ES2175519T3 - Uso de derivados de acido7-(2-oxa-5,8-diazabiciclo(4,3,0)non-8-8-il)-quinoloncarboxilico y-naftiridoncarboxilico para la fabricacion de un medicanto para la terapia de infecciones por helicobacter pylori y las enfermedades gastroduodenales asociadas con ellas. - Google Patents

Uso de derivados de acido7-(2-oxa-5,8-diazabiciclo(4,3,0)non-8-8-il)-quinoloncarboxilico y-naftiridoncarboxilico para la fabricacion de un medicanto para la terapia de infecciones por helicobacter pylori y las enfermedades gastroduodenales asociadas con ellas.

Info

Publication number
ES2175519T3
ES2175519T3 ES97954354T ES97954354T ES2175519T3 ES 2175519 T3 ES2175519 T3 ES 2175519T3 ES 97954354 T ES97954354 T ES 97954354T ES 97954354 T ES97954354 T ES 97954354T ES 2175519 T3 ES2175519 T3 ES 2175519T3
Authority
ES
Spain
Prior art keywords
naftiridoncarboxilico
oxa
therapy
helicobacter
quinoloncarboxilico
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97954354T
Other languages
English (en)
Inventor
Michael Matzke
Uwe Petersen
Thomas Jaetsch
Stephan Bartel
Thomas Schenke
Thomas Himmler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2175519T3 publication Critical patent/ES2175519T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION TRATA DE LA UTILIZACION DE DERIVADOS DEL ACIDO QUINOLON - Y - NAFTIRIDONCARBOXILICO, QUE ESTAN SUSTITUIDOS EN LA POSICION 7 POR UN RADICAL DE 2 - OXA - 5,8 DIAZABICICLO[4.3.0]NON - 8 - ILO, ASI COMO SUS HIDRATOS QUE SE UTILIZAN EN LA FARMACOLOGIA Y/O SALES PARA LA TERAPIA DEL HELICOBACTER PYLORI Y LAS ENFERMEDADES GASTRODUODENALES ASOCIADAS.
ES97954354T 1996-12-16 1997-12-04 Uso de derivados de acido7-(2-oxa-5,8-diazabiciclo(4,3,0)non-8-8-il)-quinoloncarboxilico y-naftiridoncarboxilico para la fabricacion de un medicanto para la terapia de infecciones por helicobacter pylori y las enfermedades gastroduodenales asociadas con ellas. Expired - Lifetime ES2175519T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen

Publications (1)

Publication Number Publication Date
ES2175519T3 true ES2175519T3 (es) 2002-11-16

Family

ID=7814837

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97954354T Expired - Lifetime ES2175519T3 (es) 1996-12-16 1997-12-04 Uso de derivados de acido7-(2-oxa-5,8-diazabiciclo(4,3,0)non-8-8-il)-quinoloncarboxilico y-naftiridoncarboxilico para la fabricacion de un medicanto para la terapia de infecciones por helicobacter pylori y las enfermedades gastroduodenales asociadas con ellas.

Country Status (28)

Country Link
US (2) US6133260A (es)
EP (1) EP0946176B1 (es)
JP (3) JP3463939B2 (es)
KR (1) KR100536153B1 (es)
CN (1) CN100335054C (es)
AT (1) ATE214929T1 (es)
AU (1) AU717751B2 (es)
BG (1) BG64615B1 (es)
BR (1) BR9714032A (es)
CA (1) CA2274894C (es)
CZ (2) CZ297363B6 (es)
DE (2) DE19652239A1 (es)
DK (1) DK0946176T3 (es)
EA (1) EA002477B1 (es)
EE (1) EE04090B1 (es)
ES (1) ES2175519T3 (es)
HK (1) HK1025517A1 (es)
HU (1) HU226523B1 (es)
IL (1) IL130311A (es)
NO (1) NO325617B1 (es)
NZ (2) NZ336228A (es)
PL (1) PL191193B1 (es)
PT (1) PT946176E (es)
RS (1) RS49684B (es)
SK (2) SK283224B6 (es)
TR (1) TR199901754T2 (es)
UA (1) UA57055C2 (es)
WO (1) WO1998026779A1 (es)

