BG64615B1 - Приложение на производни на 7-(2-окса-5,8-диазабицикло[4.3.0]нон-8-ил)-хинолонкарбоксилна киселина и -нафтиридонкарбоксилна киселина при терапията на неliсовастеr-pylori- инфекции и свързаните с тях гастродуоденални заболявания - Google Patents

Приложение на производни на 7-(2-окса-5,8-диазабицикло[4.3.0]нон-8-ил)-хинолонкарбоксилна киселина и -нафтиридонкарбоксилна киселина при терапията на неliсовастеr-pylori- инфекции и свързаните с тях гастродуоденални заболявания Download PDF

Info

Publication number
BG64615B1
BG64615B1 BG103474A BG10347499A BG64615B1 BG 64615 B1 BG64615 B1 BG 64615B1 BG 103474 A BG103474 A BG 103474A BG 10347499 A BG10347499 A BG 10347499A BG 64615 B1 BG64615 B1 BG 64615B1
Authority
BG
Bulgaria
Prior art keywords
fluoro
oxo
oxa
methyl
diazabicyclo
Prior art date
Application number
BG103474A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103474A (en
Inventor
Michael Matzke
Uwe Petersen
Thomas Jaetsch
Stephan Bartel
Thomas Schenke
Thomas Himmler
Bernd Baasner
Hans-Otto Werling
Klaus Schaller
Harald Labischinski
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG103474A publication Critical patent/BG103474A/xx
Publication of BG64615B1 publication Critical patent/BG64615B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG103474A 1996-12-16 1999-06-08 Приложение на производни на 7-(2-окса-5,8-диазабицикло[4.3.0]нон-8-ил)-хинолонкарбоксилна киселина и -нафтиридонкарбоксилна киселина при терапията на неliсовастеr-pylori- инфекции и свързаните с тях гастродуоденални заболявания BG64615B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen

Publications (2)

Publication Number Publication Date
BG103474A BG103474A (en) 2000-01-31
BG64615B1 true BG64615B1 (bg) 2005-09-30

Family

ID=7814837

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103474A BG64615B1 (bg) 1996-12-16 1999-06-08 Приложение на производни на 7-(2-окса-5,8-диазабицикло[4.3.0]нон-8-ил)-хинолонкарбоксилна киселина и -нафтиридонкарбоксилна киселина при терапията на неliсовастеr-pylori- инфекции и свързаните с тях гастродуоденални заболявания

Country Status (28)

Country Link
US (2) US6133260A (xx)
EP (1) EP0946176B1 (xx)
JP (3) JP3463939B2 (xx)
KR (1) KR100536153B1 (xx)
CN (1) CN100335054C (xx)
AT (1) ATE214929T1 (xx)
AU (1) AU717751B2 (xx)
BG (1) BG64615B1 (xx)
BR (1) BR9714032A (xx)
CA (1) CA2274894C (xx)
CZ (2) CZ297364B6 (xx)
DE (2) DE19652239A1 (xx)
DK (1) DK0946176T3 (xx)
EA (1) EA002477B1 (xx)
EE (1) EE04090B1 (xx)
ES (1) ES2175519T3 (xx)
HK (1) HK1025517A1 (xx)
HU (1) HU226523B1 (xx)
IL (1) IL130311A (xx)
NO (1) NO325617B1 (xx)
NZ (2) NZ336228A (xx)
PL (1) PL191193B1 (xx)
PT (1) PT946176E (xx)
RS (1) RS49684B (xx)
SK (2) SK283223B6 (xx)
TR (1) TR199901754T2 (xx)
UA (1) UA57055C2 (xx)
WO (1) WO1998026779A1 (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633805A1 (de) * 1996-02-23 1997-08-28 Bayer Ag Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
WO2000029369A1 (fr) * 1998-11-18 2000-05-25 Asahi Glass Company Ltd. Derives d'acide aminoacrylique et procede de production correspondant
DE19917617A1 (de) * 1999-04-19 2000-10-26 Bayer Ag -(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions
US6858625B1 (en) * 1999-07-01 2005-02-22 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or salts thereof
CA2387016C (en) * 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
WO2003088897A2 (en) * 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
EP1575951B1 (en) * 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
EP1669354B1 (en) 2003-09-29 2013-03-20 Daiichi Sankyo Company, Limited 8-cyanoquinolonecarboxylic acid derivative
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
PL1828167T3 (pl) * 2004-06-04 2015-02-27 Debiopharm Int Sa Pochodne akryloamidu jako środki antybiotykowe
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) * 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
KR101541823B1 (ko) * 2009-07-02 2015-08-04 알콘 리서치, 리미티드 눈, 귀, 또는 코 감염의 치료를 위한 조성물 및 방법
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ （ｅ）−ｎ−メチル−ｎ−（（３−メチルベンゾフラン−２−イル）メチル）−３−（７−オキソ−５，６，７，８−テトラヒドロ−１，８−ナフチリジン−３−イル）アクリルアミドのプロドラッグ誘導体
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
EP3033074A1 (en) 2013-08-12 2016-06-22 Novartis AG Method for treating otic infections after tympanostomy tube placement
DE102014115951A1 (de) 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
US10751351B2 (en) 2016-02-26 2020-08-25 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
CA3098060A1 (en) 2018-04-25 2019-10-31 Bayer Animal Health Gmbh Process for the hydrolysis of quinolone carboxylic esters

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5147873A (en) * 1988-08-23 1992-09-15 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5407932A (en) * 1989-03-31 1995-04-18 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and antibacterial agents containing the same
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
US5252734A (en) * 1989-04-03 1993-10-12 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
DE4200415A1 (de) 1992-01-10 1993-07-15 Bayer Ag Enantiomerenreine 2-oxa-5,8-diazabicyclo(4.3.0)nonane sowie verfahren zu ihrer herstellung
TW209865B (xx) * 1992-01-10 1993-07-21 Bayer Ag
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
DE4309964A1 (de) 1993-03-26 1994-09-29 Bayer Ag Verfahren zur Herstellung enantiomerenreiner trans-2-Oxa-5,8-diazabicyclo[4.3.0]nonane
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
DK0676199T3 (da) * 1994-04-07 1999-02-08 Pfizer Anvendelse af trovafloxacin eller derivater deraf til fremstilling af et medikament til behandling af H. pylori-infektione
GB2289674A (en) * 1994-05-23 1995-11-29 Pfizer Antibacterial naphthyridine
JPH0848629A (ja) * 1994-08-08 1996-02-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびそれを有効成分とする抗ピロリ菌剤

Also Published As

Publication number Publication date
CZ297364B6 (cs) 2006-11-15
EE04090B1 (et) 2003-08-15
KR100536153B1 (ko) 2005-12-14
CA2274894C (en) 2009-04-07
AU717751B2 (en) 2000-03-30
JP2009235106A (ja) 2009-10-15
RS49684B (sr) 2007-11-15
BG103474A (en) 2000-01-31
ATE214929T1 (de) 2002-04-15
DK0946176T3 (da) 2002-06-10
HK1025517A1 (en) 2000-11-17
WO1998026779A1 (de) 1998-06-25
CA2274894A1 (en) 1998-06-25
CN1245428A (zh) 2000-02-23
DE19652239A1 (de) 1998-06-18
AU5854198A (en) 1998-07-15
EA199900526A1 (ru) 2000-08-28
YU27499A (sh) 2002-10-18
KR20000069483A (ko) 2000-11-25
PL333928A1 (en) 2000-01-31
JP5112395B2 (ja) 2013-01-09
DE59706808D1 (de) 2002-05-02
US6432948B1 (en) 2002-08-13
NZ506162A (en) 2001-06-29
JP3463939B2 (ja) 2003-11-05
SK283223B6 (sk) 2003-03-04
PL191193B1 (pl) 2006-03-31
SK14962000A3 (sk) 2003-01-09
CZ297363B6 (cs) 2006-11-15
HUP0000450A3 (en) 2001-02-28
UA57055C2 (uk) 2003-06-16
NO992903L (no) 1999-06-14
TR199901754T2 (xx) 1999-09-21
IL130311A (en) 2004-01-04
EP0946176B1 (de) 2002-03-27
NO325617B1 (no) 2008-06-30
CN100335054C (zh) 2007-09-05
JP4463380B2 (ja) 2010-05-19
CZ216899A3 (cs) 2000-02-16
IL130311A0 (en) 2000-06-01
EE9900248A (et) 1999-12-15
PT946176E (pt) 2002-08-30
JP2000514825A (ja) 2000-11-07
HU226523B1 (en) 2009-03-30
SK79599A3 (en) 2001-01-18
HUP0000450A2 (hu) 2000-10-28
EP0946176A1 (de) 1999-10-06
EA002477B1 (ru) 2002-06-27
US6133260A (en) 2000-10-17
BR9714032A (pt) 2000-05-09
SK283224B6 (sk) 2003-03-04
JP2000351781A (ja) 2000-12-19
NZ336228A (en) 2000-12-22
ES2175519T3 (es) 2002-11-16
NO992903D0 (no) 1999-06-14

Similar Documents

Publication Publication Date Title
BG64615B1 (bg) Приложение на производни на 7-(2-окса-5,8-диазабицикло[4.3.0]нон-8-ил)-хинолонкарбоксилна киселина и -нафтиридонкарбоксилна киселина при терапията на неliсовастеr-pylori- инфекции и свързаните с тях гастродуоденални заболявания
US20160168140A1 (en) Heterocyclic compounds as antibiotic potentiators
CZ20003981A3 (cs) Imidazopyridinové deriváty inhibující sekreci žaludeční kyseliny
CS208472B2 (en) Therapeutic agents
JPH0314585A (ja) 新規な抗微生物キノロニルラクタム
PT2296651E (pt) Derivados de 5-hidroximetil-oxazolidina-2-ona para o tratamento de doenças intestinais bacterianas
NO870126L (no) 7-(azabicykloalkyl)-chinolonkarboksylsyre- og naftyridon-karboksylsyre-derivater.
US6288081B1 (en) Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith
JPH07149647A (ja) 抗真菌物質の抗真菌作用増強剤
MXPA99005558A (en) The use of 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and associated gastroduodenal diseases
RU2088581C1 (ru) Производные азетидина или их фармацевтически приемлемые соли, способ их получения и композиция, проявляющая противомикробное действие на их основе
SK283994B6 (sk) Antibakteriálne prostriedky obsahujúce N-oxidy nasýtených dusík obsahujúcich heterocyklov substituovaných chinolónkarboxylovými alebo naftyridónkarboxylovými kyselinami, účiné látky, spôsob ich výroby a ich použitie
JP2004529970A (ja) 新規のベンジルアミノピリミジン
KR890000863B1 (ko) 퀴날딘 유도체