DK0639192T3 - (Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning - Google Patents

(Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning

Info

Publication number
DK0639192T3
DK0639192T3 DK93904017.6T DK93904017T DK0639192T3 DK 0639192 T3 DK0639192 T3 DK 0639192T3 DK 93904017 T DK93904017 T DK 93904017T DK 0639192 T3 DK0639192 T3 DK 0639192T3
Authority
DK
Denmark
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkyl substituted
alkylamino alkyl
Prior art date
Application number
DK93904017.6T
Other languages
Danish (da)
English (en)
Inventor
Guy Rosalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0639192T3 publication Critical patent/DK0639192T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
DK93904017.6T 1992-02-27 1993-02-19 (Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning DK0639192T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27

Publications (1)

Publication Number Publication Date
DK0639192T3 true DK0639192T3 (da) 1996-08-19

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93904017.6T DK0639192T3 (da) 1992-02-27 1993-02-19 (Benzodioxan, benzofuran eller benzopyran)alkylamino alkyl substituerede guanidiner med selektiv karsammentrækkende virkning

Country Status (37)

Country Link
US (4) US5541180A (enExample)
EP (1) EP0639192B1 (enExample)
JP (1) JP2779268B2 (enExample)
KR (1) KR100190300B1 (enExample)
CN (1) CN1038032C (enExample)
AP (1) AP416A (enExample)
AT (1) ATE138064T1 (enExample)
AU (1) AU664237B2 (enExample)
BG (1) BG62052B1 (enExample)
CA (1) CA2117483C (enExample)
CZ (1) CZ282092B6 (enExample)
DE (1) DE69302687T2 (enExample)
DK (1) DK0639192T3 (enExample)
EE (1) EE03029B1 (enExample)
ES (1) ES2087721T3 (enExample)
FI (1) FI109122B (enExample)
GR (1) GR3019927T3 (enExample)
HR (1) HRP930235B1 (enExample)
HU (2) HU222495B1 (enExample)
IL (1) IL104868A (enExample)
LT (1) LT3049B (enExample)
LV (1) LV10715B (enExample)
MX (1) MX9301053A (enExample)
MY (1) MY110627A (enExample)
NO (1) NO306255B1 (enExample)
NZ (1) NZ249124A (enExample)
OA (1) OA10095A (enExample)
PH (1) PH31295A (enExample)
PL (1) PL174736B1 (enExample)
RO (1) RO115630B1 (enExample)
RU (1) RU2121999C1 (enExample)
SG (1) SG47763A1 (enExample)
SI (1) SI9300097B (enExample)
SK (1) SK280166B6 (enExample)
TW (1) TW225531B (enExample)
WO (1) WO1993017017A1 (enExample)
ZA (1) ZA931404B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282108B6 (sk) * 1993-08-19 2001-11-06 Janssen Pharmaceutica N. V. Substituované dihydropyranopyridíny, spôsob a medziprodukty na ich výrobu a farmaceutické prostriedky na ich báze
ATE256130T1 (de) * 1993-08-19 2003-12-15 Janssen Pharmaceutica Nv Gefässverengende dihydrobenzopyranderivate
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
ES2169102T3 (es) * 1994-10-14 2002-07-01 Merck Patent Gmbh (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central.
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
KR19990021931A (ko) * 1995-06-08 1999-03-25 디르크 반테 미세구형 전분의 항편두통 조성물
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
RU2134108C1 (ru) * 1998-10-06 1999-08-10 Заславская Рина Михайловна Средство для лечения артериальной гипертонии, способ лечения артериальной гипертонии
FR2787789B1 (fr) * 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
KR100702526B1 (ko) * 1999-06-02 2007-04-04 얀센 파마슈티카 엔.브이. 피롤리디닐, 피페리디닐 또는 호모피페리디닐 치환된(벤조디옥산, 벤조푸란 또는 벤조피란) 유도체
UA73122C2 (en) * 1999-06-02 2005-06-15 Janssen Pharmaceutica Nv Derivatives of benzodioxane, benzofuran or benzopyran substituted by aminoalkyl
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
WO2002044159A2 (en) * 2000-11-29 2002-06-06 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence
MXPA03007621A (es) * 2001-02-23 2003-12-04 Merck & Co Inc Antagonistas nr2b de n-metil-d-aspartato no arilheterociclicos n-sustituidos.
ATE352302T1 (de) 2001-07-26 2007-02-15 Merck Patent Gmbh Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze
DE60211186T2 (de) * 2001-09-19 2007-01-18 Merck Patent Gmbh Neue verwendung substituierter aminomethylchromane
EP1594558A1 (en) * 2003-01-31 2005-11-16 Zimmer Orthobiologics, Inc. Hydrogel compositions comprising nucleus pulposus tissue
ZA200507112B (en) * 2003-03-31 2007-03-28 Taisho Pharmaceutical Co Ltd Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
US20050197350A1 (en) * 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
NL296841A (enExample) * 1962-08-20
FR1366472A (fr) * 1962-09-29 1964-07-10 Glaverbel Dispositif pour la fabrication du verre en feuille
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
GR71865B (enExample) * 1978-03-20 1983-07-07 Ciba Geigy
US4405922A (en) * 1979-05-23 1983-09-20 Hitachi Koki Company, Limited Failure detection circuit for impact printers or the like
US4405622A (en) * 1980-10-16 1983-09-20 Syntex (U.S.A.) Inc. [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants
FR2524887A1 (fr) * 1982-04-08 1983-10-14 Bouchara Emile Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
CA2011899A1 (en) * 1989-03-13 1990-09-13 Masaaki Toda Benzopyran derivatives
WO1994017017A1 (en) * 1991-07-15 1994-08-04 Exxon Research And Engineering Company Benzene removal from gasoline boiling range streams
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
IL104868A (en) 1998-01-04
BG62052B1 (bg) 1999-01-29
MX9301053A (es) 1994-03-31
EE03029B1 (et) 1997-08-15
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
OA10095A (en) 1996-12-18
PH31295A (en) 1998-07-06
NZ249124A (en) 1995-08-28
SI9300097A (en) 1993-09-30
BG98870A (bg) 1995-03-31
SG47763A1 (en) 1998-04-17
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
CN1079470A (zh) 1993-12-15
WO1993017017A1 (en) 1993-09-02
IL104868A0 (en) 1993-06-10
LV10715A (lv) 1995-06-20
GR3019927T3 (en) 1996-08-31
HU222495B1 (hu) 2003-07-28
ATE138064T1 (de) 1996-06-15
MY110627A (en) 1998-09-30
NO943186D0 (no) 1994-08-29
US5607949A (en) 1997-03-04
HUT71129A (en) 1995-11-28
CA2117483A1 (en) 1993-09-02
RU94041210A (ru) 1996-07-10
EP0639192B1 (en) 1996-05-15
SK102994A3 (en) 1995-07-11
AP9300493A0 (en) 1993-04-30
JPH07504408A (ja) 1995-05-18
CA2117483C (en) 2001-01-09
AP416A (en) 1995-09-29
HRP930235A2 (en) 1997-10-31
AU3499193A (en) 1993-09-13
TW225531B (enExample) 1994-06-21
PL174736B1 (pl) 1998-09-30
ZA931404B (en) 1994-08-26
LV10715B (en) 1995-12-20
DE69302687T2 (de) 1996-11-14
JP2779268B2 (ja) 1998-07-23
HRP930235B1 (en) 1999-04-30
US5624952A (en) 1997-04-29
HU9402464D0 (en) 1994-10-28
RO115630B1 (ro) 2000-04-28
US5541180A (en) 1996-07-30
LT3049B (en) 1994-10-25
FI109122B (fi) 2002-05-31
CS202094A3 (en) 1995-01-18
ES2087721T3 (es) 1996-07-16
SI9300097B (en) 2001-12-31
AU664237B2 (en) 1995-11-09
SK280166B6 (sk) 1999-09-10
DE69302687D1 (de) 1996-06-20
NO306255B1 (no) 1999-10-11
NO943186L (no) 1994-08-29
CZ282092B6 (cs) 1997-05-14
FI943928A7 (fi) 1994-08-26
US5688952A (en) 1997-11-18
CN1038032C (zh) 1998-04-15
FI943928A0 (fi) 1994-08-26
RU2121999C1 (ru) 1998-11-20

