AU758240B2 - Enhancing the circulating half-life of antibody-based fusion proteins - Google Patents

Enhancing the circulating half-life of antibody-based fusion proteins Download PDF

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Publication number
AU758240B2
AU758240B2 AU27842/99A AU2784299A AU758240B2 AU 758240 B2 AU758240 B2 AU 758240B2 AU 27842/99 A AU27842/99 A AU 27842/99A AU 2784299 A AU2784299 A AU 2784299A AU 758240 B2 AU758240 B2 AU 758240B2
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AU
Australia
Prior art keywords
xaa xaa
antibody
protein
fusion protein
based fusion
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Ceased
Application number
AU27842/99A
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AU2784299A (en
Inventor
Stephen D. Gillies
Yan Lan
Kin-Ming Lo
John Wesolowski
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Merck Patent GmbH
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Lexigen Pharmaceuticals Corp
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Publication of AU2784299A publication Critical patent/AU2784299A/en
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Publication of AU758240B2 publication Critical patent/AU758240B2/en
Assigned to MERCK PATENT GMBH reassignment MERCK PATENT GMBH Alteration of Name(s) in Register under S187 Assignors: LEXIGEN PHARMACEUTICALS CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU27842/99A 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins Ceased AU758240B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7588798P 1998-02-25 1998-02-25
US60/075887 1998-02-25
PCT/US1999/003966 WO1999043713A1 (en) 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins

Publications (2)

Publication Number Publication Date
AU2784299A AU2784299A (en) 1999-09-15
AU758240B2 true AU758240B2 (en) 2003-03-20

Family

ID=22128576

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27842/99A Ceased AU758240B2 (en) 1998-02-25 1999-02-24 Enhancing the circulating half-life of antibody-based fusion proteins

Country Status (11)

Country Link
EP (1) EP1060194A1 (https=)
JP (1) JP2002505086A (https=)
CN (1) CN1204147C (https=)
AU (1) AU758240B2 (https=)
BR (1) BR9908226A (https=)
CA (1) CA2320403A1 (https=)
CZ (1) CZ20003099A3 (https=)
HU (1) HUP0100813A3 (https=)
NO (1) NO20004218L (https=)
PL (1) PL199659B1 (https=)
WO (1) WO1999043713A1 (https=)

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