DK1533311T3 - Sulfonamider og derivater deraf, der modulerer aktiviteten af endothelin - Google Patents
Sulfonamider og derivater deraf, der modulerer aktiviteten af endothelinInfo
- Publication number
- DK1533311T3 DK1533311T3 DK04025616T DK04025616T DK1533311T3 DK 1533311 T3 DK1533311 T3 DK 1533311T3 DK 04025616 T DK04025616 T DK 04025616T DK 04025616 T DK04025616 T DK 04025616T DK 1533311 T3 DK1533311 T3 DK 1533311T3
- Authority
- DK
- Denmark
- Prior art keywords
- endothelin
- sulfonamides
- activity
- isoxazolyl
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17410499P | 1999-12-31 | 1999-12-31 | |
PCT/US2000/035599 WO2001049685A2 (en) | 1999-12-31 | 2000-12-29 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1533311T3 true DK1533311T3 (da) | 2007-09-17 |
Family
ID=22634839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04025616T DK1533311T3 (da) | 1999-12-31 | 2000-12-29 | Sulfonamider og derivater deraf, der modulerer aktiviteten af endothelin |
Country Status (24)
Country | Link |
---|---|
US (1) | US6686382B2 (pt) |
EP (1) | EP1244657B1 (pt) |
JP (1) | JP4202649B2 (pt) |
KR (1) | KR20020072285A (pt) |
CN (1) | CN1414965A (pt) |
AT (2) | ATE286051T1 (pt) |
AU (1) | AU2464301A (pt) |
BR (1) | BR0016821A (pt) |
CA (1) | CA2395684C (pt) |
CZ (1) | CZ20022293A3 (pt) |
DE (2) | DE60034605T2 (pt) |
DK (1) | DK1533311T3 (pt) |
EA (1) | EA004735B1 (pt) |
EE (1) | EE200200363A (pt) |
ES (2) | ES2236028T3 (pt) |
HU (1) | HUP0203935A3 (pt) |
IL (1) | IL150311A0 (pt) |
MX (1) | MXPA02006461A (pt) |
NO (1) | NO20023168L (pt) |
NZ (1) | NZ519717A (pt) |
PL (1) | PL197782B1 (pt) |
PT (1) | PT1533311E (pt) |
SK (1) | SK9532002A3 (pt) |
WO (1) | WO2001049685A2 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
SG100767A1 (en) | 1997-04-28 | 2003-12-26 | Texas Biotechnology Corp | Sulfonamides for treatment of endothelin-mediated disorders |
NZ519717A (en) | 1999-12-31 | 2003-06-30 | Texas Biotechnology Corp | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
US7205307B2 (en) | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
AU2003291255A1 (en) * | 2002-11-06 | 2004-06-03 | Smithkline Beecham Corporation | Sulfonamides |
CA2557536C (en) | 2004-02-24 | 2010-07-13 | Sankyo Company Limited | Amino alcohol compound |
AU2005309865B2 (en) * | 2004-11-22 | 2011-07-28 | Eli Lilly And Company | Potentiators of glutamate receptors |
BRPI0615898B8 (pt) * | 2005-09-12 | 2021-05-25 | Actelion Pharmaceuticals Ltd | composição farmacêutica, e, uso de um composto ou de um sal, um solvato, um hidrato ou uma forma morfológica do mesmo farmaceuticamente aceitável |
MX2008011842A (es) * | 2006-03-13 | 2008-10-02 | Encysive Pharmaceuticals Inc | Procedimientos y composiciones para el tratamiento de insuficiencia cardiaca diastolica. |
RU2008136315A (ru) * | 2006-03-13 | 2010-04-20 | Инсайсив Фармасьютикалз, Инк. (US) | Композиции ситаксентана натрия |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
KR20090035741A (ko) * | 2006-08-04 | 2009-04-10 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | N-(2-아세틸-4,6-디메틸페닐)-3-{[(3,4-디메틸-5-이속사졸릴)-아미노]술포닐}-2-티오펜-카르복스아미드의 다형체 |
US7754892B2 (en) * | 2006-08-04 | 2010-07-13 | Encysive Pharmaceuticals, Inc. | Processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide |
DE602008000809D1 (de) | 2007-03-23 | 2010-04-29 | Icagen Inc | Ionenkanal-Hemmer |
EP2144903A1 (en) | 2007-04-10 | 2010-01-20 | Auspex Pharmaceuticals Inc. | Substituted deuterium enriched thiophenes for the treatment of hypertension |
KR100860539B1 (ko) * | 2007-05-11 | 2008-09-26 | 한국화학연구원 | 아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물 |
BRPI0812966A2 (pt) * | 2007-06-25 | 2017-05-16 | Encysive Pharmaceuticals Inc | formulações de n-(2-acetil-4,6-dimetilfenil)-3-{[(3,4 dimetil-5-isoxazolil)amino]sulfonil}-2-tiofenocarboxamida |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
AR089838A1 (es) * | 2012-01-31 | 2014-09-17 | Eisai R&D Man Co Ltd | Derivados de sitaxetan |
KR101197618B1 (ko) * | 2012-03-13 | 2012-11-07 | 한국화학연구원 | 결핵의 예방 또는 치료용 약제학적 조성물 |
US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
CA3217189A1 (en) | 2021-06-22 | 2022-12-29 | Alchemedicine, Inc. | Compound, endothelin a receptor antagonist and pharmaceutical composition |
TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Pparg反向激動劑及其用途 |
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-
2000
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 EE EEP200200363A patent/EE200200363A/xx unknown
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en active IP Right Grant
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 EP EP00988434A patent/EP1244657B1/en not_active Expired - Lifetime
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Application Discontinuation
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
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2002
- 2002-06-28 NO NO20023168A patent/NO20023168L/no not_active Application Discontinuation
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