CN102836487A - Double-needle piercing type dry powder inhaler - Google Patents
Double-needle piercing type dry powder inhaler Download PDFInfo
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- CN102836487A CN102836487A CN2011101669211A CN201110166921A CN102836487A CN 102836487 A CN102836487 A CN 102836487A CN 2011101669211 A CN2011101669211 A CN 2011101669211A CN 201110166921 A CN201110166921 A CN 201110166921A CN 102836487 A CN102836487 A CN 102836487A
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- diskus
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Abstract
The invention relates to a double-needle piercing type dry powder inhaler. The double-needle piercing type dry powder inhaler comprises an inhalation part and a medicine-carrying part, wherein the inhalation part is shaped like a suction tube; a transverse partition board is arranged in the middle of the suction tube and divides the suction tube into different upper and lower spaces; a gas inlet hole on one side of the transverse partition board is communicated with a downward gas inlet needle; an open hole in the center of the transverse partition board is downwards communicated with an inhalation needle; the inhalation needle and a gas inlet needle are vertical to the transverse partition board and is downwards fixed on the transverse partition board; and a capsule groove for accommodating capsules is formed on the medicine-carrying part and is connected to the lower end of the inhalation part through a buckling groove. The double-needle piercing type dry powder inhaler has the advantages of portability, simplicity and convenience in operation, high capsule emptying rate, reusability, simple structure, convenience for processing, low price and the like.
Description
Technical field
The present invention relates to a kind of medicament inhaler of Foradil Aerolizer formoterol fumarate, penetrate the formula Diskus, be applied to medical field more specifically to a kind of crosspointer.
Background technology
The characteristics of Foradil Aerolizer formoterol fumarate (DPI) are: with the DPI form administration, medicine absorbs through pulmonary and the abundant down blood capillary of respiratory mucosa, and onset is very fast; People's lung surface is long-pending big, and the alveolar surface is by the simple epithelium cellularity, and medicine is through air. and the distance of blood exchange is short, and speed is fast; Administration does not have the effect of gastrointestinal tract enzymolysis, no first pass effect of hepar.Enzymatic activity is lower; Thin and the membrane permeability advantages of higher of epithelium barrier; Be particularly useful for protein and peptide drugs administration, beta-adrenaline antagonist, cholilytic drug, 17-hydroxy-11-dehydrocorticosterone, imitate small-molecule drugs such as anesthetis, migraine and insulin, growth hormone, vaccine and new macromolecular drugs such as biological technology products by force and also can be made into the pulmonary administration preparation, play part or whole body therapeutic effect.The same MDI of DPI (quantitatively atomized inhalation) compares has tangible advantage: the patient initiatively sucks medicated powder, does not have administration coordinated problem; The non-freon propellant is avoided the pollution to atmospheric environment, and respiratory tract is not stimulated; Do not contain solvents such as ethanol and antiseptic, to pathological changes mucosa nonirritant; As solid dosage forms, be particularly suitable for polypeptide and protein drug; Do not receive the restriction of drug solubility, drug loading can be very high.
Clinical therapeutic effect directly depends on the difference of size, form, molecular weight, electric charge, moisture absorption of inside compound mode, the drug particles of delivery device etc.With regard to granular size; The drug particles of diameter 1～5 μ m is the most suitable, be referred to as to suck granule, greater than the granule of 5 μ m then the overwhelming majority be trapped within pars oralis pharyngis; Finally get in the body through swallowing; Though breathe circle down and can reach less than the granule of 0.5 μ m, when moisture was breathed, 90% microgranule excreted with expiration again.
In recent ten years; Because the rise of micronization technology such as spray drying, supercritical fluid; Multiple dose, require low novel doser to continue to bring out to gettering rate, DPI type and quantity increase rapidly, and applicable types of drugs extends to the active drug of treating each link of asthma by sodium cromoglicate originally; Develop into compound preparation by single preparations of ephedrine, just develop to antibiotic, protein and peptide drugs, genomic medicine and vaccine at present by single treatment asthma drug.
The Diskus kind is numerous, according to dosage can be divided into: single dose, depot multiple dose, multiple units dosage; Storing mode by medicine can be divided into: capsule-type, vesicle type, depot; Power resources by device can be divided into: suck air stream drives type, compressed air-driven type, battery motor-driven
The shortcoming that Diskus commonly used now exists is: volume is bigger, carries inconvenience; Use comparatively trouble of operation, often need repairing; Drug residue is higher in the device; Except that single-dose type (as rotating inhaler etc.); The all not reproducible use of all the other powder inhalers has caused the patient to repeat to buy suction apparatus, has increased the weight of the patient treatment expense; Bring unnecessary financial burden to the patient; China is a large agricultural country, and the medical apparatus and instruments of expensive is difficult to obtain peasant and low-income group's approval, and this is not suitable for improving whole people's medical environment, wide popularization and application to popular current demand; The multiple dose type that uses at present (standard receive device etc.) and store dosage form (all protects etc.) problems such as powder inhaler also exists complex structure, cost is high, and used raw material is many, pollution is big.
