JPS5663996A - Novel recombinant having gene complementary to human interferon messenger rna - Google Patents

Novel recombinant having gene complementary to human interferon messenger rna

Info

Publication number
JPS5663996A
JPS5663996A JP13928979A JP13928979A JPS5663996A JP S5663996 A JPS5663996 A JP S5663996A JP 13928979 A JP13928979 A JP 13928979A JP 13928979 A JP13928979 A JP 13928979A JP S5663996 A JPS5663996 A JP S5663996A
Authority
JP
Japan
Prior art keywords
rna
human interferon
recombinant
dna
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13928979A
Other languages
Japanese (ja)
Inventor
Haruo Sugano
Masami Muramatsu
Koreaki Taniguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japanese Foundation for Cancer Research
Original Assignee
Japanese Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japanese Foundation for Cancer Research filed Critical Japanese Foundation for Cancer Research
Priority to JP13928979A priority Critical patent/JPS5663996A/en
Priority to US06/201,359 priority patent/US5326859A/en
Priority to AU63762/80A priority patent/AU538665B2/en
Priority to IL61366A priority patent/IL61366A/en
Priority to DK458480A priority patent/DK458480A/en
Priority to NO803230A priority patent/NO158950C/en
Priority to EP80106685A priority patent/EP0028033B1/en
Priority to CA000363628A priority patent/CA1341563C/en
Priority to AT80106685T priority patent/ATE18072T1/en
Priority to DE8080106685T priority patent/DE3071435D1/en
Priority to ES496426A priority patent/ES496426A0/en
Publication of JPS5663996A publication Critical patent/JPS5663996A/en
Priority to ES507595A priority patent/ES507595A0/en
Priority to ES507596A priority patent/ES8303530A1/en
Priority to US08/400,179 priority patent/US5514567A/en
Priority to US08/463,757 priority patent/US9376478B1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NEW MATERIAL:A novel recombinant, having a gene which exhibits the complementarity to human interferon messenger RNA, being prepared by inserting ONA synthesied in the presence of its template consisting of human interferon RNA into vector DNA. EXAMPLE:Recombinant Escherichia coli plasmid DNA. USE:Production of human interferon having antiviral and antitumor action. PROCESS:The titled recombinant is obtained by extracting cytoplosmic RNA from a human fibroblast, MG63 cell, etc. induced by ploy (I)(C) (double-stranded RNA composed of polyinosinic and polycytidylic acids), etc. separating human interferon m RNA containing the polyadenylic acid sequence from the cytoplasmic RNA extracted, synthesizing double-stranded DNA with a reverse transcriptase, etc. in the presence of its template consisting of highly active one of the human interferon m RNA thus separated, and then inserting the double-stranded DNA into vector DNA accoring to the recombinant DNA technique.
JP13928979A 1979-01-30 1979-10-30 Novel recombinant having gene complementary to human interferon messenger rna Pending JPS5663996A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP13928979A JPS5663996A (en) 1979-10-30 1979-10-30 Novel recombinant having gene complementary to human interferon messenger rna
US06/201,359 US5326859A (en) 1979-10-30 1980-10-27 DNA and recombinant plasmid
AU63762/80A AU538665B2 (en) 1979-10-30 1980-10-28 Human interferon dna
IL61366A IL61366A (en) 1979-10-30 1980-10-29 Dna with interferon activity,recombinant plasmids containing it,microorganisms prepared therewith and methods for the preparation thereof
DK458480A DK458480A (en) 1979-10-30 1980-10-29 DNA, RECOMBINANT PLASMID AND MICROORGANISM CONTAINING IT, AND PROCEDURES FOR THE PRODUCTION THEREOF
NO803230A NO158950C (en) 1979-10-30 1980-10-29 DNA SEQUENCE CODING A POLYPEPTIDE WITH HUMAN FIBROBLAST INTERFERON ACTIVITY, PROCEDURE FOR ITS MANUFACTURING, AND PROCEDURE FOR MANUFACTURING A PLASMID.
CA000363628A CA1341563C (en) 1979-10-30 1980-10-30 Dna coding for human fibroblast interferon polypeptide and recombinant plasmid
EP80106685A EP0028033B1 (en) 1979-10-30 1980-10-30 Double-stranded dna which codes for a polypeptide with human fibroblast interferon activity, cloned dna, recombinant plasmid containing the dna and microorganism containing the recombinant plasmid
AT80106685T ATE18072T1 (en) 1979-10-30 1980-10-30 DOUBLE STRANDED DNA CODING FOR A POLYPEPTIDE WITH HUMAN FIBROBLAST INTERFERON ACTIVITY, CLONED DNA, RECOMBINANT PLASMID CONTAINING THE DNA, AND MICROORGANISM CONTAINING THE RECOMBINANT PLASMID.
DE8080106685T DE3071435D1 (en) 1979-10-30 1980-10-30 Double-stranded dna which codes for a polypeptide with human fibroblast interferon activity, cloned dna, recombinant plasmid containing the dna and microorganism containing the recombinant plasmid
ES496426A ES496426A0 (en) 1979-10-30 1980-10-30 A PROCEDURE FOR THE PREPARATION OF A DNA THAT CODES A POLIPEPTIDE WITH INTERFERON ACTIVITY.
ES507595A ES507595A0 (en) 1979-10-30 1981-11-30 A PROCEDURE FOR THE PRODUCTION OF A RECOMBINANT PLASMID.
ES507596A ES8303530A1 (en) 1979-10-30 1981-11-30 Double-stranded DNA which codes for a polypeptide with human fibroblast interferon activity, cloned DNA, recombinant plasmid containing the DNA and microorganism containing the recombinant plasmid.
US08/400,179 US5514567A (en) 1979-01-30 1995-03-06 DNA and recombinant plasmid
US08/463,757 US9376478B1 (en) 1979-10-30 1995-06-05 DNA and recombinant plasmid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13928979A JPS5663996A (en) 1979-10-30 1979-10-30 Novel recombinant having gene complementary to human interferon messenger rna

Publications (1)

Publication Number Publication Date
JPS5663996A true JPS5663996A (en) 1981-05-30

Family

ID=15241807

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13928979A Pending JPS5663996A (en) 1979-01-30 1979-10-30 Novel recombinant having gene complementary to human interferon messenger rna

Country Status (1)

Country Link
JP (1) JPS5663996A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5685296A (en) * 1979-11-21 1981-07-11 Yeda Res & Dev Isolation of mrna convertible to interferon and corresponding dna and production of interferonpolypeptide and high purity interferon
US7588755B1 (en) 1980-04-03 2009-09-15 Biogen Idec Ma Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PROC NATL ACAD *
PROC.NATL.ACAD.SCI.USA=1977 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5685296A (en) * 1979-11-21 1981-07-11 Yeda Res & Dev Isolation of mrna convertible to interferon and corresponding dna and production of interferonpolypeptide and high purity interferon
JPS63164896A (en) * 1979-11-21 1988-07-08 イエダ　リサ−チ　アンド　デイベロツプメント　カンパニ−　リミテツド Production of human interferon and high purity human interferon
US7588755B1 (en) 1980-04-03 2009-09-15 Biogen Idec Ma Inc. DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon-like polypeptides

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