IL62552A0 - Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides - Google Patents

Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides

Info

Publication number
IL62552A0
IL62552A0 IL62552A IL6255281A IL62552A0 IL 62552 A0 IL62552 A0 IL 62552A0 IL 62552 A IL62552 A IL 62552A IL 6255281 A IL6255281 A IL 6255281A IL 62552 A0 IL62552 A0 IL 62552A0
Authority
IL
Israel
Prior art keywords
dna sequences
polypeptides
processes
producing human
human fibroblast
Prior art date
Application number
IL62552A
Other languages
English (en)
Original Assignee
Biogen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26275083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL62552(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Nv filed Critical Biogen Nv
Priority to IL77830A priority Critical patent/IL77830A/xx
Publication of IL62552A0 publication Critical patent/IL62552A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/565IFN-beta
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/73Expression systems using phage (lambda) regulatory sequences
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/22011Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL62552A 1980-04-03 1981-04-01 Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides IL62552A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL77830A IL77830A (en) 1980-06-06 1981-04-01 Dna sequences, recombinant dna molecules and processes for producing human b-interferon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8011306 1980-04-03
GB8018701 1980-06-06

Publications (1)

Publication Number Publication Date
IL62552A0 true IL62552A0 (en) 1981-06-29

Family

ID=26275083

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62552A IL62552A0 (en) 1980-04-03 1981-04-01 Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides

Country Status (27)

