HUP0203935A2 - Az endotelin aktivitását módosító szulfonamidok és származékaik, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Az endotelin aktivitását módosító szulfonamidok és származékaik, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0203935A2 HUP0203935A2 HU0203935A HUP0203935A HUP0203935A2 HU P0203935 A2 HUP0203935 A2 HU P0203935A2 HU 0203935 A HU0203935 A HU 0203935A HU P0203935 A HUP0203935 A HU P0203935A HU P0203935 A2 HUP0203935 A2 HU P0203935A2
- Authority
- HU
- Hungary
- Prior art keywords
- endothelin
- activity
- isoxazolyl
- derivatives
- sulfonamides
- Prior art date
Links
- 108050009340 Endothelin Proteins 0.000 title abstract 5
- 102000002045 Endothelin Human genes 0.000 title abstract 4
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 3
- 229940124530 sulfonamide Drugs 0.000 title abstract 3
- 150000003456 sulfonamides Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- HLBCDKJOMBEQMZ-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)-1h-pyrrole-2-sulfonamide Chemical class C=1C=CNC=1S(=O)(=O)NC=1C=CON=1 HLBCDKJOMBEQMZ-UHFFFAOYSA-N 0.000 abstract 1
- NRNITHABNQZDAT-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NC=1C=CON=1 NRNITHABNQZDAT-UHFFFAOYSA-N 0.000 abstract 1
- WDPJORZQTNVWPF-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)furan-2-sulfonamide Chemical class C=1C=COC=1S(=O)(=O)NC=1C=CON=1 WDPJORZQTNVWPF-UHFFFAOYSA-N 0.000 abstract 1
- REPFEAIBUZAYOL-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)thiophene-2-sulfonamide Chemical class C=1C=CSC=1S(=O)(=O)NC=1C=CON=1 REPFEAIBUZAYOL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Steroid Compounds (AREA)
Abstract
A találmány tienil-, furil-, pirrolil-, fenil-szulfonamidokkal,gyógyászati szempontból alkalmazható származékaikat tartalmazógyógyszerkészítményekkel és ezeket alkalmazó eljárásokkal szolgál azendotelin-peptidek aktivitásának módosítására vagy megváltoztatására.Nevezetesen, az N-(izoxazolil)-tienil-szulfonamidokkal, N-(izoxazolil)-furil-szulfonamidokkal, N-(izoxazolil)- pirrolil-szulfonamidokkal és N-(izoxazolil)-fenil-szulfonamidokkal, ezekettartalmazó készítményekkel és ezeket alkalmazó eljárásokkal szolgál azendotelin-peptidnek az endotelin receptorokhoz történő kötődésénekgátlására azáltal, hogy a receptort érintkezésbe hozza aszulfonamiddal. A találmány tovább eljárásokat nyújt az endotelinnelkapcsolatos betegségek kezelésére, ami abból áll, hogy egy vagy többnevezett szulfonamidnak vagy gyógyászatilag alkalmazható származékánakaz endotelin aktivitását gátló, hatásos mennyiségét juttatják aszervezetbe. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17410499P | 1999-12-31 | 1999-12-31 | |
PCT/US2000/035599 WO2001049685A2 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203935A2 true HUP0203935A2 (hu) | 2003-04-28 |
HUP0203935A3 HUP0203935A3 (en) | 2006-02-28 |
Family
ID=22634839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203935A HUP0203935A3 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use |
Country Status (24)
Country | Link |
---|---|
US (1) | US6686382B2 (hu) |
EP (1) | EP1244657B1 (hu) |
JP (1) | JP4202649B2 (hu) |
KR (1) | KR20020072285A (hu) |
CN (1) | CN1414965A (hu) |
AT (2) | ATE360628T1 (hu) |
AU (1) | AU2464301A (hu) |
BR (1) | BR0016821A (hu) |
CA (1) | CA2395684C (hu) |
CZ (1) | CZ20022293A3 (hu) |
DE (2) | DE60017195T2 (hu) |
DK (1) | DK1533311T3 (hu) |
EA (1) | EA004735B1 (hu) |
EE (1) | EE200200363A (hu) |
ES (2) | ES2236028T3 (hu) |
HU (1) | HUP0203935A3 (hu) |
IL (1) | IL150311A0 (hu) |
MX (1) | MXPA02006461A (hu) |
