CN104984449B - A kind of capsule powder inhaler of turnable opening - Google Patents
A kind of capsule powder inhaler of turnable opening Download PDFInfo
- Publication number
- CN104984449B CN104984449B CN201510466554.5A CN201510466554A CN104984449B CN 104984449 B CN104984449 B CN 104984449B CN 201510466554 A CN201510466554 A CN 201510466554A CN 104984449 B CN104984449 B CN 104984449B
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- China
- Prior art keywords
- capsule
- main body
- powder inhaler
- head
- middle set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002775 capsule Substances 0.000 title claims abstract description 58
- 239000000843 powder Substances 0.000 title claims abstract description 48
- 239000003814 drug Substances 0.000 claims abstract description 40
- 230000007246 mechanism Effects 0.000 claims abstract description 15
- 239000000428 dust Substances 0.000 claims description 3
- 210000003128 head Anatomy 0.000 description 16
- 229940079593 drug Drugs 0.000 description 11
- 239000008187 granular material Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 2
- 229920000538 Poly[(phenyl isocyanate)-co-formaldehyde] Polymers 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a kind of capsule powder inhalers of turnable opening, include main body, it is characterised in that：It is equipped in the main body and inhales powder passage, the suction nozzle connected with the suction powder passage is equipped in described main body one end, it is equipped with to place the medicine support of capsule in the suction powder passage of the main body other end, the piercing device that can be pierced through and place the capsule is equipped in the main body above the medicine support, the switching mechanism that piercing device is separated with medicine support can be made by being equipped between the piercing device and main body.The purpose of the invention is to overcome shortcoming of the prior art, a kind of simple in structure, capsule powder inhaler of turnable opening easy to use is provided.
Description
Technical field
The present invention relates to a kind of capsule powder inhalers of turnable opening.
Background technology
From last century the mid-50, the inhalator of Charles Thiel inventions starts, people begin in asthma and
In the treatment of chronic obstructive disease of lung, the medical treatment device by inhaled drugs aerosol delivery to patient is used.
Compared with administering modes such as oral and hypodermic injections, inhalation-type drug administration has apparent advantage.Due to human nasal
Chamber, bronchus and the mucomembranous surface of lung accumulate very big, a total of 23 bifurcateds of respiratory tract of human body, and adult's alveolar surface area can be high
Up to 140 square metres, alveolar wall is very thin, the densely covered a large amount of capillaries of surrounding.Drug granule can be glued wherein with fast strikethrough alveolar
Membrane tissue is directly entered blood circulation.It is small rapid-action, malicious with no intestines and stomach degradation, the first pass effect without liver, dosage
Side effect is low and suitable for advantages such as large biological molecule deliverings.Lung Sucked medicine is the lungs such as treatment asthma, chronic obstructive pneumonia
The optimal treatment mode of portion's disease, had also further expanded to treatment whole body property disease in recent years, such as diabetes, market are huge
Greatly.
Existing suction apparatus have pressurized metered dose inhalers (Pressurized Metered Dose Inhaler,
PMDI), three kinds of sprayer (Nebulizer), Diskus (Dry Powder Inhaler, DPI) forms.PMDI needs to use
Propellant, although apply at present be it is environmental-friendly to hydrofluoroalkane of the atmospheric ozone layer without destruction as propellant,
But it still can bring greenhouse effect；And when using pMDI, it is necessary to which the appropriate cooperation of drug ejection-patient's sucking, otherwise inhales
It is very low to enter efficiency.Sprayer is the product that volume is big, non-portable, is generally only applicable to use in hospital or family.And DPI is not
Need propellant；Drug disperses to be triggered by patient inspiration flow, and there is no synergistic effects；And large biological molecule is in dry powder
Under, stability higher.Inhalation-type drug administration is more demanding to the aerodynamic force size of drug granule, 0.5-5 microns of aerodynamic force diameter
Between drug granule can effectively deposit to lower respiratory tract and alveolar etc., so as to effectively being absorbed by human body.More than 5 microns
Particle will deposit to oral cavity, trunnion and the upper respiratory tract；And the particle less than 0.5 micron, 90% will breathe out body with patient expiration
Outside.But the drug granule powder between 0.5-5 microns be usually easy to conglomeration, it is necessary to pharmaceutical engineering technology and inhalant it is excellent
Change design to improve the dispersiveness of drug granule.When assessing the validity of mealy medicine at the time of inhalation, there are one important parameters
It is exactly fine granular ratio (Fine Particle Fraction, FPF), represents organic in the medicament ejected in inhalator
The ratio in lung can be deposited to.In general, the ratio is defined as the particle fraction that aerodynamic diameter in medicament is less than 5 microns.
