CN1034334C - 齐酞酸钠及其药物组合物 - Google Patents
齐酞酸钠及其药物组合物 Download PDFInfo
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- CN1034334C CN1034334C CN93109828A CN93109828A CN1034334C CN 1034334 C CN1034334 C CN 1034334C CN 93109828 A CN93109828 A CN 93109828A CN 93109828 A CN93109828 A CN 93109828A CN 1034334 C CN1034334 C CN 1034334C
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- oleanolic acid
- hemiphthalate
- disodium salt
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- liver
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Abstract
Description
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 101481111111111 | --25501002550100 | 147.5±122.11600.8±1270.8^^^1347.4±1025.5850.7±717.91006.8±691.2358.2±364.2+ **233.3±84.1+***108.2±97.6+++ *** | 37.6±19.515.6±60.6^^^85.8±41.841.6±29.9**25.6±8.7***38.8±33.5+ **15.6±6.0++ ***21.6±30.1*** |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010101010 | --25501002550100 | 216.6±149.72073.4±1250.4^^1393.9±1364.11121.0±1130.11987.5±586.42603.4±1029.81846.7±1319.51878.8±378.1 | 20.6±7.588.7±37.4^^^97.5±18.184.1±16.278.2±50.191.3±41.689.6±50.184.0±44.7 |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010101010 | --25501002550100 | 210.0±143.62035.5±1420.6^^^1805.4±1093.71300.9±1021.91088.6±932.51404.2±1067.51448.8±1426.12451.5±1289.7 | 22.9±8.0131.8±81.9^^^89.9±24.490.7±24.194.7±49.595.1±45.4129.5±75.3176.9±45.9 |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010101010 | --25501002550100 | 274.3±80.13770.1±195.6^^^6614±608.9***6879±468.3***15358±1119.8***376.3±77.5***3505±103.3+ ***4319±265.0++ *** | 22.3±17.184.5±28.8^^^102.4±71.967.7±26.583.7±25.045.6±20.6+ **47.2±24.1**54.3±27.1* + |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010101010 | --25501002550100 | 310.3±141.82312.8±1506.2^^^1244.9±1143.1710.9±397.4**1876.2±1579.7823.2±687.2*387.6±104.5+ ***292.6±100.4++ *** | 131.9±48.3280.9±98.8^^^226.7±93.9105.9±77.3***85.1±59.2***167.2±85.9*115.3±41.6***70.7±407*** |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 101210881089 | 25501002550100 | 236.6±142.2672.6±361.8^^794.6±201.9768.7±576.2731.6±284.4976.5±493.5800.7±365.4550.7±203.6 | 16.3±18.497.2±47.7^^52.2±30.4*47.3±35.5*50.5±19.4**40.6±10.5**116.2±51.359.6±44.8 |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组齐墩果酸中剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 10101010 | -5050100 | 284.5±59.7300.6±87.5298.3±107.9311.4±94.6 | 79.9±36.648.3±36.156.0±32.661.4±51.1 |
组别 | 动物数 | 剂量(mg/kg) | K值 | α值 |
对照组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010 | -5010050100 | 0.021±0.0120.03±0.0180.043±0.014**0.042±0.027*0.041±0.016** | 4.165±1.7953.726±1.2253.873±0.7764.154±0.9174.173±0.89 |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1010101010101010 | --25501002550100 | 366.4±85.92472.1±900.9^^^2424.9±905.82067.9±1172.91234.9±617.5**2100.4±985.51607.8±852.1*1330.5±833.5 | 27.9±11.174.0±37.5^^^41.2±18.1*37.1±12.4**41.0±30.7*45.7±13.9*50.5±18.344.2±25.7 |
组别 | 动物数 | 剂量(mg/kg) | SGPT(U%)X±SD | TG(mg/g肝重)X±SD |
