BG60102A3 - Method for preparing of 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridyl)methyl]thionyl]-1h-ben zimidazole - Google Patents

Method for preparing of 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridyl)methyl]thionyl]-1h-ben zimidazole

Info

Publication number
BG60102A3
BG60102A3 BG94659A BG9465991A BG60102A3 BG 60102 A3 BG60102 A3 BG 60102A3 BG 94659 A BG94659 A BG 94659A BG 9465991 A BG9465991 A BG 9465991A BG 60102 A3 BG60102 A3 BG 60102A3
Authority
BG
Bulgaria
Prior art keywords
cyclopropylmethoxy
thionyl
pyridyl
fluoro
methyl
Prior art date
Application number
BG94659A
Other languages
English (en)
Inventor
Arne E Braendstroem
Per L Lindberg
Gunnel E Sunden
Original Assignee
Se Ab Haessle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Se Ab Haessle filed Critical Se Ab Haessle
Publication of BG60102A3 publication Critical patent/BG60102A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG94659A 1988-12-22 1991-06-19 Method for preparing of 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridyl)methyl]thionyl]-1h-ben zimidazole BG60102A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (1)

Publication Number Publication Date
BG60102A3 true BG60102A3 (en) 1993-10-15

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
BG94659A BG60102A3 (en) 1988-12-22 1991-06-19 Method for preparing of 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridyl)methyl]thionyl]-1h-ben zimidazole

Country Status (32)

Country Link
US (2) US5008278A (hr)
EP (1) EP0449940B1 (hr)
JP (1) JP2793906B2 (hr)
KR (1) KR910700249A (hr)
CN (1) CN1028231C (hr)
AR (1) AR248136A1 (hr)
AT (1) ATE127799T1 (hr)
AU (1) AU634741B2 (hr)
BG (1) BG60102A3 (hr)
CA (1) CA2005986C (hr)
DD (2) DD296079A5 (hr)
DE (1) DE68924273T2 (hr)
DK (1) DK170800B1 (hr)
EG (1) EG19303A (hr)
FI (2) FI913035A0 (hr)
GR (1) GR1002252B (hr)
HR (1) HRP920831A2 (hr)
HU (2) HU205927B (hr)
IE (1) IE894048L (hr)
IL (1) IL92798A0 (hr)
LT (2) LT3914B (hr)
LV (1) LV10187B (hr)
NZ (1) NZ231872A (hr)
PH (1) PH27400A (hr)
PL (1) PL161150B1 (hr)
PT (1) PT92648B (hr)
RO (1) RO110494B1 (hr)
RU (2) RU2073676C1 (hr)
SE (1) SE8804629D0 (hr)
WO (1) WO1990006925A1 (hr)
YU (1) YU46806B (hr)
ZA (2) ZA899794B (hr)

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SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
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US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
WO1999053918A1 (fr) * 1998-04-20 1999-10-28 Eisai Co., Ltd. Compositions stabilisees contenant des composes du type benzimidazole
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
DK1222922T3 (da) 1999-10-20 2007-12-03 Eisai R&D Man Co Ltd Fremgangsmåde til stabilisering af benzimidazolforbindelser
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
CA2472103A1 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
EP1487820A1 (en) * 2002-03-26 2004-12-22 Dr. Reddy's Laboratories Ltd. Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
CA2517005A1 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
US20050031700A1 (en) * 2003-07-18 2005-02-10 Sanatarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AR045062A1 (es) * 2003-07-18 2005-10-12 Santarus Inc Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas
JP4919801B2 (ja) 2003-09-26 2012-04-18 アルザ・コーポレーシヨン 高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
DK2046334T3 (da) 2006-07-25 2014-08-25 Vecta Ltd Sammensætninger og fremgangsmåder til at hæmme mavesyresekretion ved at anvende derivater af små dicarboxylsyrer i kombination med PPI
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP2344139A1 (en) 2008-09-09 2011-07-20 AstraZeneca AB Method for delivering a pharmaceutical composition to patient in need thereof
EA201290026A1 (ru) 2009-06-25 2012-07-30 Астразенека Аб Способ лечения пациента, имеющего риск развития язвы, связанной с приемом нестероидных противовоспалительных средств (nsaid)
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico

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SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
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JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
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JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ222495A (en) * 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
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JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
CA2005986A1 (en) 1990-06-22
CA2005986C (en) 1999-08-03
LTIP1726A (en) 1995-07-25
AR248136A1 (es) 1995-06-30
EP0449940A1 (en) 1991-10-09
KR910700249A (ko) 1991-03-14
NZ231872A (en) 1992-03-26
JPH04502461A (ja) 1992-05-07
HUT57202A (en) 1991-11-28
DD296079A5 (de) 1991-11-21
PH27400A (en) 1993-06-21
ZA899794B (en) 1990-08-29
DE68924273D1 (de) 1995-10-19
GR1002252B (en) 1996-04-23
US5039808A (en) 1991-08-13
DD296078A5 (de) 1991-11-21
WO1990006925A1 (en) 1990-06-28
SE8804629D0 (sv) 1988-12-22
LT3980B (en) 1996-06-25
AU634741B2 (en) 1993-03-04
DK170800B1 (da) 1996-01-22
PT92648B (pt) 1995-09-12
FI954768A (fi) 1995-10-06
YU242689A (en) 1991-04-30
AU4817590A (en) 1990-07-10
FI913035A0 (fi) 1991-06-20
DK122291D0 (da) 1991-06-21
GR890100838A (el) 1991-03-15
JP2793906B2 (ja) 1998-09-03
RO110494B1 (ro) 1996-01-30
SE8804629A (hr) 1988-12-22
LT3914B (en) 1996-04-25
YU46806B (sh) 1994-06-10
HRP920831A2 (en) 1995-12-31
HU205926B (en) 1992-07-28
CN1028231C (zh) 1995-04-19
FI954768A0 (fi) 1995-10-06
LV10187B (en) 1995-04-20
ZA899795B (en) 1990-08-29
HU205927B (en) 1992-07-28
US5008278A (en) 1991-04-16
PL161150B1 (en) 1993-05-31
RU2042673C1 (ru) 1995-08-27
EG19303A (en) 1994-11-30
PT92648A (pt) 1990-06-29
IL92798A0 (en) 1990-09-17
HU901084D0 (en) 1991-09-30
RU2073676C1 (ru) 1997-02-20
LV10187A (lv) 1994-10-20
LTIP1721A (en) 1995-07-25
EP0449940B1 (en) 1995-09-13
CN1043713A (zh) 1990-07-11
ATE127799T1 (de) 1995-09-15
IE894048L (en) 1990-06-22
DK122291A (da) 1991-06-24
DE68924273T2 (de) 1996-02-15

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