50 micrograms are generally less than for one medication amount of sucking, are usually 25-50 micrograms.It is desirable to from inhalator
The dosage of sucking-off has higher uniformity, and for the drug of predetermined close, the relative standard deviation (RSD) between each dosage is no
Should be more than 5%.So the drug for needing to suck generally is made capsule by existing way.
Existing its structure of capsule Diskus is relatively complicated, and production cost is compared with higher, while volume is inclined
It is big inconvenient to carry, and general capsule pierces through direction and is all perpendicular to suction inlet direction, it need to could be by medicine with larger suction
Powder blots only, can not use or cannot use completely for some suction patient on the weak side.
So existing capsule Diskus is up for further perfect.
The content of the invention
The purpose of the invention is to overcome shortcoming of the prior art, provide it is a kind of simple in structure, it is easy to use
Turnable opening capsule powder inhaler.
In order to achieve the above object, the present invention uses following scheme：
A kind of capsule powder inhaler of turnable opening, includes main body, it is characterised in that：It is set in the main body
Have and inhale powder passage, the suction nozzle connected with the suction powder passage is equipped in described main body one end, in the suction powder of the main body other end
Equipped with for placing the medicine support of capsule in passage, filled in the main body above the medicine support equipped with the puncture that can pierce through the capsule
It puts, the switching mechanism that piercing device is separated with medicine support can be made by being equipped between the piercing device and main body.
Switching mechanism as described above includes the middle set being hinged on by lower end in main body, the piercing device be arranged on it is described in
In set.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that set in the middle set lower end
There is upper hinged seat, portion's outer wall is equipped with lower hinged seat on the body, and the upper hinged seat passes through articulated shaft phase with lower hinged seat
It connects.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that in the main body and middle set
Between be equipped with locking mechanism.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that the locking mechanism includes
There is the lower lock being arranged on body outer wall, in the middle set with being equipped with upper lock on the corresponding position of lower lock.
The capsule powder inhaler of any turnable opening as described above, it is characterised in that the piercing device bag
Head is included, the head is arranged in middle set, the pricker that can pierce through the capsule is equipped in the head, in the head
Lower end outer wall is equipped with the /V hook for preventing head from departing from the middle set, and positioning convex platform, the /V are equipped in the middle set
Hook hook joint is on the positioning convex platform lower face.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that in the head and middle set
Between be equipped with can make head reset resetting spring.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that in the middle set lower face
Guide part is upwardly extended, the pricker is arranged in the guide part, and the resetting spring is set in the guide part outer wall
On.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that below the medicine support
It inhales and filter screen is equipped in powder passage, dust cap is arranged on the suction nozzle outer wall.
A kind of capsule powder inhaler of turnable opening as described above, it is characterised in that the medicine support includes medicine
Bracket is equipped with capsule chamber in the medicine bracket, and cavity volume is equipped in the capsule chamber, and connection is equipped in the capsule chamber lower part
The cavity volume and the through hole for inhaling powder passage.
In conclusion the present invention is compared with prior art its advantage：
The configuration of the present invention is simple covers in being hinged in main body, when in use, first opens locking mechanism, makes middle set
Overturning is opened, and capsule is put into capsule chamber, is then shut off middle set, and pressing head makes pricker move down puncture capsule, and user is just
The dry powder in capsule can be easily sucked at suction nozzle, it is easy to use.
Description of the drawings
Fig. 1 is the stereoscopic schematic diagram of the present invention；
Fig. 2 is the diagrammatic cross-section of the present invention；
Fig. 3 is the decomposition diagram of the present invention.
Specific embodiment
The invention will be further described with specific embodiment for explanation below in conjunction with the accompanying drawings：
A kind of capsule powder inhaler of turnable opening as shown in Figures 1 to 3, includes main body 1, in the main body
It is equipped in 1 and inhales powder passage 2, the suction nozzle 3 connected with the suction powder passage 2 is equipped in described 1 one end of main body, it is another in the main body 1
Equipped with for placing the medicine support 5 of capsule 4 in the suction powder passage 2 of one end, being equipped in the main body 1 above the medicine support 5 can pierce through
The piercing device 6 of the capsule 4, being equipped between the piercing device 6 and main body 1 can make what piercing device 6 and medicine support 5 separated
Switching mechanism 7.
