CN204501970U - Diskus - Google Patents
Diskus Download PDFInfo
- Publication number
- CN204501970U CN204501970U CN201520050381.4U CN201520050381U CN204501970U CN 204501970 U CN204501970 U CN 204501970U CN 201520050381 U CN201520050381 U CN 201520050381U CN 204501970 U CN204501970 U CN 204501970U
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- China
- Prior art keywords
- capsule
- horizontal
- runner chamber
- suction nozzle
- diskus
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Abstract
The utility model discloses a kind of Diskus, comprise horizontal runner chamber, described runner chamber front end is provided with suction nozzle, and described runner chamber end is provided with bonnet, and described flow passage chamber indoor are provided with impeller; Described impeller is connected with bonnet by horizontal rotating shaft; Described rotating shaft front end is provided with points to suction nozzle and for the capsule mounting groove of fixed flat capsule; Described runner chamber sidewall is provided with two piercing assemblies for the horizontal capsule that punctures; Described piercing assembly comprises: be movably connected on runner chamber sidewall and the briquetting of built-in back-moving spring, and runs through runner chamber sidewall and point to the puncture needle of horizontal capsule; Described puncture needle is fixed in briquetting, and drives by briquetting the horizontal capsule that punctures; Multiple air inlet is covered with after described; Described flow passage chamber indoor are also provided with the perpendicular screen cloth put, and described screen cloth is between suction nozzle and capsule mounting groove.This utility model Diskus, can reduce the deposition of drug particles, improves drug particles through lung delivery efficiency.
Description
Technical field
This utility model relates to Diskus, and it is sent through lung for drug particles.
Background technology
Lung Sucked medicine is the emerging drug delivery formats grown up in the last few years.As the biorgan that the mankind are important, lung is a desirable drug delivery place, and its reason is: 1) surface area is large; 2) alveolar wall is thin, and alveolar is made up of very thin (100-200nm) cell monolayer film, is conducive to rapid drug absorption; 3) rich blood vessel, alveolar is by the intensive winding of a large amount of blood capillaries, and medicine directly enters blood circulation after through the monofilm of alveolar, thus is delivered to whole body performance curative effect.So compared with oral and injection system, lung Sucked medicine has clear superiority: without gastrointestinal tract Degradation; Without liver first-pass effect; Drug absorption is rapid, rapid-action; Dosage is low, toxic and side effects is little; Non-intruding therapeutic modality, good patient compliance.
Lung Sucked medicine mainly contains three kinds of dosage forms: water smoke agent, aerosol and powder spray.Water smoke agent (spray) is atomized by the mode such as ultrasonic by drug solution, then sucks in lung with inspiratory airflow.Its device volume carries greatly that inconvenience, lung suction efficiency are low, medicinal liquid needs cold preservation, causes clinical practice very limited.Aerosol is that drug particles is placed in hermetically sealed can together with propellant, and during use, medicine is formed in aerosol suction lung through proportional valve ejection.Its drawback is: the coordinated needing medicine ejection and patient to suck in use procedure just can reach and suck effect preferably; Drug particles initial velocity is large, easily causes it to deposit in a large number in oral cavity and throat; Atmospheric ozone layer is destroyed in propellant fluorine Lyons (CFC), and new succedaneum hydrofluoroalkane (HFA) can cause a series of difficulty on preparation and still can bring greenhouse effect; Improper cooperation of easily causing patient to suck in addition in use to spray with medicine and arrive delivery efficiency is reduced greatly.Powder spray for lung inhalation is without any need for propellant; The ejection ' atomization ' of drug particles is caused, without the need of coordinated by the active inspiration air-flow of patient itself completely; And the macromolecular drug such as drug loading is large, protein is more stable when existing with dry powder.
Realize sending through lung of dry powder particle, just by there is the device of ad hoc structure to realize effective dispersion of drug particles, aerosol must be formed, effectively could enter pulmonary with inspiratory airflow in use.The kind of Diskus is more in the market, and structure, design principle, the scope of application and delivery efficiency are each variant.According to dosage divide, single dose and multiple dose Diskus can be divided into.Although multidose dry powder inhaler is commercially more active, its complex structure, medicine sealing, accurate quantification and device resistance etc. all likely become the major issue affecting its storage and service efficiency.And single dose dry powder inhaler structure is simple, medicine is generally stored in capsule, is convenient to protection against the tide and storage, thus effectively can safeguard its medicine stability and through lung delivery efficiency; It is easy to use simultaneously, and be easy to cleaning, low price, is suitable for universal.Now widely used single dose dry powder inhaler, its structure, for be equipped with an impeller in a tubular air channel middle, to be suction nozzle before impeller, and to embed capsule thereafter.During use, break capsule with acupuncture, then air-breathing, vane rotary drives capsule, and release drug particles wherein, enter respiratory tract and pulmonary with inspiratory airflow.But because impeller is in the middle of suction nozzle and medicine, drug particles first must can pass atwirl impeller, could be delivered to respiratory tract and pulmonary with inspiratory airflow.And research find, have up to about 30% drug particles can by impeller hinder get rid of on flow path wall or be adsorbed on impeller wheel sheet on, cause a large amount of drug wastes, and greatly reduce medicine through lung delivery efficiency.
