BG60433B2 - (-)-1 бета-етил-1 алфа-хидроксиметил-1,2,3,4,6,7,12,12в алфа-октахидроиндоло(2,3-а)хинолизин,методза неговото получаване и съдържащи го фармацевтични състави - Google Patents

(-)-1 бета-етил-1 алфа-хидроксиметил-1,2,3,4,6,7,12,12в алфа-октахидроиндоло(2,3-а)хинолизин,методза неговото получаване и съдържащи го фармацевтични състави Download PDF

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Publication number
BG60433B2
BG60433B2 BG98290A BG9829093A BG60433B2 BG 60433 B2 BG60433 B2 BG 60433B2 BG 98290 A BG98290 A BG 98290A BG 9829093 A BG9829093 A BG 9829093A BG 60433 B2 BG60433 B2 BG 60433B2
Authority
BG
Bulgaria
Prior art keywords
compound
formula
activity
ethyl
acid addition
Prior art date
Application number
BG98290A
Other languages
Bulgarian (bg)
English (en)
Inventor
Csaba Szantay
Lajos Szabo
Gyoergy Kalaus
Zsolt Szombathelyi
Egon Karpati
Bela Kiss
Katalin Csomor
Istvan Laszlovszky
Erzsebet Lapis
Laszlo Szporny
Lilla Forgacs
Csaba Kuthi
Aniko Gere
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Publication of BG60433B2 publication Critical patent/BG60433B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
BG98290A 1985-04-19 1993-12-10 (-)-1 бета-етил-1 алфа-хидроксиметил-1,2,3,4,6,7,12,12в алфа-октахидроиндоло(2,3-а)хинолизин,методза неговото получаване и съдържащи го фармацевтични състави BG60433B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU851519A HU194221B (en) 1985-04-19 1985-04-19 Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound

Publications (1)

Publication Number Publication Date
BG60433B2 true BG60433B2 (bg) 1995-03-31

Family

ID=10954847

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98290A BG60433B2 (bg) 1985-04-19 1993-12-10 (-)-1 бета-етил-1 алфа-хидроксиметил-1,2,3,4,6,7,12,12в алфа-октахидроиндоло(2,3-а)хинолизин,методза неговото получаване и съдържащи го фармацевтични състави

Country Status (35)

Country Link
US (1) US4806545A (de)
JP (1) JPH072637B2 (de)
CN (1) CN1023560C (de)
AR (1) AR240699A1 (de)
AT (1) AT390954B (de)
AU (1) AU591896B2 (de)
BE (1) BE904588A (de)
BG (1) BG60433B2 (de)
CA (1) CA1299574C (de)
CH (1) CH668262A5 (de)
CS (1) CS274276B2 (de)
DD (1) DD244556A5 (de)
DE (1) DE3613180C2 (de)
DK (1) DK159780C (de)
EG (1) EG18059A (de)
ES (1) ES8706152A1 (de)
FI (1) FI83870C (de)
FR (1) FR2580649B1 (de)
GB (1) GB2174701B (de)
GR (1) GR861027B (de)
HU (1) HU194221B (de)
IE (1) IE59199B1 (de)
IL (1) IL78538A (de)
IN (1) IN162810B (de)
IT (1) IT1204306B (de)
LU (1) LU86397A1 (de)
NL (1) NL8600976A (de)
NO (1) NO167143C (de)
NZ (1) NZ215879A (de)
PH (1) PH25316A (de)
PT (1) PT82424B (de)
SE (1) SE460196B (de)
SU (1) SU1438612A3 (de)
YU (1) YU44286B (de)
ZA (1) ZA862941B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
HU207070B (en) * 1990-10-31 1993-03-01 Richter Gedeon Vegyeszet Process for producing 1beta-ethyl-1alpha-hydroxymethyl-1,2,3,4,6,712,12balpha-octahydroindolo(2,3-a) quinolizine
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
IL164203A0 (en) * 2002-04-03 2005-12-18 Orion Corp Polycyclic compounds as potent alpah2-adrenoceptorantagonists
WO2003094917A1 (fr) * 2002-05-13 2003-11-20 Takata Seiyaku Co., Ltd. Composition medicinale contenant du vintoperol destinee a une administration transdermique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1499546A (en) * 1974-05-07 1978-02-01 Richter Gedeon Vegyeszet Indolo-quinolizidine derivatives and a process for the preparation thereof
HU170495B (de) * 1974-05-07 1977-06-28
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof

Also Published As

Publication number Publication date
NO167143C (no) 1991-10-09
FI83870B (fi) 1991-05-31
AU591896B2 (en) 1989-12-21
DD244556A5 (de) 1987-04-08
ZA862941B (en) 1986-12-30
PH25316A (en) 1991-04-30
NL8600976A (nl) 1986-11-17
NO167143B (no) 1991-07-01
IE861033L (en) 1986-10-19
SE8601799D0 (sv) 1986-04-18
DK159780C (da) 1991-04-22
DK179786A (da) 1986-10-20
SE460196B (sv) 1989-09-18
HUT40433A (en) 1986-12-28
PT82424A (en) 1986-05-01
AU5638386A (en) 1986-10-23
SU1438612A3 (ru) 1988-11-15
PT82424B (pt) 1988-03-03
YU44286B (en) 1990-04-30
IT1204306B (it) 1989-03-01
YU62486A (en) 1988-06-30
SE8601799L (sv) 1986-10-20
AR240699A1 (es) 1990-09-28
CN1023560C (zh) 1994-01-19
FI861641A (fi) 1986-10-20
CN86102479A (zh) 1986-10-22
GB2174701A (en) 1986-11-12
FR2580649B1 (fr) 1991-03-29
EG18059A (en) 1991-06-30
CH668262A5 (de) 1988-12-15
JPS61249986A (ja) 1986-11-07
FR2580649A1 (fr) 1986-10-24
DK159780B (da) 1990-12-03
FI861641A0 (fi) 1986-04-18
DE3613180A1 (de) 1986-10-23
AT390954B (de) 1990-07-25
ATA102986A (de) 1990-01-15
JPH072637B2 (ja) 1995-01-18
LU86397A1 (de) 1986-09-02
CA1299574C (en) 1992-04-28
GB2174701B (en) 1989-02-15
US4806545A (en) 1989-02-21
FI83870C (fi) 1991-09-10
IN162810B (de) 1988-07-09
IL78538A (en) 1989-10-31
GB8609533D0 (en) 1986-05-21
NZ215879A (en) 1989-04-26
CS286386A2 (en) 1990-09-12
ES8706152A1 (es) 1987-06-01
NO861539L (no) 1986-10-20
IT8620136A0 (it) 1986-04-18
DK179786D0 (da) 1986-04-18
IL78538A0 (en) 1986-08-31
DE3613180C2 (de) 1995-10-19
ES554143A0 (es) 1987-06-01
GR861027B (en) 1986-08-12
CS274276B2 (en) 1991-04-11
BE904588A (fr) 1986-10-14
IE59199B1 (en) 1994-01-26
HU194221B (en) 1988-01-28

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