BG63433B1 - Бензопиранови производни, имащи антагонистично действие спрямо левкотриени - Google Patents
Бензопиранови производни, имащи антагонистично действие спрямо левкотриени Download PDFInfo
- Publication number
- BG63433B1 BG63433B1 BG102775A BG10277598A BG63433B1 BG 63433 B1 BG63433 B1 BG 63433B1 BG 102775 A BG102775 A BG 102775A BG 10277598 A BG10277598 A BG 10277598A BG 63433 B1 BG63433 B1 BG 63433B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- benzopyran
- oxo
- compound
- phenyl
- group
- Prior art date
Links
- 0 CC(CI)(OC(C1=C([*-])*)=O)OC1=O Chemical compound CC(CI)(OC(C1=C([*-])*)=O)OC1=O 0.000 description 2
- ZOKPVTGSQSVRHH-UHFFFAOYSA-N NC1=CC=[I]C=C1 Chemical compound NC1=CC=[I]C=C1 ZOKPVTGSQSVRHH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009600682A ES2127106B1 (es) | 1996-03-21 | 1996-03-21 | Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos. |
PCT/EP1997/001418 WO1997034885A1 (en) | 1996-03-21 | 1997-03-20 | Benzopyran derivatives having leukotriene-antagonistic action |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102775A BG102775A (en) | 1999-08-31 |
BG63433B1 true BG63433B1 (bg) | 2002-01-31 |
Family
ID=8294261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102775A BG63433B1 (bg) | 1996-03-21 | 1998-09-17 | Бензопиранови производни, имащи антагонистично действие спрямо левкотриени |
Country Status (31)
Country | Link |
---|---|
US (1) | US5990142A (no) |
EP (1) | EP0888327B1 (no) |
JP (1) | JP3914575B2 (no) |
KR (1) | KR100378892B1 (no) |
CN (1) | CN1182129C (no) |
AT (1) | ATE219073T1 (no) |
AU (1) | AU707282B2 (no) |
BG (1) | BG63433B1 (no) |
BR (1) | BR9708215A (no) |
CA (1) | CA2249402C (no) |
CU (1) | CU22777A3 (no) |
CZ (1) | CZ296260B6 (no) |
DE (1) | DE69713300T2 (no) |
DK (1) | DK0888327T3 (no) |
EA (1) | EA001680B1 (no) |
EE (1) | EE03526B1 (no) |
ES (2) | ES2127106B1 (no) |
GE (1) | GEP20012416B (no) |
HK (1) | HK1018701A1 (no) |
HU (1) | HUP9901326A3 (no) |
IL (1) | IL126296A (no) |
NO (1) | NO319612B1 (no) |
NZ (1) | NZ331953A (no) |
PL (1) | PL189562B1 (no) |
PT (1) | PT888327E (no) |
RS (1) | RS49588B (no) |
SI (1) | SI0888327T1 (no) |
SK (1) | SK282979B6 (no) |
TR (1) | TR199801857T2 (no) |
UA (1) | UA65535C2 (no) |
WO (1) | WO1997034885A1 (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE397672T1 (de) | 1999-11-24 | 2008-06-15 | Univ New York State Res Found | Katalytische rnas mit aminoacylierender aktivität |
CA2476425C (en) * | 2002-02-15 | 2012-04-17 | The Research Foundation Of State University Of New York At Buffalo | Ribozymes with broad trna aminoacylation activity |
WO2004035741A2 (en) * | 2002-10-17 | 2004-04-29 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
US20050065099A1 (en) * | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
CN100475781C (zh) * | 2004-02-13 | 2009-04-08 | 沃尼尔·朗伯有限责任公司 | 雄激素受体调节剂 |
AP2006003700A0 (en) | 2004-02-13 | 2006-08-31 | Warner Lambert Co | Androgen receptor modulators |
US7507860B2 (en) | 2004-04-13 | 2009-03-24 | Pfizer Inc. | Androgen modulators |
BRPI0513020A (pt) * | 2004-07-08 | 2008-04-22 | Warner Lambert Co | moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação |
EP1781599A1 (en) * | 2004-08-18 | 2007-05-09 | Warner-Lambert Company LLC | Androgen modulators |
TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
JP5119444B2 (ja) * | 2005-12-06 | 2013-01-16 | 国立大学法人 東京大学 | 多目的アシル化触媒とその用途 |
ITMI20061606A1 (it) * | 2006-08-09 | 2008-02-10 | Dipharma Spa | Procedimento per la preparazione di composti nitrilici |
CN102304052A (zh) * | 2011-07-28 | 2012-01-04 | 浙江大学 | 一种制备5-溴-2-羟基-3-硝基苯乙酮的方法 |
CN103980257B (zh) * | 2014-05-28 | 2016-04-27 | 苏州开元民生科技股份有限公司 | 8-硝基-2-四氮唑基-4-羰基苯并吡喃的合成方法 |
CN104402711A (zh) * | 2014-11-12 | 2015-03-11 | 平湖优康药物研发有限公司 | 一种抗哮喘药物普伦斯特中间体的合成工艺 |
CN113651788B (zh) * | 2021-09-16 | 2023-11-21 | 东华理工大学 | 一种3-胺烷基色酮化合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977162A (en) * | 1989-07-13 | 1990-12-11 | Rorer Pharmaceutical Corporation | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments |
