BR0016821A - Sulfonamidas e derivados da mesma que modulam a atividade de endotelina - Google Patents
Sulfonamidas e derivados da mesma que modulam a atividade de endotelinaInfo
- Publication number
- BR0016821A BR0016821A BR0016821-1A BR0016821A BR0016821A BR 0016821 A BR0016821 A BR 0016821A BR 0016821 A BR0016821 A BR 0016821A BR 0016821 A BR0016821 A BR 0016821A
- Authority
- BR
- Brazil
- Prior art keywords
- endothelin
- sulfonamides
- derivatives
- isoxazolyl
- activity
- Prior art date
Links
- 108050009340 Endothelin Proteins 0.000 title abstract 6
- 150000003456 sulfonamides Chemical class 0.000 title abstract 5
- 102000002045 Endothelin Human genes 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 4
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 4
- 229940124530 sulfonamide Drugs 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- HLBCDKJOMBEQMZ-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)-1h-pyrrole-2-sulfonamide Chemical class C=1C=CNC=1S(=O)(=O)NC=1C=CON=1 HLBCDKJOMBEQMZ-UHFFFAOYSA-N 0.000 abstract 1
- NRNITHABNQZDAT-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NC=1C=CON=1 NRNITHABNQZDAT-UHFFFAOYSA-N 0.000 abstract 1
- WDPJORZQTNVWPF-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)furan-2-sulfonamide Chemical class C=1C=COC=1S(=O)(=O)NC=1C=CON=1 WDPJORZQTNVWPF-UHFFFAOYSA-N 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
"SULFONAMIDAS E DERIVADOS DAS MESMAS QUE MODULAM A ATIVIDADE DA ENDOTELINA". São fornecidas formulações de tienil-, furil-, pirrolil- e fenil-sulfonamidas, suas formulações de derivados farmaceuticamente aceitáveis e processos para modular ou alterar a atividade da família de peptídeos da endotelina. Em particular, são fornecidas N-(isoxazolil) tienil-sulfonamidas, N-(isoxazolil)-furil-sulfonamidas, N(isoxazolil)-pirrolil-sulfonamidas e N-(isoxazolil)-fenilsulfonamidas, suas formulações e processos usando essas sulfonamidas para inibir a ligação de um peptídeo de endotelina a um receptor de endotelina pelo contato do receptor com a sulfonamida. São também fornecidos processos para o tratamento de distúrbios mediados por endotelina por administração de quantidades eficazes de uma ou mais dessas sulfonamidas ou seus derivados farmaceuticamente aceitáveis, que inibam a atividade da endotelina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17410499P | 1999-12-31 | 1999-12-31 | |
| PCT/US2000/035599 WO2001049685A2 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0016821A true BR0016821A (pt) | 2002-12-10 |
Family
ID=22634839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0016821-1A BR0016821A (pt) | 1999-12-31 | 2000-12-29 | Sulfonamidas e derivados da mesma que modulam a atividade de endotelina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6686382B2 (pt) |
| EP (1) | EP1244657B1 (pt) |
| JP (1) | JP4202649B2 (pt) |
| KR (1) | KR20020072285A (pt) |
| CN (1) | CN1414965A (pt) |
| AT (2) | ATE286051T1 (pt) |
| AU (1) | AU2464301A (pt) |
| BR (1) | BR0016821A (pt) |
| CA (1) | CA2395684C (pt) |
| CZ (1) | CZ20022293A3 (pt) |
| DE (2) | DE60034605T2 (pt) |
| DK (1) | DK1533311T3 (pt) |
| EA (1) | EA004735B1 (pt) |
| EE (1) | EE200200363A (pt) |
| ES (2) | ES2285334T3 (pt) |
| HU (1) | HUP0203935A3 (pt) |
| IL (1) | IL150311A0 (pt) |
| MX (1) | MXPA02006461A (pt) |
| NO (1) | NO20023168L (pt) |
| NZ (1) | NZ519717A (pt) |
| PL (1) | PL197782B1 (pt) |
| PT (1) | PT1533311E (pt) |
| SK (1) | SK9532002A3 (pt) |
