US3635219A - Inhalation device - Google Patents

Inhalation device Download PDF

Info

Publication number
US3635219A
US3635219A US3635219DA US3635219A US 3635219 A US3635219 A US 3635219A US 3635219D A US3635219D A US 3635219DA US 3635219 A US3635219 A US 3635219A
Authority
US
United States
Prior art keywords
container
means
piercing
housing
mounted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Roger Edward Colling Altounyan
Harry Castle Howell
Martyn Omar Rowlands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Pharmaceuticals Ltd
Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB2720968A priority Critical patent/GB1268051A/en
Application filed by Fisons Pharmaceuticals Ltd filed Critical Fisons Pharmaceuticals Ltd
Application granted granted Critical
Publication of US3635219A publication Critical patent/US3635219A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Abstract

A dispensing device for dispensing finely divided medicament from a capsulelike container. A hollow elongated housing has at both ends thereof at least one passageway to permit passage of air, and one end is adapted for insertion into the mouth. A propellerlike member is rotatably mounted in the housing and has on the part thereof farthest from the end of the housing adapted for insertion into the mouth a mounting means adapted to receive the capsulelike container. Also included is a means for perforating the container.

Description

United States Patent Altounyan et al. [4 1 Jan. 18, 1972 54] INHALATION DEVICE 2,620,795 12/1952 Muhlethaler ..128/198 3,507,277 4/1970 Altounyan et al. ...l28/208 [721 lnvemors= Edward Collmgwwd Alm'myan, 3,5 1 8,992 7/1970 Altounyan et al. ..l28/208 Wilmslow; Harry Castle Howell, Connington; Martyn Omar Rowlands, Epping, all FOREIGN PATENTS OR APPLICATIONS of England 1,471,722 1/1967 France ..128/208 [73] Assignee: Fisons Pharmaceuticals Limited,

Loughborough, England Primary ExaminerJerome Schnall Assistant Examiner-R. P. Dyer [22] Flled' June 1969 Attorney-Wenderoth, Lind & Ponack [21] Appl. No.: 830,355

[57] ABSTRACT [30] Foreign Application Priority Data A dispensing device for dispensing finely divided medicament from a capsulelike container. A hollow elongated housing has June 7, 1968 Great Britain 27209/68 at both ends thereof at least one passageway to permit passage of air, and one end is adapted for insertion into the mouth. A [52] U.S. Cl ..128/266, 128/208 pmpenerlike member is rotatably mounted in the housing and [51] Ill- CI. ..A61m has on the p thereof farthest from h end f h i g [58] Flew M Search adapted for insertion into the mouth a mounting means 222/30 30/358 adapted to receive the capsulelike container. Also included is 239/309 a means for perforating the container.

[56] R f ren Cited 4 Claims, 2 Drawing lFigures UNITED STATES PATENTS 1,947,720 2/1934 Laub ..401/7 PATENTEnJmamz sum 1 UF2 FIG] INVENTORS ROGER 5c. ALTOUNYAN HARRY HOWELL MARTYN 0. ROWLANDS ATTORNEYS PATENIEU .u: z 8 33? SHEET 2 OF 2 ,AIB

L J LINVENTORS ROGER EH0 ALTOUNYAN HARRY 'OWELL 2 MARTYN O. ROWLANDS ATTORNEY5 INHALATION DEVICE The present invention relates to a device for use in the application of medicaments in finely divided form by oral inhalation.

In order to dispense its contents a container of the finely powdered medicament must be perforated and the present invention relates to the provision of such perforating means integral with a dispensing device of the type which comprises a hollow elongated housing, suitably a tubular housing, having at both ends thereof one or more passageways to permit the passage of air and having one end thereof adapted for insertion into the mouth; and a propellerlike member rotatably mounted in the housing and having, on the part thereof furthest from that end of the housing adapted for insertion into the mouth, mounting means adapted to receive a container for the finely divided medicament, such as a gelatine or like capsule. (By the term propellerlike member" is meant a member having two or more blades or vanes disposed about a central axis or hub, such that impingement of an airstream on the said vanes or blades tends to cause rotation of the member about said axis or hub).