正常组肝损伤组齐墩果酸低剂量组齐墩果酸中剂量组齐墩果酸高剂量组齐酞酸钠低剂量组齐酞酸钠中剂量组齐酞酸钠高剂量组 | 1012111111111111 | -25501002550100 | 104.4±68.6368.8±296.9^^^123.4±114.9*86.4±64.9**420.5±449.7278.9±186.856.3±75.8**365±41.1+ *** | 39.7±12.771.9±45.8^^^41.4±26.264.1±47.621.4±12.6***54.5±24.146.7±30.815.1±9.1*** |
组别 | 小白鼠(只) | 剂量(D)(mg/kg) | logD-X | 死亡只数 | 死亡(%) | P |
12345 | 1010101010 | 300825282122417851500 | 3.47833.40283.32723.25163.1761 | 88632 | 8080603020 | 0.80.80.60.30.3 |
组别 | 小白鼠(只) | 剂量(D)(mg/kg) | logD-X | 死亡只数 | 死亡(%) | P |
12345 | 1414141414 | 10092847870 | 21.96381.92481.89211.8451 | 13121074 | 92.985.771.450.028.6 | 0.9290.8570.7140.5000.286 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN93109828A CN1034334C (zh) | 1993-08-14 | 1993-08-14 | 齐酞酸钠及其药物组合物 |
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CN93109828A CN1034334C (zh) | 1993-08-14 | 1993-08-14 | 齐酞酸钠及其药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1089617A CN1089617A (zh) | 1994-07-20 |
CN1034334C true CN1034334C (zh) | 1997-03-26 |
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CN93109828A Expired - Lifetime CN1034334C (zh) | 1993-08-14 | 1993-08-14 | 齐酞酸钠及其药物组合物 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101235070B (zh) * | 2004-12-29 | 2011-01-19 | 浙江大学 | A环含双键而c环含共轭烯酮的齐墩果烷三萜及用途 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101302243B (zh) * | 2004-12-29 | 2011-05-18 | 浙江大学 | 11-溴代-12-烯齐墩果烷型五环三萜类化合物及应用 |
CN105213531A (zh) * | 2015-10-14 | 2016-01-06 | 三峡大学 | 木瓜总三萜及其组分在制药中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012991A1 (en) * | 1991-01-29 | 1992-08-06 | Shionogi Seiyaku Kabushiki Kaisha | Triterpene derivative |
EP0503582A1 (en) * | 1991-03-13 | 1992-09-16 | Senju Pharmaceutical Co., Ltd. | Glycyrrhetic acid derivatives |
-
1993
- 1993-08-14 CN CN93109828A patent/CN1034334C/zh not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012991A1 (en) * | 1991-01-29 | 1992-08-06 | Shionogi Seiyaku Kabushiki Kaisha | Triterpene derivative |
EP0503582A1 (en) * | 1991-03-13 | 1992-09-16 | Senju Pharmaceutical Co., Ltd. | Glycyrrhetic acid derivatives |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101235070B (zh) * | 2004-12-29 | 2011-01-19 | 浙江大学 | A环含双键而c环含共轭烯酮的齐墩果烷三萜及用途 |
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Publication number | Publication date |
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CN1089617A (zh) | 1994-07-20 |
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Effective date of registration: 20030404 Address after: 519041 Guangdong province Zhuhai Sanzao Airport Road No. 6 Patentee after: Mintong Pharmaceutical Research Institute of Zhuhai City Address before: 550002 No. 55 East City Road, Guizhou, Guiyang Patentee before: Guiyang College of Traditional Chinese Medicine |
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Address after: 519000 Guangdong province Zhuhai Sanzao airport Jinwan District Road No. 6 Patentee after: ZHUHAI RUNDU PHARMACEUTICAL Co.,Ltd. Address before: 519000 Guangdong province Zhuhai Sanzao airport Jinwan District Road No. 6 Patentee before: Zhuhai Rundu Mintong Pharmaceutical Co.,Ltd. |
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Expiration termination date: 20130814 Granted publication date: 19970326 |