DK179786A - (-)-1beta-ethyl-1alfa-hydroxylmethyl-1,2,3,4,6,7,12,12balfa-octa-hydroindolo(2,3-a)quinolizin og syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika - Google Patents

(-)-1beta-ethyl-1alfa-hydroxylmethyl-1,2,3,4,6,7,12,12balfa-octa-hydroindolo(2,3-a)quinolizin og syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika Download PDF

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Publication number
DK179786A
DK179786A DK179786A DK179786A DK179786A DK 179786 A DK179786 A DK 179786A DK 179786 A DK179786 A DK 179786A DK 179786 A DK179786 A DK 179786A DK 179786 A DK179786 A DK 179786A
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DK
Denmark
Prior art keywords
12balfa
hydroindolo
1alfa
quinolizin
hydroxylmethyl
Prior art date
Application number
DK179786A
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English (en)
Other versions
DK159780B (da
DK159780C (da
DK179786D0 (da
Inventor
Csaba Szantay
Lajos Szabo
Gyoergy Kalaus
Zsolt Szombathelyi
Egon Karpati
Bela Kiss
Csomor Katalin
Istvan Laszlovszky
Erzsebet Lapis
Laszlo Szporny
Lilla Forgacs
Csaba Kuthi
Aniko Gere
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK179786D0 publication Critical patent/DK179786D0/da
Publication of DK179786A publication Critical patent/DK179786A/da
Publication of DK159780B publication Critical patent/DK159780B/da
Application granted granted Critical
Publication of DK159780C publication Critical patent/DK159780C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Description

Figure DK179786AD00021
(Ha)
Figure DK179786AD00022
(Hb) hvor R^· er H, alkylcarbonyl eller eventuelt substitueret aryl- eller aralkylcarbonyl, efterfulgt af hydrolyse, hvis R1 ikke er H, og eventuelt omdannelse til et salt.
Forbindelsen (I) og dens salte er anvendelige til behandling af sygdomme, som har tilknytning til forstyrrelser i blod- og oxygentilførslen.
DK179786A 1985-04-19 1986-04-18 (-)-1beta-ethyl-1alfa-hydroxylmethyl-1,2,3,4,6,7,12,12balfa-octahydroindolo(2,3-a)quinolizin og syreadditionssalte deraf, dens fremstilling og farmaceutisk praeparat indeholdende den DK159780C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU851519A HU194221B (en) 1985-04-19 1985-04-19 Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU151985 1985-04-19

Publications (4)

Publication Number Publication Date
DK179786D0 DK179786D0 (da) 1986-04-18
DK179786A true DK179786A (da) 1986-10-20
DK159780B DK159780B (da) 1990-12-03
DK159780C DK159780C (da) 1991-04-22

Family

ID=10954847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK179786A DK159780C (da) 1985-04-19 1986-04-18 (-)-1beta-ethyl-1alfa-hydroxylmethyl-1,2,3,4,6,7,12,12balfa-octahydroindolo(2,3-a)quinolizin og syreadditionssalte deraf, dens fremstilling og farmaceutisk praeparat indeholdende den

Country Status (35)