The dispensing portion of the device of the invention may take a variety of forms and may, as described later, also be provided with a cover enclosing the device. However, in the dispensing portion of the device, it has been found that where the propellerlike member is rotatably mounted by means of a cylindrical shaft journaled in a tapered bearing tube, the bearing tube and shaft should have certain dimensional characteristics in order to optimize operation of the device. Thus, the bearing takes the form of an elongate cavity of circular cross section and the shaft is of substantially uniform circular cross section. The internal diameter of the hearing at its inner end (i.e., the end housing the free end of the shaft) is desirably from 1.5 to 6 percent preferably 2.5 to percent, e.g., 3.75 percent greater than the diameter of the shaft and the internal diameter of the hearing at its outer end is equal to the diameter of the shaft plus from L3 to 3.5 percent e.g., about 2.5 percent of the internal length of the hearing, which may be, for example, from four to 10, preferably about seven, times the diameter of the shaft. The inner end wall of the bearing is preferably flat and the end of the shaft which engages with it is suitably of frustoconical shape, preferably terminating in a hemispherical tip portion, e.g., of a radius of about half that of the shaft. It will be appreciated that the movement of the propellerlike member in the housing should not be erratic and we therefore prefer that in this form of device the shaft and bearing tube be in rolling contact during the operation of the device.

The shaft and bearing should be rigidly mounted since we have found that undue flexibility of the shaft and bearing mountings may cause malfunctioning of the device. It is also preferred to constrict the airflow past the powder container in order to increase its velocity at this part of the device. This may be achieved by providing the tubular housing with a venturi. For ease of construction and use, it may be desired to form the hollow elongate housing in two separable parts, one having the mouthpiece, the rotatable propellerlike member and its mounting; the other having the air inlet and, where provided, the constricted or venturi portion of the housing. The provision of a separable housing facilitates insertion and removal of powder containers from their mounting on the propellerlike device.

It will be appreciated that while the shaft may be rigidly mounted and the bearing be rotatable, the shaft and bearing may be transposed and the bearing rigidly in the housing while the shaft, which carries the propellerlike member, is rotatably journaled therein. The ten'n dispensing device of the type described is used herein, where the context permits, to denote both forms of bearing and shaft assembly.

Heretofore piercing means or perforating means has been provided adjacent the propellerlike member, but because the powder container is not held rigidly in position, the piercing means often does not pierce accurately and the containers have a tendency to shatter.

It is an object of the present invention to provide means for holding and piercing the containers which is integral with the dispensing device. Accordingly, there is provided a dispensing device of the type described above provided with means, mounted externally upon the device, for perforating a con tainer for a finely divided medicament.

The term perforating means as used herein is intended to denote any apparatus which may be caused to perforate a container which is subsequently to be mounted within the dispensing portion of the device. For example the perforating means may merely comprise a sheathed pin or like projection which may be unsheathed by the user and used to pierce the powder container. However, it is preferred to provide the perforating means with a cup or like receptacle into which the powder container to be perforated is placed and to use some form of retractable perforating means which may be actuated to perforate the powder container in the receptacle.

Suitably, the container perforating means may take the form of one or more spring-loaded piercing members mounted in a housing on the device so that they are normally urged, by the springs, into an inoperative position, i.e., away from the container, but which may be pressed inwards to perforate the container by the action of pushbuttons acting on the piercing members. The piercing means may also comprise a pair of opposed sharpened piercing members connected by a bent resilient bridging member and means for urging the piercing members together to pierce a container located between them. In this case the piercing members will generally be formed in one piece with the bridging members of a resilient material such as spring steel, carbon steel or stainless steel. If the piercing members are formed of a corrodible material, such as spring steel or carbon steel, they may be plated, e.g., with nickel or chromium, to inhibit corrosion. In order to facilitate the piercing operation the piercing members are advantageously provided with stops which prevent too deep a penetration of one member into the capsule before the other member comes into operation, hence ensuring equal penetration by both members. The resilient bridging member may take the form of a simply bent strip or rod of material or may be provided with one or more turns to give better resistance to fatigue. The piercing members may be urged together by pushbuttons or, preferably, by sliding cams.

It has been found that, in order to obtain optimum perforation of a gelatine capsule, the perforating end of the piercing member should not be sharpened to a conventional conical point but should be sharpened with a plane face at an acute angle to the axis thereof. Further it is desirable that the piercing member should be so orientated that the capsule pierced therewith may be mounted in the dispensing portion of the device with the lip of the perforation which has been cut with the angled plane face removed from the propellerlike member.