Country Link
US (2) US7635466B1 (xx)
EP (1) EP0041313B1 (xx)
JP (1) JP2687995B2 (xx)
KR (1) KR860001471B1 (xx)
AT (1) ATE56471T1 (xx)
AU (1) AU564690B2 (xx)
BG (1) BG60441B2 (xx)
CA (1) CA1341604C (xx)
DD (1) DD160280A5 (xx)
DE (1) DE3177213D1 (xx)
DK (1) DK170476B1 (xx)
ES (1) ES8302096A1 (xx)
FI (1) FI88175C (xx)
GR (1) GR74498B (xx)
HK (1) HK160095A (xx)
HU (1) HU193507B (xx)
IE (1) IE57069B1 (xx)
IL (1) IL62552A0 (xx)
IN (1) IN156128B (xx)
LU (1) LU90131I2 (xx)
MX (1) MX9202946A (xx)
NL (2) NL970018I1 (xx)
NO (3) NO811118L (xx)
NZ (1) NZ196706A (xx)
PL (1) PL149079B1 (xx)
PT (1) PT72786B (xx)
YU (1) YU45104B (xx)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DK171301B1 (da) * 1980-06-06 1996-08-26 Biogen Inc Plasmid-vektorer, fremgangsmåde til fremstilling deraf samt fremgangsmåde til fremstilling af polypeptid
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
IT1139487B (it) * 1980-09-25 1986-09-24 Genentech Inc Produzione microbica di interferone di fibroblasti umani
ZA816621B (en) * 1980-09-25 1982-09-29 Genentech Inc Microbial production of human fibroblast interferon
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS58141796A (ja) * 1982-02-18 1983-08-23 Kyowa Hakko Kogyo Co Ltd ペプチドの製造法
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
IL69382A (en) * 1982-08-05 1991-01-31 Carter William Alvin Method of protecting plants against viral pathogens by inserting into plant cells genes encoding polypeptides containing interferon domains
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
GR79124B (xx) * 1982-12-22 1984-10-02 Genentech Inc
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
DE3379506D1 (en) * 1983-08-22 1989-05-03 Kyowa Hakko Kogyo Kk Process for producing peptide
EP0226639B1 (en) * 1985-05-29 1990-11-14 The Green Cross Corporation Process for preparing heterogenic protein
WO1987000553A1 (en) * 1985-07-16 1987-01-29 The Green Cross Corporation Process for preparing hetero-protein
FR2635113B1 (fr) * 1988-08-05 1992-07-24 Sanofi Sa Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
CA2304808C (en) 1997-09-23 2011-03-22 Michael Tschope Liquid interferon-.beta. formulations
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
ES2484966T3 (es) 2000-04-12 2014-08-12 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
IL156059A0 (en) 2001-02-27 2003-12-23 Maxygen Aps NEW INTERFERON beta-LIKE MOLECULES
WO2003060071A2 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
US8778880B2 (en) 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
EP2076533B1 (en) 2007-05-02 2014-10-08 Ambrx, Inc. Modified interferon beta polypeptides and their uses
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1645C (da) 1898-06-20 Carl Christensen Lommekniv med et i Skaftet indskydeligt Blad.
US3699222A (en) 1958-03-11 1972-10-17 Nat Res Dev Production of viral interfering substances
US4184917A (en) 1974-04-01 1980-01-22 Sandoz Ltd. Process for producing a structurally modified interferon
NL7404589A (nl) 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het stabiliseren van interferon.
GB1521032A (en) * 1974-08-08 1978-08-09 Ici Ltd Biological treatment
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
FR2321298A1 (fr) * 1975-08-01 1977-03-18 Anvar Procede de preparation de produits a activite interferon
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4264731A (en) 1977-05-27 1981-04-28 The Regents Of The University Of California DNA Joining method
DE2724918A1 (de) 1977-06-02 1978-12-14 Thomae Gmbh Dr K Gewinnung und reinigung von humaninterferon
CS215108B2 (en) 1977-07-15 1982-07-30 Wellcome Found Method of making the interferrone
ZA782933B (en) 1977-09-23 1979-05-30 Univ California Purification of nucleotide sequences suitable for expression in bacteria
US4283489A (en) 1977-09-23 1981-08-11 The Regents Of The University Of California Purification of nucleotide sequences suitable for expression in bacteria
DK493978A (da) 1977-11-08 1979-05-09 Genentech Inc Syntetisk dna og fremgangsmaade til fremstilling deraf
GR71906B (xx) 1977-11-08 1983-08-12 Genentech Inc
NO158880C (no) 1977-11-08 1988-11-09 Genentech Inc Fremgangsmaate for fremstilling av et spesifikt pattedyrhormon.
DE2759053A1 (de) 1977-12-30 1979-07-12 Uhlin Verfahren zum herstellen von genprodukten von plasmid-dns
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
DE2961658D1 (en) 1978-05-17 1982-02-18 Thomae Gmbh Dr K Process for preparing human interferon
US4322497A (en) 1978-06-02 1982-03-30 Eli Lilly And Company Process for transducing Escherichia coli K12 χ1776
US4411994A (en) 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4307193A (en) 1978-06-09 1981-12-22 Toray Industries, Inc. Method of producing interferon
JPS5519239A (en) 1978-07-28 1980-02-09 Green Cross Corp:The Interferon-producing attractant
IE48385B1 (en) 1978-08-11 1984-12-26 Univ California Synthesis of a eucaryotic protein by a microorganism
JPS5561798A (en) 1978-10-30 1980-05-09 Noda Sangyo Kagaku Kenkyusho Preparation of novel recombination dna
JPS5564799A (en) 1978-11-07 1980-05-15 Toray Ind Inc Multi-stage concentration and purification of interferon originated from human fibroblast
IN150740B (xx) 1978-11-24 1982-12-04 Hoffmann La Roche
US4241174A (en) 1978-11-24 1980-12-23 Hoffmann-La Roche Inc. Interferon assay
NL8000127A (nl) 1979-01-15 1980-07-17 Harvard College Werkwijze voor het vormen van prokaryotische of eukaryotische proteinen alsmede een daarbij toepasbaar gekoppeld gen.
EP0014050A3 (en) 1979-01-16 1980-10-01 Beecham Group Plc Interferon production
JPS5663996A (en) 1979-10-30 1981-05-30 Japan Found Cancer Novel recombinant having gene complementary to human interferon messenger rna
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
US5514567A (en) * 1979-01-30 1996-05-07 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
JPS56131598A (en) 1980-03-19 1981-10-15 Japan Found Cancer Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
US4357421A (en) 1979-04-02 1982-11-02 G. D. Searle & Co. Synthetic gene coding for influenza hemagglutinin
FI77877C (fi) 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
