ES2115665T3 - Derivado de triterpeno. - Google Patents

Derivado de triterpeno.

Info

Publication number
ES2115665T3
ES2115665T3 ES92900597T ES92900597T ES2115665T3 ES 2115665 T3 ES2115665 T3 ES 2115665T3 ES 92900597 T ES92900597 T ES 92900597T ES 92900597 T ES92900597 T ES 92900597T ES 2115665 T3 ES2115665 T3 ES 2115665T3
Authority
ES
Spain
Prior art keywords
hydrogen
triterpen
derived
formula
antiendotheline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900597T
Other languages
English (en)
Inventor
Masafumi Fujimoto
Kensuke Sakurai
Shinichi Mihara
Miharu Nakamura
Toshiro Konoike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2115665T3 publication Critical patent/ES2115665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

UN DERIVADO DEL TRITERPENO REPRESENTADO POR LA FORMULA GENERAL (I), QUE TIENE UNA ACTIVIDAD ANTIENDOTELINA Y ES UTIL EN LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CARDIOVASCULAR, Y SU COMPOSICION FARMACEUTICA. EN LA FORMULA (I), R1 REPRESENTA HIDROGENO O UN RESIDUO DE ESTER METABOLICO; R3 REPRESENTA UN ARILO O UN GRUPO HETEROCICLICO AROMATICO QUE SE PUEDE SUBSTITUIR; UNA DE LAS X E Y ES HIDROXI Y LA OTRA ES HIDROGENO, O ALTERNATIVAMENTE X E Y SE COMBINAN ENTRE SI PARA REPRESENTAR OXO; Y Z REPRESENTA OXIGENO O DOS ATOMOS DE HIDROGENO.
ES92900597T 1991-01-29 1991-12-13 Derivado de triterpeno. Expired - Lifetime ES2115665T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2937291 1991-01-29

Publications (1)

Publication Number Publication Date
ES2115665T3 true ES2115665T3 (es) 1998-07-01

Family

ID=12274319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900597T Expired - Lifetime ES2115665T3 (es) 1991-01-29 1991-12-13 Derivado de triterpeno.

Country Status (8)

Country Link
US (1) US5248807A (es)
EP (1) EP0526642B1 (es)
JP (1) JP2950616B2 (es)
AT (1) ATE164588T1 (es)
DE (1) DE69129193T2 (es)
DK (1) DK0526642T3 (es)
ES (1) ES2115665T3 (es)
WO (1) WO1992012991A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
WO1993023404A1 (en) * 1992-05-19 1993-11-25 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
FI941826L (fi) * 1993-04-21 1994-10-22 Takeda Chemical Industries Ltd Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JP3373591B2 (ja) 1993-06-11 2003-02-04 塩野義製薬株式会社 硫酸化トリテルペン誘導体およびそれを含有するエンドセリンレセプター拮抗剤
EP0628569B1 (en) 1993-06-11 1996-09-11 Shionogi & Co., Ltd. Triterpene derivatives and endothelin-receptor antagonists containing the same
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
KR100399797B1 (ko) * 1995-06-02 2004-04-13 시오노기세이야쿠가부시키가이샤 뇌부종억제제
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) * 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TR200202738T2 (tr) 1997-04-28 2003-03-21 Texas Biotechnology Corporation Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
SK9532002A3 (en) 1999-12-31 2003-06-03 Texas Biotechnology Corp Sulfonamides and derivatives thereof that modulate the activity of endothelin
EP1489091A4 (en) * 2002-03-22 2009-06-17 Shionogi & Co METHOD FOR PRODUCING A TRITERPENDERIVATE
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
WO2005110958A1 (ja) * 2004-05-14 2005-11-24 Shionogi & Co., Ltd. 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
MX2007007517A (es) * 2004-12-21 2007-09-04 Dow Global Technologies Inc Composiciones de adhesivo con base en polipropileno.
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
BRPI0708879A2 (pt) * 2006-03-13 2011-06-14 Encysive Pharmaceuticals peocessos e composiÇÕes para o tratamento de insufiÊncia cardÍaca diastàlica
EP2001446A2 (en) * 2006-03-13 2008-12-17 Encysive Pharmaceuticals, Inc Formulations of sitaxsentan sodium
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases
TWI492745B (zh) 2008-01-11 2015-07-21 Reata Pharmaceuticals Inc 合成的三萜系化合物及其使用於治療疾病之方法
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
CN103342729B (zh) * 2013-03-26 2016-09-14 中国科学院上海药物研究所 咖啡酰基取代的五环三萜类衍生物及其用途
MX2019005401A (es) 2016-11-08 2019-08-05 Reata Pharmaceuticals Inc Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.
MX2020006995A (es) 2018-01-04 2020-09-09 Amryt Res Limited Extractos de corteza de abedul que contienen betulina y su formulacion.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
JPS63222119A (ja) * 1987-03-10 1988-09-16 Rooman Kogyo:Kk 肝臓疾患用剤
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
DE69129193T2 (de) 1998-07-30
JP2950616B2 (ja) 1999-09-20
EP0526642B1 (en) 1998-04-01
EP0526642A4 (es) 1994-02-09
US5248807A (en) 1993-09-28
DE69129193D1 (en) 1998-05-07
WO1992012991A1 (fr) 1992-08-06
DK0526642T3 (da) 1998-10-19
EP0526642A1 (en) 1993-02-10
ATE164588T1 (de) 1998-04-15

