CA2288439A1 - Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin - Google Patents
Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin Download PDFInfo
- Publication number
- CA2288439A1 CA2288439A1 CA002288439A CA2288439A CA2288439A1 CA 2288439 A1 CA2288439 A1 CA 2288439A1 CA 002288439 A CA002288439 A CA 002288439A CA 2288439 A CA2288439 A CA 2288439A CA 2288439 A1 CA2288439 A1 CA 2288439A1
- Authority
- CA
- Canada
- Prior art keywords
- biphenylsulfonamides
- endothelin
- activity
- methods
- modulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title abstract 3
- 108050009340 Endothelin Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 102000002045 Endothelin Human genes 0.000 title abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 3
- 150000003456 sulfonamides Chemical class 0.000 abstract 3
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- ADVWRTLHTOZZTC-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)-2-phenylbenzenesulfonamide Chemical class C=1C=CC=C(C=2C=CC=CC=2)C=1S(=O)(=O)NC=1C=CON=1 ADVWRTLHTOZZTC-UHFFFAOYSA-N 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided.
Methods for treating endothelia-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelia are also provided. The biphenylsulfonamides have formula I:
where Ar2 is:
Methods for treating endothelia-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelia are also provided. The biphenylsulfonamides have formula I:
where Ar2 is:
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41707595A | 1995-04-04 | 1995-04-04 | |
US41619995A | 1995-04-04 | 1995-04-04 | |
US08/417,075 | 1995-04-04 | ||
US08/416,199 | 1995-04-04 | ||
US08/477,223 US5594021A (en) | 1993-05-20 | 1995-06-06 | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US08/477,226 | 1995-06-06 | ||
CA002217169A CA2217169C (en) | 1995-04-04 | 1996-04-04 | Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002217169A Division CA2217169C (en) | 1995-04-04 | 1996-04-04 | Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2420614 Division CA2420614A1 (en) | 1995-04-04 | 1996-04-04 | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2288439A1 true CA2288439A1 (en) | 1996-10-10 |
CA2288439C CA2288439C (en) | 2003-04-01 |
Family
ID=27427394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002288439A Expired - Fee Related CA2288439C (en) | 1995-04-04 | 1996-04-04 | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2288439C (en) |
-
1996
- 1996-04-04 CA CA002288439A patent/CA2288439C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2288439C (en) | 2003-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130404 |