Utility model content
The purpose of this utility model is to provide a kind of Diskus, and it can reduce the deposition of drug particles in Diskus, improves drug particles through lung delivery efficiency.
For achieving the above object, the technical solution of the utility model is a kind of Diskus of design, and comprise horizontal runner chamber, described runner chamber front end is provided with suction nozzle, and described runner chamber end is provided with bonnet, and described flow passage chamber indoor are provided with impeller;
Described impeller is connected with bonnet by horizontal rotating shaft;
Described rotating shaft front end is provided with points to suction nozzle and for the capsule mounting groove of fixed flat capsule;
Described runner chamber sidewall is provided with two piercing assemblies for the horizontal capsule that punctures, and described two piercing assemblies are symmetrical arranged with rotating shaft;
Described piercing assembly comprises: be movably connected on runner chamber sidewall and the briquetting of built-in back-moving spring, and runs through runner chamber sidewall and point to the puncture needle of horizontal capsule; Described puncture needle is fixed in briquetting, and drives by briquetting the horizontal capsule that punctures;
Multiple air inlet is covered with after described;
Described flow passage chamber indoor are also provided with the perpendicular screen cloth put, and described screen cloth is between suction nozzle and capsule mounting groove.
Preferably, described rotating shaft and horizontal runner chamber coaxial.
Preferably, the hole of described screen cloth is square, rhombus, circle, triangle or taper.
Preferably, the cross sectional shape of described suction nozzle is the ellipse that narrow, left and right is wide up and down.
Advantage of the present utility model and beneficial effect are: provide a kind of Diskus, and it can reduce the deposition of drug particles in Diskus, improve drug particles through lung delivery efficiency.
By impeller is rearmounted, capsule is preposition, and namely structure is adjusted to suction nozzle-capsule-impeller by original suction nozzle-impeller-capsule.Cause drug particles by patient's active inspiration to discharge also ' atomization ', after drug particles release, be directly inhaled into respiratory tract and pulmonary, completely avoid the interference of impeller, solve impeller retaining and the problem such as obstruction drug particles, thus improve drug utilization and through lung delivery efficiency.
The effect of screen cloth is pharmaceutical aerosol and grid are collided, and accelerates depolymerization, and when making entrance, turbulent extent slows down, and reduces aerosol flow rates, avoids the effect such as deposition at oral cavity and bottleneck throat.
Accompanying drawing explanation
Fig. 1 is the structural representation of Diskus;
Fig. 2 is the cross-sectional schematic of Diskus;
Fig. 3 is the schematic perspective view of Diskus;
Fig. 4 is the combination schematic diagram of suction nozzle and screen cloth;
Fig. 5 is the rear end schematic diagram of Diskus.
Detailed description of the invention
Below in conjunction with drawings and Examples, detailed description of the invention of the present utility model is further described.Following examples only for clearly the technical solution of the utility model being described, and can not limit protection domain of the present utility model with this.
The technical scheme that this utility model is specifically implemented is:
As shown in Figures 1 to 5, a kind of Diskus, comprises horizontal runner chamber 1, and described runner chamber 1 front end is provided with suction nozzle 2, and described runner chamber 1 end is provided with bonnet 3, is provided with impeller 4 in described runner chamber 1;
Described impeller 4 is connected with bonnet 3 by horizontal rotating shaft 5;
Described rotating shaft 5 front end is provided with points to suction nozzle 2 and for the capsule mounting groove 51 of fixed flat capsule 8;
Described runner chamber 1 sidewall is provided with two piercing assemblies for the horizontal capsule 8 that punctures, and described two piercing assemblies are symmetrical arranged with rotating shaft 5;
Described piercing assembly comprises: be movably connected on runner chamber 1 sidewall and the briquetting 60 of built-in back-moving spring 61, and runs through runner chamber 1 sidewall and point to the puncture needle 62 of horizontal capsule 8; Described puncture needle 62 is fixed in briquetting 60, and drives by briquetting 60 the horizontal capsule 8 that punctures;
Described bonnet 3 is provided with multiple air inlet 31;
Also be provided with the perpendicular screen cloth 7 put in described runner chamber 1, described screen cloth 7 is between suction nozzle 2 and capsule mounting groove 51.