IL57108A (en) 1979-04-22 1981-12-31 Yeda Res & Dev Assay for the quantitative determination of interferon and a kit therefor
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
DK159976C (da) 1979-06-01 1991-05-27 Searle & Co Plasmidvektorer, fremgangsmaade til fremstilling deraf, bakterieceller transformeret med plasmidvektorer samt udtrykkelse af protein i transformerede bakterieceller
US4262090A (en) 1979-06-04 1981-04-14 Cetus Corporation Interferon production
WO1981000116A1 (en) 1979-07-05 1981-01-22 United States Res Corp Method for the purification and analysis of interferon
CH648331A5 (de) 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
JPS5651995A (en) 1979-10-05 1981-05-09 Green Cross Corp:The Preparation of interferon
NL7907791A (nl) 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
EP0030094A1 (en) 1979-11-30 1981-06-10 Beecham Group Plc Calcium enhanced interferon production process
DK170236B1 (da) 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
IE51030B1 (en) 1980-02-06 1986-09-17 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DK33181A (da) 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DE3005897A1 (de) 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3005843A1 (de) 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
AU546577B2 (en) 1980-02-25 1985-09-05 Trustees Of Columbia University, The Use of eucaryotic promoter sequences in the production of proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4338397A (en) 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
DE3019621C2 (de) 1980-05-22 1982-08-19 Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg Verfahren zur Herstellung von Interferon II.
DK220781A (da) 1980-05-22 1981-11-23 Deutsches Krebsforsch Fremgangsmaade til fremstilling af interferon ii og stimulerede kloner til ydfoerelse af frmgangsmaaden
JPS56167624A (en) 1980-05-29 1981-12-23 Toray Ind Inc Method of interferon production
JPS571237A (en) 1980-06-03 1982-01-06 Toshiba Corp Combined integrared circuit device
DK171301B1 (da) 1980-06-06 1996-08-26 Biogen Inc Plasmid-vektorer, fremgangsmåde til fremstilling deraf samt fremgangsmåde til fremstilling af polypeptid
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
JPS575158A (en) 1980-06-12 1982-01-11 Matsushita Electric Works Ltd Automatic resetting circuit for cpu function stopping phenomenon
CH657141A5 (de) 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
US4357422A (en) 1980-08-14 1982-11-02 Massachusetts Institute Of Technology Method of enhancing interferon production
US4874702A (en) 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
IT1139487B (it) * 1980-09-25 1986-09-24 Genentech Inc Produzione microbica di interferone di fibroblasti umani
US4315852A (en) 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
JPS58201794A (ja) 1982-05-17 1983-11-24 Toray Ind Inc ヒトインターフェロンβの濃縮精製法
US4835256A (en) 1982-09-30 1989-05-30 New York University & Juridical Foundation Human gamma interferon polypeptide having glutamine as the ninth n-terminal amino acid
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
AU594014B2 (en) 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
IL75318A (en) 1984-05-31 1994-08-26 Genentech Inc Recombinant human memotoxin and methods for its recombinant production
IL78531A0 (en) 1985-04-22 1986-08-31 Lilly Co Eli Recombinant dna expression vectors and dna compounds which encode isopenicillin n synthetase
US4892819A (en) 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
DE3781747T2 (de) 1986-08-29 1993-03-18 Tonen Corp Fuer das rinderpestvirus-antigen kodierende dns, ihre herstellung und verwendung.
DE3642096A1 (de) 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
EP0286114B1 (en) 1987-04-09 1994-03-30 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. Reg gene and protein encoded by the gene
ZA887773B (en) 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
US5258287A (en) 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
ATE56471T1 (de) 1990-09-15
GR74498B (xx) 1984-06-28
PT72786A (en) 1981-05-01
LU90131I2 (fr) 1997-11-26
NL970032I2 (nl) 1997-12-01
US7588755B1 (en) 2009-09-15
CA1341604C (en) 2010-05-04
NL970018I1 (nl) 1997-06-02
NO850734L (no) 1981-10-05
JPS56154499A (en) 1981-11-30
FI88175C (fi) 1993-04-13
YU45104B (en) 1992-03-10
ES500966A0 (es) 1982-12-16
AU6897981A (en) 1981-10-08
HU193507B (en) 1987-10-28
PL230484A1 (en) 1983-07-18
DD160280A5 (de) 1983-05-25
PL149079B1 (en) 1990-01-31
NO811118L (no) 1981-10-05
KR860001471B1 (ko) 1986-09-26
DE3177213D1 (de) 1990-10-18
FI88175B (fi) 1992-12-31
NZ196706A (en) 1988-01-08
DK170476B1 (da) 1995-09-11
AU564690B2 (en) 1987-08-20
PT72786B (en) 1983-01-10
MX9202946A (es) 1992-07-01
BG60441B2 (bg) 1995-03-31
US7635466B1 (en) 2009-12-22
YU85981A (en) 1984-04-30
EP0041313B1 (en) 1990-09-12
NL970032I1 (nl) 1997-10-01
EP0041313A3 (en) 1982-08-18
FI811008L (fi) 1981-10-04
IN156128B (xx) 1985-05-18
KR830005354A (ko) 1983-08-13
JP2687995B2 (ja) 1997-12-08
IE810756L (en) 1981-10-03
EP0041313A2 (en) 1981-12-09
NO850735L (no) 1981-10-05
DK148581A (da) 1981-10-04
ES8302096A1 (es) 1982-12-16
HK160095A (en) 1995-10-20
IE57069B1 (en) 1992-04-22

Similar Documents

Publication Publication Date Title
EP0041313A3 (en) Dna sequences, recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides
CY1346A (en) Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
GB8713482D0 (en) Stabilized molded rubber keyboard
DE3750056D1 (de) Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
ES8500996A1 (es) Meotod de producir un polipeptido.
EP0313952A3 (en) Push-button for keyboard
ZA883245B (en) Dna clone of human thrombomodulin
GR851866B (xx)
EP0244189A3 (en) Human pancreatic elastase i
EP0277609A3 (en) Flat keyboard arrangement
EP0169451A3 (en) Sinterable, finely distributed moulding composition based on vinyl chloride polymerizates
GB8607348D0 (en) Control keyboard
DE3574932D1 (de) Verwendung von 1,4 bisubstituierten anthrachinonen zur herstellung von immunsuppressiva.
ES8605460A1 (es) Procedimiento para la obtencion de hidrocarburos percloro- fluorados
GB8630347D0 (en) Carbon moulded articles
PL249410A1 (en) Alphanumeric keyboard arrangement
GB8626843D0 (en) Changeable pitch keyboard