BR112013029672A2 - uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca - Google Patents
uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíacaInfo
- Publication number
- BR112013029672A2 BR112013029672A2 BR112013029672A BR112013029672A BR112013029672A2 BR 112013029672 A2 BR112013029672 A2 BR 112013029672A2 BR 112013029672 A BR112013029672 A BR 112013029672A BR 112013029672 A BR112013029672 A BR 112013029672A BR 112013029672 A2 BR112013029672 A2 BR 112013029672A2
- Authority
- BR
- Brazil
- Prior art keywords
- cathepsin
- prophylaxis
- treatment
- heart failure
- pulmonary hypertension
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 3
- 238000011321 prophylaxis Methods 0.000 title abstract 3
- 208000002815 pulmonary hypertension Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 108010084457 Cathepsins Proteins 0.000 title abstract 2
- 102000005600 Cathepsins Human genes 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 229940122805 Cathepsin S inhibitor Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
resumo da patente de invenção para: uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca. a presente invenção relaciona-se ao uso de inibidores da catepsina k e/ou da catepsina s em um método para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11166229 | 2011-05-16 | ||
PCT/EP2012/058773 WO2012156311A1 (en) | 2011-05-16 | 2012-05-11 | Use of cathepsin k inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013029672A2 true BR112013029672A2 (pt) | 2017-01-17 |
Family
ID=46085031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013029672A BR112013029672A2 (pt) | 2011-05-16 | 2012-05-11 | uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca |
Country Status (15)
Country | Link |
---|---|
US (1) | US9943522B2 (pt) |
EP (1) | EP2709602B1 (pt) |
JP (1) | JP6000340B2 (pt) |
KR (1) | KR20140034821A (pt) |
CN (1) | CN103687593B (pt) |
AU (1) | AU2012257779A1 (pt) |
BR (1) | BR112013029672A2 (pt) |
CA (1) | CA2835913A1 (pt) |
ES (1) | ES2648819T3 (pt) |
IL (1) | IL229312A0 (pt) |
MX (1) | MX2013013281A (pt) |
RU (1) | RU2013155509A (pt) |
SG (1) | SG194842A1 (pt) |
WO (1) | WO2012156311A1 (pt) |
ZA (1) | ZA201308391B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2835913A1 (en) | 2011-05-16 | 2012-11-22 | Bayer Intellectual Property Gmbh | Use of cathepsin k inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure |
CN103381152A (zh) * | 2013-02-05 | 2013-11-06 | 吉林省金梓源生物科技有限公司 | 杨梅素作为组织蛋白酶k抑制剂的用途 |
US11766467B2 (en) | 2017-09-01 | 2023-09-26 | University Of Wyoming | Methods of treating wounds using cathepsin K inhibitors |
US10758559B1 (en) | 2017-09-01 | 2020-09-01 | University Of Wyoming | Targeting cathepsin K to facilitate wound healing |
CN109864990B (zh) * | 2017-12-05 | 2022-07-15 | 中国医学科学院药物研究所 | 巴利卡替在制备抗丝状病毒感染药物中的应用 |
CN110981937B (zh) * | 2018-09-30 | 2021-11-12 | 北京和理咨询有限公司 | Odn或衍生物的多肽偶合物及其制备方法和应用 |
WO2022072504A1 (en) * | 2020-09-29 | 2022-04-07 | Healion Bio, Inc. | Methods and compositions for the treatment of viral diseases |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8997898A (en) | 1997-09-04 | 1999-03-22 | Nippon Chemiphar Co. Ltd. | Epoxysuccinamide derivatives |
PL350132A1 (en) | 1998-12-23 | 2002-11-04 | Smithkline Beecham Corp | Protease inhibitors |
EP1178958B1 (en) | 1999-03-15 | 2004-02-18 | Axys Pharmaceuticals, Inc. | N-cyanomethyl amides as protease inhibitors |
GB0003111D0 (en) | 2000-02-10 | 2000-03-29 | Novartis Ag | Organic compounds |
AU2001243441B2 (en) | 2000-03-21 | 2004-11-25 | Smithkline Beecham Corporation | Protease inhibitors |
WO2002068579A2 (en) | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
US20040009171A1 (en) | 2001-10-18 | 2004-01-15 | Genentech, Inc. | Methods for the treatment of carcinoma |