Heretofore described switching mechanism 7 is included by the hinged middle set 71 on the body 1 in lower end, and the piercing device 6 is set
It puts in the middle set 71.
Upper hinged seat 72 is equipped in 71 lower ends of the middle set in the present invention, is equipped in 1 external wall of upper portion of main body lower hinged
Seat 720, the upper hinged seat 72 is connected with each other with lower hinged seat 720 by articulated shaft 73.
In the present invention locking mechanism 74 is equipped between the main body 1 and middle set 71.Wherein described locking mechanism 74 includes
There is the lower lock 741 being arranged on 1 outer wall of main body, upper lock is equipped with on 741 corresponding positions of lower lock in the middle set 71
742.The groove 101 opened convenient for upper lock 742 is equipped in the present invention in the main body 1 at lower lock 741, is latched on described
742 be equipped with convenient for open pulling part 7421, the pulling part 7421 be arranged on on the 101 corresponding position of groove.
Piercing device 6 of the present invention includes head 61, and the head 61 is arranged in middle set 71, in the head 61
Interior to be equipped with the pricker 62 that pierce through the capsule 4, being equipped in 61 lower end outer wall of head prevents head 61 from departing from the middle set
71 /V hook 63 is equipped with positioning convex platform 711 in the middle set 71, and 63 hook joint of /V hook is in the positioning convex platform
On 711 lower faces.
The resetting spring 64 that can reset head 61 is equipped in the present invention between the head 61 and middle set 71.
Guide part 712 is upwardly extended in the present invention in 71 lower faces of the middle set, the pricker 62 is arranged on described lead
Into portion 712, the resetting spring 64 is set on 712 outer wall of guide part.
Filter screen 8 is equipped in suction powder passage 2 in the present invention below the medicine support 5, is arranged on 3 outer wall of suction nozzle
There is dust cap 9.
Heretofore described medicine support 5 includes medicine bracket 51, capsule chamber 52 is equipped in the medicine bracket 51, in the glue
Cavity volume 53 is equipped in capsule room 52, the through hole 54 for connecting the cavity volume 53 and inhaling powder passage 2 is equipped in 52 lower part of capsule chamber.
52 top of capsule chamber is equipped with intercommunicating pore with 54 corresponding position of through hole.
The present invention when in use, first opens locking mechanism 74, opens middle 71 overturning of set, is put into capsule chamber 52
Capsule is then shut off middle set 71, and pressing head makes pricker move down puncture capsule, and user just can easily suck glue at suction nozzle
Dry powder in capsule, it is easy to use.
Basic principle of the invention and main feature and advantages of the present invention has been shown and described above.The skill of the industry
Art personnel it should be appreciated that the present invention is not limited to the above embodiments, the above embodiments and description only describe
The principle of the present invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these
Changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and
Its equivalent thereof.
Claims (9)
1. a kind of capsule powder inhaler of turnable opening, includes main body (1), it is characterised in that：In the main body (1)
Interior be equipped with inhales powder passage (2), the suction nozzle (3) connected with the suction powder passage (2) is equipped in the main body (1) one end, described
The interior medicine support (5) for being equipped with to place capsule (4) of the suction powder passage (2) of main body (1) other end, above the medicine support (5)
Main body (1) is equipped with the piercing device (6) that can pierce through the capsule (4), is set between the piercing device (6) and main body (1)
There is the switching mechanism (7) that piercing device (6) can be made to be separated with medicine support (5), the switching mechanism (7) includes being hinged on master by lower end
Middle set (71) on body (1), the piercing device (6) are arranged in the middle set (71).
2. the capsule powder inhaler of a kind of turnable opening according to claim 1, it is characterised in that in described
It covers (71) lower end and is equipped with upper hinged seat (72), lower hinged seat (720) is equipped in the main body (1) external wall of upper portion, it is described hinged
Seat (72) is connected with each other with lower hinged seat (720) by articulated shaft (73).
3. the capsule powder inhaler of a kind of turnable opening according to claim 1, it is characterised in that in the master
Locking mechanism (74) is equipped between body (1) and middle set (71).
