CN104984450A - Rotatably-openable capsule dry powder inhaler - Google Patents
Rotatably-openable capsule dry powder inhaler Download PDFInfo
- Publication number
- CN104984450A CN104984450A CN201510466621.3A CN201510466621A CN104984450A CN 104984450 A CN104984450 A CN 104984450A CN 201510466621 A CN201510466621 A CN 201510466621A CN 104984450 A CN104984450 A CN 104984450A
- Authority
- CN
- China
- Prior art keywords
- capsule
- main body
- diskus
- middle cover
- rotatable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 65
- 229940112141 dry powder inhaler Drugs 0.000 title abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 43
- 239000000843 powder Substances 0.000 claims abstract description 24
- 239000000428 dust Substances 0.000 claims description 5
- 230000007306 turnover Effects 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 1
- 210000003128 head Anatomy 0.000 description 16
- 229940079593 drug Drugs 0.000 description 8
- 239000002245 particle Substances 0.000 description 6
- 238000011282 treatment Methods 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 208000019693 Lung disease Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 229920000538 Poly[(phenyl isocyanate)-co-formaldehyde] Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a rotatably-openable capsule dry powder inhaler. The rotatably-openable capsule dry powder inhaler comprises a main body. The rotatably-openable capsule dry powder inhaler is characterized in that a powder suction channel is arranged in the main body; one end of the main body is provided with a suction nozzle communicated with the powder suction channel; a medicine support used for accommodating capsules is arranged in the powder suction channel at the other end of the main body; the main body is provided with a piercing device which is located above the medicine support and can pierce the capsules arranged in the medicine support; and a turnover mechanism which can make the piercing device and the medicine support separated from each other is arranged between the piercing device and the main body. The objective of the invention is to eliminate defects in the prior art. The rotatably-openable capsule dry powder inhaler has the advantages of simple structure and convenient use, and can be opened in a turnover manner.
Description
Technical field
The present invention relates to a kind of rotatable capsule Diskus opened.
Background technology
From the mid-50 in last century, the inhaler that Charles Thiel invents starts, and people just start, in the treatment of asthma and chronic obstructive disease of lung, to use inhaled drugs aerosol delivery to the medical treatment device of patient.
Relative to administering modes such as oral and subcutaneous injections, inhalation-type drug administration has advantage clearly.Mucomembranous surface due to human body nasal cavity, bronchus and pulmonary is long-pending very large, and the respiratory tract of human body always has 23 bifurcateds, and adult's alveolar surface area can up to 140 square metres, and alveolar wall is very thin, and around gather a large amount of blood capillary.Drug particles can be organized and directly enter blood circulation by fast strikethrough alveolar mucosa wherein.Have without intestines and stomach Degradation, without the first pass effect of liver, dosage little rapid-action, toxic and side effects is low and be applicable to biomacromolecule and the advantage such as send.Lung Sucked medicine is the optimal treatment mode of pulmonary disease such as treatment asthma, chronic obstructive pneumonia etc., and also further expanded to treatment whole body property disease in recent years, as diabetes etc., its market is huge.
Existing suction apparatus has pressurized metered dose inhalers (Pressurized Metered DoseInhaler, pMDI), aerosol apparatus (Nebulizer), Diskus (Dry PowderInhaler, DPI) three kinds of forms.PMDI need use propellant, although at present application be eco-friendly to atmospheric ozone layer without the hydrofluoroalkane of destruction as propellant, it still can bring greenhouse effect; And when using pMDI, need the appropriate cooperation that medicine ejection-patient sucks, otherwise suction efficiency is very low.Aerosol apparatus is that volume is large, the product of non-portable, is generally only applicable to use in hospital or family.And DPI does not need propellant; Medicine dispersion is caused by patient inspiration flow, there is not cooperative effect; And biomacromolecule is under dry powder, its stability is higher.The aerodynamic force dimensional requirement of inhalation-type drug administration to drug particles is higher, aerodynamic force diameter 0.5 ?drug particles between 5 microns can effectively deposit to the place such as lower respiratory tract and alveolar, thus effectively to be absorbed by human body.The granule being greater than 5 microns will deposit to oral cavity, trunnion and upper respiratory tract; And be less than the granule of 0.5 micron, 90% will breathe out with patient expiration external.But 0.5 ?drug particles powder between 5 microns be usually easy to conglomeration, need the optimal design of pharmaceutical engineering technology and inhalant to improve the dispersibility of drug particles.Have an important parameter to be exactly fine granular ratio (FineParticle Fraction, FPF) when assessing the effectiveness of mealy medicine when sucking, it represents in the medicament ejected in inhaler the ratio having an opportunity to deposit in lung.Usually, this ratio is defined as the particle fraction that aerodynamic diameter in medicament is less than 5 microns.
