BG60441B2 - Днк последователности,рекомбинантни днк молекули и методи за получаване на пептиди,подобни на човешки фибробластен интерферон - Google Patents
Днк последователности,рекомбинантни днк молекули и методи за получаване на пептиди,подобни на човешки фибробластен интерферон Download PDFInfo
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- BG60441B2 BG60441B2 BG098456A BG9845694A BG60441B2 BG 60441 B2 BG60441 B2 BG 60441B2 BG 098456 A BG098456 A BG 098456A BG 9845694 A BG9845694 A BG 9845694A BG 60441 B2 BG60441 B2 BG 60441B2
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- interferon
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/73—Expression systems using phage (lambda) regulatory sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
- C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8011306 | 1980-04-03 | ||
| GB8018701 | 1980-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60441B2 true BG60441B2 (bg) | 1995-03-31 |
Family
ID=26275083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098456A BG60441B2 (bg) | 1980-04-03 | 1994-02-11 | Днк последователности,рекомбинантни днк молекули и методи за получаване на пептиди,подобни на човешки фибробластен интерферон |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7588755B1 (ko) |
| EP (1) | EP0041313B1 (ko) |
| JP (1) | JP2687995B2 (ko) |
| KR (1) | KR860001471B1 (ko) |
| AT (1) | ATE56471T1 (ko) |
| AU (1) | AU564690B2 (ko) |
| BG (1) | BG60441B2 (ko) |
| CA (1) | CA1341604C (ko) |
| DD (1) | DD160280A5 (ko) |
| DE (1) | DE3177213D1 (ko) |
| DK (1) | DK170476B1 (ko) |
| ES (1) | ES500966A0 (ko) |
| FI (1) | FI88175C (ko) |
| GR (1) | GR74498B (ko) |
| HK (1) | HK160095A (ko) |
| HU (1) | HU193507B (ko) |
| IE (1) | IE57069B1 (ko) |
| IL (1) | IL62552A0 (ko) |
| IN (1) | IN156128B (ko) |
| LU (1) | LU90131I2 (ko) |
| MX (1) | MX9202946A (ko) |
| NL (2) | NL970018I1 (ko) |
| NO (3) | NO811118L (ko) |
| NZ (1) | NZ196706A (ko) |
| PL (1) | PL149079B1 (ko) |
| PT (1) | PT72786B (ko) |
| YU (1) | YU45104B (ko) |
Families Citing this family (39)
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|---|---|---|---|---|
| US5554513A (en) * | 1979-11-21 | 1996-09-10 | Yeda Research & Development Co. Ltd. | Production of recombinant human interferon-beta2 |
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| US5510472A (en) * | 1979-11-21 | 1996-04-23 | Yeda Research And Development Co. Ltd. | Production of recombinant human interferon-beta2 |
| DK33181A (da) * | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
| DE3005843A1 (de) * | 1980-02-16 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
| PH22618A (en) * | 1980-06-06 | 1988-10-28 | Biogen Nv | Improved vectors and method for making such vectors and for expressing cloned genes |
| ATE25985T1 (de) * | 1980-06-12 | 1987-04-15 | Japan Found Cancer | Plasmid. |
| US4874702A (en) * | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
| ZA816621B (en) * | 1980-09-25 | 1982-09-29 | Genentech Inc | Microbial production of human fibroblast interferon |
| IL63916A0 (en) * | 1980-09-25 | 1981-12-31 | Genentech Inc | Microbial production of human fibroblast interferon |
| IL63327A (en) * | 1981-07-16 | 1985-11-29 | Yeda Res & Dev | Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria |
| GB2108510B (en) * | 1981-10-03 | 1984-12-12 | Ciba Geigy Ag | Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof |
| JPS58110600A (ja) * | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
| JPS58141796A (ja) * | 1982-02-18 | 1983-08-23 | Kyowa Hakko Kogyo Co Ltd | ペプチドの製造法 |
| US4582800A (en) * | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| IL69382A (en) * | 1982-08-05 | 1991-01-31 | Carter William Alvin | Method of protecting plants against viral pathogens by inserting into plant cells genes encoding polypeptides containing interferon domains |
| FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| GR79124B (ko) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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| US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| EP0152483B1 (en) * | 1983-08-22 | 1989-03-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing peptide |
| EP0226639B1 (en) * | 1985-05-29 | 1990-11-14 | The Green Cross Corporation | Process for preparing heterogenic protein |
| WO1987000553A1 (en) * | 1985-07-16 | 1987-01-29 | The Green Cross Corporation | Process for preparing hetero-protein |
| FR2635113B1 (fr) * | 1988-08-05 | 1992-07-24 | Sanofi Sa | Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees |
| US5545723A (en) * | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
| JP4293497B2 (ja) | 1997-09-23 | 2009-07-08 | レントシュレール ビオテクノロジー ゲー・エム・ベー・ハー | インターフェロン−β液状組成物 |
| US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| US7431921B2 (en) | 2000-04-14 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
| US7144574B2 (en) | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
| US6926898B2 (en) | 2000-04-12 | 2005-08-09 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| MXPA03007619A (es) | 2001-02-27 | 2003-12-04 | Maxygen Aps | Nuevas moleculas similares a interferon beta. |
| ES2500918T3 (es) | 2001-12-21 | 2014-10-01 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina e interferón beta |
| US8906676B2 (en) | 2004-02-02 | 2014-12-09 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
| AU2008247815B2 (en) | 2007-05-02 | 2012-09-06 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| DE102009032179A1 (de) | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
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| FR2321298A1 (fr) * | 1975-08-01 | 1977-03-18 | Anvar | Procede de preparation de produits a activite interferon |
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| FR2422956A1 (fr) | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| EP0005476B1 (de) | 1978-05-17 | 1981-12-30 | Dr. Karl Thomae GmbH | Verfahren zur Herstellung von Humaninterferon |
| US4322497A (en) | 1978-06-02 | 1982-03-30 | Eli Lilly And Company | Process for transducing Escherichia coli K12 χ1776 |
| US4411994A (en) | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
| US4307193A (en) | 1978-06-09 | 1981-12-22 | Toray Industries, Inc. | Method of producing interferon |
| JPS5519239A (en) | 1978-07-28 | 1980-02-09 | Green Cross Corp:The | Interferon-producing attractant |
| FI792481A (fi) | 1978-08-11 | 1980-02-12 | Univ California | Syntes av enkaroytiskt protein genom anvaendning av mikro-organismer |
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| JPS5564799A (en) | 1978-11-07 | 1980-05-15 | Toray Ind Inc | Multi-stage concentration and purification of interferon originated from human fibroblast |
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| NL8000127A (nl) | 1979-01-15 | 1980-07-17 | Harvard College | Werkwijze voor het vormen van prokaryotische of eukaryotische proteinen alsmede een daarbij toepasbaar gekoppeld gen. |
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| JPS5663996A (en) | 1979-10-30 | 1981-05-30 | Japan Found Cancer | Novel recombinant having gene complementary to human interferon messenger rna |
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| US4357421A (en) | 1979-04-02 | 1982-11-02 | G. D. Searle & Co. | Synthetic gene coding for influenza hemagglutinin |
| FI77877C (fi) | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Foerfarande foer framstaellning och rening av human le-formig interferonprotein. |