Similar Documents

Publication Publication Date Title
ES2115665T3 (es) Derivado de triterpeno.
ES2194986T3 (es) Compuestos de carbonil-piperazinilo y piperidinilo que inhiben la farnesil-protein-transferasa.
IL109526A0 (en) Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
NO972156L (no) 2-cyanacrylsyre-estere
FR2679140B1 (fr) Composition cosmetique ou dermatologique depigmentante contenant des derives d'arbutoside.
ATE16488T1 (de) M-4- und isom-4-derivate, ihre herstellung und diese enthaltende zusammensetzungen.
IT1229570B (it) Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
ZA911728B (en) Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
IL88848A0 (en) Immunoassays utilizing chemiluminescent esters,thioesters and amides as the labels
IT1229569B (it) Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
TR199902350T2 (xx) Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler.
ATE138571T1 (de) Verwendung von dioxabicyclo (3.3.0>octane derivaten zur herstellung eines arzneimittels zur hemmung des cholesterinmetabolismus.
AU3381389A (en) Derivative of caffeic acid and pharmaceutical composition containing the same
ATE95178T1 (de) Octahydronaphthalenoxim-derivate fuer cholesterolsynthese-inhibierung, verfahren fuer deren herstellung und diese enthaltende zusammenstellungen.
ATE125278T1 (de) Biologisch abbaubarer copolyester von 4- hydroxyprolin und diesen enthaltende pharmazeutische zusammensetzung.
MX9300205A (es) Compuestos policiclicos disubstituidos y composicion farmaceutica que los contiene.
MX9300203A (es) Compuestos policiclicos disubstituidos y composicion farmaceutica que los contiene.
HUT75647A (en) Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia
DE69023939D1 (de) Förderung der Osteogenese durch Verwendung von Vitamin D-Derivaten.
ATE113293T1 (de) Biaromatische ester von makroliden antibiotika und linkosamiden antibiotika, verfahren zu ihren herstellung und die sie enthaltenden pharmazeutischen und kosmetischen zusammensetzungen.
ATE70050T1 (de) 1-benzoyl-2-oxo-5-alkoxy-pyrrolidin-derivate, ihre herstellung und verwendung als heilmittel und zubereitungen, die sie enthalten.
ES2080445T3 (es) Derivados de ursano, su preparacion y formulaciones farmaceuticas de los mismos.
JPS6422852A (en) Novel derivative of 1-arylsulfonyl-1,5-dihydro- 2h-pyrrole-2-one, manufacture and intermediate, use as drug and composition
NO951309L (no) Forbindelser for bruk som additiver i oljeholdige sammensetninger

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 526642

Country of ref document: ES