NO (1) | NO20023168L (hu) |
NZ (1) | NZ519717A (hu) |
PL (1) | PL197782B1 (hu) |
PT (1) | PT1533311E (hu) |
SK (1) | SK9532002A3 (hu) |
WO (1) | WO2001049685A2 (hu) |
Families Citing this family (24)
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US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
BR9812258A (pt) | 1997-04-28 | 2000-07-25 | Texas Biotechnology Corp | Sulfonamidas para tratamento de distúrbios mediados por endotelina |
ATE360628T1 (de) | 1999-12-31 | 2007-05-15 | Encysive Pharmaceuticals Inc | Sulfonamide und deren derivate als modulatoren der endothelin-aktivität |
CA2473461C (en) | 2002-01-11 | 2011-11-01 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
US7205307B2 (en) * | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
WO2004043917A1 (en) * | 2002-11-06 | 2004-05-27 | Smithkline Beecham Corporation | Sulfonamides |
KR101182619B1 (ko) | 2004-02-24 | 2012-09-18 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
RS52268B (en) * | 2004-11-22 | 2012-10-31 | Eli Lilly And Company | GLUTAMATERGIC RECEPTOR AMPLIFIERS |
ES2393117T3 (es) | 2005-09-12 | 2012-12-18 | Actelion Pharmaceuticals Ltd. | Composición farmacéutica estable que comprende una pirimidina-sulfamida |
RU2008136317A (ru) * | 2006-03-13 | 2010-04-20 | Инсайсив Фармасьютикалз, Инк. (US) | Способы и композиции для лечения диагностикой сердечной недостаточности |
BRPI0709588A2 (pt) * | 2006-03-13 | 2011-07-19 | Encysive Pharmaceuticals Inc | formulações de sitaxsentan sódico |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
KR20090036126A (ko) * | 2006-08-04 | 2009-04-13 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | N-(2-아세틸-4,6-디메틸페닐)-3-{[(3,4 디메틸-5-이속사졸릴)아미노]술포닐}-2-티오펜카르복스아미드의 제조 방법 |
US20080070961A1 (en) * | 2006-08-04 | 2008-03-20 | Reichwein John F | Polymorphs of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)-amino]sulfonyl}-2-thiophene-carboxamide |
WO2008118758A1 (en) | 2007-03-23 | 2008-10-02 | Icagen, Inc. | Inhibitors of ion channels |
BRPI0809740A2 (pt) | 2007-04-10 | 2014-11-04 | Auspex Pharmaceuticals Inc | "composto, composição farmacêutica, método para tratamento, prevenção ou melhora de um ou mais sintomas de uma desordem mediada pela endotelina, método de inibição da ligação de uma endotelina para um receptor et ou et e, método para modular atividade mediada pelo recptor de endotelina" |
KR100860539B1 (ko) * | 2007-05-11 | 2008-09-26 | 한국화학연구원 | 아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 |
JP2010531357A (ja) * | 2007-06-25 | 2010-09-24 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | N−(2−アセチル−4,6−ジメチルフェニル)−3−{[(3,4−ジメチル−5−イソオキサゾリル)アミノ]スルホニル}−2−チオフェンカルボキサミドの製剤 |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
KR101933251B1 (ko) * | 2012-01-31 | 2018-12-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 시탁센탄 유도체 |
KR101197618B1 (ko) * | 2012-03-13 | 2012-11-07 | 한국화학연구원 | 결핵의 예방 또는 치료용 약제학적 조성물 |
US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
CN117255791A (zh) | 2021-06-22 | 2023-12-19 | 亚克医药株式会社 | 化合物、内皮素a受体拮抗剂及医药组合物 |
CA3237199A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
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2000
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 EP EP00988434A patent/EP1244657B1/en not_active Expired - Lifetime
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en active IP Right Grant
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Application Discontinuation
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
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