JPH0395144A (ja) * | 1989-08-04 | 1991-04-19 | Ono Pharmaceut Co Ltd | アミノフェノール誘導体の製造方法 |
-
1996
- 1996-03-21 ES ES009600682A patent/ES2127106B1/es not_active Expired - Lifetime
-
1997
- 1997-03-20 NZ NZ331953A patent/NZ331953A/xx not_active IP Right Cessation
- 1997-03-20 EE EE9800318A patent/EE03526B1/xx not_active IP Right Cessation
- 1997-03-20 DE DE69713300T patent/DE69713300T2/de not_active Expired - Fee Related
- 1997-03-20 AU AU21587/97A patent/AU707282B2/en not_active Ceased
- 1997-03-20 CA CA002249402A patent/CA2249402C/en not_active Expired - Fee Related
- 1997-03-20 BR BR9708215-5A patent/BR9708215A/pt not_active Application Discontinuation
- 1997-03-20 SI SI9730340T patent/SI0888327T1/xx unknown
- 1997-03-20 US US09/142,922 patent/US5990142A/en not_active Expired - Fee Related
- 1997-03-20 EP EP97914280A patent/EP0888327B1/en not_active Expired - Lifetime
- 1997-03-20 CZ CZ0299598A patent/CZ296260B6/cs not_active IP Right Cessation
- 1997-03-20 JP JP53315997A patent/JP3914575B2/ja not_active Expired - Fee Related
- 1997-03-20 WO PCT/EP1997/001418 patent/WO1997034885A1/en active IP Right Grant
- 1997-03-20 CN CNB971931933A patent/CN1182129C/zh not_active Expired - Fee Related
- 1997-03-20 TR TR1998/01857T patent/TR199801857T2/xx unknown
- 1997-03-20 KR KR10-1998-0707399A patent/KR100378892B1/ko not_active IP Right Cessation
- 1997-03-20 UA UA98094930A patent/UA65535C2/uk unknown
- 1997-03-20 GE GEAP19974493A patent/GEP20012416B/en unknown
- 1997-03-20 IL IL12629697A patent/IL126296A/en not_active IP Right Cessation
- 1997-03-20 HU HU9901326A patent/HUP9901326A3/hu unknown
- 1997-03-20 ES ES97914280T patent/ES2176719T3/es not_active Expired - Lifetime
- 1997-03-20 PL PL97329027A patent/PL189562B1/pl not_active IP Right Cessation
- 1997-03-20 DK DK97914280T patent/DK0888327T3/da active
- 1997-03-20 PT PT97914280T patent/PT888327E/pt unknown
- 1997-03-20 SK SK1272-98A patent/SK282979B6/sk not_active IP Right Cessation
- 1997-03-20 EA EA199800738A patent/EA001680B1/ru unknown
- 1997-03-20 AT AT97914280T patent/ATE219073T1/de not_active IP Right Cessation
-
1998
- 1998-09-17 BG BG102775A patent/BG63433B1/bg unknown
- 1998-09-17 NO NO19984330A patent/NO319612B1/no not_active IP Right Cessation
- 1998-09-18 CU CU1998130A patent/CU22777A3/es not_active IP Right Cessation
- 1998-09-18 RS YUP-407/98A patent/RS49588B/sr unknown
-
1999
- 1999-08-31 HK HK99103747A patent/HK1018701A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG63433B1 (bg) | Бензопиранови производни, имащи антагонистично действие спрямо левкотриени | |
KR890000292B1 (ko) | 항 알레르기제로서 유용한 신규의 산성 인돌화합물 및 그 제조방법 | |
IL201407A (en) | 1 – aryl – 3 – sulfonyl – 5,4 – dihydro-H1 – pyrazole – carboxylic acids and their esters | |
US5175173A (en) | Carboxamides useful as antiemetic or antipsychotic agents | |
US5684046A (en) | Hydrogenated naphthalenes and related LTB4 antagonists | |
EP0775133B1 (en) | Naphthalene amides having leukotriene-antagonistic action | |
JP2939280B2 (ja) | フッ素置換メトキシキノロンカルボン酸誘導体 | |
US4778903A (en) | Substituted dihydrobenzopyrans | |
FI101300B (fi) | Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-e tikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät k inoliinijohdannaiset | |
JPS6023112B2 (ja) | 新規なベンゾ〔c〕キノリン類製造用中間体 | |
US5236935A (en) | Benzopyran derivatives and processes for the preparation thereof | |
Gao et al. | Synthesis and Cyclization of 8‐Formyl‐2‐(phenoxymethyl) quinoline‐3‐carboxylic Acids | |
JPH07215952A (ja) | カテコール誘導体 | |
JP2992033B2 (ja) | オキソキノリンカルボン酸誘導体の製造中間体 | |
KR101620158B1 (ko) | 1-알킬-2-페닐-4-퀴놀론의 제조방법 | |
Ayoub | Synthetic Study of Ethyl (2E)-4-bromo-3-ethoxybut-2-enoate: Synthesis of New 1, 4-Benzoxazines and Pyrrole-2-ones | |
JPH0250113B2 (no) | ||
SK278786B6 (sk) | Spôsob výroby 1,2,3,9-tetrahydro-9-metyl-3-[(2-met | |
IE43737B1 (en) | 3-hydroxymethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid esters |