AU578724B2 - Dihydropyridines and their preparation and pharmaceutical formulation - Google Patents

Dihydropyridines and their preparation and pharmaceutical formulation

Info

Publication number
AU578724B2
AU578724B2 AU46576/85A AU4657685A AU578724B2 AU 578724 B2 AU578724 B2 AU 578724B2 AU 46576/85 A AU46576/85 A AU 46576/85A AU 4657685 A AU4657685 A AU 4657685A AU 578724 B2 AU578724 B2 AU 578724B2
Authority
AU
Australia
Prior art keywords
acid
compounds
formula
ester
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU46576/85A
Other languages
English (en)
Other versions
AU4657685A (en
Inventor
Alan David Borthwick
Giovanni Gaviraghi
Dino Micheli
Daniele Pieraccioli
Claudio Semeraro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo SpA filed Critical Glaxo SpA
Publication of AU4657685A publication Critical patent/AU4657685A/en
Application granted granted Critical
Publication of AU578724B2 publication Critical patent/AU578724B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
AU46576/85A 1984-08-22 1985-08-22 Dihydropyridines and their preparation and pharmaceutical formulation Expired AU578724B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT22383/84 1984-08-22
IT21460/85 1985-07-05
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (2)

Publication Number Publication Date
AU4657685A AU4657685A (en) 1986-02-27
AU578724B2 true AU578724B2 (en) 1988-11-03

Family

ID=26327905

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46576/85A Expired AU578724B2 (en) 1984-08-22 1985-08-22 Dihydropyridines and their preparation and pharmaceutical formulation

Country Status (33)

Country Link
US (2) US4801599A (enExample)
JP (2) JPS6193162A (enExample)
KR (1) KR920004482B1 (enExample)
AT (1) AT394042B (enExample)
AU (1) AU578724B2 (enExample)
BE (1) BE903103A (enExample)
BG (1) BG60409B2 (enExample)
CA (1) CA1268180A (enExample)
CH (1) CH666684A5 (enExample)
CS (1) CS403091A3 (enExample)
CY (1) CY1494A (enExample)
DE (1) DE3529997C2 (enExample)
DK (1) DK165949C (enExample)
ES (5) ES8703839A1 (enExample)
FI (1) FI81568C (enExample)
FR (1) FR2569402B1 (enExample)
GB (1) GB2164336B (enExample)
GR (1) GR852016B (enExample)
HK (1) HK52990A (enExample)
HU (1) HU196754B (enExample)
IE (1) IE58486B1 (enExample)
LU (2) LU86047A1 (enExample)
MX (1) MX159974A (enExample)
NL (2) NL193065C (enExample)
NO (2) NO167142C (enExample)
NZ (1) NZ212895A (enExample)
PH (1) PH22014A (enExample)
PT (1) PT81000B (enExample)
SA (1) SA91120277B1 (enExample)
SE (1) SE459920B (enExample)
SG (1) SG40889G (enExample)
SK (1) SK278327B6 (enExample)
ZW (1) ZW13185A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588352B2 (en) * 1985-08-21 1989-09-14 Glaxo S.P.A. 4-phenyl-1,4-dihydro-3,5-pyridine dicarboxylic acid derivatives

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
US5102709A (en) 1989-04-27 1992-04-07 Canon Kabushiki Kaisha Optical recording medium and process for production thereof
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
EA200500234A1 (ru) 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
SG141430A1 (en) * 2003-05-30 2008-04-28 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CA2574958A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
WO2006113309A1 (en) 2005-04-15 2006-10-26 Dr. Reddy's Laboratories Ltd. Lacidipine particles
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
WO2007050783A2 (en) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
BRPI0618379A2 (pt) * 2005-11-08 2011-08-30 Ranbaxy Lab Ltd processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
AU2007274724B2 (en) * 2006-07-14 2012-07-26 Ranbaxy Laboratories Limited Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
ITMI20131485A1 (it) 2012-09-10 2014-03-11 Rivopharm Sa Composizione farmaceutica comprendente lacipidina e processo di preparazione
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588352B2 (en) * 1985-08-21 1989-09-14 Glaxo S.P.A. 4-phenyl-1,4-dihydro-3,5-pyridine dicarboxylic acid derivatives

Also Published As

Publication number Publication date
JPS6479152A (en) 1989-03-24
KR870002073A (ko) 1987-03-28
FI853206L (fi) 1986-02-23
NL193065C (nl) 1998-09-08
LU86047A1 (fr) 1986-02-28
ZW13185A1 (en) 1986-03-19
LU88267I2 (enExample) 1994-02-03
SG40889G (en) 1989-12-22
NL193065B (nl) 1998-05-06
NL980037I1 (nl) 1999-02-01
JPH0686430B2 (ja) 1994-11-02
DK378085D0 (da) 1985-08-20
GB8520924D0 (en) 1985-09-25
FR2569402A1 (fr) 1986-02-28
JPS6193162A (ja) 1986-05-12
PT81000B (pt) 1988-03-03
FI81568B (fi) 1990-07-31
SA91120277B1 (ar) 2006-05-15
ES8707931A1 (es) 1987-09-01
NL980037I2 (nl) 1999-03-01
ES8707930A1 (es) 1987-09-01
ES8707932A1 (es) 1987-09-01
US5011848A (en) 1991-04-30
GB2164336A (en) 1986-03-19
IE852054L (en) 1986-02-22
ES8703839A1 (es) 1987-03-01
NO1999007I1 (no) 1999-04-23
HU196754B (en) 1989-01-30
ATA245485A (de) 1991-07-15
BG60409B2 (bg) 1995-02-28
CA1268180A (en) 1990-04-24
FI853206A0 (fi) 1985-08-21
SE8503888L (sv) 1986-02-23
NO167142C (no) 1991-10-09
ES552050A0 (es) 1987-09-01
SE8503888D0 (sv) 1985-08-20
NL8502296A (nl) 1986-03-17
DE3529997C2 (de) 1996-01-18
JPH0550506B2 (enExample) 1993-07-29
GR852016B (enExample) 1985-12-19
KR920004482B1 (ko) 1992-06-05
NO167142B (no) 1991-07-01
DK165949B (da) 1993-02-15
IE58486B1 (en) 1993-09-22
NO853293L (no) 1986-02-24
US4801599A (en) 1989-01-31
PH22014A (en) 1988-05-02
DE3529997A1 (de) 1986-03-06
DK378085A (da) 1986-02-23
GB2164336B (en) 1988-06-08
MX159974A (es) 1989-10-17
HUT40625A (en) 1987-01-28
AT394042B (de) 1992-01-27
FI81568C (fi) 1990-11-12
ES8802497A1 (es) 1988-07-01
CH666684A5 (de) 1988-08-15
CS403091A3 (en) 1992-06-17
ES552048A0 (es) 1987-09-01
DK165949C (da) 1993-07-05
AU4657685A (en) 1986-02-27
SE459920B (sv) 1989-08-21
FR2569402B1 (fr) 1989-09-22
BE903103A (fr) 1986-02-24
PT81000A (en) 1985-09-01
CY1494A (en) 1990-02-16
ES552051A0 (es) 1987-09-01
SK278327B6 (en) 1996-11-06
HK52990A (en) 1990-07-20
ES552049A0 (es) 1988-07-01
ES546324A0 (es) 1987-03-01
NZ212895A (en) 1988-07-28

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