As stated above, the perforating means is mounted externally upon the housing of the dispensing ortion of the device. The position upon which it is mounted is, within reason, immaterial. However, for convenience it is preferred to mount the perforating means approximately half way along the tubular body of the dispensing portion of the device and to form the housing for the perforating means in the form of a lateral arm extending radially from the tubular housing. The arm may be provided with a receptacle into which a powder container is placed for piercing. In is preferred that the arm be moulded integrally with the tubular housing, the whole being made from, for example, a plastic such as a nylon, polystyrene or a rigid polyethylene.

Suitably the powder container used in the device is a capsule, for example a gelatine or plastic capsule, and conveniently the capsule perforating means is so arranged to provide two or more holes, suitably of about 0.6-0.65 mm. in diameter, desirably in the part of the capsule which will be furthest from the propellerlike member when in position, advantageously in the shoulders of the capsule. Where the perforating means is so arranged as to provide two or more holes in the container, these are conveniently positioned symmetrically around the container.

ln a preferred version of the device of the invention, the dispenser and the perforating means are housed within a split shell cover which may be removed to permit the loading and piercing of a powder container in the piercing means and subsequent transfer of the pierced container to its mounting means on the propellerlike member. The cover acts to protect the device from damage due to dust and grit. Where the device is provided with such a cover it is convenient to use the housing for the perforating means as a support for an annular collar lying in a plane which is approximately at right angles to the longitudinal axis of the tubular housing of the dispenser. The collar may also be supported by struts mounted on the tubular housing. The collar is adapted to receive each half of the split shell cover in, for example, a snap fit which permits secure mounting of the cover yet enables ready removal of each half of the cover to expose the two ends of the tubular housing. As indicated above, the elongate housing of the device may be formed in two separable halves. Since that portion having the air inlet and the constricted or venturi portion will usually hinder access to the powder container mounting means, it is generally necessary to remove that portion of the housing during the loading or unloading of powder containers. It is, therefore, convenient to attach that part of the split shell cover enclosing the portion of the housing hindering free access to the container mounting means to that portion of the housing. By this means, removal of the shell cover also removes the housing. The attachment of the housing and cover may be by means of struts or the like.

The device according to the invention is suitable for the administration of medicaments for the alleviation of ailments of the respiratory tract and of the lungs. The device may also be used for the administration of medicaments having systemic action, for example, it may be used for the administration of antidotes to poisonous substances such as nerve gases as it provides a very simple method of carrying medicaments which have to be used rapidly or in emergency. If desired, the device of the insertion may be provided with clips, cuplike receptacles or the like on the lateral arm carrying the piercer or within the split shell covers, whereby a number of powder containers may be stored within the device for future use. By this means a user is provided with a device whereby a drug may be administered speedily and easily and with a ready supply of capsules for his immediate needs, for example a days supply of four to six capsules.

By way of example a device according to the invention will be described with reference to the accompanying drawings in which FIG. 1 is a vertical section through the device and P16. 2 is a view of the device from above with the upper cover and constricted portion of the housing removed. Like numerals denote like parts.

Referring now to FIG. 1 of the drawings, the device comprises a cigar-shaped tubular housing of approximately circular cross section comprising two engaging members 1 and 2, member 2 being provided with a mouthpiece 3 for insertion into the mouth of the user. Mounted rigidly in and coaxially with member 2 is a shaft 4 upon which is loosely and rotatably mounted propellerlike member 5 having blades 6 and an elongated tapered bearing tube. The internal diameter at the inner end of the bearing tube is about 3.75 percent greater than the diameter of shaft 4 and the internal diameter at the outer end of the bearing tube is equal to the diameter of shaft 4 plus about 2.5 percent of the internal length of the bearing, which is about seven times the diameter of shaft 4.

The tip of shaft 4 is conical in shape, having a cone angle of about 30, and terminates in a substantially hemispherical portion having a diameter of about half the diameter of shaft 4.

The relative dimensions of the device, notably of the shaft, bearing tube and propellerlike member, may be varied over considerable ranges to produce a number of permutations which will give rise to satisfactory operation of the device. We have found that where the shaft 4 is a cold drawn stainless steel wire of diameter about 2.03 mm., and the bearing tube is a hard nylon having an internal diameter at its inner end of about 2.08 mm., and of about 2.44 mm., at its outer end and a length of about 12.7 mm., satisfactory operation of the device is achieved for a capsule of internal diameter about 6.3 mm., mounted on the propellerlike member with the base of its parallel walled portion about 5.1 mm. from the top of the bearing tube.

