AU664237B2 - {(benzodioxan, benzofuran or benzopyran)-alkylamino} alkyl substituted guanidines as selective vascoconstrictors - Google Patents
{(benzodioxan, benzofuran or benzopyran)-alkylamino} alkyl substituted guanidines as selective vascoconstrictors Download PDFInfo
- Publication number
- AU664237B2 AU664237B2 AU34991/93A AU3499193A AU664237B2 AU 664237 B2 AU664237 B2 AU 664237B2 AU 34991/93 A AU34991/93 A AU 34991/93A AU 3499193 A AU3499193 A AU 3499193A AU 664237 B2 AU664237 B2 AU 664237B2
- Authority
- AU
- Australia
- Prior art keywords
- formula
- hydrogen
- alk
- amino
- benzopyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Phenolic Resins Or Amino Resins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84256092A | 1992-02-27 | 1992-02-27 | |
| US842560 | 1992-02-27 | ||
| PCT/EP1993/000435 WO1993017017A1 (en) | 1992-02-27 | 1993-02-19 | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3499193A AU3499193A (en) | 1993-09-13 |
| AU664237B2 true AU664237B2 (en) | 1995-11-09 |
Family
ID=25287639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU34991/93A Expired AU664237B2 (en) | 1992-02-27 | 1993-02-19 | {(benzodioxan, benzofuran or benzopyran)-alkylamino} alkyl substituted guanidines as selective vascoconstrictors |
Country Status (37)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282108B6 (sk) * | 1993-08-19 | 2001-11-06 | Janssen Pharmaceutica N. V. | Substituované dihydropyranopyridíny, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky na ich báze |
| ATE256130T1 (de) * | 1993-08-19 | 2003-12-15 | Janssen Pharmaceutica Nv | Gefässverengende dihydrobenzopyranderivate |
| PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
| HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
| FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
| ES2169102T3 (es) * | 1994-10-14 | 2002-07-01 | Merck Patent Gmbh | (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central. |
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| KR19990021931A (ko) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | 미세구형 전분의 항편두통 조성물 |
| FR2752735B1 (fr) * | 1996-09-05 | 1998-10-02 | Synthelabo | Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux |
| TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| RU2134108C1 (ru) * | 1998-10-06 | 1999-08-10 | Заславская Рина Михайловна | Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии |
| FR2787789B1 (fr) * | 1998-12-29 | 2002-06-14 | Lipha | Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations |
| KR100702526B1 (ko) * | 1999-06-02 | 2007-04-04 | 얀센 파마슈티카 엔.브이. | 피롤리디닐, 피페리디닐 또는 호모피페리디닐 치환된(벤조디옥산, 벤조푸란 또는 벤조피란) 유도체 |
| UA73122C2 (en) * | 1999-06-02 | 2005-06-15 | Janssen Pharmaceutica Nv | Derivatives of benzodioxane, benzofuran or benzopyran substituted by aminoalkyl |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| JO2352B1 (en) * | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| WO2002044159A2 (en) * | 2000-11-29 | 2002-06-06 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence |
| MXPA03007621A (es) * | 2001-02-23 | 2003-12-04 | Merck & Co Inc | Antagonistas nr2b de n-metil-d-aspartato no arilheterociclicos n-sustituidos. |
| ATE352302T1 (de) | 2001-07-26 | 2007-02-15 | Merck Patent Gmbh | Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze |
| DE60211186T2 (de) * | 2001-09-19 | 2007-01-18 | Merck Patent Gmbh | Neue verwendung substituierter aminomethylchromane |
| EP1594558A1 (en) * | 2003-01-31 | 2005-11-16 | Zimmer Orthobiologics, Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| ZA200507112B (en) * | 2003-03-31 | 2007-03-28 | Taisho Pharmaceutical Co Ltd | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| US20050197350A1 (en) * | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| CN105061392B (zh) * | 2015-07-20 | 2017-07-18 | 上海现代哈森（商丘）药业有限公司 | 一种硫酸胍生合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| AU5314894A (en) * | 1993-02-09 | 1994-08-11 | Bayer Aktiengesellschaft | Novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1366479A (fr) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels |
| NL296841A (enExample) * | 1962-08-20 | |||
| FR1366472A (fr) * | 1962-09-29 | 1964-07-10 | Glaverbel | Dispositif pour la fabrication du verre en feuille |
| GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GR71865B (enExample) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
| US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
| FR2524887A1 (fr) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
| CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| WO1994017017A1 (en) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Benzene removal from gasoline boiling range streams |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/sl unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-19 ES ES93904017T patent/ES2087721T3/es not_active Expired - Lifetime
- 1993-02-19 AT AT93904017T patent/ATE138064T1/de active
- 1993-02-19 JP JP5514541A patent/JP2779268B2/ja not_active Expired - Lifetime
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/cs unknown
- 1993-02-19 EP EP93904017A patent/EP0639192B1/en not_active Expired - Lifetime
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-19 CA CA002117483A patent/CA2117483C/en not_active Expired - Lifetime
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/ko not_active Expired - Lifetime
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/en not_active Ceased
- 1993-02-19 SK SK1029-94A patent/SK280166B6/sk not_active IP Right Cessation
- 1993-02-19 NZ NZ249124A patent/NZ249124A/xx not_active IP Right Cessation
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/da active
- 1993-02-19 PL PL93304902A patent/PL174736B1/pl unknown
- 1993-02-19 DE DE69302687T patent/DE69302687T2/de not_active Expired - Lifetime
- 1993-02-19 RO RO94-01432A patent/RO115630B1/ro unknown
- 1993-02-19 RU RU94041210A patent/RU2121999C1/ru active
- 1993-02-19 HU HU9402464A patent/HU222495B1/hu active IP Right Grant
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/es unknown
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/xx not_active IP Right Cessation
- 1993-02-26 ZA ZA931404A patent/ZA931404B/xx unknown
- 1993-02-26 CN CN93103671A patent/CN1038032C/zh not_active Expired - Lifetime
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-26 LT LTIP367A patent/LT3049B/lt not_active IP Right Cessation
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
-
1994
- 1994-06-24 BG BG98870A patent/BG62052B1/bg unknown
- 1994-08-19 OA OA60555A patent/OA10095A/fr unknown
- 1994-08-26 FI FI943928A patent/FI109122B/fi not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/no not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/xx unknown
-
1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/hu unknown
-
1996
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
| AU5314894A (en) * | 1993-02-09 | 1994-08-11 | Bayer Aktiengesellschaft | Novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid |
Also Published As
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