CN1204147C - 提高以抗体为基础的融合蛋白的循环半衰期的方法 - Google Patents

提高以抗体为基础的融合蛋白的循环半衰期的方法 Download PDF

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Publication number
CN1204147C
CN1204147C CN99803277.8A CN99803277A CN1204147C CN 1204147 C CN1204147 C CN 1204147C CN 99803277 A CN99803277 A CN 99803277A CN 1204147 C CN1204147 C CN 1204147C
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CN1291995A (zh
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S·D·吉利斯
劳健明
兰燕
J·维索洛夫斯基
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Lexigen Pharmaceuticals Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN99803277.8A 1998-02-25 1999-02-24 提高以抗体为基础的融合蛋白的循环半衰期的方法 Expired - Fee Related CN1204147C (zh)

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US7588798P 1998-02-25 1998-02-25
US60/075,887 1998-02-25

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CN1291995A CN1291995A (zh) 2001-04-18
CN1204147C true CN1204147C (zh) 2005-06-01

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CN99803277.8A Expired - Fee Related CN1204147C (zh) 1998-02-25 1999-02-24 提高以抗体为基础的融合蛋白的循环半衰期的方法

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EP (1) EP1060194A1 (https=)
JP (1) JP2002505086A (https=)
CN (1) CN1204147C (https=)
AU (1) AU758240B2 (https=)
BR (1) BR9908226A (https=)
CA (1) CA2320403A1 (https=)
CZ (1) CZ20003099A3 (https=)
HU (1) HUP0100813A3 (https=)
NO (1) NO20004218L (https=)
PL (1) PL199659B1 (https=)
WO (1) WO1999043713A1 (https=)

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