Similar Documents

Publication Publication Date Title
NO306255B1 (no) [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer
NO20002074L (no) (Benzodioksan, benzofuran eller benzopyran) derivater med fundus avslappende egenskaper
FI891345A7 (fi) Snabbkopplingsstycke foer felxibla tuber eller tubroer med konisk spaerring.
FI931360A0 (fi) System foer icke-joniska ytaktiva substanser, vilka innehaoller polyhydroxifettsyraamider och en eller flere ytterligare icke-jonisk ytaktiv substans
DK344485A (da) Anvendelse af chromanderivater
DK344585A (da) Anvendelse af chromanderivater
NO912874L (no) Fremgangsmaate for fremstilling av nye carbocykliske analoger av visse nucleosider.
KR950700288A (ko) 5-에이취티4 길항제로서의 벤조피란, 벤조티오피란 및 벤조푸란 유도체(Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists)
FI832483A0 (fi) Foerfarande baserande sig pao eklodning med ultraljud, foer att foelja med banbildning och/eller massasuspensionstroemmen pao en pappersmaskins viradel och/eller i inloppslaodan samt anvaendning afoerfarandet eller anordningen
FI901480A0 (fi) Inriktning av glasskiva med avseende pao boejningsredskap och/eller andra vaermebehandlingar.
FI89980C (fi) Anordning foer att paoverka en materialbana med luft eller ett annat stroemmande medium
DK1187829T3 (da) Aminoalkylsubstituerede (benzodioxan, benzofuran eller benzopyran) derivater
FI882770A0 (fi) Foerfarande och anordning foer klyvning eller avskaerning av styvt, skaerbart gods, saerskilt virke.
FI894368L (fi) Rekombinationssystem foer expression av en kolera b-underenhet med hjaelp av fraemmande promotorer och/eller huvudpeptider.
DK622089A (da) Benzopyranderivater
FI930895A7 (fi) Saett att operera med en traodstyrd, i luft eller vatten roerlig farkost och en anordning foer att genomfoera saettet
FI915300A0 (fi) Foerfarande och system foer att motverka marinbiologisk tillvaext pao ett fartygsskrov eller en undervattenskonstruktion.
FI894254A7 (fi) Oeverdragna baerare med ultratunt av ett eller flera skikt bestaoende oeverdrag, foerfarande foer deras framstaellning och polyestrar anvaenda saosom mellanprodukter vid framstaellningen av de oeverdragna baerarna.
NO862664D0 (no) Stablebart brett eller trau.
DK366282A (da) Furan-chromonderivater
FI894572L (fi) Stoedvals foer transportband, processband eller pressar vid sk. dubbelbandspressar.
FI880039A0 (fi) Betongvikt med inbaeddade eller faestade anoder foer katodiskt skydd av bultar och bultfoerbindningar.
FI882727A7 (fi) Foerfarande och anordning foer att avlaegsna skinnet pao ett djur eller flao ett djur.
DK442486A (da) Benzopyranderivater
FI880804A0 (fi) Betongprodukt eller -konstruktion belagd med en soemloes keramisk eller metallisk ytbelaeggning och foerfarande foer dess framstaellning.