Potion medication amount for sucking generally is less than 50 micrograms, is generally 25-50 microgram.People wish to have higher concordance from the dosage of inhaler sucking-off, and for the medicine of predetermined close, the relative standard deviation (RSD) between each dosage should more than 5%.So existing way generally will need the medicine sucked to make capsule.
Existing its structure of capsule Diskus is relatively complicated, production cost is relative to higher, volume is bigger than normal simultaneously carries inconvenience, and general capsule pierces through direction and is all perpendicular to suction inlet direction, medicated powder need could be blotted only with larger suction, the patient that some suction are on the weak side cannot be used or can not be used completely.
So existing capsule Diskus awaits perfect further.
Summary of the invention
The object of the invention is to overcome weak point of the prior art, a kind of Novel capsule powder inhaler that a kind of structure is simple, easy to use, easy to carry, suction requirement is low is provided.
Summary of the invention
The object of the invention is to overcome weak point of the prior art, providing a kind of structure simple, the rotatable capsule Diskus opened easy to use.
In order to achieve the above object, the present invention adopts following scheme:
A kind of rotatable capsule Diskus opened, include main body, it is characterized in that: in described main body, be provided with suction passage, the suction nozzle with described suction powder channel connection is provided with in described main body one end, the medicine holder for placing capsule is provided with in the suction powder passage of the described main body other end, main body above described medicine holder is provided with the piercing device that can pierce through and place described capsule, between described piercing device and main body, is provided with the rotating mechanism that piercing device can be made to separate with medicine holder.
A kind of rotatable capsule Diskus opened as above, it is characterized in that described rotating mechanism includes middle cover, be provided with rotating shaft in described middle cover lower end, end is provided with axle sleeve on the body, described rotating shaft is arranged in described axle sleeve, and described piercing device is arranged in described middle cover.
A kind of rotatable capsule Diskus opened as above, is characterized in that between described middle cover and main body, be provided with the locking mechanism that middle cover can be locked in main body.
A kind of rotatable capsule Diskus opened as above, it is characterized in that described locking mechanism includes setting lower snap close on the body, the position that described middle cover is corresponding with lower snap close is provided with snap close, locks described in described lower snap close snaps onto and buckle.
Any one rotatable capsule Diskus opened as above, it is characterized in that described piercing device includes head, described head is arranged in middle cover, the pricker that can pierce through described capsule is provided with in described head, described head lower end outer wall be provided with prevent head from departing from cover spacing snap fit, in described middle cover, be provided with positioning boss, described spacing snap fit hook joint is on described positioning boss lower surface.
A kind of rotatable capsule Diskus opened as above, is characterized in that between described head and middle cover, be provided with the back-moving spring that head can be made to reset.
A kind of rotatable capsule Diskus opened as above, it is characterized in that upwards being extended with guide part in described middle cover lower surface, described pricker is arranged in described guide part, and described back-moving spring is set on described guide part outer wall.
A kind of rotatable capsule Diskus opened as above, is characterized in that being provided with drainage screen in the suction powder passage below described medicine holder.
A kind of rotatable capsule Diskus opened as above, is characterized in that being arranged with dust cap on described suction nozzle outer wall.
A kind of rotatable capsule Diskus opened as above, it is characterized in that described medicine holder includes medicine bracket, in described medicine bracket, be provided with capsule chamber, in described capsule chamber, be provided with cavity volume, be provided with the through hole being communicated with described cavity volume and inhaling powder passage in described capsule chamber bottom.
In sum, the present invention relative to its beneficial effect of prior art is:
Structure of the present invention is simple, overlap during main body is hinged with, only need during use to rotate clockwise middle cover, the capsule chamber of medicine holder is opened, capsule is put in capsule chamber, then closing pressing head makes pricker be pierced through by capsule, and user just can suck the dry powder in capsule easily from suction nozzle, uses simple.
Accompanying drawing explanation
Fig. 1 is schematic diagram of the present invention;
Fig. 2 is one of generalized section of the present invention;
Fig. 3 is generalized section two of the present invention;
Fig. 4 is decomposing schematic representation of the present invention;
Fig. 5 is the schematic perspective view overlapped in the present invention.
Detailed description of the invention
Illustrate that the invention will be further described with detailed description of the invention below in conjunction with accompanying drawing:
A kind of rotatable capsule Diskus opened as shown in Fig. 1 to 5, include main body 1, be provided with in described main body 1 and inhale powder passage 2, the suction nozzle 3 be communicated with described suction powder passage 2 is provided with in described main body 1 one end, the medicine holder 5 for placing capsule 4 is provided with in the suction powder passage 2 of described main body 1 other end, main body 1 above described medicine holder 5 is provided with the piercing device 6 that can pierce through and place described capsule 4, between described piercing device 6 and main body 1, is provided with the rotating mechanism 7 that piercing device 6 and medicine holder 5 can be made to separate.
Rotating mechanism 7 described in the present invention includes middle cover 71, and be provided with rotating shaft 72 in described middle cover 71 lower end, be provided with axle sleeve 73 in described main body 1 upper end, described rotating shaft 72 is arranged in described axle sleeve 73, and described piercing device 6 is arranged in described middle cover 71.
Between described middle cover 71 and main body 1, the locking mechanism 74 that middle cover 71 can be locked on the body 1 is provided with in the present invention.
Wherein said locking mechanism 74 includes the lower snap close 741 be arranged in described main body 1, and the position that described middle cover 71 is corresponding with lower snap close 741 is provided with snap close 742, and described lower snap close 741 snaps onto on described upper snap close 742.Described in the present invention, the opening of lower snap close 741 is arranged on the direction of middle cover 71 rotation, and when described medicine holder 5 closed by central cover 71, described upper snap close 742 screws in lower snap close 741 and also locks.Convenient and fast connection.
Piercing device 6 described in the present invention includes head 61, described head 61 is arranged in middle cover 71, the pricker 62 that can pierce through described capsule 4 is provided with in described head 61, described head 61 lower end outer wall be provided with prevent head 61 from departing from cover 71 spacing snap fit 63, in described middle cover 71, be provided with positioning boss 711, described spacing snap fit 63 hook joint is on described positioning boss 711 lower surface.
Between described head 61 and middle cover 71, the back-moving spring 64 that head 61 can be made to reset is provided with in the present invention.
Upwards be extended with guide part 712 in described middle cover 71 lower surface in the present invention, described pricker 62 is arranged in described guide part 712, and described back-moving spring 64 is set on described guide part 712 outer wall.
Drainage screen 8 is provided with in suction powder passage 2 in the present invention below described medicine holder 5.In the present invention, drainage screen 8 can filter by dry powder that is effectively that granule is excessive or conglomeration, ensures the drug effect sucked.
On described suction nozzle 3 outer wall, dust cap 9 is arranged with in the present invention.Dust cap 9 can effectively prevent the pollutant such as dust from entering suction nozzle, safety and sanitation.
The holder of medicine described in the present invention 5 includes medicine bracket 51, in described medicine bracket 51, be provided with capsule chamber 52, in described capsule chamber 52, be provided with cavity volume 53, is provided with the through hole 54 being communicated with described cavity volume 53 and inhaling powder passage 2 in described capsule chamber 52 bottom.The position that described capsule chamber 52 top is corresponding with through hole 54 is provided with intercommunicating pore.
Structure of the present invention is simple, only needs to rotate clockwise middle cover, the capsule chamber of medicine holder is opened during use, capsule is put in capsule chamber, then closing pressing head makes pricker be pierced through by capsule, and user just can suck the dry powder in capsule easily from suction nozzle, uses simple.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (10)
1. the rotatable capsule Diskus opened, include main body (1), it is characterized in that: be provided with in described main body (1) and inhale powder passage (2), the suction nozzle (3) be communicated with described suction powder passage (2) is provided with in described main body (1) one end, the medicine holder (5) for placing capsule (4) is provided with in the suction powder passage (2) of described main body (1) other end, the main body (1) of described medicine holder (5) top is provided with the piercing device (6) that can pierce through and place described capsule (4), the rotating mechanism (7) that piercing device (6) and medicine holder (5) can be made to separate is provided with between described piercing device (6) and main body (1).
2. a kind of rotatable capsule Diskus opened according to claim 1, it is characterized in that described rotating mechanism (7) includes middle cover (71), rotating shaft (72) is provided with in described middle cover (71) lower end, axle sleeve (73) is provided with in described main body (1) upper end, described rotating shaft (72) is arranged in described axle sleeve (73), and described piercing device (6) is arranged in described middle cover (71).
3. a kind of rotatable capsule Diskus opened according to claim 2, is characterized in that between described middle cover (71) and main body (1), be provided with the locking mechanism (74) that middle cover (71) can be locked in main body (1).