CA2477657C (en) | 2002-03-05 | 2011-04-26 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Cathepsin cysteine protease inhibitors |
CA2490468A1 (fr) | 2002-07-04 | 2004-01-22 | Aventis Pharma S.A. | Nouveaux derives acyl hydrazino du thiophene, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
WO2004058238A1 (en) * | 2002-12-23 | 2004-07-15 | Alcon, Inc. | Use of cathepsin k inhibitors for the treatment of glaucoma |
JP4616168B2 (ja) | 2003-04-25 | 2011-01-19 | 日本ケミファ株式会社 | (2s,3s)−3−[[(1s)−1−イソブトキシメチル−3−メチルブチル]カルバモイル]オキシラン−2−カルボン酸の塩 |
WO2006076796A1 (en) | 2005-01-19 | 2006-07-27 | Merck Frosst Canada Ltd. | Cathepsin k inhibitors and obesity |
EP1841730A4 (en) * | 2005-01-19 | 2010-10-27 | Merck Frosst Canada Ltd | CATHEPSIN K INHIBITORS AND ATHEROSCLEROSIS |
CN101218207A (zh) | 2005-07-06 | 2008-07-09 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
ES2703274T3 (es) * | 2008-04-18 | 2019-03-07 | Reata Pharmaceuticals Inc | Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17 |
CA2731769C (en) | 2008-07-21 | 2013-09-10 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
US8314137B2 (en) | 2008-07-22 | 2012-11-20 | Trustess Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
CA2835913A1 (en) | 2011-05-16 | 2012-11-22 | Bayer Intellectual Property Gmbh | Use of cathepsin k inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure |
-
2012
- 2012-05-11 CA CA2835913A patent/CA2835913A1/en not_active Abandoned
- 2012-05-11 WO PCT/EP2012/058773 patent/WO2012156311A1/en active Application Filing
- 2012-05-11 JP JP2014510748A patent/JP6000340B2/ja active Active
- 2012-05-11 KR KR1020137032862A patent/KR20140034821A/ko not_active Application Discontinuation
- 2012-05-11 EP EP12720863.5A patent/EP2709602B1/en not_active Not-in-force
- 2012-05-11 US US14/118,222 patent/US9943522B2/en active Active
- 2012-05-11 ES ES12720863.5T patent/ES2648819T3/es active Active
- 2012-05-11 RU RU2013155509/15A patent/RU2013155509A/ru unknown
- 2012-05-11 AU AU2012257779A patent/AU2012257779A1/en not_active Abandoned
- 2012-05-11 MX MX2013013281A patent/MX2013013281A/es not_active Application Discontinuation
- 2012-05-11 CN CN201280035300.2A patent/CN103687593B/zh not_active Expired - Fee Related
- 2012-05-11 SG SG2013082672A patent/SG194842A1/en unknown
- 2012-05-11 BR BR112013029672A patent/BR112013029672A2/pt not_active IP Right Cessation
-
2013
- 2013-11-07 IL IL229312A patent/IL229312A0/en unknown
- 2013-11-07 ZA ZA2013/08391A patent/ZA201308391B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2709602B1 (en) | 2017-08-23 |
US9943522B2 (en) | 2018-04-17 |
CN103687593B (zh) | 2016-09-28 |
JP2014518868A (ja) | 2014-08-07 |
RU2013155509A (ru) | 2015-06-27 |
WO2012156311A1 (en) | 2012-11-22 |
SG194842A1 (en) | 2013-12-30 |
MX2013013281A (es) | 2013-12-06 |
ZA201308391B (en) | 2015-02-25 |
US20140155383A1 (en) | 2014-06-05 |
IL229312A0 (en) | 2014-01-30 |
KR20140034821A (ko) | 2014-03-20 |
CN103687593A (zh) | 2014-03-26 |
JP6000340B2 (ja) | 2016-09-28 |
ES2648819T3 (es) | 2018-01-08 |
CA2835913A1 (en) | 2012-11-22 |
EP2709602A1 (en) | 2014-03-26 |
AU2012257779A1 (en) | 2013-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B15I | Others concerning applications: loss of priority |
Free format text: PERDA DA PRIORIDADE EP 11166229.2 DE 06/05/2011 REIVINDICADA NO PCT/EP2012/058773 POR NAO ENVIO DE DOCUMENTO COMPROBATORIO DE CESSAO DA MESMA CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 6O, ITEM 27 DO ATO NORMATIVO 128/97 E NO ART. 28 DA RESOLUCAO INPI-PR 77/2013 UMA VEZ QUE DEPOSITANTE CONSTANTE DA PETICAO DE REQUERIMENTO DO PEDIDO PCT E DISTINTO DAQUELE QUE DEPOSITOU A PRIORIDADE REIVINDICADA. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |