YU27499A - Upotreba derivata 7-(2-oksa-5,8-diazabiciklo/4.3.0/non-8-il) -hinolin-karbonske kiseline za pripremanje farmaceutske kompozicije za tretiranje helikobakter-pilori infekcija i sa time povezanih gastroduodenskim oboljenjima - Google Patents

Upotreba derivata 7-(2-oksa-5,8-diazabiciklo/4.3.0/non-8-il) -hinolin-karbonske kiseline za pripremanje farmaceutske kompozicije za tretiranje helikobakter-pilori infekcija i sa time povezanih gastroduodenskim oboljenjima

Info

Publication number
YU27499A
YU27499A YU27499A YU27499A YU27499A YU 27499 A YU27499 A YU 27499A YU 27499 A YU27499 A YU 27499A YU 27499 A YU27499 A YU 27499A YU 27499 A YU27499 A YU 27499A
Authority
YU
Yugoslavia
Prior art keywords
quinolone
oxa
diazabicyclo
substituted
carboxylic acid
Prior art date
Application number
YU27499A
Other languages
English (en)
Inventor
Michael Matzke
Uwe Petersen
Thomas Jaetsch
Stephan Bartel
Thomas Schenke
Thomas Himmler
Bernd Baasner
Hans-Otto Werling
Klaus Schaller
Harald Labischinski
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of YU27499A publication Critical patent/YU27499A/sh
Publication of RS49684B publication Critical patent/RS49684B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Pronalazak se odnosi na pripremanje derivata hinolon- i nafthiridon-karbonske kiseline, koji su u 7-položaju supstituisani sa 2-oksa-5,8- diazabiciklo[4.3.0]bib-8-il ostatkom, opšte formule (I) u kojoj oznake, A, R1, R2, R4 i R6 imaju značenja navedena u opisu, kao i njihovih hidrata i/ili soli, na primenu pomenutih jedinjenja za pripremanje farmaceutskih kompozicija za tretiranje helikobakter-pilori infekcija i sa time povezanih gastroduodenskih oboljenja.[The invention relates to the use of quinolone and naphthyridon carboxylic acid derivatives, which are substituted by a 2-oxa-5,8- diazabicyclo[4.3.0]-non-8-yl-radical in position seven, as well as to their pharmaceutically applicable hydrates and/or salts in the treatment of Helicobacter pylori infections and associated gastroduodenal diseases.
YUP-274/99A 1996-12-16 1997-12-04 Upotreba derivata 7-(2-oksa-5,8- diazabiciklo[4.3.0]non-8-il)-hinolon- karbonske kiseline i nafthiridonkarbonske kiseline za pripremanje leka za terapiju helikobakter-pilori infekcija i sa time povezanim gastroduodenalnim oboljenjima RS49684B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen

Publications (2)

Publication Number Publication Date
YU27499A true YU27499A (sh) 2002-10-18
RS49684B RS49684B (sr) 2007-11-15

Family

ID=7814837

Country Status (28)

Country Link
US (2) US6133260A (sh)
EP (1) EP0946176B1 (sh)
JP (3) JP3463939B2 (sh)
KR (1) KR100536153B1 (sh)
CN (1) CN100335054C (sh)
AT (1) ATE214929T1 (sh)
AU (1) AU717751B2 (sh)
BG (1) BG64615B1 (sh)
BR (1) BR9714032A (sh)
CA (1) CA2274894C (sh)
CZ (2) CZ297364B6 (sh)
DE (2) DE19652239A1 (sh)
DK (1) DK0946176T3 (sh)
EA (1) EA002477B1 (sh)
EE (1) EE04090B1 (sh)
ES (1) ES2175519T3 (sh)
HK (1) HK1025517A1 (sh)
HU (1) HU226523B1 (sh)
IL (1) IL130311A (sh)
NO (1) NO325617B1 (sh)
NZ (2) NZ336228A (sh)
PL (1) PL191193B1 (sh)
PT (1) PT946176E (sh)
RS (1) RS49684B (sh)
SK (2) SK283223B6 (sh)
TR (1) TR199901754T2 (sh)
UA (1) UA57055C2 (sh)
WO (1) WO1998026779A1 (sh)

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ES2203254T3 (es) * 1998-11-18 2004-04-01 Asahi Glass Company Ltd. Derivados de acido aminoacrilico y procedimiento de produccion correspondiente.
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JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
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ES2402420T3 (es) 2003-09-29 2013-05-03 Daiichi Sankyo Company, Limited Derivado del ácido 8-cianoquinolonacarboxílico
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US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
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US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
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KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
US20150045739A1 (en) 2013-08-12 2015-02-12 Novartis Ag Method for treating otic infections after tympanostomy tube placement
DE102014115951A1 (de) 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
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Also Published As

Publication number Publication date
IL130311A (en) 2004-01-04
HUP0000450A3 (en) 2001-02-28
ATE214929T1 (de) 2002-04-15
ES2175519T3 (es) 2002-11-16
JP2009235106A (ja) 2009-10-15
JP2000514825A (ja) 2000-11-07
EA002477B1 (ru) 2002-06-27
HU226523B1 (en) 2009-03-30
JP2000351781A (ja) 2000-12-19
PL191193B1 (pl) 2006-03-31
SK14962000A3 (sk) 2003-01-09
NO992903L (no) 1999-06-14
NO992903D0 (no) 1999-06-14
CA2274894A1 (en) 1998-06-25
BG64615B1 (bg) 2005-09-30
RS49684B (sr) 2007-11-15
TR199901754T2 (xx) 1999-09-21
BR9714032A (pt) 2000-05-09
KR20000069483A (ko) 2000-11-25
IL130311A0 (en) 2000-06-01
CN1245428A (zh) 2000-02-23
CN100335054C (zh) 2007-09-05
JP5112395B2 (ja) 2013-01-09
DE19652239A1 (de) 1998-06-18
AU717751B2 (en) 2000-03-30
PL333928A1 (en) 2000-01-31
HUP0000450A2 (hu) 2000-10-28
JP4463380B2 (ja) 2010-05-19
EP0946176B1 (de) 2002-03-27
CZ297363B6 (cs) 2006-11-15
SK283224B6 (sk) 2003-03-04
NZ506162A (en) 2001-06-29
CZ216899A3 (cs) 2000-02-16
CZ297364B6 (cs) 2006-11-15
US6432948B1 (en) 2002-08-13
AU5854198A (en) 1998-07-15
DK0946176T3 (da) 2002-06-10
WO1998026779A1 (de) 1998-06-25
EE9900248A (et) 1999-12-15
NZ336228A (en) 2000-12-22
JP3463939B2 (ja) 2003-11-05
SK79599A3 (en) 2001-01-18
UA57055C2 (uk) 2003-06-16
EP0946176A1 (de) 1999-10-06
KR100536153B1 (ko) 2005-12-14
PT946176E (pt) 2002-08-30
SK283223B6 (sk) 2003-03-04
HK1025517A1 (en) 2000-11-17
US6133260A (en) 2000-10-17
BG103474A (en) 2000-01-31
EE04090B1 (et) 2003-08-15
DE59706808D1 (de) 2002-05-02
EA199900526A1 (ru) 2000-08-28
CA2274894C (en) 2009-04-07
NO325617B1 (no) 2008-06-30

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