| IL57108A (en) | 1979-04-22 | 1981-12-31 | Yeda Res & Dev | Assay for the quantitative determination of interferon and a kit therefor |
| US4293652A (en) | 1979-05-25 | 1981-10-06 | Cetus Corporation | Method for synthesizing DNA sequentially |
| GB2052516B (en) | 1979-06-01 | 1983-06-29 | Searle & Co | Plasmid vectors production and use thereof |
| US4262090A (en) | 1979-06-04 | 1981-04-14 | Cetus Corporation | Interferon production |
| WO1981000116A1 (en) | 1979-07-05 | 1981-01-22 | United States Res Corp | Method for the purification and analysis of interferon |
| CH648331A5 (de) | 1979-07-31 | 1985-03-15 | Hoffmann La Roche | Homogenes fibroblasten-interferon und dessen herstellung. |
| JPS5651995A (en) | 1979-10-05 | 1981-05-09 | Green Cross Corp:The | Preparation of interferon |
| NL7907791A (nl) | 1979-10-23 | 1981-04-27 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
| AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
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| EP0030094A1 (en) | 1979-11-30 | 1981-06-10 | Beecham Group Plc | Calcium enhanced interferon production process |
| ES8308534A1 (es) | 1980-01-08 | 1983-09-01 | Biogen Nv | Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos. |
| DK33181A (da) | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
| GB2068970B (en) * | 1980-02-06 | 1983-06-22 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
| IE51030B1 (en) | 1980-02-06 | 1986-09-17 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
| DE3005843A1 (de) | 1980-02-16 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
| DE3005897A1 (de) | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
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-
1981
- 1981-04-01 FI FI811008A patent/FI88175C/fi not_active IP Right Cessation
- 1981-04-01 HU HU81841A patent/HU193507B/hu unknown
- 1981-04-01 JP JP56047361A patent/JP2687995B2/ja not_active Expired - Lifetime
- 1981-04-01 NO NO811118A patent/NO811118L/no unknown
- 1981-04-01 IN IN188/DEL/81A patent/IN156128B/en unknown
- 1981-04-01 CA CA374378A patent/CA1341604C/en active Active
- 1981-04-01 PT PT72786A patent/PT72786B/pt unknown
- 1981-04-01 YU YU859/81A patent/YU45104B/xx unknown
- 1981-04-01 ES ES500966A patent/ES500966A0/es active Granted
- 1981-04-01 AU AU68979/81A patent/AU564690B2/en not_active Expired
- 1981-04-01 IL IL62552A patent/IL62552A0/xx unknown
- 1981-04-01 EP EP81301414A patent/EP0041313B1/en not_active Revoked
- 1981-04-01 GR GR64561A patent/GR74498B/el unknown
- 1981-04-01 DK DK148581A patent/DK170476B1/da not_active IP Right Cessation
- 1981-04-01 NZ NZ196706A patent/NZ196706A/en unknown
- 1981-04-01 DE DE8181301414T patent/DE3177213D1/de not_active Revoked
- 1981-04-01 IE IE756/81A patent/IE57069B1/en not_active IP Right Cessation
- 1981-04-01 KR KR1019810001103A patent/KR860001471B1/ko active
- 1981-04-01 AT AT81301414T patent/ATE56471T1/de active
- 1981-04-02 DD DD81228897A patent/DD160280A5/de active IP Right Maintenance
- 1981-04-02 PL PL1981230484A patent/PL149079B1/pl unknown
-
1985
- 1985-02-22 NO NO850734A patent/NO850734L/no unknown
- 1985-02-22 NO NO850735A patent/NO850735L/no unknown
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1992
- 1992-06-17 MX MX9202946A patent/MX9202946A/es unknown
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1994
- 1994-02-11 BG BG098456A patent/BG60441B2/bg unknown
-
1995
- 1995-05-25 US US08/449,930 patent/US7588755B1/en active Active
- 1995-05-25 US US08/452,658 patent/US7635466B1/en active Active
- 1995-10-12 HK HK160095A patent/HK160095A/xx not_active IP Right Cessation
-
1997
- 1997-04-07 NL NL970018C patent/NL970018I1/nl unknown
- 1997-08-13 NL NL970032C patent/NL970032I2/nl unknown
- 1997-09-03 LU LU90131C patent/LU90131I2/fr unknown
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