The present invention is directed to the many scarce limit of above-mentioned inhaler, provide a kind of and be easy to carry about with one, easy and simple to handle; Medicine less residue in the device; Reusable, simple in structure, economical and practical crosspointer penetrates the formula Diskus; It can be widely used as the doser that sucks medicine, supplies the patient of diseases such as asthma, laryngopharyngeal diseases, tracheitis, bronchitis to use.
Summary of the invention
The object of the present invention is to provide a kind of medicament inhaler of Foradil Aerolizer formoterol fumarate, be applied to medical field.
To achieve these goals, crosspointer provided by the invention penetrates the formula Diskus and comprises: inhalation part and medicine carrying parts, wherein the medicine carrying parts are connected the lower end of inhalation part through buckle slot.
The inhalation part that above-mentioned crosspointer penetrates the formula Diskus is the suction pipe shape; The centre position of this suction pipe is provided with diaphragm plate suction pipe is divided into different space up and down; One side of diaphragm plate has air inlet to be connected with downward air inlet needle; The diaphragm plate center drilling is connected with the suction pin downwards, and said suction pin and air inlet needle also are fixed on the diaphragm plate downwards perpendicular to diaphragm plate simultaneously; Said medicine carrying parts have lays capsular capsule groove, is connected the lower end of inhalation part through buckle slot.
Wherein, the upper space of inhalation part suction pipe is provided with a plurality of dilution holes symmetrically near the diaphragm plate position on the suction pipe wall, on suction pipe inwall above the dilution holes, is provided with to be used for drug powder is sieved filtering screen cloth.
The lower space internal face of above-mentioned inhalation part suction pipe is provided with buckle slot, and the outside wall surface of medicine carrying parts is provided with many circle buckles.
Wherein, the outer wall of inhalation part suction pipe is provided with as oral area and correctly contains pattern or the literal of receiving with direction signs.
The suction pipe mouth outer wall surface of above-mentioned inhalation part is provided with the multiple tracks oral area and contains and receive the groove of anti-skidding usefulness.
Wherein, suck pin and be connected with the bottom of suction pipe, air inlet needle is connected with air inlet, and the suction pin is shorter than air inlet needle, and the needle point that promptly sucks pin is in the needle point upper end position of air inlet needle.
The internal diameter of above-mentioned suction pin, air inlet needle is 0.3～5.0mm, and needle point vertical direction distance is 0.5～2.5mm.
The present invention has following beneficial effect:
Crosspointer of the present invention penetrates the formula Diskus through air inlet needle and suction pin; Puncture capsule and be deep into capsule from the capsule top; Utilizing air communication to cross air inlet needle kicks up drug powder; Defectives such as drug powder is crossed the suction faller gill with air communication and gone out capsule, and the interior drug residue of device that has solved existing suction apparatus existence is many, and the active drug amount of entering human body is few.
The present invention has and is easy to carry about with one, and is easy and simple to handle, medicine less residue in the device; Characteristics such as reusable, simple in structure, economical and practical, suitable suitability for industrialized production; Can be widely used as the doser that sucks medicine, supply the patient of diseases such as asthma, laryngopharyngeal diseases, tracheitis, bronchitis to use.
Description of drawings
Fig. 1 is the overall structure sketch map that crosspointer of the present invention penetrates the formula Diskus.
Fig. 2 is the structural representation that this crosspointer penetrates the inhalation part of formula Diskus.
Fig. 3 is the side view that this crosspointer penetrates the inhalation part of formula Diskus.
Fig. 4 is the structural representation that this crosspointer penetrates the medicine carrying parts of formula Diskus.
Fig. 5 is the side view that this crosspointer penetrates the medicine carrying parts of formula Diskus.
Fig. 6 is the profile along A-A line among Fig. 3.
Reference numeral
The specific embodiment
The accompanying drawings specific embodiment of the present invention.
