BG108098A - 3-(4-амидопирол-2-илметлиден)-2-индолинонови производни като инхибитори на протеин киназа - Google Patents

3-(4-амидопирол-2-илметлиден)-2-индолинонови производни като инхибитори на протеин киназа Download PDF

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Publication number
BG108098A
BG108098A BG108098A BG10809803A BG108098A BG 108098 A BG108098 A BG 108098A BG 108098 A BG108098 A BG 108098A BG 10809803 A BG10809803 A BG 10809803A BG 108098 A BG108098 A BG 108098A
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BG
Bulgaria
Prior art keywords
oxo
dihydro
methyl
pyrrole
dimethyl
Prior art date
Application number
BG108098A
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Bulgarian (bg)
English (en)
Inventor
Huiping Guan
Congxin Liang
Li Sun
Peng Tang
Chung Wei
Michael Mauragis
Tomas Vojkovsky
Qingwu Jin
Paul Herrington
Original Assignee
Sugen, Inc
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Sugen, Inc, Pharmacia & Upjohn Company filed Critical Sugen, Inc
Publication of BG108098A publication Critical patent/BG108098A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG108098A 2001-02-15 2003-08-15 3-(4-амидопирол-2-илметлиден)-2-индолинонови производни като инхибитори на протеин киназа BG108098A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26868301P 2001-02-15 2001-02-15
US31236101P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
BG108098A true BG108098A (bg) 2005-12-30

Family

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Family Applications (1)

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BG108098A BG108098A (bg) 2001-02-15 2003-08-15 3-(4-амидопирол-2-илметлиден)-2-индолинонови производни като инхибитори на протеин киназа

Country Status (41)

Country Link
US (4) US6653308B2 (is)
EP (1) EP1370554B1 (is)
JP (1) JP3677501B2 (is)
KR (1) KR100884858B1 (is)
CN (1) CN100338059C (is)
AP (1) AP1718A (is)
AR (1) AR042586A1 (is)
AT (1) ATE307128T1 (is)
AU (1) AU2002247133B2 (is)
BG (1) BG108098A (is)
BR (1) BR0207494A (is)
CA (1) CA2438314C (is)
CR (1) CR7056A (is)
CZ (1) CZ20032414A3 (is)
DE (1) DE60206736T2 (is)
DK (1) DK1370554T3 (is)
EA (1) EA007186B1 (is)
EE (1) EE200300385A (is)
ES (1) ES2251580T3 (is)
GE (1) GEP20053600B (is)
HK (1) HK1059621A1 (is)
HR (1) HRP20030657B1 (is)
HU (1) HUP0303146A3 (is)
IL (2) IL157418A0 (is)
IS (1) IS2411B (is)
MA (1) MA26997A1 (is)
MX (1) MXPA03007367A (is)
MY (1) MY126235A (is)
NO (1) NO326604B1 (is)
NZ (1) NZ527572A (is)
OA (1) OA12834A (is)
PE (1) PE20021006A1 (is)
PL (1) PL364176A1 (is)
RS (1) RS51026B (is)
SI (1) SI1370554T1 (is)
SK (1) SK11332003A3 (is)
TN (1) TNSN03055A1 (is)
TW (1) TWI324155B (is)
UA (1) UA75635C2 (is)
WO (1) WO2002066463A1 (is)
ZA (2) ZA200306335B (is)

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