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JP4553338B2 (ja) * 1998-11-18 2010-09-29 旭硝子株式会社 アミノアクリル酸誘導体およびその製造方法
DE19917617A1 (de) * 1999-04-19 2000-10-26 Bayer Ag -(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions
IL147043A0 (en) * 1999-07-01 2002-08-14 Wakunaga Pharma Co Ltd Quinolinecarboxylic acid derivative or salts thereof
BRPI0014470B1 (pt) * 1999-10-08 2016-08-23 Affinium Pharm Inc compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas
EP1560584B1 (en) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
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US7723524B2 (en) 2003-09-29 2010-05-25 Daiichi Pharmaceutical Co., Ltd. 8-cyanoquinolonecarboxylic acid derivative
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
PT1828167E (pt) 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
ES2694775T3 (es) * 2009-07-02 2018-12-27 Merlion Pharmaceuticals Pte., Ltd. Composiciones que comprenden finafloxacina y métodos de tratamiento de infecciones oftálmicas, óticas y nasales
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
LT2861608T (lt) 2012-06-19 2019-07-10 Debiopharm International Sa (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-nafthidrin-3-il)akrilamido provaisto dariniai
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
MX2016001912A (es) 2013-08-12 2016-06-02 Novartis Ag Metodos para tratar infecciones oticas luego de la colocacion de un tubo de timpanostomia.
DE102014115951A1 (de) * 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
JP6998881B2 (ja) 2016-02-26 2022-02-10 デビオファーム・インターナショナル・エス・アー 糖尿病性足感染症の処置のための医薬
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
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Also Published As

Publication number Publication date
JP2009235106A (ja) 2009-10-15
EA002477B1 (ru) 2002-06-27
JP2000351781A (ja) 2000-12-19
PL333928A1 (en) 2000-01-31
US6432948B1 (en) 2002-08-13
EA199900526A1 (ru) 2000-08-28
JP2000514825A (ja) 2000-11-07
BG103474A (en) 2000-01-31
NO992903D0 (no) 1999-06-14
SK14962000A3 (sk) 2003-01-09
HK1025517A1 (en) 2000-11-17
NO992903L (no) 1999-06-14
CA2274894C (en) 2009-04-07
JP4463380B2 (ja) 2010-05-19
US6133260A (en) 2000-10-17
PT946176E (pt) 2002-08-30
PL191193B1 (pl) 2006-03-31
DE19652239A1 (de) 1998-06-18
NZ336228A (en) 2000-12-22
SK283224B6 (sk) 2003-03-04
HUP0000450A2 (hu) 2000-10-28
JP5112395B2 (ja) 2013-01-09
CN100335054C (zh) 2007-09-05
CZ297364B6 (cs) 2006-11-15
DE59706808D1 (de) 2002-05-02
RS49684B (sr) 2007-11-15
DK0946176T3 (da) 2002-06-10
CA2274894A1 (en) 1998-06-25
HU226523B1 (en) 2009-03-30
JP3463939B2 (ja) 2003-11-05
SK79599A3 (en) 2001-01-18
KR100536153B1 (ko) 2005-12-14
HUP0000450A3 (en) 2001-02-28
BR9714032A (pt) 2000-05-09
KR20000069483A (ko) 2000-11-25
CZ216899A3 (cs) 2000-02-16
ATE214929T1 (de) 2002-04-15
NO325617B1 (no) 2008-06-30
BG64615B1 (bg) 2005-09-30
UA57055C2 (uk) 2003-06-16
AU5854198A (en) 1998-07-15
NZ506162A (en) 2001-06-29
YU27499A (sh) 2002-10-18
EP0946176A1 (de) 1999-10-06
EE9900248A (et) 1999-12-15
AU717751B2 (en) 2000-03-30
TR199901754T2 (xx) 1999-09-21
WO1998026779A1 (de) 1998-06-25
EP0946176B1 (de) 2002-03-27
SK283223B6 (sk) 2003-03-04
IL130311A0 (en) 2000-06-01
EE04090B1 (et) 2003-08-15
CN1245428A (zh) 2000-02-23
CZ297363B6 (cs) 2006-11-15
IL130311A (en) 2004-01-04

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