HUP0203935A3 - Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use - Google Patents
Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their useInfo
- Publication number
- HUP0203935A3 HUP0203935A3 HU0203935A HUP0203935A HUP0203935A3 HU P0203935 A3 HUP0203935 A3 HU P0203935A3 HU 0203935 A HU0203935 A HU 0203935A HU P0203935 A HUP0203935 A HU P0203935A HU P0203935 A3 HUP0203935 A3 HU P0203935A3
- Authority
- HU
- Hungary
- Prior art keywords
- endothelin
- sulfonamides
- modulate
- derivatives
- activity
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17410499P | 1999-12-31 | 1999-12-31 | |
PCT/US2000/035599 WO2001049685A2 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203935A2 HUP0203935A2 (hu) | 2003-04-28 |
HUP0203935A3 true HUP0203935A3 (en) | 2006-02-28 |
Family
ID=22634839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203935A HUP0203935A3 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use |
Country Status (24)
Country | Link |
---|---|
US (1) | US6686382B2 (hu) |
EP (1) | EP1244657B1 (hu) |
JP (1) | JP4202649B2 (hu) |
KR (1) | KR20020072285A (hu) |
CN (1) | CN1414965A (hu) |
AT (2) | ATE360628T1 (hu) |
AU (1) | AU2464301A (hu) |
BR (1) | BR0016821A (hu) |
CA (1) | CA2395684C (hu) |
CZ (1) | CZ20022293A3 (hu) |
DE (2) | DE60017195T2 (hu) |
DK (1) | DK1533311T3 (hu) |
EA (1) | EA004735B1 (hu) |
EE (1) | EE200200363A (hu) |
ES (2) | ES2236028T3 (hu) |
HU (1) | HUP0203935A3 (hu) |
IL (1) | IL150311A0 (hu) |
MX (1) | MXPA02006461A (hu) |
NO (1) | NO20023168L (hu) |
NZ (1) | NZ519717A (hu) |
PL (1) | PL197782B1 (hu) |
PT (1) | PT1533311E (hu) |
SK (1) | SK9532002A3 (hu) |
WO (1) | WO2001049685A2 (hu) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
BR9812258A (pt) | 1997-04-28 | 2000-07-25 | Texas Biotechnology Corp | Sulfonamidas para tratamento de distúrbios mediados por endotelina |
ATE360628T1 (de) | 1999-12-31 | 2007-05-15 | Encysive Pharmaceuticals Inc | Sulfonamide und deren derivate als modulatoren der endothelin-aktivität |
CA2473461C (en) | 2002-01-11 | 2011-11-01 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
US7205307B2 (en) * | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
WO2004043917A1 (en) * | 2002-11-06 | 2004-05-27 | Smithkline Beecham Corporation | Sulfonamides |
KR101182619B1 (ko) | 2004-02-24 | 2012-09-18 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
RS52268B (en) * | 2004-11-22 | 2012-10-31 | Eli Lilly And Company | GLUTAMATERGIC RECEPTOR AMPLIFIERS |
ES2393117T3 (es) | 2005-09-12 | 2012-12-18 | Actelion Pharmaceuticals Ltd. | Composición farmacéutica estable que comprende una pirimidina-sulfamida |
RU2008136317A (ru) * | 2006-03-13 | 2010-04-20 | Инсайсив Фармасьютикалз, Инк. (US) | Способы и композиции для лечения диагностикой сердечной недостаточности |
BRPI0709588A2 (pt) * | 2006-03-13 | 2011-07-19 | Encysive Pharmaceuticals Inc | formulações de sitaxsentan sódico |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
KR20090036126A (ko) * | 2006-08-04 | 2009-04-13 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | N-(2-아세틸-4,6-디메틸페닐)-3-{[(3,4 디메틸-5-이속사졸릴)아미노]술포닐}-2-티오펜카르복스아미드의 제조 방법 |
US20080070961A1 (en) * | 2006-08-04 | 2008-03-20 | Reichwein John F | Polymorphs of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)-amino]sulfonyl}-2-thiophene-carboxamide |
WO2008118758A1 (en) | 2007-03-23 | 2008-10-02 | Icagen, Inc. | Inhibitors of ion channels |
BRPI0809740A2 (pt) | 2007-04-10 | 2014-11-04 | Auspex Pharmaceuticals Inc | "composto, composição farmacêutica, método para tratamento, prevenção ou melhora de um ou mais sintomas de uma desordem mediada pela endotelina, método de inibição da ligação de uma endotelina para um receptor et ou et e, método para modular atividade mediada pelo recptor de endotelina" |
KR100860539B1 (ko) * | 2007-05-11 | 2008-09-26 | 한국화학연구원 | 아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 |
JP2010531357A (ja) * | 2007-06-25 | 2010-09-24 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | N−(2−アセチル−4,6−ジメチルフェニル)−3−{[(3,4−ジメチル−5−イソオキサゾリル)アミノ]スルホニル}−2−チオフェンカルボキサミドの製剤 |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
KR101933251B1 (ko) * | 2012-01-31 | 2018-12-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 시탁센탄 유도체 |
KR101197618B1 (ko) * | 2012-03-13 | 2012-11-07 | 한국화학연구원 | 결핵의 예방 또는 치료용 약제학적 조성물 |
US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
CN117255791A (zh) | 2021-06-22 | 2023-12-19 | 亚克医药株式会社 | 化合物、内皮素a受体拮抗剂及医药组合物 |
CA3237199A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