Embodiment one
Like Fig. 1, Fig. 2, Fig. 4 and shown in Figure 5; A kind of crosspointer penetrates the formula Diskus; Comprise inhalation part: suction pipe 1, screen cloth 2, dilution holes 3, air inlet 4, suck pin 5, air inlet needle 6, buckle slot 7 and diaphragm plate 12, the medicine carrying parts: capsule groove 8, first buckle 9, second buckle 10 and the 3rd buckle 11.Wherein the medicine carrying parts are connected with buckle slot 7 on the inhalation part through first buckle 9, second buckle 10 or the 3rd buckle 11.The inhalation part upper end is the suction pipe shape of suction pipe 1; The centre position of suction pipe 1 is provided with diaphragm plate 12 suction pipe is divided into different space up and down; One side of diaphragm plate 12 has air inlet 4 to be connected with downward air inlet needle 6; Diaphragm plate 12 center drillings are connected with suction pin 5 downwards, and said suction pin 5 also is fixed on downwards on the diaphragm plate 12 perpendicular to diaphragm plate 12 with air inlet needle 6 simultaneously.The medicine carrying parts have lays capsular capsule groove 8, is connected the lower end of inhalation part through buckle slot 7.The upper space of inhalation part suction pipe 1 is provided with a plurality of dilution holes 3 symmetrically near diaphragm plate 12 positions on the suction pipe wall, on suction pipe inwall above the dilution holes 3, be provided with to be used for drug powder is sieved filtering screen cloth 2.The lower space internal face of inhalation part suction pipe 1 is provided with buckle slot 7, and the outside wall surface of medicine carrying parts is provided with many circle buckles 9,10,11.The outer wall of inhalation part suction pipe 1 is provided with as oral area and correctly contains pattern or the literal of receiving with direction signs.Suction pipe mouth outer wall surface is provided with the multiple tracks oral area and contains and receive the groove of anti-skidding usefulness.Suck pin 5 and be connected with the bottom of suction pipe 1, air inlet needle 6 is connected with air inlet 4, and suction pin 5 is shorter than air inlet needle 6, and the needle point that promptly sucks pin 5 is in the needle point upper end position of air inlet needle 6.The internal diameter that sucks pin 5, air inlet needle 6 is 0.3～5.0mm, and needle point vertical direction distance is 0.5～2.5mm.
Crosspointer shown in Figure 1 penetrates the formula Diskus through following manner work: after in the capsule groove 8 of medicine carrying parts, vertically filling in pharmaceutical capsules; In below inhalation part, upwards pushing the medicine carrying parts, at first is that first buckle 9 gets in the buckle slot 7, when continuing upwards to push the medicine carrying parts; First buckle 9 is deviate from buckle slot 7; Then second buckle 10 gets in the buckle slot 7, when buckle slot 7 is in the position between first buckle 9 and second buckle 10, stationary state at this moment is called one-level fixes; This moment, air inlet needle 6 also was in the capsule top with suction pin 5, capsule was not punctured.When continuing upwards to push the medicine carrying parts; Buckle slot 7 moves down along the outer wall of medicine carrying parts; Be sticked in the buckle slot 7 up to the 3rd buckle 11, the stationary state of this moment is that secondary is fixed, and air inlet needle 6 successively punctured capsule and was deep into capsule from the capsule top with suction pin 5 this moment.The air-flow that utilization gets into from air inlet 4 is kicked up drug powder through air inlet needle 6, and drug powder is crossed suction pin 5 with air communication and discharged capsules, and the upper space that gets into diaphragm plate 12 is in the suction pipe 1.In addition, the air-flow that from a plurality of dilution holes 3, gets into suction pipe 1 is sheared dispersion with drug powder, and these drug powders are inhaled into and accomplish administration in patient's body through screen cloth 2.Briefly, drug powder is inhaled in the suction pipe 1 along sucking pin 5 from capsule along with the inspiratory airflow that comes self-straw 1, through being inhaled into behind the screen cloth 2 in patient's body, accomplishes administration again.
It should be noted that crosspointer of the present invention penetrate the formula Diskus inhalation part can also with other device coupling such as vacuum pump, making things convenient for the derivation of the drug powder in the confined space, thereby constitute the part of content that the present invention protects.
Although above-mentionedly embodiment of the present invention has been carried out at length explaining and describing; Yet; The cited embodiment of the present invention only is schematic; Those skilled in the art inspires through thought of the present invention, can obtain various embodiment, and such embodiment drops within protection scope of the present invention also.
Claims (9)
1. a crosspointer penetrates the formula Diskus, it is characterized in that, this inhaler comprises: inhalation part and medicine carrying parts, wherein the medicine carrying parts are connected the lower end of inhalation part through buckle slot.
2. crosspointer according to claim 1 penetrates the formula Diskus; It is characterized in that; The inhalation part that said crosspointer penetrates the formula Diskus is the suction pipe shape, and the centre position of this suction pipe is provided with diaphragm plate suction pipe is divided into different space up and down, and a side of diaphragm plate has air inlet to be connected with downward air inlet needle; The diaphragm plate center drilling is connected with the suction pin downwards, and said suction pin and air inlet needle also are fixed on the diaphragm plate downwards perpendicular to diaphragm plate simultaneously.
