JPS56131598A - Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna - Google Patents

Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna

Info

Publication number
JPS56131598A
JPS56131598A JP3393180A JP3393180A JPS56131598A JP S56131598 A JPS56131598 A JP S56131598A JP 3393180 A JP3393180 A JP 3393180A JP 3393180 A JP3393180 A JP 3393180A JP S56131598 A JPS56131598 A JP S56131598A
Authority
JP
Japan
Prior art keywords
human
interferon
recombinant plasmid
messenger rna
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3393180A
Other languages
Japanese (ja)
Other versions
JPH0129557B2 (en
Inventor
Haruo Sugano
Masami Muramatsu
Koreaki Taniguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japanese Foundation for Cancer Research
Original Assignee
Japanese Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japanese Foundation for Cancer Research filed Critical Japanese Foundation for Cancer Research
Priority to JP3393180A priority Critical patent/JPS56131598A/en
Priority to AU63762/80A priority patent/AU538665B2/en
Priority to DK458480A priority patent/DK458480A/en
Priority to IL61366A priority patent/IL61366A/en
Priority to NO803230A priority patent/NO158950C/en
Priority to AT80106685T priority patent/ATE18072T1/en
Priority to CA000363628A priority patent/CA1341563C/en
Priority to ES496426A priority patent/ES496426A0/en
Priority to DE8080106685T priority patent/DE3071435D1/en
Priority to EP80106685A priority patent/EP0028033B1/en
Publication of JPS56131598A publication Critical patent/JPS56131598A/en
Priority to ES507595A priority patent/ES507595A0/en
Priority to ES507596A priority patent/ES8303530A1/en
Publication of JPH0129557B2 publication Critical patent/JPH0129557B2/ja
Priority to US08/400,179 priority patent/US5514567A/en
Priority to US08/463,757 priority patent/US9376478B1/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Abstract

NEW MATERIAL:A novel recombinant plasmid, having a gene containing at least all code parts of human fibrolastic interferon messenger RNA, and prepared by inserting DNA synthesized with human fibroblastic interferon messenger RNA as its template into vector plasmid DNA. EXAMPLE:A recombined Escherichia coli plasmid. USE:Useful for preparing antiviral and antitumor human interferon in a large quantity and at a low cost after multiplied in bacteria, e.g. Escherichia coli. PROCESS:Cytoplasmic RNA is extracted from a human fibroblast, etc. induced by poly (I)(C), etc. From the cytoplasmic RNA thus extracted is separated human fibroblastic interferon mRNA, among which a highly active one is used as a template to synthesize double stranded DNA with a reverse trancriptase, etc. The resultant double stranded DNA is inserted into vector DNA to produce recombinats, from which the titled recombinant plasmid is obtained by making a search therefor with a probe.
JP3393180A 1979-01-30 1980-03-19 Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna Granted JPS56131598A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP3393180A JPS56131598A (en) 1980-03-19 1980-03-19 Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
AU63762/80A AU538665B2 (en) 1979-10-30 1980-10-28 Human interferon dna
DK458480A DK458480A (en) 1979-10-30 1980-10-29 DNA, RECOMBINANT PLASMID AND MICROORGANISM CONTAINING IT, AND PROCEDURES FOR THE PRODUCTION THEREOF
IL61366A IL61366A (en) 1979-10-30 1980-10-29 Dna with interferon activity,recombinant plasmids containing it,microorganisms prepared therewith and methods for the preparation thereof
NO803230A NO158950C (en) 1979-10-30 1980-10-29 DNA SEQUENCE CODING A POLYPEPTIDE WITH HUMAN FIBROBLAST INTERFERON ACTIVITY, PROCEDURE FOR ITS MANUFACTURING, AND PROCEDURE FOR MANUFACTURING A PLASMID.
ES496426A ES496426A0 (en) 1979-10-30 1980-10-30 A PROCEDURE FOR THE PREPARATION OF A DNA THAT CODES A POLIPEPTIDE WITH INTERFERON ACTIVITY.
CA000363628A CA1341563C (en) 1979-10-30 1980-10-30 Dna coding for human fibroblast interferon polypeptide and recombinant plasmid
AT80106685T ATE18072T1 (en) 1979-10-30 1980-10-30 DOUBLE STRANDED DNA CODING FOR A POLYPEPTIDE WITH HUMAN FIBROBLAST INTERFERON ACTIVITY, CLONED DNA, RECOMBINANT PLASMID CONTAINING THE DNA, AND MICROORGANISM CONTAINING THE RECOMBINANT PLASMID.
DE8080106685T DE3071435D1 (en) 1979-10-30 1980-10-30 Double-stranded dna which codes for a polypeptide with human fibroblast interferon activity, cloned dna, recombinant plasmid containing the dna and microorganism containing the recombinant plasmid
EP80106685A EP0028033B1 (en) 1979-10-30 1980-10-30 Double-stranded dna which codes for a polypeptide with human fibroblast interferon activity, cloned dna, recombinant plasmid containing the dna and microorganism containing the recombinant plasmid
ES507595A ES507595A0 (en) 1979-10-30 1981-11-30 A PROCEDURE FOR THE PRODUCTION OF A RECOMBINANT PLASMID.
ES507596A ES8303530A1 (en) 1979-10-30 1981-11-30 Double-stranded DNA which codes for a polypeptide with human fibroblast interferon activity, cloned DNA, recombinant plasmid containing the DNA and microorganism containing the recombinant plasmid.
US08/400,179 US5514567A (en) 1979-01-30 1995-03-06 DNA and recombinant plasmid
US08/463,757 US9376478B1 (en) 1979-10-30 1995-06-05 DNA and recombinant plasmid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3393180A JPS56131598A (en) 1980-03-19 1980-03-19 Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna

Publications (2)

Publication Number Publication Date
JPS56131598A true JPS56131598A (en) 1981-10-15
JPH0129557B2 JPH0129557B2 (en) 1989-06-12

Family

ID=12400254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3393180A Granted JPS56131598A (en) 1979-01-30 1980-03-19 Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna

Country Status (1)

Country Link
JP (1) JPS56131598A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58224690A (en) * 1982-03-08 1983-12-27 ジエネンテツク・インコ−ポレイテツド Animal interferon
US7588755B1 (en) 1980-04-03 2009-09-15 Biogen Idec Ma Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5685296A (en) * 1979-11-21 1981-07-11 Yeda Res & Dev Isolation of mrna convertible to interferon and corresponding dna and production of interferonpolypeptide and high purity interferon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5685296A (en) * 1979-11-21 1981-07-11 Yeda Res & Dev Isolation of mrna convertible to interferon and corresponding dna and production of interferonpolypeptide and high purity interferon

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7588755B1 (en) 1980-04-03 2009-09-15 Biogen Idec Ma Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides
JPS58224690A (en) * 1982-03-08 1983-12-27 ジエネンテツク・インコ−ポレイテツド Animal interferon

Also Published As

Publication number Publication date
JPH0129557B2 (en) 1989-06-12

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