| WO (1) | WO2001049685A2 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| JP3455233B2 (ja) | 1997-04-28 | 2003-10-14 | テキサス・バイオテクノロジー・コーポレイシヨン | エンドテリン介在障害治療用のスルホンアミド類 |
| DE60034605T2 (de) | 1999-12-31 | 2007-09-06 | Encysive Pharmaceuticals, Inc., Houston | Sulfonamide und deren Derivate als Modulatoren der Endothelin-Aktivität |
| AU2003202495B2 (en) | 2002-01-11 | 2006-07-20 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
| US7205307B2 (en) * | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
| WO2004043917A1 (en) * | 2002-11-06 | 2004-05-27 | Smithkline Beecham Corporation | Sulfonamides |
| TWI355934B (en) | 2004-02-24 | 2012-01-11 | Sankyo Co | Pharmaceutical composition for treatment or prophy |
| SI1817301T1 (sl) * | 2004-11-22 | 2012-04-30 | Lilly Co Eli | Ojačevalci glutamatnih receptorjev |
| PT1928409E (pt) | 2005-09-12 | 2012-11-27 | Actelion Pharmaceuticals Ltd | Composição farmacêutica estável que compreende uma pirimidina-sulfamida |
| MX2008011844A (es) * | 2006-03-13 | 2008-10-02 | Encysive Pharmaceuticals Inc | Formulaciones de sitaxsentano de sodio. |
| CN101404981A (zh) * | 2006-03-13 | 2009-04-08 | 恩希赛弗制药公司 | 治疗舒张性心力衰竭的方法和组合物 |
| US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
| KR20090036126A (ko) * | 2006-08-04 | 2009-04-13 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | Ｎ-(2-아세틸-4,6-디메틸페닐)-3-｛[(3,4 디메틸-5-이속사졸릴)아미노]술포닐｝-2-티오펜카르복스아미드의 제조 방법 |
| RU2009103040A (ru) * | 2006-08-04 | 2010-09-10 | Инсайсив Фармасьютикалз, Инк. (US) | Полиморфы n-(2-ацетил-4,6-диметилфенил)-3-{[4-диметил-5-изоксазолил)амино]сульфонил}-2-тиофен-карбоксамида |
| CL2008000835A1 (es) | 2007-03-23 | 2008-10-03 | Icagen Inc Pfizer Ltd | Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm |
| AU2008237062A1 (en) | 2007-04-10 | 2008-10-16 | Auspex Pharmaceuticals, Inc. | Substituted deuterium enriched thiophenes for the treatment of hypertension |
| KR100860539B1 (ko) * | 2007-05-11 | 2008-09-26 | 한국화학연구원 | 아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 |
| MX2009013022A (es) * | 2007-06-25 | 2010-01-20 | Encysive Pharmaceuticals Inc | Formulaciones de n-(2-acetil-4,6-dimetilfenil)-3-{[3,4-dimetil-5-i soxazolil)amino]sulfonil}-2-tiofenocarboxamida. |
| MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| AU2013216122B9 (en) * | 2012-01-31 | 2017-02-02 | Eisai R&D Management Co., Ltd. | Sitaxsentan derivative |
| KR101197618B1 (ko) * | 2012-03-13 | 2012-11-07 | 한국화학연구원 | 결핵의 예방 또는 치료용 약제학적 조성물 |
| US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
| BR112023019460A2 (pt) * | 2021-06-22 | 2024-01-23 | Alchemedicine Inc | Composto, antagonista do receptor de endotelina a e composição farmacêutica que compreendem o mesmo e usos do composto como terapia e na produção de um antagonista do receptor de endotelina a |
| WO2023078252A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
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-
2000
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 EP EP00988434A patent/EP1244657B1/en not_active Expired - Lifetime
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 EE EEP200200363A patent/EE200200363A/xx unknown
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Application Discontinuation
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en active IP Right Grant
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
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2002
- 2002-06-28 NO NO20023168A patent/NO20023168L/no not_active Application Discontinuation
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