3. crosspointer according to claim 1 penetrates the formula Diskus, it is characterized in that, said medicine carrying parts have lays capsular capsule groove, is connected the lower end of inhalation part through buckle slot.
4. crosspointer according to claim 2 penetrates the formula Diskus; It is characterized in that; The upper space of said inhalation part suction pipe is provided with a plurality of dilution holes symmetrically near the diaphragm plate position on the suction pipe wall, on suction pipe inwall above the dilution holes, be provided with to be used for drug powder is sieved filtering screen cloth.
5. crosspointer according to claim 1 penetrates the formula Diskus, it is characterized in that, the lower space internal face of said inhalation part suction pipe is provided with buckle slot, and the outside wall surface of medicine carrying parts is provided with many circle buckles.
6. crosspointer according to claim 1 penetrates the formula Diskus, it is characterized in that, the outer wall of said inhalation part suction pipe is provided with as oral area and correctly contains pattern or the literal of receiving with direction signs.
7. crosspointer according to claim 1 penetrates the formula Diskus, it is characterized in that, the suction pipe mouth outer wall surface of said inhalation part is provided with the multiple tracks oral area and contains and receive the groove of anti-skidding usefulness.
8. crosspointer according to claim 2 penetrates the formula Diskus; It is characterized in that said suction pin is connected with the bottom of suction pipe, air inlet needle is connected with air inlet; And suck pin and be shorter than air inlet needle, the needle point that promptly sucks pin is in the needle point upper end position of air inlet needle.
9. crosspointer according to claim 2 penetrates the formula Diskus, it is characterized in that, the internal diameter of said suction pin, air inlet needle is 0.3～5.0mm, and needle point vertical direction distance is 0.5～2.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110166921.1A CN102836487B (en) | 2011-06-21 | Crosspointer penetrates formula Diskus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110166921.1A CN102836487B (en) | 2011-06-21 | Crosspointer penetrates formula Diskus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102836487A true CN102836487A (en) | 2012-12-26 |
| CN102836487B CN102836487B (en) | 2016-12-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920709A (en) * | 2016-06-06 | 2016-09-07 | 王天星 | Capsule breaking mechanism for dry powder inhalation delivery device |
| CN110170091A (en) * | 2019-04-30 | 2019-08-27 | 深圳市博迪科技开发有限公司 | A kind of atomizer and its component suction nozzle |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
| US20030150454A1 (en) * | 2001-11-14 | 2003-08-14 | Inhale Therapeutic Systems, Inc. | Aerosolization apparatus with removable mouthpiece |
| CN1726045A (en) * | 2002-12-13 | 2006-01-25 | 大塚制药株式会社 | Freeze-dried interferon-gamma composition for transpulmonary administration and inhalation system therefor |
| CN2917673Y (en) * | 2006-07-06 | 2007-07-04 | 兴安药业有限公司 | Capsule type dry powder inhaler |
| CN201036654Y (en) * | 2007-02-07 | 2008-03-19 | 郝承红 | Medicinal powder inhaler |
| CN101401793A (en) * | 2008-11-11 | 2009-04-08 | 南昌弘益科技有限公司 | Capsule type inhalation dust cloud agent |
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
| US20030150454A1 (en) * | 2001-11-14 | 2003-08-14 | Inhale Therapeutic Systems, Inc. | Aerosolization apparatus with removable mouthpiece |
| CN1726045A (en) * | 2002-12-13 | 2006-01-25 | 大塚制药株式会社 | Freeze-dried interferon-gamma composition for transpulmonary administration and inhalation system therefor |
| CN2917673Y (en) * | 2006-07-06 | 2007-07-04 | 兴安药业有限公司 | Capsule type dry powder inhaler |
| CN201036654Y (en) * | 2007-02-07 | 2008-03-19 | 郝承红 | Medicinal powder inhaler |
| CN101401793A (en) * | 2008-11-11 | 2009-04-08 | 南昌弘益科技有限公司 | Capsule type inhalation dust cloud agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920709A (en) * | 2016-06-06 | 2016-09-07 | 王天星 | Capsule breaking mechanism for dry powder inhalation delivery device |
| CN110170091A (en) * | 2019-04-30 | 2019-08-27 | 深圳市博迪科技开发有限公司 | A kind of atomizer and its component suction nozzle |
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Effective date of registration: 20210113 Address after: No.16, Xingning Road, biomedical industrial park, Xianning Economic Development Zone, Hubei Province 437100 Patentee after: Hubei Zhenao Pharmaceutical Research Institute Co.,Ltd. Address before: 102206 b-239, 29 shengshengyuan Road, Changping District, Beijing Patentee before: Beijing Wanda Chuangzhi Technology Co.,Ltd. Patentee before: Luo Xielong |
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