ES462774A1 (es) * | 1977-09-29 | 1978-05-16 | Andreu Sa Dr | Procedimiento para la obtencion de nuevos ftalil derivados de sulfamidas. |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4914112A (en) | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5306822A (en) | 1988-05-25 | 1994-04-26 | Warner-Lambert Company | Arylmethylenyl derivatives of oxazolidinone |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
JPH0347163A (ja) | 1989-06-30 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | アントラキノン誘導体およびその製造 |
US5230999A (en) | 1989-07-24 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Monoclonal antibody to endothelin-3 or precursor thereof and use thereof |
CA2032559C (en) | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
EP0523141A4 (en) | 1990-03-30 | 1993-04-21 | Merck & Co. Inc. | Substituted pyrazoles, isoxazoles and isothiazoles |
CA2059380A1 (en) | 1991-01-24 | 1992-07-25 | Yiu-Kuen T. Lam | Endothelin receptor antagonists isolated from microbispora |
ES2115665T3 (es) | 1991-01-29 | 1998-07-01 | Shionogi & Co | Derivado de triterpeno. |
ES2089256T3 (es) | 1991-02-15 | 1996-10-01 | Takeda Chemical Industries Ltd | Antagonista de la endotelina. |
TW270116B (hu) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
US5382569A (en) | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
FR2679906B1 (fr) | 1991-07-31 | 1995-01-20 | Adir | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
GB2259450A (en) | 1991-09-11 | 1993-03-17 | Fujisawa Pharmaceutical Co | Compositions with endothelin antagonist activity |
JP2667294B2 (ja) | 1991-11-05 | 1997-10-27 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗剤 |
US5198548A (en) | 1992-01-30 | 1993-03-30 | Warner-Lambert Company | Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof |
US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW224462B (hu) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
US5240910A (en) | 1992-04-17 | 1993-08-31 | Merck & Co., Inc. | Antihypertensive compounds produced by fermentation |
NZ247440A (en) | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
US5514696A (en) | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
US5352800A (en) | 1993-03-11 | 1994-10-04 | Merck & Co., Inc. | Process for the production of a novel endothelin antagonist |
US5334598A (en) | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
US6030991A (en) | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
EP0714391A1 (en) | 1993-08-19 | 1996-06-05 | Warner-Lambert Company | Substituted 2(5h)furanone, 2(5h)thiophenone and 2(5h)pyrrolone derivatives, their preparation and their use as endothelin antagonists |
US6063911A (en) | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5962682A (en) | 1994-12-20 | 1999-10-05 | Hoffmann-La Roche Inc. | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists |
KR100359396B1 (ko) | 1995-04-04 | 2003-03-15 | 텍사스 바이오테크놀로지 코포레이션 | 엔도텔린의활성을조절하는티에닐-,푸릴-및피롤릴설폰아미드및이의유도체 |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
US5922759A (en) | 1996-06-21 | 1999-07-13 | Warner-Lambert Company | Butenolide endothelin antagonists |
US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
DE69612874T2 (de) | 1995-12-20 | 2001-10-04 | Yamanouchi Pharma Co Ltd | Arylethensulfonamid-derivate und diese enthaltende medikamente |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
AU2529297A (en) | 1996-04-10 | 1997-10-29 | Warner-Lambert Company | Ketoacid endothelin antagonists |
US6133263A (en) | 1996-04-10 | 2000-10-17 | Warner-Lambert Company | Endothelin antagonists with ether-linked groups |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
BR9812258A (pt) * | 1997-04-28 | 2000-07-25 | Texas Biotechnology Corp | Sulfonamidas para tratamento de distúrbios mediados por endotelina |
US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
ATE360628T1 (de) | 1999-12-31 | 2007-05-15 | Encysive Pharmaceuticals Inc | Sulfonamide und deren derivate als modulatoren der endothelin-aktivität |
-
2000
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 EP EP00988434A patent/EP1244657B1/en not_active Expired - Lifetime
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en active IP Right Grant
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Application Discontinuation
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
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2002
- 2002-06-28 NO NO20023168A patent/NO20023168L/no not_active Application Discontinuation
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