaft 4.

Housing member 1 has in its end wall air passages 10 to permit the passage of air and constricting member 11 which serves to constrict the air stream through the device and thus increase its velocity past the capsule.

Mounted on the outside of housing member 1 are two hollow projections 12 and 12a having slidably engaged therein push buttons 13 and 13a. Push buttons 13 and 13a are retained in projections 12 and 12a by means of pins 14 and 14a engaging in slots in the push buttons, and are urged outwardly from housing member 1 by means of springs 15 and 15a. Attached to push buttons 13 and 13a are piercing pins 16 and 16a. For purposes of illustration, one assembly is shown in the non-piercing position whereas the other assembly is shown with the tip of pin 16a having pierced capsule 7, push button 13a having been depressed against the action of spring 15a.

In operation, housing members 1 and 2 are separated and capsule 7 is loaded into propeller-like device 5. Housing members 1 and 2 are then clipped together again and the device is ready for use. In use, the user first depresses buttons 13 and 13a to cause pins 16 and 16a to pierce capsule 7. He then releases buttons 13 and 13a to remove pins 16 and 16a from the capsule and subsequently inhales through the device to obtain, by inhalation, the contents of capsule 7.

We claim:

1. A device for the oral inhalation of medicaments in finely divided form which comprises a hollow elongate housing having at both ends thereof at least one passageway to permit passage of air and one of said ends being adapted for insertion into the mouth of the user; a propellet means rotatably mounted in said housing on a rigid shaft secured in said housing and co-axial with the longitudinal axis of said housing, said propeller means having on its end furthest from said one end of said housing a mounting means for receiving a container of said finely divided medicaments; and means mounted on said housing for perforating said container While said container is mounted on said mounting means, said perforating means comprising at least one spring loaded piercing member mounted in said housing and having push button means attached thereto for pressing said piercing members into said container.

2. An inhalation device according to claim 1, further comprising a bearing engaging said shaft, said bearing having an internal diameter at its inner end from 1.5 to 6% greater than the diameter of said shaft and an internal diameter at its outer end equal to the diameter of said shaft plus from 1.3 to 3.5% of the total length of said bearing.

3. An inhalation device according to claim 1 in which the piercing members are provided with piercing points taking the form of a plane face at an acute angle to the axis of said member.

4. An inhalation device according to claim 2 in which the internal diameter of the bearing at its inner end is from 2.5 to 5% greater than said diameter of said shaft.

5. An inhalation device according to claim 2 in which the internal diameter of said bearing at its inner end is about 3.75% greater than the diameter of said shaft and said internal diameter of said hearing at its outer end is equal to the diameter of said shaft plus about 2.5 of the length of said bearing.

6. An inhalationdevice according to claim 1, further comprising a bearing engaging said shaft, the length of said bearing being from 4 to 10 times the diameter of said shaft.

References Cited UNITED STATES PATENTS 2,517,482 8/1950 Hall 128-206 2,573,918 11/1951 McCuiston 128206 ANTON 0. OESCHSLE, Primary Examiner P. E. SHAPIRO, Assistant Examiner US. Cl. X.R. 128206

US3507277D 1966-09-17 1967-09-15 Inhalation device Expired - Lifetime US3507277A (en)

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Cited By (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US3807400A (en) * 1971-07-17 1974-04-30 Isf Spa Inhaling device for medicinal powder compositions
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US3888253A (en) * 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
US3906950A (en) * 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US4098273A (en) * 1975-01-13 1978-07-04 Syntex Puerto Rico, Inc. Inhalation device
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5577497A (en) * 1991-05-20 1996-11-26 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
FR2791532A1 (en) * 1999-04-02 2000-10-06 Robert Mahiguian Hair band with perfume diffuser comprises side housings for perfume cartridges and perforator rod activated by push button
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
WO2002092154A1 (en) 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US20030131847A1 (en) * 2002-01-16 2003-07-17 Fabrizio Niccolai Device usable in the treatment of affections of the airways
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US20070051362A1 (en) * 2004-04-23 2007-03-08 Sullivan Timothy R Multiple unit dose drug delivery system
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
US20070240712A1 (en) * 2006-04-05 2007-10-18 Scott Fleming Variable dose inhalation device
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US20080177246A1 (en) * 2007-01-09 2008-07-24 First City Tower Intranasal Cartridge Devices
US20090071108A1 (en) * 2007-09-14 2009-03-19 Mystic Pharmaceuticals, Inc. Deep draw container forming method
US20090084379A1 (en) * 2007-10-02 2009-04-02 Baxter International Inc. Dry powder inhaler
US20090090361A1 (en) * 2007-10-09 2009-04-09 Anand Gumaste Inhalation device
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler
US20090217925A1 (en) * 2008-02-29 2009-09-03 Anand Gumaste Method and apparatus for driving a transducer of an inhalation device
US20100037890A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7669597B2 (en) 2007-05-16 2010-03-02 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
US20100087416A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20100087386A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Topical use of levofloxacin for reducing lung inflammation
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
EP2357015A2 (en) 2006-04-05 2011-08-17 MicroDose Therapeutx, Inc. Variable dose inhalation device
CN102836487A (en) * 2011-06-21 2012-12-26 北京万达创制科技有限公司 Double-needle piercing type dry powder inhaler
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US8748488B2 (en) 2008-05-30 2014-06-10 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
WO2016007356A1 (en) 2014-07-07 2016-01-14 Microdose Therapeutx, Inc. Inhalation device
WO2016014586A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder medicament de-agglomerator
WO2016014154A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder nebulizer
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CN105311717A (en) * 2014-08-01 2016-02-10 心诚镁行动医电股份有限公司 Portable ultrasonic atomizer and medicine storing structure thereof
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof

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Patent Citations (2)

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US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
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Cited By (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device
US3807400A (en) * 1971-07-17 1974-04-30 Isf Spa Inhaling device for medicinal powder compositions
US3888253A (en) * 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US3906950A (en) * 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US4098273A (en) * 1975-01-13 1978-07-04 Syntex Puerto Rico, Inc. Inhalation device
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5577497A (en) * 1991-05-20 1996-11-26 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5715810A (en) * 1991-07-25 1998-02-10 Sepracor Inc. Inhalation devices
US5529059A (en) * 1991-08-01 1996-06-25 Sepracor Inc. Inhalation devices
US5337740A (en) * 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
FR2791532A1 (en) * 1999-04-02 2000-10-06 Robert Mahiguian Hair band with perfume diffuser comprises side housings for perfume cartridges and perforator rod activated by push button
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20110030679A1 (en) * 2000-06-28 2011-02-10 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US7950390B2 (en) 2000-06-28 2011-05-31 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US20090314288A1 (en) * 2000-06-28 2009-12-24 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US20060237011A1 (en) * 2000-06-28 2006-10-26 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US7810495B2 (en) 2000-06-28 2010-10-12 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US8573202B2 (en) 2000-06-28 2013-11-05 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
WO2002092154A1 (en) 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US6705313B2 (en) * 2002-01-16 2004-03-16 Ph&T S.P.A. Device usable in the treatment of affections of the airways
US20030131847A1 (en) * 2002-01-16 2003-07-17 Fabrizio Niccolai Device usable in the treatment of affections of the airways
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
US20100229860A1 (en) * 2004-02-24 2010-09-16 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US7318434B2 (en) 2004-02-24 2008-01-15 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US7334577B2 (en) 2004-02-24 2008-02-26 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20080115784A1 (en) * 2004-02-24 2008-05-22 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US9764104B2 (en) 2004-02-24 2017-09-19 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US20060174869A1 (en) * 2004-02-24 2006-08-10 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
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