4. a kind of rotatable capsule Diskus opened according to claim 3, it is characterized in that described locking mechanism (74) includes the lower snap close (741) be arranged in described main body (1), the position that described middle cover (71) is corresponding with lower snap close (741) is provided with upper snap close (742), and described lower snap close (741) snaps onto on described upper snap close (742).
5. any one the rotatable capsule Diskus opened according to claim 2-4, it is characterized in that described piercing device (6) includes head (61), described head (61) is arranged in middle cover (71), the pricker (62) that can pierce through described capsule (4) is provided with in described head (61), described head (61) lower end outer wall be provided with prevent head (61) from departing from cover (71) spacing snap fit (63), positioning boss (711) is provided with in described middle cover (71), described spacing snap fit (63) hook joint is on described positioning boss (711) lower surface.
6. a kind of rotatable capsule Diskus opened according to claim 5, is characterized in that between described head (61) and middle cover (71), be provided with the back-moving spring (64) that head (61) can be made to reset.
7. a kind of rotatable capsule Diskus opened according to claim 6, it is characterized in that upwards being extended with guide part (712) in described middle cover (71) lower surface, described pricker (62) is arranged in described guide part (712), and described back-moving spring (64) is set on described guide part (712) outer wall.
8. a kind of rotatable capsule Diskus opened according to claim 5, is characterized in that being provided with drainage screen (8) in the suction powder passage (2) of described medicine holder (5) below.
9. a kind of rotatable capsule Diskus opened according to claim 5, is characterized in that being arranged with dust cap (9) on described suction nozzle (3) outer wall.
10. a kind of rotatable capsule Diskus opened according to claim 5, it is characterized in that described medicine holder (5) includes medicine bracket (51), capsule chamber (52) is provided with in described medicine bracket (51), in described capsule chamber (52), be provided with cavity volume (53), be provided with the through hole (54) being communicated with described cavity volume (53) and inhaling powder passage (2) in described capsule chamber (52) bottom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466621.3A CN104984450B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule Diskus of rotatable opening |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510466621.3A CN104984450B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule Diskus of rotatable opening |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104984450A true CN104984450A (en) | 2015-10-21 |
| CN104984450B CN104984450B (en) | 2018-05-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510466621.3A Active CN104984450B (en) | 2015-07-30 | 2015-07-30 | A kind of capsule Diskus of rotatable opening |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104984450B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2753402Y (en) * | 2004-12-17 | 2006-01-25 | 上海医药工业研究院 | Capsule dry-powder inhaling device |
| CN2917672Y (en) * | 2006-07-06 | 2007-07-04 | 兴安药业有限公司 | Gas flow means of capsule type dry powder inhaler |
| CN102671270A (en) * | 2012-05-18 | 2012-09-19 | 泰安弗瑞斯医药科技有限公司 | Medicine sucking device for dry powder suction preparation |
| CN204501970U (en) * | 2015-01-22 | 2015-07-29 | 苏州惠仁生物科技有限公司 | Diskus |
| CN204910375U (en) * | 2015-08-04 | 2015-12-30 | 中山市美捷时包装制品有限公司 | Rotatory vertical capsule dry powder type suction apparatus |
-
2015
- 2015-07-30 CN CN201510466621.3A patent/CN104984450B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2753402Y (en) * | 2004-12-17 | 2006-01-25 | 上海医药工业研究院 | Capsule dry-powder inhaling device |
| CN2917672Y (en) * | 2006-07-06 | 2007-07-04 | 兴安药业有限公司 | Gas flow means of capsule type dry powder inhaler |
| CN102671270A (en) * | 2012-05-18 | 2012-09-19 | 泰安弗瑞斯医药科技有限公司 | Medicine sucking device for dry powder suction preparation |
| CN204501970U (en) * | 2015-01-22 | 2015-07-29 | 苏州惠仁生物科技有限公司 | Diskus |
| CN204910375U (en) * | 2015-08-04 | 2015-12-30 | 中山市美捷时包装制品有限公司 | Rotatory vertical capsule dry powder type suction apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104984450B (en) | 2018-05-04 |
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Address after: No.21 Jiankang Road, Torch Development Zone, Zhongshan City, Guangdong Province 528400 Patentee after: Guangdong Meijieshi Holdings Co.,Ltd. Address before: No.21 Jiankang Road, Torch Development Zone, Zhongshan City, Guangdong Province 528400 Patentee before: MAJESTY PACKAGING SYSTEMS Ltd. |