Described rotating shaft 5 is coaxial with horizontal runner chamber 1.
The hole of described screen cloth 7 is square, rhombus, circle, triangle or taper.
The cross sectional shape of described suction nozzle 2 is the ellipse that narrow, left and right is wide up and down.
The above is only preferred implementation of the present utility model; should be understood that; for those skilled in the art; under the prerequisite not departing from this utility model know-why; can also make some improvements and modifications, these improvements and modifications also should be considered as protection domain of the present utility model.
Claims (4)
1. Diskus, is characterized in that, comprises horizontal runner chamber, and described runner chamber front end is provided with suction nozzle, and described runner chamber end is provided with bonnet, and described flow passage chamber indoor are provided with impeller;
Described impeller is connected with bonnet by horizontal rotating shaft;
Described rotating shaft front end is provided with points to suction nozzle and for the capsule mounting groove of fixed flat capsule;
Described runner chamber sidewall is provided with two piercing assemblies for the horizontal capsule that punctures, and described two piercing assemblies are symmetrical arranged with rotating shaft;
Described piercing assembly comprises: be movably connected on runner chamber sidewall and the briquetting of built-in back-moving spring, and runs through runner chamber sidewall and point to the puncture needle of horizontal capsule; Described puncture needle is fixed in briquetting, and drives by briquetting the horizontal capsule that punctures;
Multiple air inlet is covered with after described;
Described flow passage chamber indoor are also provided with the perpendicular screen cloth put, and described screen cloth is between suction nozzle and capsule mounting groove.
2. Diskus according to claim 1, is characterized in that, described rotating shaft and horizontal runner chamber coaxial.
3. Diskus according to claim 2, is characterized in that, the hole of described screen cloth is square, rhombus, circle, triangle or taper.
4. Diskus according to claim 3, is characterized in that, the cross sectional shape of described suction nozzle is the ellipse that narrow, left and right is wide up and down.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520050381.4U CN204501970U (en) | 2015-01-22 | 2015-01-22 | Diskus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520050381.4U CN204501970U (en) | 2015-01-22 | 2015-01-22 | Diskus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204501970U true CN204501970U (en) | 2015-07-29 |
Family
ID=53699974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520050381.4U Expired - Fee Related CN204501970U (en) | 2015-01-22 | 2015-01-22 | Diskus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204501970U (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984450A (en) * | 2015-07-30 | 2015-10-21 | 中山市美捷时包装制品有限公司 | Rotatably-openable capsule dry powder inhaler |
| WO2017079397A1 (en) * | 2015-11-05 | 2017-05-11 | Otitopic Inc. | Dry powder inhalation device |
| CN106948154A (en) * | 2017-04-20 | 2017-07-14 | 广州视源电子科技股份有限公司 | Fountain cleaning device |
| CN109078245A (en) * | 2018-10-11 | 2018-12-25 | 上海博极给药医药科技有限公司 | A kind of double-capsule type powder inhaler |
| CN110812635A (en) * | 2019-11-18 | 2020-02-21 | 德必来福有限公司 | Administration device for inhaling powder inhalation |
| EP3714928A4 (en) * | 2017-11-23 | 2021-08-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Novel dry powder inhalation device |
| CN115429986A (en) * | 2022-08-25 | 2022-12-06 | 苏州易合医药有限公司 | Inhalation device for soft-ball particle drug delivery |
-
2015
- 2015-01-22 CN CN201520050381.4U patent/CN204501970U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984450A (en) * | 2015-07-30 | 2015-10-21 | 中山市美捷时包装制品有限公司 | Rotatably-openable capsule dry powder inhaler |
| CN104984450B (en) * | 2015-07-30 | 2018-05-04 | 中山市美捷时包装制品有限公司 | A kind of capsule Diskus of rotatable opening |
| WO2017079397A1 (en) * | 2015-11-05 | 2017-05-11 | Otitopic Inc. | Dry powder inhalation device |
| CN106948154A (en) * | 2017-04-20 | 2017-07-14 | 广州视源电子科技股份有限公司 | Fountain cleaning device |
| EP3714928A4 (en) * | 2017-11-23 | 2021-08-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Novel dry powder inhalation device |
| US11931506B2 (en) | 2017-11-23 | 2024-03-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Dry powder inhaler |
| CN109078245A (en) * | 2018-10-11 | 2018-12-25 | 上海博极给药医药科技有限公司 | A kind of double-capsule type powder inhaler |
| CN110812635A (en) * | 2019-11-18 | 2020-02-21 | 德必来福有限公司 | Administration device for inhaling powder inhalation |
| CN115429986A (en) * | 2022-08-25 | 2022-12-06 | 苏州易合医药有限公司 | Inhalation device for soft-ball particle drug delivery |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150729 Termination date: 20210122 |