The propellerlike member 5 has a cup-shaped member 7 adapted to receive and hold a capsule or container or finely powdered medicament (shown in dotted outline).

The member 1 has a constriction 8 which acts as a venturi and increases the velocity of the airstream past the capsule when a user inhales air through the mouthpiece 3. Mounted externally upon the waist of the housing 2 is a radial sidearm which carries a cup-shaped receptacle 9 for a powder container and a needle piercer 10 mounted in a carrier 11 which carrier is adapted to slide forward against a return spring 12, housed within the sidearm and which bears against the carrier slide. The forward movement of carrier 11 carries the needle 10 across the mouth of the receptacle 9.

The receptacle 9 is provided with slots 13 through which the needle 10 may pass when it is moved forward.

The free end of the sidearm also acts as a support for a collar 14 which encircles the waist of the cigar-shaped tubular housing and the sidearm The member 2 also carries support struts 15 (of which only one is visible) for the collar 14. The collar is provided with an upper and a lower rim which are adapted to accept an upper and lower cover 16 and 17 in a snap fit. The two covers form the halves of a split shell which encases the whole of the device. While the overall configuration of the collar 14 and covers 16 and 17 is of minor significance, it is essential that, in this form of the device, the collar 14 should be spaced from the walls of the members 1 and 2 and from the sidearm to provide air passages 18 across the plane of the collar. The air passages 18 are more readily visible in FIG. 2 which is a top view of the device with the top cover 16 and member I removed.

It will of course be appreciated that the elongated bearing tube may be mounted rigidly and substantially coaxially with member 2 and the shaft 4 may be mounted on the propellerlike member 5.

In use, the top cover 16 and the attached member 1 are removed, a powder container is inserted in the receptacle 9 and pierced by forward movement of the needle 10 and carrier 11 such that the needle 10 passes through the powder container. The needle is withdrawn by the action of the return spring 12 and the container then inserted in the cup 7 of the propeller 5. It will be appreciated that the container is mounted so that powder may issue from the perforations, in this case with the pierced end directed away from the mouthpiece 3. The upper cover 16 and member 1 are then replaced and the lower cover 17 removed, exposing the mouthpiece 3. The user sucks through the mouthpiece drawing a stream of air through the tubular housing via the air passages 18. The stream of air causes the propeller 5 to rotate and vibrate. The powder in the container is dispensed into the airstream and is inhaled by the user.

We claim:

1. A dispensing device comprising a hollow elongated housing having at both ends thereof at least one passageway to permit the passage of air and having one end thereof adapted for insertion into the mouth, a propellerlike member rotatably mounted in the housing and having, on the part thereof furthest from that end of the housing adapted for insertion into the mouth, mounting means adapted to receive a container for a finely divided medicament, and means mounted externally upon the device for perforating a container for a finely divided medicament, said externally mounted means having therein a recess opening outwardly of the externally mounted means which recess has a size and shape-for receiving substantially the entire medicament container and holding the container firmly with only a small portion of the container projecting from the recess, and further having container piercing means movably mounted relative to said externally mounted means for movement a distance at least equal to the distance across said recess, and a single piercing member on said piercing means closely adjacent the recess opening and movable completely across said recess during movement of said piercing means for perforating both sides of the container, whereby the medicament container is held tightly during piercing and the piercing member moves across the recess opening close to the top surface of said externally mounted means to carry out precise piercing of the medicament container to reduce the danger of shattering the medicament con tainer.

Claims (4)