A kind of 4. capsule powder inhaler of turnable opening according to claim 3, it is characterised in that the locking
Mechanism (74) includes the lower lock (741) being arranged on main body (1) outer wall, right in the middle set (71) and lower lock (741)
The position answered is equipped with upper lock (742).
5. the capsule powder inhaler of the turnable opening according to Claims 2 or 3, it is characterised in that described to pierce through dress
It puts (6) and includes head (61), the head (61) is arranged in middle set (71), and institute can be pierced through by being equipped in the head (61)
The pricker (62) of capsule (4) is stated, being equipped in the head (61) lower end outer wall prevents head (61) from departing from the middle set (71)
/V hook (63) is equipped with positioning convex platform (711) in the middle set (71), and /V hook (63) hook joint is in the positioning
On boss (711) lower face.
6. the capsule powder inhaler of a kind of turnable opening according to claim 5, it is characterised in that pressed described
The resetting spring (64) that can reset head (61) is equipped between head (61) and middle set (71).
7. the capsule powder inhaler of a kind of turnable opening according to claim 6, it is characterised in that in described
Set (71) lower face has upwardly extended guide part (712), and the pricker (62) is arranged in the guide part (712), described multiple
Position spring (64) is set on the guide part (712) outer wall.
8. the capsule powder inhaler of a kind of turnable opening according to claim 5, it is characterised in that in the medicine
It holds in the palm and filter screen (8) is equipped in the suction powder passage (2) below (5), dust cap (9) is arranged on the suction nozzle (3) outer wall.
A kind of 9. capsule powder inhaler of turnable opening according to claim 5, it is characterised in that the medicine support
(5) include medicine bracket (51), capsule chamber (52) is equipped in the medicine bracket (51), be equipped with and hold in the capsule chamber (52)
Chamber (53) is equipped with the through hole (54) for connecting the cavity volume (53) and inhaling powder passage (2) in the capsule chamber (52) lower part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466554.5A CN104984449B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule powder inhaler of turnable opening |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466554.5A CN104984449B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule powder inhaler of turnable opening |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104984449A CN104984449A (en) | 2015-10-21 |
| CN104984449B true CN104984449B (en) | 2018-06-01 |
Family
ID=54296419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510466554.5A Active CN104984449B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule powder inhaler of turnable opening |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104984449B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020231100A1 (en) * | 2019-03-05 | 2021-07-15 | Philip Morris Products S.A. | Holder for inhaler article |
| KR20240036934A (en) * | 2022-09-14 | 2024-03-21 | 주식회사 케이티앤지 | Inhaler |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209755A (en) * | 1996-01-29 | 1999-03-03 | 厄恩斯特·赫尔林 | Capsule oppening apparatus for use in powder inhaler |
| CN1867369A (en) * | 2003-10-17 | 2006-11-22 | 维克多瑞有限公司 | Inhaler |
| CN2915141Y (en) * | 2006-07-06 | 2007-06-27 | 福建精致模具有限公司 | A capsule type dry powder inhaler |
| CN101389367A (en) * | 2006-02-24 | 2009-03-18 | 阿哈塑料技术有限公司 | Dry powder inhaler |
| CN204972573U (en) * | 2015-07-30 | 2016-01-20 | 中山市美捷时包装制品有限公司 | Folding horizontal capsule dry powder type suction apparatus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3011898B2 (en) * | 1997-02-20 | 2000-02-21 | フォルテ グロウ メディカル株式会社 | Aspirator |
-
2015
- 2015-07-30 CN CN201510466554.5A patent/CN104984449B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209755A (en) * | 1996-01-29 | 1999-03-03 | 厄恩斯特·赫尔林 | Capsule oppening apparatus for use in powder inhaler |
| CN1867369A (en) * | 2003-10-17 | 2006-11-22 | 维克多瑞有限公司 | Inhaler |
| CN101389367A (en) * | 2006-02-24 | 2009-03-18 | 阿哈塑料技术有限公司 | Dry powder inhaler |
| CN2915141Y (en) * | 2006-07-06 | 2007-06-27 | 福建精致模具有限公司 | A capsule type dry powder inhaler |
| CN204972573U (en) * | 2015-07-30 | 2016-01-20 | 中山市美捷时包装制品有限公司 | Folding horizontal capsule dry powder type suction apparatus |
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| Publication number | Publication date |
|---|---|
| CN104984449A (en) | 2015-10-21 |
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