Country Link
US (1) US4806545A (da)
JP (1) JPH072637B2 (da)
CN (1) CN1023560C (da)
AR (1) AR240699A1 (da)
AT (1) AT390954B (da)
AU (1) AU591896B2 (da)
BE (1) BE904588A (da)
BG (1) BG60433B2 (da)
CA (1) CA1299574C (da)
CH (1) CH668262A5 (da)
CS (1) CS274276B2 (da)
DD (1) DD244556A5 (da)
DE (1) DE3613180C2 (da)
DK (1) DK159780C (da)
EG (1) EG18059A (da)
ES (1) ES8706152A1 (da)
FI (1) FI83870C (da)
FR (1) FR2580649B1 (da)
GB (1) GB2174701B (da)
GR (1) GR861027B (da)
HU (1) HU194221B (da)
IE (1) IE59199B1 (da)
IL (1) IL78538A (da)
IN (1) IN162810B (da)
IT (1) IT1204306B (da)
LU (1) LU86397A1 (da)
NL (1) NL8600976A (da)
NO (1) NO167143C (da)
NZ (1) NZ215879A (da)
PH (1) PH25316A (da)
PT (1) PT82424B (da)
SE (1) SE460196B (da)
SU (1) SU1438612A3 (da)
YU (1) YU44286B (da)
ZA (1) ZA862941B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
HU207070B (en) * 1990-10-31 1993-03-01 Richter Gedeon Vegyeszet Process for producing 1beta-ethyl-1alpha-hydroxymethyl-1,2,3,4,6,712,12balpha-octahydroindolo(2,3-a) quinolizine
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
CA2480695A1 (en) * 2002-04-03 2003-10-09 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
JPWO2003094917A1 (ja) * 2002-05-13 2005-09-08 高田製薬株式会社 ビントペロール含有経皮投与用医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1499546A (en) * 1974-05-07 1978-02-01 Richter Gedeon Vegyeszet Indolo-quinolizidine derivatives and a process for the preparation thereof
HU170495B (da) * 1974-05-07 1977-06-28
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof

Also Published As

Publication number Publication date
DK159780B (da) 1990-12-03
NZ215879A (en) 1989-04-26
DK159780C (da) 1991-04-22
IT1204306B (it) 1989-03-01
YU44286B (en) 1990-04-30
LU86397A1 (da) 1986-09-02
EG18059A (en) 1991-06-30
PT82424A (en) 1986-05-01
IN162810B (da) 1988-07-09
NO167143B (no) 1991-07-01
AT390954B (de) 1990-07-25
GB2174701A (en) 1986-11-12
FI861641A0 (fi) 1986-04-18
CS274276B2 (en) 1991-04-11
IT8620136A0 (it) 1986-04-18
BE904588A (fr) 1986-10-14
HU194221B (en) 1988-01-28
CN1023560C (zh) 1994-01-19
AR240699A1 (es) 1990-09-28
AU5638386A (en) 1986-10-23
BG60433B2 (bg) 1995-03-31
JPH072637B2 (ja) 1995-01-18
ES8706152A1 (es) 1987-06-01
CN86102479A (zh) 1986-10-22
JPS61249986A (ja) 1986-11-07
IE861033L (en) 1986-10-19
NO167143C (no) 1991-10-09
IL78538A (en) 1989-10-31
FR2580649A1 (fr) 1986-10-24
GB2174701B (en) 1989-02-15
HUT40433A (en) 1986-12-28
AU591896B2 (en) 1989-12-21
NL8600976A (nl) 1986-11-17
DD244556A5 (de) 1987-04-08
FI83870C (fi) 1991-09-10
ES554143A0 (es) 1987-06-01
GB8609533D0 (en) 1986-05-21
CH668262A5 (de) 1988-12-15
YU62486A (en) 1988-06-30
ZA862941B (en) 1986-12-30
DE3613180C2 (de) 1995-10-19
NO861539L (no) 1986-10-20
SU1438612A3 (ru) 1988-11-15
IE59199B1 (en) 1994-01-26
ATA102986A (de) 1990-01-15
SE8601799D0 (sv) 1986-04-18
PH25316A (en) 1991-04-30
FI861641A (fi) 1986-10-20
FI83870B (fi) 1991-05-31
CS286386A2 (en) 1990-09-12
CA1299574C (en) 1992-04-28
PT82424B (pt) 1988-03-03
US4806545A (en) 1989-02-21
GR861027B (en) 1986-08-12
DE3613180A1 (de) 1986-10-23
SE460196B (sv) 1989-09-18
SE8601799L (sv) 1986-10-20
IL78538A0 (en) 1986-08-31
FR2580649B1 (fr) 1991-03-29
DK179786D0 (da) 1986-04-18

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