1. A dispensing device comprising a hollow elongated housing having at both ends thereof at least one passageway to permit the passage of air and having one end thereof adapted for insertion into the mouth, a propellerlike member rotatably mounted in the housing and having, on the part thereof furthest from that end of the housing adapted for insertion into the mouth, mounting means adapted to receive a container for a finely divided medicament, and means mounted externally upon the device for perforating a container for a finely divided medicament, said externally mounted means having therein a recess opening outwardly of the externally mounted means which recess has a size and shape for receiving substantially the entire medicament container and holding the container firmly with only a small portion of the container projecting from the recess, and further having container piercing means movably mounted relative to said externally mounted means for movement a distance at least equal to the distance across said recess, and a single piercing member on said piercing means closely adjacent the recess opening and movable completely across said recess during movement of said piercing means for perforating both sides of the container, whereby the medicament container is held tightly during piercing and the piercing member moves across the recess opening close to the top surface of said externally mounted means to carry out precise piercing of the medicament container to reduce the danger of shattering the medicament container.
2. A device as claimed in claim 1 further comprising a housing on the device, and said piercing means comprises a spring-loaded member mounted in the housing.
3. A device according to claim 1 wherein the perforating means has a lateral sidearm provided on the elongated housing and extending radially from the elongated housing, said piercing means being mounted on said sidearm and said sidearm having said recess therein.
4. A device according to claim 1 wherein the piercing member has a sharpened end with a plane face at an acute angle to the axis thereof.
US3635219D 1968-06-07 1969-06-04 Inhalation device Expired - Lifetime US3635219A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2720968A GB1268051A (en) 1968-06-07 1968-06-07 Inhalation device

Publications (1)

Publication Number Publication Date
US3635219A true US3635219A (en) 1972-01-18

Family

ID=10255943

Family Applications (1)

Application Number Title Priority Date Filing Date
US3635219D Expired - Lifetime US3635219A (en) 1968-06-07 1969-06-04 Inhalation device

Country Status (3)

Country Link
US (1) US3635219A (en)
GB (1) GB1268051A (en)
IE (1) IE32849B1 (en)

Cited By (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2335122A1 (en) * 1972-08-04 1974-02-14 Beecham Group Ltd Device for the oral inhalation of finely divided, solid drug
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US3807400A (en) * 1971-07-17 1974-04-30 Isf Spa Inhaling device for medicinal powder compositions
US3837341A (en) * 1972-08-23 1974-09-24 Fisons Ltd Medicament inhalation device with audible indicating means
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3888252A (en) * 1974-01-23 1975-06-10 Anthony J Side Powder inhaler
US3918451A (en) * 1973-09-18 1975-11-11 Ritzau Pari Werk Kg Paul Inhalator for pulverulent substances
US3921637A (en) * 1973-07-23 1975-11-25 Bespak Industries Ltd Inhaler for powdered medicament
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4137914A (en) * 1975-12-12 1979-02-06 Aktiebolaget Draco Aerosol inhalation device
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4627432A (en) * 1982-10-08 1986-12-09 Glaxo Group Limited Devices for administering medicaments to patients
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5577497A (en) * 1991-05-20 1996-11-26 Dura Pharmaceuticals, Inc. Dry powder inhaler
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6679254B1 (en) * 1999-02-05 2004-01-20 Smithkline Beecham Corporation Inhalation device
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US20040151059A1 (en) * 2002-05-01 2004-08-05 Roberts Ii William Leroy Deagglomerator apparatus and method
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
US20050211364A1 (en) * 2001-07-28 2005-09-29 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US20070209661A1 (en) * 2006-03-03 2007-09-13 Hugh Smyth Dry powder inhaler with aeroelastic dispersion mechanism
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
US20070240712A1 (en) * 2006-04-05 2007-10-18 Scott Fleming Variable dose inhalation device
US20070277820A1 (en) * 2003-10-27 2007-12-06 Timothy Crowder Blister packages and associated methods of fabricating dry powder drug containment systems
US20080105256A1 (en) * 2004-11-10 2008-05-08 Cipla Limited Inhaler
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US20090025721A1 (en) * 2007-06-12 2009-01-29 Alkermes, Inc. Powder inhaler devices
US20090090361A1 (en) * 2007-10-09 2009-04-09 Anand Gumaste Inhalation device
US20090217925A1 (en) * 2008-02-29 2009-09-03 Anand Gumaste Method and apparatus for driving a transducer of an inhalation device
US20100040560A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100087416A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20100087386A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Topical use of levofloxacin for reducing lung inflammation
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
EP2357015A2 (en) 2006-04-05 2011-08-17 MicroDose Therapeutx, Inc. Variable dose inhalation device
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US8748488B2 (en) 2008-05-30 2014-06-10 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
WO2015075433A1 (en) 2013-11-19 2015-05-28 Cipla Limited Inhaler device
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
WO2016007356A1 (en) 2014-07-07 2016-01-14 Microdose Therapeutx, Inc. Inhalation device
WO2016014586A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder medicament de-agglomerator
WO2016014154A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder nebulizer
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5469843A (en) * 1991-11-12 1995-11-28 Minnesota Mining And Manufacturing Company Inhalation device
AU4829593A (en) * 1992-09-23 1994-04-12 Fisons Plc Inhalation device
US5437271A (en) * 1993-04-06 1995-08-01 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
US5372128A (en) * 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1947720A (en) * 1931-04-09 1934-02-20 Stanley V Laub Toothbrush
US2620795A (en) * 1949-11-03 1952-12-09 Ernest F Muhlethaler Nose clip for administering medicines
FR1471722A (en) * 1965-03-19 1967-03-03 Fisons Pharmaceuticals Ltd Device for inhalations
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1947720A (en) * 1931-04-09 1934-02-20 Stanley V Laub Toothbrush
US2620795A (en) * 1949-11-03 1952-12-09 Ernest F Muhlethaler Nose clip for administering medicines
FR1471722A (en) * 1965-03-19 1967-03-03 Fisons Pharmaceuticals Ltd Device for inhalations
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device

