PE20020044A1 - Tiazina oxazolidinona - Google Patents
Tiazina oxazolidinonaInfo
- Publication number
- PE20020044A1 PE20020044A1 PE2001000542A PE2001000542A PE20020044A1 PE 20020044 A1 PE20020044 A1 PE 20020044A1 PE 2001000542 A PE2001000542 A PE 2001000542A PE 2001000542 A PE2001000542 A PE 2001000542A PE 20020044 A1 PE20020044 A1 PE 20020044A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- antibiotics
- refers
- compound
- thiazine oxazolidinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
SE REFIERE A UN COMPUESTO TIAZINA OXAZOLIDINONA DE FORMULA I N-({(5S)-3-[4-(1,1-DIOXIDO-4-TIOMORFOLINIL)-3,5-DIFLUOROFENIL-2-OXO-1,3-OXAZOLIDIN-5-IL}METIL) ACETAMIDA UTIL COMO AGENTE ANTIMICROBIANO QUE SE ADMINISTRA EN UNA CANTIDAD COMPRENDIDA ENTRE 0,1mg/kg A 100 mg/kg DE PESO CORPORAL/DIA . SE REFIERE TAMBIEN A UNA TERAPIA COMBINADA DONDE EL COMPUESTO DE FORMULA I SE ADMINISTRA JUNTO A OTROS ANTIBIOTICOS CON ACTIVIDAD SOBRE MICROORGANISMOS GRAM NEGATIVOS O UNA COMPOSICION COMPOSICION FARMACEUTICA QUE COMPRENDE: a) EL COMPUESTO DE FORMULA I; b) UNO O MAS ANTIBIOTICOS TAL COMO AMIKACINA, GENTAMICINA, TOBRAMICINA, IMIPENEM, MEROPENEM, ENTRE OTROS Y c) UN VEHICULO FARMACEUTICAMENTE ACEPTABLE.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21247400P | 2000-06-16 | 2000-06-16 | |
US23659500P | 2000-09-29 | 2000-09-29 | |
US28558701P | 2001-04-20 | 2001-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020044A1 true PE20020044A1 (es) | 2002-01-30 |
Family
ID=27395744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000542A PE20020044A1 (es) | 2000-06-16 | 2001-06-11 | Tiazina oxazolidinona |
Country Status (16)
Country | Link |
---|---|
US (1) | US6605609B2 (es) |
EP (1) | EP1294717B1 (es) |
JP (1) | JP2004501150A (es) |
KR (1) | KR20030010721A (es) |
CN (1) | CN1430618A (es) |
AR (1) | AR028706A1 (es) |
AT (1) | ATE312098T1 (es) |
AU (1) | AU2001266567A1 (es) |
BR (1) | BR0111520A (es) |
CA (1) | CA2410358A1 (es) |
DE (1) | DE60115644T2 (es) |
ES (1) | ES2253392T3 (es) |
MX (1) | MXPA02012494A (es) |
PE (1) | PE20020044A1 (es) |
TW (1) | TW583184B (es) |
WO (1) | WO2001098297A2 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US6696426B2 (en) * | 2000-08-22 | 2004-02-24 | Pharmacia Corporation | Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems |
PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
MXPA03009643A (es) * | 2001-04-20 | 2004-05-21 | Upjohn Co | Un metodo para la preparacion de oxazolidinonas. |
NZ528996A (en) | 2001-04-20 | 2006-01-27 | Upjohn Co | Process to prepare oxazolidinones |
JP2005502628A (ja) * | 2001-07-10 | 2005-01-27 | ファルマシア・アンド・アップジョン・カンパニー | 結晶性チアジンオキサゾリジノン |
AU2003224345A1 (en) * | 2002-04-30 | 2003-11-17 | Orchid Chemicals & Pharmaceuticals | Antibacterial agents |
KR101178005B1 (ko) * | 2002-05-07 | 2012-08-28 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 표적 기관지내 요법을 위한 방법, 장치 및 제제 |
TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
EP1648418A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
JP2006528189A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
AU2004258953B2 (en) | 2003-07-21 | 2011-02-10 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
CA2535177A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
US8062672B2 (en) | 2003-08-12 | 2011-11-22 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
AU2004270170B2 (en) * | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
EP1663169A4 (en) | 2003-09-15 | 2010-11-24 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, ITS USE AND FORMULATION |
TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
WO2005113520A1 (en) * | 2004-05-20 | 2005-12-01 | Pharmacia & Upjohn Company Llc | Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents |
JP2008505124A (ja) | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