Cited By (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3807400A (en) * 1971-07-17 1974-04-30 Isf Spa Inhaling device for medicinal powder compositions
DE2335122A1 (en) * 1972-08-04 1974-02-14 Beecham Group Ltd Device for the oral inhalation of finely divided, solid drug
US3837341A (en) * 1972-08-23 1974-09-24 Fisons Ltd Medicament inhalation device with audible indicating means
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3921637A (en) * 1973-07-23 1975-11-25 Bespak Industries Ltd Inhaler for powdered medicament
US3918451A (en) * 1973-09-18 1975-11-11 Ritzau Pari Werk Kg Paul Inhalator for pulverulent substances
US3888252A (en) * 1974-01-23 1975-06-10 Anthony J Side Powder inhaler
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4137914A (en) * 1975-12-12 1979-02-06 Aktiebolaget Draco Aerosol inhalation device
US4627432A (en) * 1982-10-08 1986-12-09 Glaxo Group Limited Devices for administering medicaments to patients
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5577497A (en) * 1991-05-20 1996-11-26 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6679254B1 (en) * 1999-02-05 2004-01-20 Smithkline Beecham Corporation Inhalation device
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20110030679A1 (en) * 2000-06-28 2011-02-10 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US7950390B2 (en) 2000-06-28 2011-05-31 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7810495B2 (en) 2000-06-28 2010-10-12 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US20060237011A1 (en) * 2000-06-28 2006-10-26 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US8573202B2 (en) 2000-06-28 2013-11-05 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US20060283448A1 (en) * 2001-04-16 2006-12-21 Advanced Inhalation Research, Inc. Inhalation device and method
US20040216738A1 (en) * 2001-04-16 2004-11-04 Advanced Inhalation Research, Inc. Inhalation device and method
US20040154618A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US20040154619A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US7278425B2 (en) 2001-04-16 2007-10-09 Alkermes, Inc. Inhalation device and method
US7146978B2 (en) 2001-04-16 2006-12-12 Advanced Inhalation Research, Inc. Inhalation device and method
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US20050211364A1 (en) * 2001-07-28 2005-09-29 Boehringer Ingelheim Pharma Kg Method and apparatus for sealing medicinal capsules
US20040151059A1 (en) * 2002-05-01 2004-08-05 Roberts Ii William Leroy Deagglomerator apparatus and method
US20070277820A1 (en) * 2003-10-27 2007-12-06 Timothy Crowder Blister packages and associated methods of fabricating dry powder drug containment systems
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
WO2005081833A2 (en) 2004-02-24 2005-09-09 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US9764104B2 (en) 2004-02-24 2017-09-19 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US7318434B2 (en) 2004-02-24 2008-01-15 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US7334577B2 (en) 2004-02-24 2008-02-26 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20080115784A1 (en) * 2004-02-24 2008-05-22 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US20060174869A1 (en) * 2004-02-24 2006-08-10 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
US8322338B2 (en) 2004-02-24 2012-12-04 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US20100229860A1 (en) * 2004-02-24 2010-09-16 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US9162031B2 (en) 2004-02-24 2015-10-20 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US8474452B2 (en) 2004-02-24 2013-07-02 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US20080105256A1 (en) * 2004-11-10 2008-05-08 Cipla Limited Inhaler
US8006695B2 (en) 2004-11-10 2011-08-30 Cipla Limited Inhaler
US20100040560A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100158957A1 (en) * 2005-05-18 2010-06-24 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100166673A1 (en) * 2005-05-18 2010-07-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100037890A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20070209661A1 (en) * 2006-03-03 2007-09-13 Hugh Smyth Dry powder inhaler with aeroelastic dispersion mechanism
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
EP2357015A2 (en) 2006-04-05 2011-08-17 MicroDose Therapeutx, Inc. Variable dose inhalation device
US20070240712A1 (en) * 2006-04-05 2007-10-18 Scott Fleming Variable dose inhalation device
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US8496002B2 (en) 2007-06-12 2013-07-30 Civitas Therapeutics, Inc. Powder inhaler devices
US20090025721A1 (en) * 2007-06-12 2009-01-29 Alkermes, Inc. Powder inhaler devices
US20090090361A1 (en) * 2007-10-09 2009-04-09 Anand Gumaste Inhalation device
US9539400B2 (en) 2007-10-09 2017-01-10 Microdose Therapeutx, Inc. Inhalation device
US9132246B2 (en) 2007-10-09 2015-09-15 Microdose Therapeutx, Inc. Inhalation device
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
US20090217925A1 (en) * 2008-02-29 2009-09-03 Anand Gumaste Method and apparatus for driving a transducer of an inhalation device
US8371294B2 (en) 2008-02-29 2013-02-12 Microdose Therapeutx, Inc. Method and apparatus for driving a transducer of an inhalation device
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8748488B2 (en) 2008-05-30 2014-06-10 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US20100087416A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US20100087386A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Topical use of levofloxacin for reducing lung inflammation
US9717738B2 (en) 2008-10-07 2017-08-01 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10149854B2 (en) 2008-10-07 2018-12-11 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US9326936B2 (en) 2008-10-07 2016-05-03 Raptor Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US8763606B2 (en) 2009-05-21 2014-07-01 Microdose Therapeutx, Inc. Rotary cassette system for dry powder inhaler
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10231975B2 (en) 2009-09-04 2019-03-19 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
EP3431128A1 (en) 2010-01-05 2019-01-23 MicroDose Therapeutx, Inc. Inhalation device and method
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US8651104B2 (en) 2010-12-07 2014-02-18 Respira Therapeutics, Inc. Bead-containing dry powder inhaler
WO2015075433A1 (en) 2013-11-19 2015-05-28 Cipla Limited Inhaler device
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
WO2016007356A1 (en) 2014-07-07 2016-01-14 Microdose Therapeutx, Inc. Inhalation device
WO2016014154A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder nebulizer
WO2016014586A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder medicament de-agglomerator

Also Published As

Publication number Publication date
IE32849B1 (en) 1973-12-28
GB1268051A (en) 1972-03-22
IE32849L (en) 1969-12-07

Similar Documents

Publication Publication Date Title
US3587573A (en) Inhalation device with rupturable microscopic capsules
ES2238536T3 (en) Powder inhaler.
US5027806A (en) Medication delivery system phase two
RU2077893C1 (en) Inhaler for dosimetric administration of medicinal powder by natural inhalation
ES2265157T3 (en) Inhaler for dry powder medicaments provided with means for the division of the flow driven by the inspiration to cause drug administration.
EP0773807B1 (en) Inhalation device
US7424888B2 (en) Medicament dispenser
US4648393A (en) Breath activated medication spray
EP0533683B1 (en) Device intended for measuring a dose of powdered medicament for inhalation
US10194693B2 (en) Aerosol generating device
US6526969B2 (en) Method and device for releasing powder
US5855564A (en) Aerosol extrusion mechanism
CA1038346A (en) Unitary therapeutic aerosol dispenser
US6012454A (en) Dry powder inhalation device
US4013075A (en) Inhalers and insufflators having a cutting means
JP4601627B2 (en) Sublingual drug delivery device
CA2245799C (en) Powdered medication inhaler
JP2844261B2 (en) Inhaler
US7032593B2 (en) Inhalation device and method
RU2150298C1 (en) Method and inhaler for liquefying powdery medicinal preparation
US5619985A (en) Inhaler type medicine administering device
EP2319334A1 (en) A smoking system having a liquid storage portion
ES2481565T3 (en) Visual indicator for an apparatus for dispensing aerosol medications and corresponding system
EP1106196A2 (en) Inhalant medicator
US5477849A (en) Spacer for medication inhaler