AU2006339058B2 (en) | 2005-08-11 | 2012-09-06 | Targanta Therapeutics Inc. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US8299052B2 (en) * | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
EP2018864A1 (en) | 2007-07-23 | 2009-01-28 | Biomet Deutschland GmbH | Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
JP2012505222A (ja) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 肺炎症を低減するためのレボフロキサシンの吸入 |
JP2012505223A (ja) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 薬物動態の改善のためのエアゾールフルオロキノロン配合物 |
AU2010289326B2 (en) | 2009-09-04 | 2015-09-24 | Horizon Therapeutics U.S. Holding Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
US10010758B2 (en) * | 2015-07-20 | 2018-07-03 | Kinetic Furniture Of Vermont, Llc | Exercise chair |
CN106770222A (zh) * | 2016-11-23 | 2017-05-31 | 百奥森(江苏)食品安全科技有限公司 | 一种食品中甲硝唑的检测试剂盒 |
CN108239098B (zh) * | 2016-12-26 | 2021-01-12 | 中国医学科学院药物研究所 | 含四氢吡啶的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途 |
CN110612101A (zh) * | 2017-04-14 | 2019-12-24 | 安能泰制药有限公司 | 含有莫西沙星的预填充注射器 |
WO2021184339A1 (en) * | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
CN111870594B (zh) * | 2020-08-27 | 2022-03-22 | 首都医科大学附属北京胸科医院 | 苯乙肼在制备抗偶发分枝杆菌感染的药物中的应用 |
WO2024035618A1 (en) * | 2022-08-10 | 2024-02-15 | Merck Sharp & Dohme Llc | Processes for preparing oxazolidinone compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
KR100463772B1 (ko) | 1995-09-01 | 2005-11-09 | 파마시아 앤드 업존 캄파니 엘엘씨 | 4내지8원헤테로사이클릭환에탄소-탄소결합을갖는페닐옥사졸리디논 |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
JP2001524074A (ja) * | 1997-03-13 | 2001-11-27 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 金属−β−ラクタマーゼ阻害特性を有するピロリジンおよびチアゾール誘導体 |
WO2001034128A2 (en) | 1999-11-08 | 2001-05-17 | Pharmacia & Upjohn Company | Admixture for intravenous administration of linezolid and other antibacterial agents |
-
2001
- 2001-06-11 PE PE2001000542A patent/PE20020044A1/es not_active Application Discontinuation
- 2001-06-12 AR ARP010102780A patent/AR028706A1/es unknown
- 2001-06-14 EP EP01944126A patent/EP1294717B1/en not_active Expired - Lifetime
- 2001-06-14 DE DE60115644T patent/DE60115644T2/de not_active Expired - Fee Related
- 2001-06-14 JP JP2002504253A patent/JP2004501150A/ja not_active Withdrawn
- 2001-06-14 BR BR0111520-0A patent/BR0111520A/pt not_active IP Right Cessation
- 2001-06-14 AT AT01944126T patent/ATE312098T1/de not_active IP Right Cessation
- 2001-06-14 ES ES01944126T patent/ES2253392T3/es not_active Expired - Lifetime
- 2001-06-14 WO PCT/US2001/014854 patent/WO2001098297A2/en active IP Right Grant
- 2001-06-14 AU AU2001266567A patent/AU2001266567A1/en not_active Abandoned
- 2001-06-14 KR KR1020027017088A patent/KR20030010721A/ko not_active Application Discontinuation
- 2001-06-14 CA CA002410358A patent/CA2410358A1/en not_active Abandoned
- 2001-06-14 CN CN01809867A patent/CN1430618A/zh active Pending
- 2001-06-14 MX MXPA02012494A patent/MXPA02012494A/es not_active Application Discontinuation
- 2001-06-15 US US09/881,189 patent/US6605609B2/en not_active Expired - Fee Related
- 2001-06-15 TW TW090114508A patent/TW583184B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW583184B (en) | 2004-04-11 |
KR20030010721A (ko) | 2003-02-05 |
WO2001098297A3 (en) | 2002-06-13 |
US6605609B2 (en) | 2003-08-12 |
ATE312098T1 (de) | 2005-12-15 |
CN1430618A (zh) | 2003-07-16 |
AR028706A1 (es) | 2003-05-21 |
DE60115644D1 (en) | 2006-01-12 |
BR0111520A (pt) | 2003-03-18 |
CA2410358A1 (en) | 2001-12-27 |
WO2001098297A2 (en) | 2001-12-27 |
DE60115644T2 (de) | 2006-07-06 |
ES2253392T3 (es) | 2006-06-01 |
EP1294717B1 (en) | 2005-12-07 |
US20020156072A1 (en) | 2002-10-24 |
JP2004501150A (ja) | 2004-01-15 |
EP1294717A2 (en) | 2003-03-26 |
MXPA02012494A (es) | 2003-04-25 |
AU2001266567A1 (en) | 2002-01-02 |
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Legal Events
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FC | Refusal |